DK2861223T3 - Sammensætninger og metoder til transmukosal absorption - Google Patents

Sammensætninger og metoder til transmukosal absorption Download PDF

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Publication number
DK2861223T3
DK2861223T3 DK13804115.7T DK13804115T DK2861223T3 DK 2861223 T3 DK2861223 T3 DK 2861223T3 DK 13804115 T DK13804115 T DK 13804115T DK 2861223 T3 DK2861223 T3 DK 2861223T3
Authority
DK
Denmark
Prior art keywords
compositions
methods
transmucosal absorption
transmucosal
absorption
Prior art date
Application number
DK13804115.7T
Other languages
English (en)
Inventor
Harry Brittain
Giorgio Reiner
Seth Lederman
Original Assignee
Tonix Pharma Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tonix Pharma Holdings Ltd filed Critical Tonix Pharma Holdings Ltd
Application granted granted Critical
Publication of DK2861223T3 publication Critical patent/DK2861223T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
DK13804115.7T 2012-06-15 2013-06-14 Sammensætninger og metoder til transmukosal absorption DK2861223T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261660593P 2012-06-15 2012-06-15
US201261667774P 2012-07-03 2012-07-03
US201261725402P 2012-11-12 2012-11-12
US201361792900P 2013-03-15 2013-03-15
PCT/US2013/046023 WO2013188847A1 (en) 2012-06-15 2013-06-14 Compositions and methods for transmucosal absorption

Publications (1)

Publication Number Publication Date
DK2861223T3 true DK2861223T3 (da) 2022-11-07

Family

ID=49758769

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13804115.7T DK2861223T3 (da) 2012-06-15 2013-06-14 Sammensætninger og metoder til transmukosal absorption

Country Status (26)

Country Link
US (1) US20140171515A1 (da)
EP (1) EP2861223B1 (da)
JP (5) JP6259452B2 (da)
CN (2) CN104684550A (da)
AR (1) AR092330A1 (da)
AU (2) AU2013274003B2 (da)
BR (1) BR112014031394B1 (da)
CA (2) CA2876902C (da)
DK (1) DK2861223T3 (da)
ES (1) ES2929133T3 (da)
HK (1) HK1209361A1 (da)
HR (1) HRP20221325T1 (da)
HU (1) HUE060175T2 (da)
IL (1) IL236268B (da)
LT (1) LT2861223T (da)
MX (2) MX2014015436A (da)
MY (1) MY194495A (da)
NZ (2) NZ726488A (da)
PL (1) PL2861223T3 (da)
PT (1) PT2861223T (da)
RS (1) RS63822B1 (da)
SG (2) SG10201605407TA (da)
SI (1) SI2861223T1 (da)
TW (3) TWI683660B (da)
WO (1) WO2013188847A1 (da)
ZA (1) ZA201500288B (da)

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* Cited by examiner, † Cited by third party
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PT2501234T (pt) 2009-11-20 2017-12-13 Tonix Pharma Holdings Ltd Métodos e composições para o tratamento de sintomas associados com distúrbios de stress pós-traumático utilizando ciclobenzaprina
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
CA2904812C (en) 2013-03-15 2021-07-20 Tonix Pharmaceuticals, Inc. Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
CN107072968B (zh) * 2014-09-18 2021-01-12 通尼克斯制药控股有限公司 环苯扎林盐酸盐的低共熔混合物配制剂
BR112018000707A2 (pt) * 2015-07-15 2018-09-18 Theranexus ?composições terapêuticas e produto de combinação?
WO2018045367A1 (en) * 2016-09-02 2018-03-08 Nova Southeastern University Atropine sulfate rapidly-disintegrating sublingual tablets for treatment of acute organophosphate toxicity
US11517557B2 (en) * 2017-07-13 2022-12-06 Tonix Pharmaceuticals Holding Corp. Analogs of cyclobenzaprine and amitriptyline
CN107519142B (zh) * 2017-08-24 2021-02-26 正大制药（青岛）有限公司 一种盐酸环苯扎林舌下片及其制备方法
CN107496355B (zh) * 2017-08-24 2021-04-30 正大制药（青岛）有限公司 一种盐酸环苯扎林舌下喷雾剂及其制备方法
AU2018379448A1 (en) * 2017-12-08 2020-03-12 F. Hoffmann-La Roche Ag Pharmaceutical formulation
AU2018383098A1 (en) 2017-12-11 2020-05-28 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
CN108721240A (zh) * 2018-06-08 2018-11-02 华益药业科技(安徽)有限公司 一种25mg阿米替林薄膜包衣片处方和工艺规程
CA3109258A1 (en) 2018-08-20 2020-02-27 Tonix Pharma Holdings Limited Methods of treating acute stress disorder and posttraumatic stress disorder
CA3156118A1 (en) * 2019-09-30 2021-04-08 Cadila Healthcare Limited INTRANASAL PHARMACEUTICAL COMPOSITIONS OF CYCLOBENZAPRINE
CA3179754A1 (en) * 2020-04-08 2021-10-14 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for sexual dysfunction
WO2022109218A1 (en) 2020-11-20 2022-05-27 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for alcohol use disorder
CN116940340A (zh) 2020-12-07 2023-10-24 通尼克斯医药控股公司 纤维肌痛的环苯扎林治疗
WO2022170107A2 (en) 2021-02-04 2022-08-11 Tonix Pharmaceuticals Holding Corp. An improved method of assessing clinical response in the treatment of ptsd symptoms
WO2023059728A1 (en) 2021-10-06 2023-04-13 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients
US20230414536A1 (en) 2022-06-21 2023-12-28 Tonix Pharmaceuticals Holding Corp. CYCLOBENZAPRINE TREATMENT FOR POST-ACUTE SEQUELAE OF (SARS)-CoV-2 INFECTION (PASC)

