DK3294073T3 - Systemer og fremgangsmåder til dyrkning af en biofilm af probiotiske bakterier på faste partikler til kolonisering af bakterier i tarmen - Google Patents

Systemer og fremgangsmåder til dyrkning af en biofilm af probiotiske bakterier på faste partikler til kolonisering af bakterier i tarmen Download PDF

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DK3294073T3
DK3294073T3 DK16792262.4T DK16792262T DK3294073T3 DK 3294073 T3 DK3294073 T3 DK 3294073T3 DK 16792262 T DK16792262 T DK 16792262T DK 3294073 T3 DK3294073 T3 DK 3294073T3
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bacteria
biofilm
intestines
cultivating
systems
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DK16792262.4T
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English (en)
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David Baram
Rachel Diamant
David Daboush
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Mybiotics Pharma Ltd
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    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • CCHEMISTRY; METALLURGY
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    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
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    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C12N11/12Cellulose or derivatives thereof
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    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14Enzymes or microbial cells immobilised on or in an inorganic carrier
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/169Plantarum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • A61K2035/115Probiotics

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  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK16792262.4T 2015-05-11 2016-05-09 Systemer og fremgangsmåder til dyrkning af en biofilm af probiotiske bakterier på faste partikler til kolonisering af bakterier i tarmen DK3294073T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562159846P 2015-05-11 2015-05-11
US201562159849P 2015-05-11 2015-05-11
PCT/IB2016/000933 WO2016181228A2 (fr) 2015-05-11 2016-05-09 Systèmes et procédés pour faire croître un biofilm de bactéries probiotiques sur des particules solides pour la colonisation de l'intestin par les bactéries

Publications (1)

Publication Number Publication Date
DK3294073T3 true DK3294073T3 (da) 2022-11-14

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DK16792262.4T DK3294073T3 (da) 2015-05-11 2016-05-09 Systemer og fremgangsmåder til dyrkning af en biofilm af probiotiske bakterier på faste partikler til kolonisering af bakterier i tarmen

Country Status (11)

Country Link
US (4) US10793847B2 (fr)
EP (1) EP3294073B1 (fr)
JP (2) JP6990922B2 (fr)
CN (2) CN114990099A (fr)
AU (1) AU2016259871B2 (fr)
BR (1) BR112017024265B1 (fr)
CA (1) CA2985729C (fr)
DK (1) DK3294073T3 (fr)
ES (1) ES2929893T3 (fr)
IL (2) IL255583B (fr)
WO (1) WO2016181228A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014071182A1 (fr) 2012-11-01 2014-05-08 Massachusetts Institute Of Technology Évolution dirigée d'une batterie de gènes synthétiques
WO2016181228A2 (fr) * 2015-05-11 2016-11-17 Mybiotix Pharma Ltd. Systèmes et procédés pour faire croître un biofilm de bactéries probiotiques sur des particules solides pour la colonisation de l'intestin par les bactéries
MX2018000615A (es) 2015-07-13 2018-08-01 Pivot Bio Inc Metodos y composiciones para mejorar atributos de plantas.
US11479516B2 (en) 2015-10-05 2022-10-25 Massachusetts Institute Of Technology Nitrogen fixation using refactored NIF clusters
RU2018141320A (ru) * 2016-05-25 2020-06-25 Майбиотикс Фарма Лтд. Композиция и способы для микробиотной терапии
WO2017208237A1 (fr) 2016-05-29 2017-12-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Procédé de production de compositions bactériennes
US10707087B2 (en) * 2016-12-28 2020-07-07 Invensas Bonding Technologies, Inc. Processing stacked substrates
CN110799474B (zh) 2017-01-12 2022-07-26 皮沃特生物公司 用于改良植物性状的方法及组合物
EP3630944A4 (fr) * 2017-05-29 2021-03-31 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Procédé de génération de compositions bactériennes comprenant un biofilm avec des bactéries bénéfiques
CA3079955A1 (fr) 2017-10-25 2019-05-02 Pivot Bio, Inc. Methodes et compositions pour ameliorer des microbes genetiquement modifies qui fixent l'azote
CA3103977A1 (fr) 2018-06-27 2020-01-02 Pivot Bio, Inc. Compositions agricoles comprenant des microbes de fixation d'azote remodeles
EP3874022A4 (fr) * 2018-11-01 2022-11-16 Pivot Bio, Inc. Compositions de biofilm à stabilité améliorée pour produits microbiens fixant l'azote
CN110051698A (zh) * 2019-03-18 2019-07-26 天津大学 基于微囊化处理的肠道原生菌基因改造的方法
SG11202110741YA (en) * 2019-03-28 2021-10-28 Mybiotics Pharma Ltd Probiotic biofilm compositions and methods of preparing same
EP4021467A4 (fr) 2019-08-28 2023-09-13 Xbiome Inc. Compositions contenant des espèces bactériennes et méthodes associées
CN111012804B (zh) * 2019-12-16 2022-05-17 南京大学 益生菌矿物材料复合制剂、矿物材料在制备抑制恶性肿瘤生长药物中的应用
IL286748A (en) * 2021-09-27 2023-04-01 Mybiotics Pharma Ltd Antimicrobial preparations and methods for their preparation
WO2023119287A1 (fr) * 2021-12-22 2023-06-29 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) Bactéries nomades et leurs utilisations

