DK2750660T3 - Indgivelse med langvarig frigørelse af aktive midler til behandling af glaukom og okulær hypertension - Google Patents
Indgivelse med langvarig frigørelse af aktive midler til behandling af glaukom og okulær hypertension Download PDFInfo
- Publication number
- DK2750660T3 DK2750660T3 DK12827871.0T DK12827871T DK2750660T3 DK 2750660 T3 DK2750660 T3 DK 2750660T3 DK 12827871 T DK12827871 T DK 12827871T DK 2750660 T3 DK2750660 T3 DK 2750660T3
- Authority
- DK
- Denmark
- Prior art keywords
- implant
- latanoprost
- lacrimal
- drug
- eye
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Implantat til indsætning i en tårekanal, hvilket implantat omfatter: et første element (305), der definerer en første akse og har en første ende langs den første akse, hvor det første element (305) er konfigureret til at strække sig ind i kanalen; et andet element (310), der definerer en anden akse og har en anden ende langs den anden akse, hvor det andet element (310) er udformet til at sidde i den vertikale del (220, 222) af kanalen og til at strække sig til åbningen af, eller ud af åbningen af, de tilhørende tårepunkter; et tredje element (330), der forbinder den første ende af det første element og den anden ende af det andet element ved en første vinkel for at danne et vinklet skæringspunkt; det tredje element omfatter en boring (385), der er kendetegnet ved en tredje akse og en anden vinkel; hvor boringen (385) er konfigureret til at være tilgængelig for et indføringsredskab for at lette indsætning af implantatet; endvidere hvor den første vinkel er defineret af den første akse i forhold til den anden akse og den anden vinkel er defineret af den første akse i forhold til den tredje akse; og endvidere hvor boringen (385) strækker sig fra en øvre overflade (360) ind i det tredje element (330), hvor den øvre overflade strækker sig ud over skæringspunktet med det andet element (310); hvor den første vinkel er fra ca. 30 grader til ca. 150 grader; hvor den anden vinkel er fra ca. 15 grader til ca. 90 grader.
2. Implantat ifølge krav 1, hvor implantatet er fremstillet af et materiale, der er udvalgt fra gruppen bestående af: plast, gummi, polymer og en komposit.
3. Implantat ifølge krav 1 eller krav 2, hvor den første vinkel er ca. 90 grader.
4. Implantat ifølge et hvilket som helst af de foregående krav, hvor det første element (305) omfatter et mellemliggende segment (315), et spidssegment (325) og et forrest segment (320) mellem det mellemliggende segment (315) og spidssegmentet (325).
5. Implantat ifølge krav 4, hvor det forreste segment (320) tilspidser og har en konisk form, således at det forreste segment (320) forbinder det mellemliggende segment (315) ved én ende og spidssegmentet (325) ved den anden ende.
6. Implantat ifølge krav 4 eller krav 5, hvor det mellemliggende segment (315) har en cylindrisk form.
7. Implantat ifølge et hvilket som helst af kravene 4 til 6, hvor spidssegmentet (325) i alt væsentligt er en halvkugle eller en del af en halvkugle.
8. Implantat ifølge et hvilket som helst af kravene 4 til 7, hvor længden af det mellemliggende segment (315) er fra ca. 1 mm til ca. 2,8 mm; radiussen af spidssegmentet eller spidsen (325) er ca. 0,20 mm; og længden af det forreste segment (320) er fra ca. 1,7 mm til ca. 3,5 mm.
9. Implantat ifølge et hvilket som helst af de foregående krav, hvor det tredje element (330) indbefatter et hælforbindelsessegment (375), der er udformet til at koble det tredje element (330) til det første element (305), hvor en bredde af hælforbindelsessegmentet (375) i retningen af den anden akse varierer langs retningen af den første akse.
10. Implantat ifølge et hvilket som helst af de foregående krav, hvor den anden vinkel er ca. 45 grader.
11. Implantat ifølge et hvilket som helst af de foregående krav, hvor boringen (385) har en dybde langs retningen af den tredje akse, der er fra ca. 0,3 mm til ca. 0,7 mm.
