DK3351620T3 - Metabolsk optimeret cellekultur - Google Patents

Metabolsk optimeret cellekultur Download PDF

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Publication number
DK3351620T3
DK3351620T3 DK18161278.9T DK18161278T DK3351620T3 DK 3351620 T3 DK3351620 T3 DK 3351620T3 DK 18161278 T DK18161278 T DK 18161278T DK 3351620 T3 DK3351620 T3 DK 3351620T3
Authority
DK
Denmark
Prior art keywords
metabolic
cell culture
optimized cell
optimized
culture
Prior art date
Application number
DK18161278.9T
Other languages
English (en)
Inventor
Shawn Lawrence
Ann Kim
Amy Johnson
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52813657&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3351620(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3351620T3 publication Critical patent/DK3351620T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production
DK18161278.9T 2013-10-11 2014-10-10 Metabolsk optimeret cellekultur DK3351620T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361889815P 2013-10-11 2013-10-11
EP14851841.8A EP3055409B1 (en) 2013-10-11 2014-10-10 Metabolically optimized cell culture

Publications (1)

Publication Number Publication Date
DK3351620T3 true DK3351620T3 (da) 2020-10-26

Family

ID=52813657

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18161278.9T DK3351620T3 (da) 2013-10-11 2014-10-10 Metabolsk optimeret cellekultur
DK14851841.8T DK3055409T3 (da) 2013-10-11 2014-10-10 Metabolisk optimeret cellekultur

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14851841.8T DK3055409T3 (da) 2013-10-11 2014-10-10 Metabolisk optimeret cellekultur

Country Status (18)

Country Link
US (2) US20160244725A1 (da)
EP (3) EP3812453A1 (da)
JP (3) JP6663854B2 (da)
KR (4) KR102510238B1 (da)
CN (2) CN105637085A (da)
AU (2) AU2014331776B2 (da)
CA (1) CA2926049C (da)
DK (2) DK3351620T3 (da)
EA (2) EA201991976A1 (da)
ES (2) ES2678945T3 (da)
HK (2) HK1223122A1 (da)
HU (2) HUE039551T2 (da)
IL (2) IL244511A0 (da)
MX (2) MX2016004564A (da)
PL (2) PL3055409T3 (da)
SG (2) SG11201601681QA (da)
WO (1) WO2015054554A1 (da)
ZA (1) ZA201601550B (da)

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KR102510238B1 (ko) 2013-10-11 2023-03-16 리제너론 파마슈티칼스 인코포레이티드 대사적으로 최적화된 세포 배양
US20160244726A1 (en) * 2013-10-11 2016-08-25 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
JP7260011B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260020B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260018B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7310947B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7272480B2 (ja) * 2017-04-27 2023-05-12 株式会社三洋物産 遊技機
JP7260021B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7310945B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7260012B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7310952B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7260009B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7260013B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
CN111344558A (zh) 2017-10-06 2020-06-26 龙沙有限公司 使用拉曼光谱法自动控制细胞培养
EP4039786A1 (en) 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use
US20200385673A1 (en) * 2017-11-30 2020-12-10 Hoffmann-La Roche Inc. Process for culturing mammalian cells
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
JP2020151559A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
JP2020151560A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機

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US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
US6165741A (en) 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
DE60211329T2 (de) 2001-01-16 2007-05-24 Regeneron Pharmaceuticals, Inc. Isolierung von sezernierte proteine exprimierenden zellen
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
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US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
ES2344789T5 (es) 2003-05-15 2017-06-14 Wyeth Llc Alimentación restringida de glucosa para el cultivo de células animales
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US7335491B2 (en) 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI364458B (en) * 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
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MX2009004519A (es) 2006-11-03 2009-05-12 Wyeth Corp Sustancias que inhiben la glucolisis en un cultivo de celulas.
EP2150617B1 (en) 2007-06-04 2014-10-22 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
EP3327132A3 (en) 2007-08-09 2018-07-18 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
US20090325287A1 (en) * 2008-06-13 2009-12-31 Haimanti Dorai Methods for Obtaining High Viable Cell Density in Mammalian Cell Culture
US8470552B2 (en) * 2009-10-12 2013-06-25 Keck Graduate Institute Strategy to reduce lactic acid production and control PH in animal cell culture
SG185038A1 (en) * 2010-04-26 2012-11-29 Novartis Ag Improved cell culture medium
WO2011150241A2 (en) * 2010-05-28 2011-12-01 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
KR102510238B1 (ko) 2013-10-11 2023-03-16 리제너론 파마슈티칼스 인코포레이티드 대사적으로 최적화된 세포 배양

Also Published As

Publication number Publication date
KR20160062032A (ko) 2016-06-01
CN105637085A (zh) 2016-06-01
ES2833471T3 (es) 2021-06-15
SG10201800772TA (en) 2018-03-28
EA201690600A1 (ru) 2016-09-30
ZA201601550B (en) 2023-05-31
AU2014331776B2 (en) 2020-10-22
CN114717196A (zh) 2022-07-08
JP7377243B2 (ja) 2023-11-09
KR20230038324A (ko) 2023-03-17
KR20220020415A (ko) 2022-02-18
EP3055409A4 (en) 2016-09-28
KR20210046835A (ko) 2021-04-28
JP2016532457A (ja) 2016-10-20
AU2021200193A1 (en) 2021-03-18
MX2016004564A (es) 2016-07-12
DK3055409T3 (da) 2018-07-30
HK1223122A1 (zh) 2017-07-21
US20210087535A1 (en) 2021-03-25
KR102243980B1 (ko) 2021-04-26
EP3055409B1 (en) 2018-04-25
KR102358807B1 (ko) 2022-02-08
IL262833A (en) 2018-12-31
ES2678945T3 (es) 2018-08-21
JP6663854B2 (ja) 2020-03-13
EP3812453A1 (en) 2021-04-28
PL3055409T3 (pl) 2018-10-31
EA033783B1 (ru) 2019-11-25
AU2014331776A1 (en) 2016-03-24
EP3351620A1 (en) 2018-07-25
KR102610425B1 (ko) 2023-12-06
CA2926049A1 (en) 2015-04-16
EA201991976A1 (ru) 2020-04-02
EP3351620B1 (en) 2020-09-02
US20160244725A1 (en) 2016-08-25
IL244511A0 (en) 2016-04-21
HUE051049T2 (hu) 2021-01-28
EP3055409A1 (en) 2016-08-17
CA2926049C (en) 2023-09-05
JP2022009453A (ja) 2022-01-14
AU2021200193B2 (en) 2023-08-24
JP2020072760A (ja) 2020-05-14
HK1253275A1 (zh) 2019-06-14
KR102510238B1 (ko) 2023-03-16
MX2020011334A (es) 2021-07-30
PL3351620T3 (pl) 2021-03-08
HUE039551T2 (hu) 2019-01-28
WO2015054554A1 (en) 2015-04-16
JP6967620B2 (ja) 2021-11-17
SG11201601681QA (en) 2016-04-28

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