DK2708541T3 - 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese - Google Patents

5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese Download PDF

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Publication number
DK2708541T3
DK2708541T3 DK12199177.2T DK12199177T DK2708541T3 DK 2708541 T3 DK2708541 T3 DK 2708541T3 DK 12199177 T DK12199177 T DK 12199177T DK 2708541 T3 DK2708541 T3 DK 2708541T3
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DK
Denmark
Prior art keywords
synthesis
volume
acetonitrile
alkyl
oligonucleotide
Prior art date
Application number
DK12199177.2T
Other languages
English (en)
Inventor
Ravikumar Vasulinga
Wang Zhiwei
Raju Krishna Kumar
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2708541T3 publication Critical patent/DK2708541T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Claims (12)

1. Forbindelse med formlen:
hvor R1 er aryl, cycloalkyl, umættet cycloalkyl, alkyl, umættet alkyl, heterocyclyl, umættet heterocyclyl, heteroaryl eller acyl, hvor R1 eventuelt er substitueret med én eller flere substituenter.
2. Forbindelsen ifølge krav 1 med formlen:
3. Forbindelsen ifølge krav 1, hvor R1 yderligere er substitueret med fra 1 til 5 substituenter.
4. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er aryl, der eventuelt er yderligere substitueret.
5. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-4, hvor R1 er phenyl eller naphthyl, der eventuelt er yderligere substitueret.
6. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-4, hvor R1 er phenyl eller naphthyl, der er usubstitueret eller substitueret med fra 1 til ca. 5 medlemmer af gruppen bestående af F, Cl, Br, I, NO2, C1-C12 alkyl eller CF3.
7. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-5, hvor R1 er phenyl eller naphthyl, der er usubstitueret.
8. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er heterocyclyl, og R1 eventuelt er yderligere substitueret.
9. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridiyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, furanyl, thiophenyl, thiazolyl, pyrrolyl eller imidazolyl og R1 eventuelt er yderligere substitueret.
10. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridyl, furanyl eller thiophenyl og R1 eventuelt er yderligere substitueret.
11. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridiyl, furanyl, eller thiophenyl, og R1 ikke er yderligere substitueret.
12. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er N-alkyl-morpholinyl, N-alkyl-piperidinyl eller Ν,Ν'-dialkylpiperazinyl, og R1 eventuelt er yderligere substitueret.
DK12199177.2T 2003-11-13 2004-11-15 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese DK2708541T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52017903P 2003-11-13 2003-11-13
US53047703P 2003-12-16 2003-12-16
US56464904P 2004-04-21 2004-04-21
EP04811142A EP1692139B1 (en) 2003-11-13 2004-11-15 5,6 -dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis

Publications (1)

Publication Number Publication Date
DK2708541T3 true DK2708541T3 (da) 2015-02-23

Family

ID=34623783

Family Applications (2)

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DK04811142.1T DK1692139T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer
DK12199177.2T DK2708541T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese

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DK04811142.1T DK1692139T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer

Country Status (4)

Country Link
EP (2) EP1692139B1 (da)
DK (2) DK1692139T3 (da)
ES (2) ES2535033T3 (da)
WO (1) WO2005049621A1 (da)

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US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
AU2007258117B2 (en) 2006-05-05 2013-05-30 Isis Pharmaceuticals, Inc. Compounds and methods for modulating gene expression
RU2559536C2 (ru) 2007-03-24 2015-08-10 Джензим Корпорейшн Введение антисмысловых олигонуклеотидов, комплементарных человеческому аполипопротеину в
US9107933B2 (en) 2009-03-16 2015-08-18 Isis Pharmaceuticals, Inc. Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
JP5360763B2 (ja) 2009-10-21 2013-12-04 日東電工株式会社 核酸固相合成用リンカー及び担体
JP6028979B2 (ja) 2012-01-30 2016-11-24 日東電工株式会社 核酸固相合成用リンカー及び担体
EP2666794A1 (en) 2012-05-23 2013-11-27 Nitto Denko Corporation Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method
JO3563B1 (ar) 2014-05-13 2020-07-05 Novartis Ag مركبات وتركيبات لتحفيز تكوين الغضاريف
JP6537338B2 (ja) 2015-04-24 2019-07-03 日東電工株式会社 核酸固相合成用リンカー及び担体
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Also Published As

Publication number Publication date
EP2708541A1 (en) 2014-03-19
EP1692139B1 (en) 2013-02-13
ES2535033T3 (es) 2015-05-04
EP1692139A1 (en) 2006-08-23
EP2708541B1 (en) 2015-01-28
DK1692139T3 (da) 2013-03-11
WO2005049621A1 (en) 2005-06-02
ES2403937T3 (es) 2013-05-22

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