DK3222617T3 - Psma-målretningsforbindelser og anvendelser deraf - Google Patents
Psma-målretningsforbindelser og anvendelser deraf Download PDFInfo
- Publication number
- DK3222617T3 DK3222617T3 DK17169052.2T DK17169052T DK3222617T3 DK 3222617 T3 DK3222617 T3 DK 3222617T3 DK 17169052 T DK17169052 T DK 17169052T DK 3222617 T3 DK3222617 T3 DK 3222617T3
- Authority
- DK
- Denmark
- Prior art keywords
- targeting compounds
- psma targeting
- psma
- compounds
- targeting
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K51/0421—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0472—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/342—Prostate diseases, e.g. BPH, prostatitis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16148409P | 2009-03-19 | 2009-03-19 | |
US16148509P | 2009-03-19 | 2009-03-19 | |
US24806709P | 2009-10-02 | 2009-10-02 | |
US24893409P | 2009-10-06 | 2009-10-06 | |
EP10754194.8A EP2408755B1 (en) | 2009-03-19 | 2010-03-19 | Urea-based peptide compounds useful for detecting inter alia prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3222617T3 true DK3222617T3 (da) | 2022-10-03 |
Family
ID=42740262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17169052.2T DK3222617T3 (da) | 2009-03-19 | 2010-03-19 | Psma-målretningsforbindelser og anvendelser deraf |
Country Status (11)
Country | Link |
---|---|
US (4) | US9056841B2 (da) |
EP (4) | EP3964498A1 (da) |
CA (3) | CA2755965C (da) |
DK (1) | DK3222617T3 (da) |
ES (2) | ES2636618T3 (da) |
HR (1) | HRP20221195T1 (da) |
HU (1) | HUE059796T2 (da) |
LT (1) | LT3222617T (da) |
PL (1) | PL3222617T3 (da) |
PT (1) | PT3222617T (da) |
WO (1) | WO2010108125A2 (da) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI492761B (zh) | 2006-11-08 | 2015-07-21 | Molecular Insight Pharm Inc | 麩胺酸之異二聚物 |
CN104873982A (zh) | 2007-08-17 | 2015-09-02 | 普渡研究基金会 | Psma结合配体-接头缀合物及其使用方法 |
US9422234B2 (en) * | 2007-11-30 | 2016-08-23 | The Johns Hopkins University | Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer |
DK3222617T3 (da) | 2009-03-19 | 2022-10-03 | Univ Johns Hopkins | Psma-målretningsforbindelser og anvendelser deraf |
US20180009767A9 (en) | 2009-03-19 | 2018-01-11 | The Johns Hopkins University | Psma targeted fluorescent agents for image guided surgery |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
WO2012135592A2 (en) | 2011-03-31 | 2012-10-04 | The Johns Hopkins University | Theranostic imaging agents and methods of use |
EP2739316B1 (en) * | 2011-08-05 | 2019-04-10 | Molecular Insight Pharmaceuticals, Inc. | Radiolabeled prostate specific membrane antigen inhibitors |
CA2846629C (en) | 2011-08-25 | 2023-08-01 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising a c-terminal bax peptide |
US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
EP2785712B1 (en) * | 2011-11-30 | 2019-05-01 | The Johns Hopkins University | Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof |
WO2013130177A1 (en) * | 2012-02-28 | 2013-09-06 | Cornell University | Psma as a biomarker for androgen activity in prostate cancer |
EP3858341A1 (en) | 2012-11-15 | 2021-08-04 | Endocyte, Inc. | Psma ligand-containing conjugates for the treatment of prostate cancer |
FR2998298B1 (fr) | 2012-11-21 | 2020-11-20 | Univ Bourgogne | Synthese de sels d’imidazo[1,2-a]pyrazin-4-ium pour la synthese du 1,4,7-triazacyclononane (tacn) et de ses derives n- et/ou c-fonctionnalises |
US9447121B2 (en) * | 2013-01-14 | 2016-09-20 | Molecular Insight Pharmaceuticals, Inc. | Triazine based radiopharmaceuticals and radioimaging agents |
CN105407920B (zh) * | 2013-05-03 | 2019-12-13 | 耶鲁大学 | 靶向癌症、尤其是***癌的合成性抗体模拟化合物(SyAMs) |
WO2015057692A1 (en) * | 2013-10-14 | 2015-04-23 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
KR101947053B1 (ko) | 2013-10-18 | 2019-02-12 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원(psma)의 표지된 억제제, 조영제로서의 이의 용도 및 전립선암 치료용 약제 |
