DK3309248T3 - Method for manipulating T cells for immunotherapy using an RNA-guided CAS nuclease system - Google Patents

Method for manipulating T cells for immunotherapy using an RNA-guided CAS nuclease system Download PDF

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Publication number
DK3309248T3
DK3309248T3 DK17183472.4T DK17183472T DK3309248T3 DK 3309248 T3 DK3309248 T3 DK 3309248T3 DK 17183472 T DK17183472 T DK 17183472T DK 3309248 T3 DK3309248 T3 DK 3309248T3
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immunotherapy
manipulating
rna
cells
cas nuclease
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DK17183472.4T
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Danish (da)
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Philippe Duchateau
ANDRé CHOULIKA
Laurent Poirot
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Cellectis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2510/00—Genetically modified cells

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DK17183472.4T 2013-05-29 2014-04-01 Method for manipulating T cells for immunotherapy using an RNA-guided CAS nuclease system DK3309248T3 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA201370297 2013-05-29
US201361888259P 2013-10-08 2013-10-08
US201361907874P 2013-11-22 2013-11-22
US201361907858P 2013-11-22 2013-11-22
DKPA201370771 2013-12-13
EP2014051458 2014-01-24
EP14714278.0A EP3004337B1 (en) 2013-05-29 2014-04-01 Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system

Publications (1)

Publication Number Publication Date
DK3309248T3 true DK3309248T3 (en) 2021-08-02

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ID=51988043

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DK14714278.0T DK3004337T3 (en) 2013-05-29 2014-04-01 Method for constructing T cells for immunotherapy using RNA-guided Cas nuclease system
DK17183472.4T DK3309248T3 (en) 2013-05-29 2014-04-01 Method for manipulating T cells for immunotherapy using an RNA-guided CAS nuclease system

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US (1) US9890393B2 (en)
EP (2) EP3309248B1 (en)
JP (1) JP6608807B2 (en)
AU (1) AU2014273490B2 (en)
CA (1) CA2913830C (en)
DK (2) DK3004337T3 (en)
ES (1) ES2645393T3 (en)
WO (1) WO2014191128A1 (en)

Families Citing this family (280)

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