DK3041946T3 - Fermentative production of oligosaccharides - Google Patents
Fermentative production of oligosaccharides Download PDFInfo
- Publication number
- DK3041946T3 DK3041946T3 DK14842725.5T DK14842725T DK3041946T3 DK 3041946 T3 DK3041946 T3 DK 3041946T3 DK 14842725 T DK14842725 T DK 14842725T DK 3041946 T3 DK3041946 T3 DK 3041946T3
- Authority
- DK
- Denmark
- Prior art keywords
- oligosaccharides
- fermentative production
- fermentative
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01051—Alpha-L-fucosidase (3.2.1.51)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201370498 | 2013-09-06 | ||
| PCT/DK2014/050272 WO2015032412A1 (en) | 2013-09-06 | 2014-09-05 | Fermentative production of oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3041946T3 true DK3041946T3 (da) | 2021-08-23 |
Family
ID=52627834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14842725.5T DK3041946T3 (da) | 2013-09-06 | 2014-09-05 | Fermentative production of oligosaccharides |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9902984B2 (da) |
| EP (1) | EP3041946B1 (da) |
| CN (2) | CN111172220B (da) |
| DK (1) | DK3041946T3 (da) |
| WO (1) | WO2015032412A1 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2931737A4 (en) * | 2012-12-14 | 2016-11-16 | Glycom As | MIXTURE FROM FUCOSYLATE LACTOSES |
| US9902984B2 (en) * | 2013-09-06 | 2018-02-27 | Glycom A/S | Fermentative production of oligosaccharides |
| US10500221B2 (en) | 2014-12-05 | 2019-12-10 | Glycom A/S | Crystalline difucosyllactose |
| WO2017084673A1 (en) | 2015-11-17 | 2017-05-26 | Glycom A/S | Synthetic Composition for Treating Antibiotic Associated Complications |
| US11432578B2 (en) | 2015-12-15 | 2022-09-06 | Glycom A/S | Mixture of HMOs |
| EP3390652A4 (en) | 2015-12-18 | 2019-06-12 | Glycom A/S | Fermentative preparation of oligosaccharides |
| EP3375291B1 (en) | 2017-03-17 | 2022-08-10 | Chr. Hansen HMO GmbH | A method of inhibiting isomerization of a reducing saccharide upon thermal treatment |
| CN110914284A (zh) | 2017-07-12 | 2020-03-24 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| US20210071134A1 (en) * | 2018-04-23 | 2021-03-11 | Dupont Nutrition Biosciences Aps | Increasing activity of 2'fucosyllactose transporters endogenous to microbial cells |
| WO2019209241A1 (en) * | 2018-04-23 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| WO2019222391A1 (en) * | 2018-05-15 | 2019-11-21 | The Board Of Trustees Of The University Of Illinois | Engineered microorganisms for production of 2' fucosyllactose and l-fucose |
| EP3569713A1 (en) | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
| CA3122178A1 (en) | 2018-12-19 | 2020-06-25 | Basf Se | Method for separating biomass from a solution comprising biomass and at least one oligosaccaride |
| US20220081732A1 (en) * | 2019-01-21 | 2022-03-17 | Dupont Nutrition Biosciences Aps | Process for making l-fucose |
| WO2021064629A1 (en) * | 2019-10-01 | 2021-04-08 | Glycom A/S | Separation of neutral oligosaccharides from fermentation broth |
| WO2021094133A2 (en) | 2019-11-13 | 2021-05-20 | Basf Se | Enzymatic hydrolysis of 2',3-difucosyllactose |
| WO2021122103A1 (de) * | 2019-12-18 | 2021-06-24 | Basf Se | Verfahren zur reduktion des säuregehaltes in humanen milcholigosacchariden |
| CN116075517A (zh) | 2020-06-12 | 2023-05-05 | 巴斯夫欧洲公司 | 改进的发酵液的脱矿化与诸如寡糖的精细化学品的纯化 |
| CN113025548B (zh) * | 2021-04-08 | 2023-06-20 | 西南大学 | 基于kosakonia sp.菌株生产2’-岩藻糖基乳糖的重组菌及其方法和应用 |
| CN114480240B (zh) * | 2022-02-22 | 2024-03-26 | 江南大学 | 一种产岩藻糖基乳糖的基因工程菌及生产方法 |
| WO2024123084A1 (ko) * | 2022-12-06 | 2024-06-13 | (주)에이피테크놀로지 | 베타-갈락토시다아제가 발현되도록 형질전환된 재조합 코리네박테리움 글루타미쿰을 이용한 푸코실락토오스의 생산방법 |
