DK2914748T3 - Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal - Google Patents

Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal Download PDF

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Publication number
DK2914748T3
DK2914748T3 DK13850210.9T DK13850210T DK2914748T3 DK 2914748 T3 DK2914748 T3 DK 2914748T3 DK 13850210 T DK13850210 T DK 13850210T DK 2914748 T3 DK2914748 T3 DK 2914748T3
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Denmark
Prior art keywords
human
predicting
evolution
toxicity
cells
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DK13850210.9T
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English (en)
Inventor
Alan Smith
Paul West
Jessica Palmer
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Stemina Biomarker Discovery Inc
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Publication of DK2914748T3 publication Critical patent/DK2914748T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • G01N33/6815Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/225Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion
    • G01N23/2255Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion using incident ion beams, e.g. proton beams
    • G01N23/2258Measuring secondary ion emission, e.g. secondary ion mass spectrometry [SIMS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK13850210.9T 2012-11-02 2013-11-01 Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal DK2914748T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721746P 2012-11-02 2012-11-02
US201361827407P 2013-05-24 2013-05-24
PCT/US2013/067980 WO2014071137A1 (en) 2012-11-02 2013-11-01 Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios

Publications (1)

Publication Number Publication Date
DK2914748T3 true DK2914748T3 (da) 2019-06-11

Family

ID=50628081

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13850210.9T DK2914748T3 (da) 2012-11-02 2013-11-01 Forudsigelse af udviklingen af toxicitet af farmaceutika for mennesker, under anvendelse af humane stamcellelignende celler og metaboliske forholdstal

Country Status (9)

Country Link
US (3) US20150301025A1 (da)
EP (1) EP2914748B1 (da)
JP (2) JP6339581B2 (da)
CN (1) CN104822843B (da)
CA (1) CA2888064C (da)
DK (1) DK2914748T3 (da)
HU (1) HUE043604T2 (da)
MX (1) MX362991B (da)
WO (1) WO2014071137A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016000293A (es) * 2013-07-09 2016-06-21 Stemina Biomarker Discovery Inc Biomarcadores del trastrono del espectro autista.
FI126398B (en) 2014-12-18 2016-11-15 Upm Kymmene Corp Procedure for testing chemicals
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN109207551B (zh) * 2017-07-07 2023-05-26 上海睿智化学研究有限公司 一种筛选叶酸代谢相关药物的方法
EP3762715A4 (en) * 2018-03-09 2022-08-10 Stemina Biomarker Discovery, Inc. IN VITRO CARDIOTOXICITY PREDICTION TEST
CN116547722A (zh) * 2020-11-30 2023-08-04 赛诺菲 剂量-反应图的图像分类

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
KR20080014775A (ko) * 2005-05-13 2008-02-14 렉시컨 파마슈티컬스 인코퍼레이티드 다환 화합물 및 그의 사용 방법
BRPI0710054B8 (pt) * 2006-04-10 2021-07-27 Wisconsin Alumni Res Found métodos para identificar um ou uma pluralidade de metabólitos celulares, para triar um composto de teste, e, para testar um composto de teste
HUE039900T2 (hu) * 2010-03-22 2019-02-28 Stemina Biomarker Discovery Inc Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával
CA2798132A1 (en) * 2010-05-14 2011-11-17 Deseret Biologicals, Inc. Formulations of diluted genetic material and methods for making same
US9447506B2 (en) 2012-07-30 2016-09-20 David Whitmore Cathodic protection of a concrete structure

Also Published As

Publication number Publication date
MX362991B (es) 2019-03-01
US20180128814A1 (en) 2018-05-10
CN104822843A (zh) 2015-08-05
CN104822843B (zh) 2020-01-21
JP6581244B2 (ja) 2019-09-25
HUE043604T2 (hu) 2019-08-28
MX2015005476A (es) 2015-10-29
EP2914748B1 (en) 2019-03-13
JP2018157823A (ja) 2018-10-11
US10209240B2 (en) 2019-02-19
US20190128872A1 (en) 2019-05-02
CA2888064A1 (en) 2014-05-08
JP6339581B2 (ja) 2018-06-06
WO2014071137A1 (en) 2014-05-08
JP2016501516A (ja) 2016-01-21
EP2914748A4 (en) 2016-06-01
CA2888064C (en) 2023-05-30
EP2914748A1 (en) 2015-09-09
US20150301025A1 (en) 2015-10-22

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