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US4968507A (en) * 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (en) * 1997-10-16 1999-04-22 Merck & Co., Inc. New cyclobenzaprine composition
ATE229326T1 (de) * 1998-05-14 2002-12-15 Alza Corp Therapie von depressionen
AU6634000A (en) 1999-08-13 2001-03-13 Vela Pharmaceuticals Inc. Cyclobenzaprine for treating generalized anxiety disorder and compositions thereof
ES2245944T3 (es) 1999-08-13 2006-02-01 Vela Pharmaceuticals Inc Uso de composiciones para tratar o prevenir alteraciones del sueño utilizando dosis muy bajas de ciclobenzaprina.
WO2001089476A1 (en) * 2000-05-19 2001-11-29 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
WO2002094229A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of muscle relaxants through an inhalation route
JP2006516963A (ja) * 2003-02-04 2006-07-13 クリサリス テクノロジーズ インコーポレイテッド エアロゾル製剤及びブスピロン、ブプレノルフィン、トリアゾラム、シクロベンザプリン及びゾルピデムのエアロゾル送出
WO2006105205A1 (en) * 2005-03-29 2006-10-05 University Of Kentucky Research Foundation Sublingual spray for the treatment of pain
US20090148532A1 (en) * 2007-12-06 2009-06-11 Venkatesh Gopi M Preparation of controlled release skeletal muscle relaxant dosage forms
JP2009079060A (ja) * 2008-10-15 2009-04-16 Novadel Pharma Inc 極性または非極性の、バッカルスプレーまたはカプセル
US20100266682A1 (en) * 2008-12-10 2010-10-21 Nipun Davar Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
PT2501234T (pt) * 2009-11-20 2017-12-13 Tonix Pharma Holdings Ltd Métodos e composições para o tratamento de sintomas associados com distúrbios de stress pós-traumático utilizando ciclobenzaprina
US20110319389A1 (en) * 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
ITMI20110558A1 (it) * 2011-04-06 2012-10-07 Campiglio Consulting Srl Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale
CA2904812C (en) * 2013-03-15 2021-07-20 Tonix Pharmaceuticals, Inc. Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

Also Published As

Publication number Publication date
CA3118913A1 (en) 2013-12-19
IL236268B (en) 2022-03-01
MX2014015436A (es) 2015-07-14
AU2013274003B2 (en) 2018-07-05
HK1209361A1 (en) 2016-04-01
TWI642429B (zh) 2018-12-01
AU2013274003A1 (en) 2015-02-05
AU2018241128A1 (en) 2018-10-25
SG11201408318RA (en) 2015-01-29
PL2861223T3 (pl) 2022-12-12
JP6259452B2 (ja) 2018-01-10
CN111388430A (zh) 2020-07-10
JP2015519404A (ja) 2015-07-09
ZA201500288B (en) 2022-05-25
US20140171515A1 (en) 2014-06-19
MY194495A (en) 2022-11-30
BR112014031394A8 (pt) 2021-11-03
AU2018241128B2 (en) 2020-05-21
MX2021005317A (es) 2022-12-16
HUE060175T2 (hu) 2023-02-28
CN104684550A (zh) 2015-06-03
SI2861223T1 (sl) 2023-01-31
NZ726488A (en) 2018-10-26
WO2013188847A8 (en) 2015-02-05
TW201731494A (zh) 2017-09-16
PT2861223T (pt) 2022-11-07
ES2929133T3 (es) 2022-11-25
RS63822B1 (sr) 2023-01-31
SG10201605407TA (en) 2016-08-30
TWI683660B (zh) 2020-02-01
WO2013188847A1 (en) 2013-12-19
CA3118913C (en) 2024-04-30
EP2861223A1 (en) 2015-04-22
BR112014031394B1 (pt) 2022-10-18
HRP20221325T1 (hr) 2022-12-23
LT2861223T (lt) 2022-12-12
BR112014031394A2 (pt) 2017-06-27
CA2876902A1 (en) 2013-12-19
JP2019123757A (ja) 2019-07-25
TWI590820B (zh) 2017-07-11
EP2861223A4 (en) 2016-01-27
JP2021138765A (ja) 2021-09-16
AR092330A1 (es) 2015-04-15
JP2024032964A (ja) 2024-03-12
TW201408281A (zh) 2014-03-01
TW201842903A (zh) 2018-12-16
NZ631144A (en) 2016-12-23
EP2861223B1 (en) 2022-08-03
CA2876902C (en) 2021-07-13
IL236268A0 (en) 2015-02-26
JP2017222726A (ja) 2017-12-21

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