DK3301107T3 - Nye peptider der bindes til typer af mhc klasse ii og deres anvendelse ved diagnosticering og behandling - Google Patents
Nye peptider der bindes til typer af mhc klasse ii og deres anvendelse ved diagnosticering og behandling Download PDFInfo
- Publication number
- DK3301107T3 DK3301107T3 DK17200662.9T DK17200662T DK3301107T3 DK 3301107 T3 DK3301107 T3 DK 3301107T3 DK 17200662 T DK17200662 T DK 17200662T DK 3301107 T3 DK3301107 T3 DK 3301107T3
- Authority
- DK
- Denmark
- Prior art keywords
- diagnostication
- types
- treatment
- mhc class
- peptides binding
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161472122P | 2011-04-05 | 2011-04-05 | |
SE1150297 | 2011-04-05 | ||
EP12768393.6A EP2694530B1 (en) | 2011-04-05 | 2012-04-05 | Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3301107T3 true DK3301107T3 (da) | 2020-05-18 |
Family
ID=46969450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17200662.9T DK3301107T3 (da) | 2011-04-05 | 2012-04-05 | Nye peptider der bindes til typer af mhc klasse ii og deres anvendelse ved diagnosticering og behandling |
Country Status (5)
Country | Link |
---|---|
US (4) | US20150218546A1 (da) |
EP (4) | EP2694530B1 (da) |
DK (1) | DK3301107T3 (da) |
ES (1) | ES2777502T3 (da) |
WO (1) | WO2012138294A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2560012T3 (es) * | 2011-05-10 | 2016-02-17 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos y composiciones farmacéuticas para el tratamiento de enfermedades autoinmunitarias |
GB201214007D0 (en) | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
CN106488932B (zh) * | 2013-12-20 | 2020-07-14 | 财团法人生物技术开发中心 | α-烯醇化酶特异性抗体及其在癌症治疗中的使用方法 |
US9382331B2 (en) * | 2013-12-27 | 2016-07-05 | Development Center For Biotechnology | Alpha-enolase specific antibodies and methods of uses in cancer therapy |
WO2015181393A1 (en) * | 2014-05-30 | 2015-12-03 | Per-Johan Jakobsson | Novel sfti and cyclotide based peptides |
CA2984499A1 (en) * | 2015-05-29 | 2016-12-08 | Arrowhead Pharmaceuticals, Inc. | Biologically cleavable tetrapeptide linking agents |
GB201512703D0 (en) * | 2015-07-20 | 2015-08-26 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520542D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
CN110041404B (zh) * | 2019-04-08 | 2020-10-09 | 北京大学人民医院(北京大学第二临床医学院) | 瓜氨酸化抗原修饰肽及其应用 |
GB201909774D0 (en) * | 2019-07-08 | 2019-08-21 | Apitope Tech Bristol Limited | Method |
EP4021490A4 (en) * | 2019-08-30 | 2023-10-25 | Universidad De Chile | AUTOANTIGEN PEPTIDES (CALVICIFIV), PRESENTED BY TOLEROGENED DENTRIC CELLS, FOR THE PERSONALIZED TREATMENT OF RHEUMATOID ARTHRITIS |
CA3220978A1 (en) * | 2021-06-01 | 2022-12-08 | Lars Klareskog | Novel peptide mimics and their use |
IL310434A (en) | 2021-07-29 | 2024-03-01 | Sonoma Biotherapeutics Inc | A chimeric extracellular matrix-specific antigen receptor from a destroyer to target regulatory T cells for the treatment of autoimmune diseases |
WO2023030407A1 (zh) * | 2021-08-31 | 2023-03-09 | 首都医科大学附属北京同仁医院 | 靶向夏科-莱登结晶蛋白的多肽及其应用 |
WO2023196925A2 (en) * | 2022-04-07 | 2023-10-12 | Guardant Health, Inc. | Methods and systems for allele typing |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08151396A (ja) * | 1994-11-28 | 1996-06-11 | Teijin Ltd | Hla結合性オリゴペプチド及びそれを含有する免疫調節剤 |
WO1996020950A2 (en) * | 1995-01-06 | 1996-07-11 | Immulogic Pharmaceutical Corporation | Compositions and methods for treating rheumatoid arthritis |
US20040226056A1 (en) * | 1998-12-22 | 2004-11-11 | Myriad Genetics, Incorporated | Compositions and methods for treating neurological disorders and diseases |
EP1420806B1 (en) * | 2001-07-12 | 2013-05-01 | Rikard Holmdahl | Antibody detection method using triple polypeptide complexes derived from collagen ii |
NL1019540C2 (nl) | 2001-12-11 | 2003-07-01 | Stichting Tech Wetenschapp | Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit. |
EP1332760A1 (en) * | 2002-02-04 | 2003-08-06 | Academisch Ziekenhuis Leiden | Novel epitopes for celiac disease and autoimmune diseases, methods for detecting those and novel non-antigenic food compounds |
