DK2982681T3 - Wt1-antigenpeptidkonjugatvaccine - Google Patents
Wt1-antigenpeptidkonjugatvaccine Download PDFInfo
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- DK2982681T3 DK2982681T3 DK14775899.9T DK14775899T DK2982681T3 DK 2982681 T3 DK2982681 T3 DK 2982681T3 DK 14775899 T DK14775899 T DK 14775899T DK 2982681 T3 DK2982681 T3 DK 2982681T3
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- Prior art keywords
- peptide
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- amino acid
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Claims (19)
1. Forbindelse vist med formlen (1):
hvor Xa og Ya hver er en enkeltbinding, cancerantigenpeptid A er et peptid bestående af en hvilken som helst aminosyresekvens valgt fra følgende aminosyresekvenser: RMFPNAPYL (SEQ ID NO: 2), ALLPAVPSL (SEQ ID NO: 5), SLGEQQYSV (SEQ ID NO: 6) og RVPGVAPTL (SEQ ID NO: 7), en aminogruppe af en N-terminal aminosyre af cancerantigenpeptid A der binder til Ya i formlen (1), og en carbonylgruppe afen C-terminal aminosyre af cancerantigenpeptid A der binder til en hydroxylgruppe i formlen (1), R1 er et cancerantigenpeptid C, cancerantigenpeptid C har en sekvens forskellig fra den for cancerantigenpeptid A, som er et peptid bestående af en hvilken som helst aminosyresekvens valgt fra følgende aminosyresekvenser: CMTWNQMNL (SEQ ID NO: 3) og CYTWNQMNL (SEQ ID NO: 4), og en thioethergruppe af cysteinresten fra cancerantigenpeptid C er bundet til thioethergruppen i formlen (1), eller et farmaceutisk acceptabelt salt deraf.
2. Forbindelsen ifølge krav 1, hvor forbindelsen vist med formlen (1) er en forbindelse vist med formlen (4):
CRMFPNAPYL I Η) CMTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, eller et farmaceutisk acceptabelt salt deraf.
3. Forbindelsen ifølge krav 1, hvor forbindelsen vist med formlen (1) er en forbindelse vist med formlen (5): CRMFPNAPYL I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, eller et farmaceutisk acceptabelt salt deraf.
4. Farmaceutisk sammensætning omfattende forbindelsen ifølge et hvilket som helst af kravene 1 til 3, eller et farmaceutisk acceptabelt salt deraf, og en farmaceutisk acceptabel bærer.
5. Farmaceutisk sammensætning ifølge krav 4, omfattende mindst ét peptid bestående af en aminosyresekvens valgt fra gruppen bestående af følgende aminosyresekvenser: CNKRYFKLSHLQMHSRK (SEQ ID NO: 22), CNKRYFKLSHLQMHSRKH (SEQ ID NO: 23), CNKRYFKLSHLQMHSRKHTG (SEQ ID NO: 24), WAPVLDFAPPGASAYGSL (SEQ ID NO: 244), CWAPVLDFAPPGASAYGSL (SEQ ID NO: 242) og WAPVLDFAPPGASAYGSLC (SEQ ID NO: 243).
6. Farmaceutisk sammensætning ifølge krav 5, hvor den farmaceutiske sammensætning omfatter forbindelsen vist med formlen (4): CRMFPNAPYL ... I (4} CMTWNQMNL hvor bindingen mellem C og C er en disulfidbinding.
7. Farmaceutisk sammensætning ifølge krav 5, hvor den farmaceutiske sammensætning omfatter forbindelsen vist med formlen (5): CRMFPNAPYL I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding.
8. Farmaceutisk sammensætning ifølge krav 5, hvor den farmaceutiske sammensætning omfatter forbindelsen vist med formlen (4): (^RMFPNAPYL CMTWNQMNL( hvor bindingen mellem C og C er en disulfidbinding, og peptidet bestående af aminosyresekvensen: WAPVLDFAPPGASAYGSL (SEQ ID NO: 244).
9. Farmaceutisk sammensætning ifølge krav 5, hvor den farmaceutiske sammensætning omfatter forbindelsen vist med formlen (5): CRMFPNAPYL ,_4 I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, og peptidet bestående af aminosyresekvensen: WAPVLDFAPPGASAYGSL (SEQ ID NO: 244).
10. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 4-9, til anvendelse i behandlingen af cancer der udtrykker WTl-gen eller cancer associeret med en stigning i WTl-genekspressionsniveauet.
11. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 4-9, til anvendelse i induktionen af CTLs i cellulær immunoterapi af cancer.
12. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 4-9, til anvendelse som en cancervaccine.
13. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 10-12, hvor canceren er hæmatologisk cancer valgt fra leukæmi, myelodysplastisk syndrom, multipel myelom, og malign lymphom, eller fast cancer valgt fra gastrisk cancer, kolorektal cancer, lungecancer, brystcancer, kimcellecancer, levercancer, hudcancer, urinblærecancer, prostatacancer, livmodercancer, livmoderhalscancer, æggestokcancer, og hjernetumor.
14. Sammensætning omfattende en forbindelse valgt fra gruppen bestående af en forbindelse vist med formlen (4): CRMFPNAPYL CMTWNQMNL( hvor bindingen mellem C og C er en disulfidbinding, og en forbindelse vist med formlen (5): CRMFPNAPYL I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, og mindst ét peptid bestående af en aminosyresekvens valgt fra gruppen bestående af følgende aminosyresekvenser: CNKRYFKLSHLQMHSRK (SEQ ID NO: 22), CNKRYFKLSHLQMHSRKH (SEQ ID NO: 23), CNKRYFKLSHLQMHSRKHTG (SEQ ID NO: 24), WAPVLDFAPPGASAYGSL (SEQ ID NO: 244), CWAPVLDFAPPGASAYGSL (SEQ ID NO: 242) og WAPVLDFAPPGASAYGSLC (SEQ ID NO: 243).
15. Sammensætningen ifølge krav 14, hvor sammensætningen omfatter forbindelsen vist med formlen (4): (^RMFPNAPYL CMTWNQMNL W hvor bindingen mellem C og C er en disulfidbinding.
16. Sammensætningen ifølge krav 14, hvor sammensætningen omfatter forbindelsen vist med formlen (5): CRMFPNAPYL I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding.
17. Sammensætningen ifølge et hvilket som helst af kravene 14-16, hvor sammensætningen omfatter mindst ét peptid bestående af en aminosyresekvens valgt fra gruppen bestående af aminosyresekvensens: WAPVLDFAPPGASAYGSL (SEQ ID NO: 244), CWAPVLDFAPPGASAYGSL (SEQ ID NO: 242) og WAPVLDFAPPGASAYGSLC (SEQ ID NO: 243).
18. Sammensætningen ifølge krav 14 omfattende forbindelsen vist med formlen (4): CRMFPNAPYL,,, I (4) CMTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, og et peptid bestående af aminosyresekvensen: WAPVLDFAPPGASAYGSL (SEQ ID NO: 244).
19. Sammensætningen ifølge krav 14 omfattende en forbindelse vist med formlen (5): CRMFPNAPYL I (5) CYTWNQMNL hvor bindingen mellem C og C er en disulfidbinding, og et peptid bestående af aminosyresekvensen: WAPVLDFAPPGASAYGSL (SEQ ID NO: 244).
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