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5391113A (en) 1977-01-21 1978-08-10 Meiji Seika Kaisha Ltd Preparation of suppository of antibiotics
US5443826A (en) 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
EP0975285B1 (fr) * 1997-04-01 2008-10-01 CAP Biotechnology, Inc. Microsupports et microspheres a base de phosphate de calcium
JP2003522731A (ja) 1998-12-11 2003-07-29 ウレックス バイオテック インク. 泌尿生殖器感染に対する処置および防止のための乳酸菌の経口投与方法
WO2001044437A1 (fr) 1999-12-17 2001-06-21 Chisso Corporation Incubateur de micro-organismes et milieu de culture de micro-organismes comprenant ledit incubateur
KR100375422B1 (ko) 1999-12-21 2003-03-10 한국과학기술연구원 다공성 키토산 구슬 및 그의 제조 방법
US6599696B2 (en) * 2000-04-17 2003-07-29 University Technologies International, Inc. Effects of materials and surface coatings on encrustation and biofilm formation
FR2808689B1 (fr) 2000-05-11 2004-09-03 Agronomique Inst Nat Rech Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs
US7214370B2 (en) 2000-12-18 2007-05-08 Probiohealth, Llc Prebiotic and preservative uses of oil-emulsified probiotic encapsulations
WO2003042352A1 (fr) 2001-11-16 2003-05-22 Phytoculture Control Co., Ltd. Appareil et procede de culture d'un organisme
US20050186633A9 (en) 2002-05-15 2005-08-25 Christophe Lacroix In vitro gastrointestinal model system and uses thereof
CN1461734A (zh) * 2002-05-30 2003-12-17 上海鸿宝绿色水产科技发展有限公司 微胶囊益生净水复合菌修复水产养殖环境的方法
WO2004011616A2 (fr) 2002-07-26 2004-02-05 The General Hospital Corporation Systemes et procede de conservation des cellules
IL151660A0 (en) 2002-09-09 2003-04-10 Univ Ben Gurion Method for isolating and culturing unculturable microorganisms
GB0330009D0 (en) 2003-12-24 2004-01-28 Ferrosan As Probiotic tablet formulations
ITRM20040166A1 (it) 2004-03-31 2004-06-30 Alberto Cresci Ceppi batterici lab con proprieta' probiotiche e composizioni che contengono gli stessi.
JP4811760B2 (ja) 2004-12-27 2011-11-09 独立行政法人農業・食品産業技術総合研究機構 ダイゼイン資化によるエコール生成能を改善するための腸内細菌およびその利用
EP1776877A1 (fr) 2005-10-21 2007-04-25 N.V. Nutricia Méthode de stimulation de la flore intestinale
CN101351124B (zh) 2005-12-29 2014-09-03 希尔氏宠物营养品公司 用于改变动物的肠道菌群的方法
ITMI20061421A1 (it) 2006-07-20 2008-01-21 Velleja Res Srl Composizioni farmaceutiche topiche vaginali
WO2009017124A1 (fr) * 2007-07-31 2009-02-05 Nihon University Procédé de production d'un biofilm
WO2009092810A2 (fr) 2008-01-24 2009-07-30 Bacterfield Oü Composition pharmaceutique unique contenant des antibiotiques et des probiotiques
CN101368154B (zh) 2008-06-18 2012-02-01 华中农业大学 一种人肠道菌群连续培养的***及方法
WO2010054439A1 (fr) 2008-11-14 2010-05-20 Unistraw Patent Holdings Limited Compositions probiotiques, procédés et appareil pour leur administration
CN101440395A (zh) 2008-12-15 2009-05-27 浙江大学 一种肠道细菌培养方法及其培养基
ZA201107285B (en) * 2009-03-06 2012-12-27 Delivtx Inc Microencapsulated bioactive agents for oral delivery and methods of the thereof
IT1400821B1 (it) 2009-03-09 2013-07-02 Probiotical Spa Sospensione oleosa contenente batteri probiotici per uso pediatrico
GB0906236D0 (en) 2009-04-14 2009-05-20 Univ Gent Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interaction
AU2010240486B2 (en) 2009-04-22 2014-09-18 Ofir Menashe Microorganism comprising particles and uses of same
JP5561642B2 (ja) * 2009-05-14 2014-07-30 株式会社みすずコーポレーション ヨーグルト
US20120129693A1 (en) * 2009-05-28 2012-05-24 Takashi Ano Seed having inoculated with bacterial bilfilm
GB0916335D0 (en) 2009-09-17 2009-10-28 Martin W J Medicaments
TWI461213B (zh) * 2009-11-05 2014-11-21 Fmc Corp 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物
EP2338476B1 (fr) 2009-12-02 2012-06-20 Bettina Heil Suppositoire pour administration rectale, vaginale ou urétrale contenant un probiotique, un antibiotique et un acide gras insaturé non-estérifié