CA2518187A1 (en) * | 2003-03-07 | 2004-09-16 | London Health Sciences Centre Reseach, Inc. | Peptides associated with hla-dr mhc class ii molecules involved in autoimmune diseases |
US7393920B2 (en) | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
DE602005004902T2 (de) * | 2005-06-02 | 2008-10-16 | Entelechon Gmbh | Künstliches Protein, Verfahren für absolute Quantifizierung der Proteine und seine Benutzung |
FI20050814A0 (fi) | 2005-08-11 | 2005-08-11 | Procollagen Oy | Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi |
EP2008100A4 (en) * | 2006-04-18 | 2009-12-16 | Univ Leland Stanford Junior | ESTABLISHING ANTIBODY PROFILES FOR DETERMINING PATIENT SENSITIVITY TO TREATMENT |
WO2007133702A2 (en) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Reagents for the detection of protein acetylation signaling pathways |
US20100047256A1 (en) * | 2007-01-25 | 2010-02-25 | Imperial Innovations Limited | Methods |
WO2008099419A2 (en) * | 2007-02-14 | 2008-08-21 | Council Of Scientific & Industrial Research | Autoantibodies for protein antigens as markers for cancer of gingivo-buccal complex |
US8728744B2 (en) * | 2007-10-26 | 2014-05-20 | The Regents Of The University Of California | Salivary protein biomarkers for human oral cancer |
DE102007059924A1 (de) * | 2007-12-03 | 2009-06-04 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Allel- und Isotyp-spezifische Intervention an mit Autoimmunerkrankungen assoziierten MHC-Klasse-II-Molekülen durch Peptide |
CA2707132A1 (en) | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
WO2010085763A1 (en) * | 2009-01-23 | 2010-07-29 | Inova Diagnostics, Inc. | Methods for detecting antibodies associated with autoimmune diseases utilizing a three dimensionally heterogeneous peptide antigen |
NZ608489A (en) * | 2009-03-30 | 2014-08-29 | Nestec Sa | Citrullinated peptides for diagnosing and prognosing rheumatiod arthritis |
US9695410B2 (en) * | 2010-07-15 | 2017-07-04 | Technion Research & Development Foundation Limited | Isolated high affinity entities with T-cell receptor like specificity towards native complexes of MHC class II and glutamic acid decarboxylase (GAD) autoantigenic peptides |
EP2667888A4 (en) * | 2011-01-28 | 2015-11-11 | Univ Oregon Health & Science | LIGMPHES OF RECOMBINANT T LYMPHOCYTES AND ANTIBODIES BINDING TO LYMPHOCYTES B FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
ES2560012T3 (es) * | 2011-05-10 | 2016-02-17 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos y composiciones farmacéuticas para el tratamiento de enfermedades autoinmunitarias |
-
2012
- 2012-04-05 ES ES15197682T patent/ES2777502T3/es active Active
- 2012-04-05 EP EP12768393.6A patent/EP2694530B1/en active Active
- 2012-04-05 WO PCT/SE2012/050378 patent/WO2012138294A1/en active Application Filing
- 2012-04-05 US US14/009,886 patent/US20150218546A1/en not_active Abandoned
- 2012-04-05 DK DK17200662.9T patent/DK3301107T3/da active
- 2012-04-05 EP EP17200662.9A patent/EP3301107B1/en active Active
- 2012-04-05 EP EP15197682.6A patent/EP3045468B1/en active Active
- 2012-04-05 EP EP18151231.0A patent/EP3412680B1/en active Active
-
2015
- 2015-11-30 US US14/953,484 patent/US10774129B2/en active Active
-
2020
- 2020-05-20 US US16/879,706 patent/US20200277357A1/en active Pending
- 2020-09-08 US US17/014,463 patent/US20200407424A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3045468B1 (en) | 2020-01-15 |
EP3412680B1 (en) | 2020-11-04 |
EP3301107A1 (en) | 2018-04-04 |
US20200277357A1 (en) | 2020-09-03 |
EP2694530A1 (en) | 2014-02-12 |
US20200407424A1 (en) | 2020-12-31 |
WO2012138294A1 (en) | 2012-10-11 |
EP3412680A2 (en) | 2018-12-12 |
US20150218546A1 (en) | 2015-08-06 |
EP3045468A3 (en) | 2016-09-14 |
US10774129B2 (en) | 2020-09-15 |
EP2694530A4 (en) | 2015-03-18 |
US20160130323A1 (en) | 2016-05-12 |
ES2777502T3 (es) | 2020-08-05 |
EP2694530B1 (en) | 2018-02-14 |
EP3045468A2 (en) | 2016-07-20 |
EP3301107B1 (en) | 2020-05-06 |
EP3412680A3 (en) | 2018-12-19 |
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