EP3777898A3 (en) * | 2013-11-14 | 2021-04-21 | Endocyte, Inc. | Compounds for positron emission tomography |
WO2015142860A1 (en) * | 2014-03-18 | 2015-09-24 | The Methodist Hospital System | Ph sensitive fluorescent compounds and methods for tumor detection |
EP3140282B1 (en) * | 2014-05-06 | 2019-07-10 | The Johns Hopkins University | Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy |
CA2949365A1 (en) * | 2014-05-16 | 2015-11-19 | Memorial Sloan Kettering Cancer Center | One-step labeling of antibodies to high specific activity with actinium-225 |
US10588972B2 (en) | 2014-06-02 | 2020-03-17 | Li-Cor, Inc. | Phthalocyanine probes and uses thereof |
EP3170003A4 (en) | 2014-07-18 | 2018-03-28 | University of Central Florida Research Foundation, Inc. | Methods and compositions comprising a ct20 peptide |
WO2016030329A1 (en) * | 2014-08-24 | 2016-03-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer |
US10736974B2 (en) * | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
US9886665B2 (en) * | 2014-12-08 | 2018-02-06 | International Business Machines Corporation | Event detection using roles and relationships of entities |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
WO2016176462A1 (en) * | 2015-04-28 | 2016-11-03 | University Of Central Florida Foundation, Inc. | Methods and compositions for theranostic nanoparticles |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
US20180158559A1 (en) * | 2015-06-05 | 2018-06-07 | Ncm Usa Bronx Llc | Method and system for producing gallium-68 radioisotope by solid targeting in a cyclotron |
WO2017021385A1 (en) * | 2015-08-06 | 2017-02-09 | F. Hoffmann-La Roche Ag | Processes for the preparation of galnac acid derivatives |
US20180236109A1 (en) * | 2015-08-20 | 2018-08-23 | Universitat Zu Koln | Pain Tracking by PET-imaging (Pain-TraP) |
US10842887B2 (en) * | 2015-09-09 | 2020-11-24 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
US9808538B2 (en) | 2015-09-09 | 2017-11-07 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
PL3356385T3 (pl) | 2015-09-30 | 2021-06-28 | Deutsches Krebsforschungszentrum | Tagowane 18F inhibitory antygenu błonowego specyficznego dla gruczołu krokowego (PSMA) i ich zastosowanie jako środków do obrazowania w nowotworze gruczołu krokowego |
US10898594B2 (en) | 2015-10-27 | 2021-01-26 | The Johns Hopkins University | PAMAM dendrimer based CEST imaging agents and uses thereof |
US10405753B2 (en) * | 2015-11-10 | 2019-09-10 | Intuitive Surgical Operations, Inc. | Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes |
WO2017084987A1 (en) | 2015-11-16 | 2017-05-26 | F. Hoffmann-La Roche Ag | GalNAc CLUSTER PHOSPHORAMIDITE |
SI3925952T1 (sl) | 2016-03-22 | 2024-03-29 | The Johns Hopkins University | Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate |
US20170296679A1 (en) * | 2016-04-18 | 2017-10-19 | Intuitive Surgical Operations, Inc. | Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands |
US10980902B2 (en) | 2016-07-14 | 2021-04-20 | University Of Central Florida Research Foundation, Inc. | Bi-DOTA complex-loaded dendritic polymer nanoparticles |
MX2019005742A (es) * | 2016-11-23 | 2019-09-13 | Cancer Targeted Tech Llc | Inhibidores de antigeno de membrana especifico de la prostata (psma) de union a albumina. |
US10975060B2 (en) | 2016-11-28 | 2021-04-13 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
WO2018136681A1 (en) | 2017-01-20 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Rotatable surgical table |
JP7373998B2 (ja) | 2017-05-02 | 2023-11-06 | コーネル・ユニバーシティー | 有効性がより大きくかつ毒性がより少ない腫瘍標的指向方法及び試薬 |
WO2018215049A1 (en) | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
US11478558B2 (en) | 2017-05-30 | 2022-10-25 | The Johns Hopkins University | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer |
EP3634474A1 (en) | 2017-06-09 | 2020-04-15 | GEMoaB Monoclonals GmbH | Targeting modules for universal chimeric antigen receptor expressing immune cells and use in the treatment of cancer infections and autoimmune disorders |