CN101724622B (zh) * 2009-12-07 2011-12-14 天津科技大学 一种干酪乳杆菌微胶囊的制备方法
HRP20220751T1 (hr) 2010-02-01 2022-09-02 Rebiotix, Inc. Bakterioterapija clostridium difficile kolitisa
SG187713A1 (en) 2010-08-04 2013-03-28 Borody Thomas J Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
US9080199B2 (en) 2010-10-29 2015-07-14 The Regents Of The University Of California Method to generate novel bioactive molecules
IT1403661B1 (it) 2011-01-28 2013-10-31 Probiotical Spa Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali.
ES2636439T3 (es) 2011-03-09 2017-10-05 Regents Of The University Of Minnesota Composiciones y métodos para el trasplante de microbiota de colon
US10173937B2 (en) 2011-06-06 2019-01-08 Cool Planet Energy Systems, Inc. Biochar as a microbial carrier
US20130022575A1 (en) 2011-07-19 2013-01-24 Microbial Rx Systems and methods of replacing intestinal flora
JP2013150599A (ja) * 2011-12-27 2013-08-08 Nihon Univ 抗菌物質生産菌と発酵菌を共培養する発酵法
ITMI20120131A1 (it) 2012-02-01 2013-08-02 Probiotical Spa Batteri probiotici microincapsulati multistrato, loro produzione ed uso
CA2914636C (fr) 2013-06-05 2021-04-06 Rebiotix, Inc. Compositions de therapie de retablissement de microbiote (mrt) et procedes de fabrication
DE202013103204U1 (de) 2013-07-17 2013-07-26 Pharmaceutical Biotechnology S.R.O. Präparat, welches eine probiotische Kultur enthält
JP6754694B2 (ja) 2014-03-06 2020-09-16 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル プロバイオティクス製剤および使用のための方法
WO2016181228A2 (fr) 2015-05-11 2016-11-17 Mybiotix Pharma Ltd. Systèmes et procédés pour faire croître un biofilm de bactéries probiotiques sur des particules solides pour la colonisation de l'intestin par les bactéries
RU2580002C1 (ru) 2015-05-19 2016-04-10 Дмитрий Евгеньевич Денисов Способ получения аутопробиотика, содержащего живые бифидобактерии и лактобактерии
CN105193856A (zh) 2015-09-25 2015-12-30 南昌大学 一种人工培养粪便菌群移植在肠道疾病治疗中的应用
WO2017083549A1 (fr) 2015-11-10 2017-05-18 Probiotech Llc Systèmes d'administration de probiotiques
CN109803666A (zh) 2015-11-30 2019-05-24 医迈霖科技公司 包括益生菌的组合物及其使用方法
RU2018141320A (ru) 2016-05-25 2020-06-25 Майбиотикс Фарма Лтд. Композиция и способы для микробиотной терапии
WO2017208237A1 (fr) 2016-05-29 2017-12-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Procédé de production de compositions bactériennes
WO2018013583A2 (fr) 2016-07-11 2018-01-18 The Brigham And Women's Hospital, Inc. Cocktail de lactobacillus vaginal médicinal
US20180030403A1 (en) 2016-07-28 2018-02-01 Bobban Subhadra Devices, systems and methods for the production of humanized gut commensal microbiota
US10258567B1 (en) 2016-11-17 2019-04-16 Grace Procurements Llc Vaginal probiotic products and related processes
US20190209626A1 (en) 2018-01-05 2019-07-11 Human Longevity, Inc. Probiotic compositions comprising bacteria from bacteroids and firmicutes phyla
AU2019247650A1 (en) 2018-04-02 2020-10-29 President And Fellows Of Harvard College Complex human gut microbiome cultured in an anaerobic human gut-on-a-chip
US20230141737A1 (en) 2018-10-22 2023-05-11 Research Institute At Nationwide Children's Hospital Compositions and methods for preventing and treating antibiotic induced pathologies using probiotics in the biofilm state
WO2020180037A1 (fr) 2019-03-04 2020-09-10 경북대학교 산학협력단 Composition pour la culture d'un mimétique du microbiome intestinal humain, procédé de culture d'un mimétique du microbiome intestinal humain à l'aide d'un système de culture anaérobie, agent microbien préparé à l'aide de ce dernier, et son utilisation
CA3130816A1 (fr) 2019-04-15 2020-10-22 Josep M. Sune Negre Composition de microbiote fecal vivant stable a long terme
JP2023527876A (ja) 2020-06-01 2023-06-30 フェリング ベスローテン フェンノートシャップ 膣内微生物叢組成物