| CN117646048A (zh) * | 2023-12-08 | 2024-03-05 | 重庆智合生物医药有限公司 | 一种缩短岩藻多糖发酵时间的生产方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1355347A (en) * | 1970-08-25 | 1974-06-05 | Glaxo Lab Ltd | Recovery of cephalosporin c and derivatives thereof |
| DE3300633A1 (de) | 1982-08-10 | 1984-03-01 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von rhamnose oder fucose |
| US6713287B1 (en) | 1995-10-24 | 2004-03-30 | The Scripps Research Institute | Enzymatic synthesis of L-fucose and L-fucose analogs |
| FR2796082B1 (fr) | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
| US7037378B2 (en) | 2003-09-24 | 2006-05-02 | Danisco Sweetners Oy | Separation of sugars |
| US20100120701A1 (en) * | 2008-09-25 | 2010-05-13 | Glycosyn, Inc. | Compositions and Methods For Engineering Probiotic Yeast |
| IT1392456B1 (it) | 2008-12-18 | 2012-03-09 | Inalco Spa | Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati. |
| CN102257128A (zh) | 2008-12-19 | 2011-11-23 | 詹内怀恩生物技术股份有限公司 | 岩藻糖化化合物的合成 |
| BRPI1013822A2 (pt) | 2009-04-07 | 2015-08-25 | Glycom As | Método para síntese de um trissacarídeo. |
| RU2517602C2 (ru) | 2009-06-08 | 2014-05-27 | Йенневайн Биотехнологи Гмбх | Синтез нмо |
| EP2571891A1 (en) | 2010-05-19 | 2013-03-27 | Glycom A/S | Method for crystallization of fucose |
| IT1405680B1 (it) | 2010-09-13 | 2014-01-24 | Inalco Spa | Processo per la produzione di l-fucosio. |
| EP2479263B1 (en) | 2011-01-20 | 2013-11-27 | Jennewein Biotechnologie GmbH | Novel Fucosyltransferases and their applications |
| DE12746649T1 (de) * | 2011-02-16 | 2016-09-29 | Glycosyn LLC | Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien |
| EP2522232A1 (en) * | 2011-05-13 | 2012-11-14 | Nestec S.A. | Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof |
| US20140235848A1 (en) | 2011-09-30 | 2014-08-21 | Glycom A/S | Method for making a precursor of l-fucose from d-glucose |
| US20140235840A1 (en) | 2011-09-30 | 2014-08-21 | Glycom A/S | New synthesis of fucose |
| WO2013087884A1 (en) | 2011-12-16 | 2013-06-20 | Universiteit Gent | Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides |
| EP2859112A4 (en) * | 2012-06-08 | 2015-10-28 | Glycom As | PROCESS FOR THE PREPARATION OF OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION |
| US9816122B2 (en) * | 2012-09-25 | 2017-11-14 | Glycom A/S | Glycoconjugate synthesis |
| ES2640978T3 (es) * | 2012-10-31 | 2017-11-07 | Jennewein Biotechnologie Gmbh | Proceso de producción de monosacáridos |
| EP2931737A4 (en) * | 2012-12-14 | 2016-11-16 | Glycom As | MIXTURE FROM FUCOSYLATE LACTOSES |
| US9902984B2 (en) * | 2013-09-06 | 2018-02-27 | Glycom A/S | Fermentative production of oligosaccharides |
| EP3154995B1 (en) * | 2014-06-11 | 2023-11-01 | Glycom A/S | Separation of 2'-o-fucosyllactose from fermentation broth |
| CN115279778A (zh) * | 2020-03-12 | 2022-11-01 | 格礼卡姆股份公司 | 2’-fl的结晶 |
-
2014
- 2014-09-05 US US14/915,421 patent/US9902984B2/en active Active
- 2014-09-05 EP EP14842725.5A patent/EP3041946B1/en active Active
- 2014-09-05 CN CN202010058657.9A patent/CN111172220B/zh active Active
- 2014-09-05 DK DK14842725.5T patent/DK3041946T3/da active
- 2014-09-05 CN CN201480048938.9A patent/CN105683387B/zh active Active
- 2014-09-05 WO PCT/DK2014/050272 patent/WO2015032412A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP3041946A1 (en) | 2016-07-13 |
| WO2015032412A1 (en) | 2015-03-12 |
| EP3041946A4 (en) | 2017-09-13 |
| CN105683387A (zh) | 2016-06-15 |
| US20160208302A1 (en) | 2016-07-21 |
| CN111172220A (zh) | 2020-05-19 |
| CN111172220B (zh) | 2023-08-04 |
| CN105683387B (zh) | 2020-02-21 |
| EP3041946B1 (en) | 2021-05-26 |
| US9902984B2 (en) | 2018-02-27 |
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