DK2949658T3 - Peptider, som specifikt binder HGF-receptor (cMet) og anvendelser deraf - Google Patents
Peptider, som specifikt binder HGF-receptor (cMet) og anvendelser deraf Download PDFInfo
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- DK2949658T3 DK2949658T3 DK15157779.8T DK15157779T DK2949658T3 DK 2949658 T3 DK2949658 T3 DK 2949658T3 DK 15157779 T DK15157779 T DK 15157779T DK 2949658 T3 DK2949658 T3 DK 2949658T3
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- Prior art keywords
- cmet
- binding
- seq
- polypeptide
- cys
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Classifications
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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Claims (10)
1. Isoleret polypeptid, som binder cMet eller et kompleks omfattende cMet og HGF, hvor polypeptidet omfatter aminosyresekvensen fremsat som GSX1X2X3CX4X5X6X7CX8X9X10APGGK (SEQ ID NO:525), i hvilken XI er F, L, S, W, Y, eller M; X2 er I, Y, Η, T, eller N; X3 er I, L, D, M, F, eller S, fortrinsvis I; X4 er P, R, W, N, eller E, fortrinsvis W eller P; X5 er W, Y, E, P, L, T, eller G; X6 er S, T, D, F, E, W, G, eller Q; X7 er F, W, N, Q, E, R, eller A; X8 er G, N, H, R, M, I, D, V, eller T; X9 er S, K, F, Μ, T, D, eller L; og X10 er S, P, T, L, Y, N, H, Q, eller W;
2. Det isolerede polypeptid ifølge krav 1, hvor polypeptidet omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NOs: 1-10.
3. Det isolerede polypeptid ifølge krav 1 eller krav 2, hvor polypeptidet er multimerisk.
4. Det isolerede polypeptid ifølge et hvilket som helst af kravene 1-3, hvor polypeptidet er konjugeret til et mærke passende til diagnostisk detektion, eventuelt via en linker, til at danne et diagnostisk billeddannelseskontrastmiddel.
5. Det isolerede polypeptid ifølge krav 4, hvor mærket er valgt fra gruppen bestående af et enzym, en fluorescerende forbindelse, et ultralydskontrastmiddel, et liposom og et optisk farvestof.
6. Det isolerede polypeptid ifølge krav 4 eller 5, hvor mærket er: (i) et radioaktivt mærke, som eventuelt er valgt fra gruppen bestående af 18F, 1241, 1251, 1311, 77Br, 76Br, 99mTc, 51Cr, 67Ga, 68Ga, 47Sc, 167Tm, 141Ce, lllln, 168Yb, 175Yb, 140La, 90Y, 88Y, 153Sm, I66H0, 165Dy, 62Cu, 64Cu, 67Cu, 97Ru, 103Ru, 186Re, 188Re, 203Pb, 211ΒΪ, 212ΒΪ, 213ΒΪ, 214ΒΪ, 105Rh, 109Pd, 117mSn, 149Pm, 161 Tb, 177Lu, 198Au og 199 Au, eller (ii) et paramagnetisk metalatom valgt fra gruppen bestående af Gd3+, Mn2+ Cu2+ Fe2+ Co2+, Ni2+, Eu3+, Dy3+, Pr3+, Cr3+, Co3+, Fe3+, Ti3+, Tb3+, Nd3+, Sm3+, Ho3+ , Er3+, Pa4+, og Eu2+.
7. Det isolerede polypeptid ifølge et hvilket som helst af kravene 4-6, hvor polypeptidet er inkorporeret i ultralydsbobler, mikropartikler, mikrokugler, emulsioner, eller liposomer.
8. Isoleret polypeptid som defineret i et hvilket som helst af kravene 4-7, hvor det diagnostiske billeddannelseskontrastmiddel er til anvendelse i in vivo diagnostisk billeddannelse, som involverer at detektere en hyperproliferativ lidelse, angiogenese eller neovaskularisering.
9. Det isolerede polypeptid ifølge krav 8, hvor billeddannelsen er magnetisk resonansbilleddannelse (MRI), ultralydsbilleddannelse, optisk billeddannelse, sonoluminescens billeddannelse, fotoakustisk billeddannelse, røntgenbilleddannelse, eller radionuklid billeddannelse.
10. Fremgangsmåde til oprensning af cMet eller et cMet- og HGF-kompleks fra en opløsning indeholdende denne, hvilken fremgangsmåde omfatter: (a) at bringe opløsningen i kontakt med mindst et polypeptid fremsat i krav 1, som er immobiliseret på et fast substrat, og (b) at separere polypeptidet fra opløsningen.
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US45158803P | 2003-03-03 | 2003-03-03 | |
EP10185426.3A EP2284180B1 (en) | 2003-03-03 | 2004-03-03 | Uses of peptides that specifically bind HGF receptor (cMET) |
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DK15157779.8T DK2949658T3 (da) | 2003-03-03 | 2004-03-03 | Peptider, som specifikt binder HGF-receptor (cMet) og anvendelser deraf |
DK10185426.3T DK2284180T3 (da) | 2003-03-03 | 2004-03-03 | Anvendelser af peptider, som specifikt binder sig til HGF-receptor (cMET) |
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