DK3286177T3 - Quinolinderivater som tam rtk-inhibitorer - Google Patents
Quinolinderivater som tam rtk-inhibitorer Download PDFInfo
- Publication number
- DK3286177T3 DK3286177T3 DK16716247.8T DK16716247T DK3286177T3 DK 3286177 T3 DK3286177 T3 DK 3286177T3 DK 16716247 T DK16716247 T DK 16716247T DK 3286177 T3 DK3286177 T3 DK 3286177T3
- Authority
- DK
- Denmark
- Prior art keywords
- rtk inhibitors
- quinolin derivatives
- tam rtk
- tam
- quinolin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147262P | 2015-04-14 | 2015-04-14 | |
| US201562147925P | 2015-04-15 | 2015-04-15 | |
| PCT/EP2016/058284 WO2016166250A1 (en) | 2015-04-14 | 2016-04-14 | Quinoline derivatives as tam rtk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3286177T3 true DK3286177T3 (da) | 2020-06-08 |
Family
ID=55752298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16716247.8T DK3286177T3 (da) | 2015-04-14 | 2016-04-14 | Quinolinderivater som tam rtk-inhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10934274B2 (da) |
| EP (1) | EP3286177B1 (da) |
| JP (2) | JP6654646B2 (da) |
| KR (1) | KR102499359B1 (da) |
| CN (1) | CN107667101B (da) |
| AU (1) | AU2016249860B2 (da) |
| BR (1) | BR112017021929B1 (da) |
| CA (1) | CA2980652C (da) |
| DK (1) | DK3286177T3 (da) |
| ES (1) | ES2807851T3 (da) |
| HK (1) | HK1243707A1 (da) |
| HU (1) | HUE049856T2 (da) |
| IL (1) | IL254898B (da) |
| MX (1) | MX2017013144A (da) |
| MY (1) | MY196078A (da) |
| PH (1) | PH12017501822A1 (da) |
| RU (1) | RU2750727C9 (da) |
| SG (1) | SG11201707638UA (da) |
| WO (1) | WO2016166250A1 (da) |
| ZA (1) | ZA201706380B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10882841B2 (en) | 2016-03-01 | 2021-01-05 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| US20200199096A1 (en) * | 2017-05-11 | 2020-06-25 | Kumiai Chemical Industry Co., Ltd. | Pyrazole-3-carboxylic acid amide derivative and pest control agent |
| CN109896997A (zh) * | 2017-12-08 | 2019-06-18 | 中国药科大学 | N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途 |
| CN112020500A (zh) | 2017-12-22 | 2020-12-01 | 拉文纳制药公司 | 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物 |
| CN112313213B (zh) * | 2018-03-27 | 2023-01-31 | 上海海和药物研究开发股份有限公司 | 3-氨基吡唑类化合物及其应用 |
| IL278960B1 (en) * | 2018-05-30 | 2024-04-01 | Qurient Co Ltd | History of quinoline as inhibitors of AXL/MER RTK and CSF1R |
| BR112021003447A2 (pt) * | 2018-08-24 | 2021-05-18 | Nanjing Transthera Biosciences Co., Ltd. | inibidor derivado de quinolina inovador |
| CN111053771A (zh) * | 2018-10-16 | 2020-04-24 | 正大天晴药业集团股份有限公司 | 用于治疗食道鳞状细胞癌的喹啉类化合物或其药学上可接受的盐 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2023283369A1 (en) * | 2021-07-08 | 2023-01-12 | Vibliome Therapeutics, Llc | Modulators of protein kinases |
| WO2023114809A1 (en) | 2021-12-16 | 2023-06-22 | Kinnate Biopharma Inc. | Inhibitors of met kinase |
| WO2023183444A1 (en) * | 2022-03-24 | 2023-09-28 | Vibliome Therapeutics, Llc | Modulators of protein kinases |