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JP2018517430A (ja) 2018-07-05
BR112017024265A2 (pt) 2018-07-24
RU2017143181A (ru) 2019-06-13
US10793847B2 (en) 2020-10-06
EP3294073B1 (fr) 2022-08-10
AU2016259871B2 (en) 2020-04-16
US11680257B2 (en) 2023-06-20
EP3294073A4 (fr) 2019-03-13
AU2016259871A1 (en) 2018-01-04
CA2985729A1 (fr) 2016-11-17
WO2016181228A3 (fr) 2017-01-05
IL255583B (en) 2021-10-31
US20210002627A1 (en) 2021-01-07
CN108135240B (zh) 2022-06-17
JP2021104042A (ja) 2021-07-26
US11001828B2 (en) 2021-05-11
RU2017143181A3 (fr) 2019-10-18
IL287585A (en) 2021-12-01
US20210009985A1 (en) 2021-01-14
WO2016181228A2 (fr) 2016-11-17
CN114990099A (zh) 2022-09-02
EP3294073A2 (fr) 2018-03-21
IL255583A (en) 2018-01-31
CN108135240A (zh) 2018-06-08
US20180355343A1 (en) 2018-12-13
JP6990922B2 (ja) 2022-01-12
BR112017024265B1 (pt) 2022-08-09
US20230227806A1 (en) 2023-07-20
ES2929893T3 (es) 2022-12-02
CA2985729C (fr) 2023-05-09

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