WO2018232280A1 (en) * | 2017-06-15 | 2018-12-20 | The Johns Hopkins University | Psma targeted fluorescent agents for image guided surgery |
EP3668518A1 (en) | 2017-08-18 | 2020-06-24 | Li-Cor, Inc. | Sonodynamic therapy |
JP2021500373A (ja) | 2017-10-23 | 2021-01-07 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 線維芽細胞活性化タンパク質α(FAP−α)を標的とする撮像剤および放射線療法用薬剤 |
JP2021502399A (ja) | 2017-11-13 | 2021-01-28 | ドイチェス クレブスフォルシュンクスツェントルム | 分子イメージングのための二重標識プローブ及びその使用 |
CN111356482A (zh) * | 2017-11-21 | 2020-06-30 | 德国癌症研究中心 | 用于分子成像的双标记的探针及其用途 |
JP2021513542A (ja) | 2018-02-06 | 2021-05-27 | ザ・ジョンズ・ホプキンス・ユニバーシティ | がん放射線治療法のための、psmaをターゲットとした放射性ハロゲン化した尿素‐ポリアミノカルボン酸塩 |
WO2019183633A1 (en) | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
EP3781019A4 (en) * | 2018-04-17 | 2022-04-13 | Cornell University | FLUORINE-18 LABELED COMPOSITIONS AND THEIR USE IN BIOLOGICAL TISSUE IMAGING |
WO2020028323A1 (en) * | 2018-07-30 | 2020-02-06 | The Johns Hopkins Universtiy | Competitive prostate-specific membrane antigen (psma) binding agents for the reduction of non-target organ uptake of radiolabeled psma inhibitors for psma positive tumor imaging and radiopharmaceutical therapy |
EP3636635A1 (en) | 2018-10-11 | 2020-04-15 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Imaging agents |
PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
BR112021015109A2 (pt) | 2019-01-30 | 2022-01-11 | Coherent Biopharma Suzhou Ltd | Conjugado de fármaco-ligante duplo e uso do mesmo |
CN113117100B (zh) * | 2019-12-31 | 2024-03-01 | 广东精观生物医药科技有限公司 | 一种靶向psma的荧光分子探针及其制备方法和应用 |
EP4185336A1 (en) * | 2020-07-23 | 2023-05-31 | Technische Universität München | Silicon-containing ligand compounds |
EP4244216A1 (en) | 2020-11-12 | 2023-09-20 | ABX Advanced Biochemical Compounds GmbH | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks |
JP2024513906A (ja) | 2021-04-07 | 2024-03-27 | センチュリー セラピューティクス,インコーポレイテッド | 人工多能性幹細胞からアルファ-ベータt細胞を生成するための組成物および方法 |
WO2022216514A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells |
CA3214661A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof |
WO2023240147A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Genetically engineered cells expressing cd16 variants and nkg2d and uses thereof |
WO2024064969A2 (en) | 2022-09-23 | 2024-03-28 | Nuclidium Ag | High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9704186D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
US6159657A (en) | 1999-08-31 | 2000-12-12 | Eastman Kodak Company | Thermal imaging composition and member containing sulfonated ir dye and methods of imaging and printing |
JP2004509152A (ja) | 2000-05-12 | 2004-03-25 | ユニバーシティ ホスピタル | 放射性金属標識分子のプロキレート剤 |
US6663847B1 (en) | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
BR0115584A (pt) | 2000-11-24 | 2003-09-23 | Breath Ltd | Esterilização de produtos farmacêuticos |
CA2473289C (en) | 2002-01-10 | 2014-07-29 | The Johns Hopkins University | Asymmetric urea compounds useful as naaladase and psma imaging agents |
FR2903952B1 (fr) | 2006-07-21 | 2009-06-12 | Renault Sas | Dispositif et procede de surveillance de la commande du braquage de roue arriere directrice. |
WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
WO2009002529A2 (en) * | 2007-06-26 | 2008-12-31 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents |
CN104873982A (zh) | 2007-08-17 | 2015-09-02 | 普渡研究基金会 | Psma结合配体-接头缀合物及其使用方法 |
US9422234B2 (en) * | 2007-11-30 | 2016-08-23 | The Johns Hopkins University | Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer |
JP2009169768A (ja) | 2008-01-17 | 2009-07-30 | Fuji Xerox Co Ltd | 情報処理装置及びプログラム |
WO2010065899A2 (en) * | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
US20180009767A9 (en) | 2009-03-19 | 2018-01-11 | The Johns Hopkins University | Psma targeted fluorescent agents for image guided surgery |