12. Implantat ifølge et hvilket som helst af de foregående krav, hvilket implantat endvidere omfatter et hulrum (458), der er konfigureret til at indeholde en kerne af et terapeutiske middel.
13. Implantat ifølge krav 12, hvor implantatet har form af en enhedsdosis af et antiglaukommiddel.
14. Implantat ifølge krav 13, hvor antiglaukommidlet er latanoprost.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161528736P | 2011-08-29 | 2011-08-29 | |
US201261644397P | 2012-05-08 | 2012-05-08 | |
PCT/IB2012/002210 WO2013030679A2 (en) | 2011-08-29 | 2012-08-29 | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2750660T3 true DK2750660T3 (da) | 2016-12-12 |
Family
ID=47744708
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17183171.2T DK3290024T3 (da) | 2011-08-29 | 2012-08-29 | Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension |
DK12827871.0T DK2750660T3 (da) | 2011-08-29 | 2012-08-29 | Indgivelse med langvarig frigørelse af aktive midler til behandling af glaukom og okulær hypertension |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17183171.2T DK3290024T3 (da) | 2011-08-29 | 2012-08-29 | Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension |
Country Status (8)
Country | Link |
---|---|
US (4) | US20130053794A1 (da) |
EP (3) | EP3120834A1 (da) |
JP (1) | JP6100782B2 (da) |
CN (2) | CN107669399B (da) |
CA (1) | CA2846384C (da) |
DK (2) | DK3290024T3 (da) |
ES (2) | ES2611807T3 (da) |
WO (1) | WO2013030679A2 (da) |
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US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
SG187770A1 (en) | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A liposomal formulation for ocular drug delivery |
CN104622790A (zh) | 2010-11-01 | 2015-05-20 | 普西维达公司 | 用于递送治疗剂的可生物侵蚀的硅基装置 |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
WO2013030679A2 (en) * | 2011-08-29 | 2013-03-07 | Qlt Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
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JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
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2012
- 2012-08-29 WO PCT/IB2012/002210 patent/WO2013030679A2/en active Application Filing
- 2012-08-29 EP EP16187646.1A patent/EP3120834A1/en not_active Withdrawn
- 2012-08-29 CN CN201710802890.1A patent/CN107669399B/zh active Active
- 2012-08-29 DK DK17183171.2T patent/DK3290024T3/da active
- 2012-08-29 US US13/598,573 patent/US20130053794A1/en not_active Abandoned
- 2012-08-29 ES ES12827871.0T patent/ES2611807T3/es active Active
- 2012-08-29 EP EP17183171.2A patent/EP3290024B1/en active Active
- 2012-08-29 CN CN201280052847.3A patent/CN103889401B/zh active Active
- 2012-08-29 JP JP2014527756A patent/JP6100782B2/ja active Active
- 2012-08-29 EP EP12827871.0A patent/EP2750660B1/en active Active
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ES2611807T3 (es) | 2017-05-10 |
US20140350103A1 (en) | 2014-11-27 |
EP2750660A2 (en) | 2014-07-09 |
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WO2013030679A2 (en) | 2013-03-07 |
CN103889401A (zh) | 2014-06-25 |
EP3290024A1 (en) | 2018-03-07 |
CA2846384C (en) | 2020-12-15 |
CN103889401B (zh) | 2017-10-13 |
CN107669399B (zh) | 2019-11-19 |
US9610271B2 (en) | 2017-04-04 |
CA2846384A1 (en) | 2013-03-07 |
EP3120834A1 (en) | 2017-01-25 |
EP2750660B1 (en) | 2016-10-12 |
WO2013030679A3 (en) | 2013-05-02 |
EP2750660A4 (en) | 2015-03-18 |
US20130053794A1 (en) | 2013-02-28 |
JP6100782B2 (ja) | 2017-03-22 |
US20170202853A1 (en) | 2017-07-20 |
ES2727203T3 (es) | 2019-10-14 |
US20200323685A1 (en) | 2020-10-15 |
EP3290024B1 (en) | 2019-04-17 |
CN107669399A (zh) | 2018-02-09 |
JP2014530645A (ja) | 2014-11-20 |
US10632012B2 (en) | 2020-04-28 |
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