| CN117624128A (zh) * | 2022-08-30 | 2024-03-01 | 药捷安康(南京)科技股份有限公司 | 喹啉衍生物抑制剂的晶型及其制备方法及用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US20080004273A1 (en) | 2006-05-30 | 2008-01-03 | Stephane Raeppel | Inhibitors of protein tyrosine kinase activity |
| EP2423208A1 (en) * | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
| CA2820709C (en) | 2011-02-28 | 2016-02-16 | Sunshine Lake Pharma Co., Ltd. | Substituted quinoline compounds and methods of use |
| HUE033032T2 (hu) | 2011-11-14 | 2017-11-28 | Ignyta Inc | Uracil-származékok mint AXL és c-MET kináz inhibitorok |
-
2016
- 2016-04-14 BR BR112017021929-8A patent/BR112017021929B1/pt active IP Right Grant
- 2016-04-14 AU AU2016249860A patent/AU2016249860B2/en active Active
- 2016-04-14 MX MX2017013144A patent/MX2017013144A/es unknown
- 2016-04-14 CN CN201680022317.2A patent/CN107667101B/zh active Active
- 2016-04-14 CA CA2980652A patent/CA2980652C/en active Active
- 2016-04-14 KR KR1020177032859A patent/KR102499359B1/ko active IP Right Grant
- 2016-04-14 HU HUE16716247A patent/HUE049856T2/hu unknown
- 2016-04-14 WO PCT/EP2016/058284 patent/WO2016166250A1/en active Application Filing
- 2016-04-14 DK DK16716247.8T patent/DK3286177T3/da active
- 2016-04-14 SG SG11201707638UA patent/SG11201707638UA/en unknown
- 2016-04-14 ES ES16716247T patent/ES2807851T3/es active Active
- 2016-04-14 MY MYPI2017703610A patent/MY196078A/en unknown
- 2016-04-14 EP EP16716247.8A patent/EP3286177B1/en active Active
- 2016-04-14 US US15/563,123 patent/US10934274B2/en active Active
- 2016-04-14 RU RU2017139515A patent/RU2750727C9/ru active
- 2016-04-14 JP JP2017553406A patent/JP6654646B2/ja active Active
-
2017
- 2017-09-21 ZA ZA2017/06380A patent/ZA201706380B/en unknown
- 2017-10-03 IL IL254898A patent/IL254898B/en active IP Right Grant
- 2017-10-04 PH PH12017501822A patent/PH12017501822A1/en unknown
-
2018
- 2018-03-08 HK HK18103281.2A patent/HK1243707A1/zh unknown
-
2019
- 2019-10-25 JP JP2019194258A patent/JP2020012001A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2807851T3 (es) | 2021-02-24 |
| HUE049856T2 (hu) | 2020-10-28 |
| JP2020012001A (ja) | 2020-01-23 |
| US20180093968A1 (en) | 2018-04-05 |
| EP3286177A1 (en) | 2018-02-28 |
| KR20170135971A (ko) | 2017-12-08 |
| CA2980652C (en) | 2021-04-27 |
| EP3286177B1 (en) | 2020-05-06 |
| JP2018511624A (ja) | 2018-04-26 |
| BR112017021929A2 (pt) | 2018-07-03 |
| RU2750727C9 (ru) | 2021-08-16 |
| PH12017501822A1 (en) | 2018-04-23 |
| MY196078A (en) | 2023-03-13 |
| IL254898A0 (en) | 2017-12-31 |
| IL254898B (en) | 2020-11-30 |
| KR102499359B1 (ko) | 2023-02-10 |
| US10934274B2 (en) | 2021-03-02 |
| CN107667101B (zh) | 2021-07-30 |
| JP6654646B2 (ja) | 2020-02-26 |
| RU2750727C2 (ru) | 2021-07-01 |
| WO2016166250A1 (en) | 2016-10-20 |
| RU2017139515A3 (da) | 2019-07-17 |
| HK1243707A1 (zh) | 2018-07-20 |
| AU2016249860A1 (en) | 2017-10-12 |
| MX2017013144A (es) | 2018-07-06 |
| CA2980652A1 (en) | 2016-10-20 |
| RU2017139515A (ru) | 2019-05-14 |
| CN107667101A (zh) | 2018-02-06 |
| SG11201707638UA (en) | 2017-10-30 |
| ZA201706380B (en) | 2022-03-30 |
| BR112017021929B1 (pt) | 2023-05-09 |
| AU2016249860B2 (en) | 2019-10-10 |
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