DK3222617T3 (da) | 2009-03-19 | 2022-10-03 | Univ Johns Hopkins | Psma-målretningsforbindelser og anvendelser deraf |
EP2785712B1 (en) * | 2011-11-30 | 2019-05-01 | The Johns Hopkins University | Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof |
EP3601724A4 (en) | 2017-03-28 | 2020-12-23 | Baker Hughes, a GE company, LLC | WIRE ROPE, IN PARTICULAR WITH SELF-SUPPORTING ROPE |
-
2010
- 2010-03-19 DK DK17169052.2T patent/DK3222617T3/da active
- 2010-03-19 LT LTEP17169052.2T patent/LT3222617T/lt unknown
- 2010-03-19 ES ES10754194.8T patent/ES2636618T3/es active Active
- 2010-03-19 CA CA2755965A patent/CA2755965C/en active Active
- 2010-03-19 EP EP21198593.2A patent/EP3964498A1/en active Pending
- 2010-03-19 CA CA3131469A patent/CA3131469A1/en active Pending
- 2010-03-19 PL PL17169052.2T patent/PL3222617T3/pl unknown
- 2010-03-19 HR HRP20221195TT patent/HRP20221195T1/hr unknown
- 2010-03-19 PT PT171690522T patent/PT3222617T/pt unknown
- 2010-03-19 EP EP21198449.7A patent/EP3964502A1/en active Pending
- 2010-03-19 ES ES17169052T patent/ES2928480T3/es active Active
- 2010-03-19 WO PCT/US2010/028020 patent/WO2010108125A2/en active Application Filing
- 2010-03-19 US US13/257,499 patent/US9056841B2/en active Active
- 2010-03-19 CA CA3035532A patent/CA3035532C/en active Active
- 2010-03-19 HU HUE17169052A patent/HUE059796T2/hu unknown
- 2010-03-19 EP EP17169052.2A patent/EP3222617B1/en active Active
- 2010-03-19 EP EP10754194.8A patent/EP2408755B1/en active Active
-
2014
- 2014-04-02 US US14/243,535 patent/US9776977B2/en active Active
-
2022
- 2022-04-12 US US17/718,812 patent/US11661402B2/en active Active
- 2022-11-04 US US18/052,804 patent/US20230348405A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230348405A1 (en) | 2023-11-02 |
PT3222617T (pt) | 2022-09-30 |
US20220259161A1 (en) | 2022-08-18 |
CA2755965C (en) | 2019-04-16 |
EP3964502A1 (en) | 2022-03-09 |
EP3222617B1 (en) | 2022-07-06 |
LT3222617T (lt) | 2022-10-25 |
WO2010108125A3 (en) | 2011-03-24 |
CA3035532C (en) | 2021-10-26 |
US9056841B2 (en) | 2015-06-16 |
EP2408755A2 (en) | 2012-01-25 |
WO2010108125A2 (en) | 2010-09-23 |
EP2408755B1 (en) | 2017-05-03 |
EP2408755A4 (en) | 2012-09-12 |
US11661402B2 (en) | 2023-05-30 |
CA3131469A1 (en) | 2010-09-23 |
PL3222617T3 (pl) | 2023-01-02 |
EP3222617A1 (en) | 2017-09-27 |
HUE059796T2 (hu) | 2022-12-28 |
US20120009121A1 (en) | 2012-01-12 |
US9776977B2 (en) | 2017-10-03 |
US20150104387A1 (en) | 2015-04-16 |
HRP20221195T1 (hr) | 2022-12-09 |
CA2755965A1 (en) | 2010-09-23 |
ES2928480T3 (es) | 2022-11-18 |
ES2636618T3 (es) | 2017-10-06 |
EP3964498A1 (en) | 2022-03-09 |
CA3035532A1 (en) | 2010-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3222617T3 (da) | Psma-målretningsforbindelser og anvendelser deraf | |
DK2437790T3 (da) | Konjugeringsfremgangsmåder | |
DK2462134T3 (da) | N1-sulfonyl-5-fluorpyrimidinonderivater | |
DK2414015T3 (da) | Laryngoskopsystem | |
DE112010004215A5 (de) | Hydrostataktor | |
DE112010002949A5 (de) | Kupplungstastpunkte | |
DK2411442T4 (da) | Umættet polyesterresin | |
BRPI1008827A2 (pt) | deisobutenizador | |
DK2430035T3 (da) | Uracylspipooxetannukleosider | |
BRPI1014968A2 (pt) | subalargador | |
DE112010002728A5 (de) | Turboinhalator | |
DE112009005323A5 (de) | Hebelarmprüfmaschine | |
DE112010004249A5 (de) | Spindelaktor | |
DE112009005462T8 (de) | Lenkungsssteuervorrichtung | |
BR112012004964A2 (pt) | girocóptero | |
BRPI1008070A2 (pt) | tricianoboratos | |
DK2483126T3 (da) | Skinnekøretøj | |
DE112010004865T8 (de) | Lamellennassreibkupplung | |
DK2506968T3 (da) | Faujasit-zeolit | |
DE112010003255A5 (de) | Fördergutverteiler | |
BRPI1010159A2 (pt) | bistuti | |
DE602010000025D1 (de) | Fahrzeugsitzgurtvorrichtung | |
BRPI0924738A2 (pt) | Herbicidas | |
ES1070429Y (es) | Traspaleta mejorada | |
BR112012003616A2 (pt) | metilpirroloprimidinacarboxamidas |