DK2914748T3 - Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal - Google Patents
Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal Download PDFInfo
- Publication number
- DK2914748T3 DK2914748T3 DK13850210.9T DK13850210T DK2914748T3 DK 2914748 T3 DK2914748 T3 DK 2914748T3 DK 13850210 T DK13850210 T DK 13850210T DK 2914748 T3 DK2914748 T3 DK 2914748T3
- Authority
- DK
- Denmark
- Prior art keywords
- human
- predicting
- evolution
- toxicity
- cells
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
- G01N23/225—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion
- G01N23/2255—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion using incident ion beams, e.g. proton beams
- G01N23/2258—Measuring secondary ion emission, e.g. secondary ion mass spectrometry [SIMS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261721746P | 2012-11-02 | 2012-11-02 | |
US201361827407P | 2013-05-24 | 2013-05-24 | |
PCT/US2013/067980 WO2014071137A1 (en) | 2012-11-02 | 2013-11-01 | Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2914748T3 true DK2914748T3 (da) | 2019-06-11 |
Family
ID=50628081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13850210.9T DK2914748T3 (da) | 2012-11-02 | 2013-11-01 | Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal |
Country Status (9)
Country | Link |
---|---|
US (3) | US20150301025A1 (da) |
EP (1) | EP2914748B1 (da) |
JP (2) | JP6339581B2 (da) |
CN (1) | CN104822843B (da) |
CA (1) | CA2888064C (da) |
DK (1) | DK2914748T3 (da) |
HU (1) | HUE043604T2 (da) |
MX (1) | MX362991B (da) |
WO (1) | WO2014071137A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2016000293A (es) * | 2013-07-09 | 2016-06-21 | Stemina Biomarker Discovery Inc | Biomarcadores del trastrono del espectro autista. |
FI126398B (en) | 2014-12-18 | 2016-11-15 | Upm Kymmene Corp | Procedure for testing chemicals |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN109207551B (zh) * | 2017-07-07 | 2023-05-26 | 上海睿智化学研究有限公司 | 一种筛选叶酸代谢相关药物的方法 |
EP3762715A4 (en) * | 2018-03-09 | 2022-08-10 | Stemina Biomarker Discovery, Inc. | IN VITRO CARDIOTOXICITY PREDICTION TEST |
CN116547722A (zh) * | 2020-11-30 | 2023-08-04 | 赛诺菲 | 剂量-反应图的图像分类 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
KR20080014775A (ko) * | 2005-05-13 | 2008-02-14 | 렉시컨 파마슈티컬스 인코퍼레이티드 | 다환 화합물 및 그의 사용 방법 |
BRPI0710054B8 (pt) * | 2006-04-10 | 2021-07-27 | Wisconsin Alumni Res Found | métodos para identificar um ou uma pluralidade de metabólitos celulares, para triar um composto de teste, e, para testar um composto de teste |
HUE039900T2 (hu) * | 2010-03-22 | 2019-02-28 | Stemina Biomarker Discovery Inc | Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával |
CA2798132A1 (en) * | 2010-05-14 | 2011-11-17 | Deseret Biologicals, Inc. | Formulations of diluted genetic material and methods for making same |
US9447506B2 (en) | 2012-07-30 | 2016-09-20 | David Whitmore | Cathodic protection of a concrete structure |
-
2013
- 2013-11-01 EP EP13850210.9A patent/EP2914748B1/en active Active
- 2013-11-01 JP JP2015540802A patent/JP6339581B2/ja active Active
- 2013-11-01 US US14/439,723 patent/US20150301025A1/en not_active Abandoned
- 2013-11-01 WO PCT/US2013/067980 patent/WO2014071137A1/en active Application Filing
- 2013-11-01 CN CN201380057328.0A patent/CN104822843B/zh active Active
- 2013-11-01 HU HUE13850210A patent/HUE043604T2/hu unknown
- 2013-11-01 MX MX2015005476A patent/MX362991B/es unknown
- 2013-11-01 DK DK13850210.9T patent/DK2914748T3/da active
- 2013-11-01 CA CA2888064A patent/CA2888064C/en active Active
-
2017
- 2017-12-20 US US15/848,188 patent/US10209240B2/en active Active
-
2018
- 2018-05-10 JP JP2018091559A patent/JP6581244B2/ja active Active
- 2018-12-18 US US16/224,150 patent/US20190128872A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX362991B (es) | 2019-03-01 |
US20180128814A1 (en) | 2018-05-10 |
CN104822843A (zh) | 2015-08-05 |
CN104822843B (zh) | 2020-01-21 |
JP6581244B2 (ja) | 2019-09-25 |
HUE043604T2 (hu) | 2019-08-28 |
MX2015005476A (es) | 2015-10-29 |
EP2914748B1 (en) | 2019-03-13 |
JP2018157823A (ja) | 2018-10-11 |
US10209240B2 (en) | 2019-02-19 |
US20190128872A1 (en) | 2019-05-02 |
CA2888064A1 (en) | 2014-05-08 |
JP6339581B2 (ja) | 2018-06-06 |
WO2014071137A1 (en) | 2014-05-08 |
JP2016501516A (ja) | 2016-01-21 |
EP2914748A4 (en) | 2016-06-01 |
CA2888064C (en) | 2023-05-30 |
EP2914748A1 (en) | 2015-09-09 |
US20150301025A1 (en) | 2015-10-22 |
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