DK2794624T3 - Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde - Google Patents

Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde Download PDF

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Publication number
DK2794624T3
DK2794624T3 DK12859248.2T DK12859248T DK2794624T3 DK 2794624 T3 DK2794624 T3 DK 2794624T3 DK 12859248 T DK12859248 T DK 12859248T DK 2794624 T3 DK2794624 T3 DK 2794624T3
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Prior art keywords
influencers
telomere length
guanine analogues
telomerase substrates
telomerase
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DK12859248.2T
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English (en)
Inventor
Sergei M Gryaznov
Ronald A Pruzan
Krisztina Pongracz
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Geron Corp
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Publication of DK2794624T3 publication Critical patent/DK2794624T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK12859248.2T 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde DK2794624T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579575P 2011-12-22 2011-12-22
PCT/US2012/000586 WO2013095684A1 (en) 2011-12-22 2012-12-21 Guanine analogs as telomerase substrates and telomere length affectors

Publications (1)

Publication Number Publication Date
DK2794624T3 true DK2794624T3 (da) 2019-07-22

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DK12859248.2T DK2794624T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
DK19173147.0T DK3578563T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde

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DK19173147.0T DK3578563T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde

Country Status (8)

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US (5) US9593137B2 (da)
EP (2) EP3578563B1 (da)
JP (2) JP6113185B2 (da)
CA (1) CA2857490C (da)
DK (2) DK2794624T3 (da)
ES (2) ES2874774T3 (da)
HK (1) HK1205515A1 (da)
WO (1) WO2013095684A1 (da)

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* Cited by examiner, † Cited by third party
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CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN107849071B (zh) 2015-08-10 2021-03-09 默沙东公司 抗病毒的β氨基酸酯膦酰二胺化合物
EP3386512B1 (en) 2015-12-10 2023-11-22 Merck Sharp & Dohme LLC Antiviral phosphodiamide prodrugs of tenofovir
US10450335B2 (en) 2015-12-15 2019-10-22 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
US10736908B2 (en) 2016-10-26 2020-08-11 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
CN110035760A (zh) 2016-12-22 2019-07-19 默沙东公司 抗病毒苯甲基胺磷酰二胺化合物
TW202402300A (zh) 2017-01-31 2024-01-16 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
US11826375B2 (en) 2018-07-19 2023-11-28 Merck Sharp & Dohme Llc Phosphinic amide prodrugs of tenofovir
CN111205326B (zh) * 2020-02-13 2020-09-22 南京道尔医药科技有限公司 一种绿色环保的泰诺福韦制备方法

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Publication number Publication date
EP3578563A1 (en) 2019-12-11
EP2794624B1 (en) 2019-05-15
EP2794624A1 (en) 2014-10-29
EP2794624A4 (en) 2015-04-29
ES2734495T3 (es) 2019-12-10
JP2017081961A (ja) 2017-05-18
US11279720B2 (en) 2022-03-22
US20220306660A1 (en) 2022-09-29
US10035814B2 (en) 2018-07-31
US20150299232A1 (en) 2015-10-22
DK3578563T3 (da) 2021-05-31
JP6113185B2 (ja) 2017-04-12
US20200283461A1 (en) 2020-09-10
HK1205515A1 (en) 2015-12-18
US20190106447A1 (en) 2019-04-11
US20170233419A1 (en) 2017-08-17
WO2013095684A1 (en) 2013-06-27
CA2857490C (en) 2020-03-31
EP3578563B1 (en) 2021-04-14
JP2015502979A (ja) 2015-01-29
US9593137B2 (en) 2017-03-14
ES2874774T3 (es) 2021-11-05
CA2857490A1 (en) 2013-06-27
US10562926B2 (en) 2020-02-18

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