DK1692139T3 - 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer - Google Patents
5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomererInfo
- Publication number
- DK1692139T3 DK1692139T3 DK04811142.1T DK04811142T DK1692139T3 DK 1692139 T3 DK1692139 T3 DK 1692139T3 DK 04811142 T DK04811142 T DK 04811142T DK 1692139 T3 DK1692139 T3 DK 1692139T3
- Authority
- DK
- Denmark
- Prior art keywords
- linkers
- dihydroxy
- oligomers
- solid phase
- phase synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52017903P | 2003-11-13 | 2003-11-13 | |
US53047703P | 2003-12-16 | 2003-12-16 | |
US56464904P | 2004-04-21 | 2004-04-21 | |
PCT/US2004/038325 WO2005049621A1 (en) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1692139T3 true DK1692139T3 (da) | 2013-03-11 |
Family
ID=34623783
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12199177.2T DK2708541T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese |
DK04811142.1T DK1692139T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12199177.2T DK2708541T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP2708541B1 (da) |
DK (2) | DK2708541T3 (da) |
ES (2) | ES2535033T3 (da) |
WO (1) | WO2005049621A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7888324B2 (en) | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
EP1569695B1 (en) * | 2002-11-13 | 2013-05-15 | Genzyme Corporation | Antisense modulation of apolipoprotein b expression |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
AU2007253909B2 (en) | 2006-05-05 | 2012-08-09 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of GCCR |
US9347061B2 (en) | 2007-03-24 | 2016-05-24 | Genzyme Corporation | Administering antisense oligonucleotides complementary to human apolipoprotein B |
US9107933B2 (en) | 2009-03-16 | 2015-08-18 | Isis Pharmaceuticals, Inc. | Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III |
JP5360763B2 (ja) | 2009-10-21 | 2013-12-04 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
EP2620444B1 (en) * | 2012-01-30 | 2015-05-06 | Nitto Denko Corporation | Linker and support for solid phase synthesis of nucleic acid |
EP2666794A1 (en) | 2012-05-23 | 2013-11-27 | Nitto Denko Corporation | Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method |
JP6479051B2 (ja) | 2014-05-13 | 2019-03-06 | ノバルティス アーゲー | 軟骨形成を誘導するための化合物および組成物 |
JP6537338B2 (ja) | 2015-04-24 | 2019-07-03 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
KR20190133173A (ko) | 2017-03-29 | 2019-12-02 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 유니링커 신속 절단 |
EP3765473A1 (en) | 2018-03-14 | 2021-01-20 | F. Hoffmann-La Roche AG | Lna-dicarboxylic acid derivatives and process for their preparation |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
USRE34069E (en) | 1983-08-18 | 1992-09-15 | Biosyntech Gmbh | Process for the preparation of oligonucleotides |
DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
US5750666A (en) | 1988-05-26 | 1998-05-12 | Competitve Technologies, Inc. | Polynucleotide phosphorodithioate compounds |
CA1339987C (en) | 1988-09-01 | 1998-08-04 | Robert Bruce Merrifield | Peptide synthesis method and solid support for use in the method |
US6300486B1 (en) | 1989-06-15 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Large scale synthesis of oligonucleotides and their associated analogs |
US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
US5166387A (en) | 1990-01-12 | 1992-11-24 | Applied Biosystems, Inc. | Method of synthesizing sulfurized oligonucleotide analogs with thiuram disulfides |
JP3231168B2 (ja) * | 1992-12-22 | 2001-11-19 | 三井化学株式会社 | 感熱記録材料 |
US5391667A (en) | 1993-03-04 | 1995-02-21 | Isis Pharmaceuticals | Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis |
US5614621A (en) | 1993-07-29 | 1997-03-25 | Isis Pharmaceuticals, Inc. | Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents |
US6001982A (en) | 1993-07-29 | 1999-12-14 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
US5889136A (en) | 1995-06-09 | 1999-03-30 | The Regents Of The University Of Colorado | Orthoester protecting groups in RNA synthesis |
US5734041A (en) | 1995-10-20 | 1998-03-31 | Mcgill University | Preparation of chiral phosphorothioate oligomers |
US6476216B1 (en) | 1995-10-20 | 2002-11-05 | Mcgill University | Preparation of phosphorothioate oligomers |
US5705621A (en) | 1995-11-17 | 1998-01-06 | Isis Pharmaceuticals, Inc. | Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same |
US6043353A (en) | 1995-12-22 | 2000-03-28 | University Technologies International, Inc. | Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof |
AU725690B2 (en) * | 1995-12-22 | 2000-10-19 | University Technologies International Inc. | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
GB9612600D0 (en) | 1996-06-13 | 1996-08-21 | Ciba Geigy Ag | Chemical compounds |
US5955600A (en) | 1996-12-27 | 1999-09-21 | Isis Pharmaceuticals, Inc. | Method for the synthesis of nucleotide or oligonucleotide phosphoramidites |
DE19811096A1 (de) | 1997-04-30 | 1998-11-05 | Schaeffler Waelzlager Ohg | Synchronisiervorrichtung |
US6114519A (en) | 1997-10-15 | 2000-09-05 | Isis Pharmaceuticals, Inc. | Synthesis of sulfurized oligonucleotides |
US6242591B1 (en) | 1997-10-15 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Synthesis of sulfurized 2'-substituted oligonucleotides |
US6020475A (en) | 1998-02-10 | 2000-02-01 | Isis Pharmeuticals, Inc. | Process for the synthesis of oligomeric compounds |
US6111086A (en) | 1998-02-27 | 2000-08-29 | Scaringe; Stephen A. | Orthoester protecting groups |
US6274725B1 (en) | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
US6335439B1 (en) | 1998-06-11 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Method of preparing phosphoramidites |
US6465628B1 (en) | 1999-02-04 | 2002-10-15 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
US6147200A (en) | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US20040152905A1 (en) * | 2003-01-31 | 2004-08-05 | Guzaev Andrei P. | Universal building blocks and support media for synthesis of oligonucleotides and their analogs |
KR101595393B1 (ko) | 2014-05-22 | 2016-02-18 | 엘지전자 주식회사 | 정보 제공 시스템 및 그 방법 |
-
2004
- 2004-11-15 ES ES12199177.2T patent/ES2535033T3/es active Active
- 2004-11-15 EP EP12199177.2A patent/EP2708541B1/en active Active
- 2004-11-15 ES ES04811142T patent/ES2403937T3/es active Active
- 2004-11-15 EP EP04811142A patent/EP1692139B1/en active Active
- 2004-11-15 DK DK12199177.2T patent/DK2708541T3/da active
- 2004-11-15 DK DK04811142.1T patent/DK1692139T3/da active
- 2004-11-15 WO PCT/US2004/038325 patent/WO2005049621A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2403937T3 (es) | 2013-05-22 |
ES2535033T3 (es) | 2015-05-04 |
EP2708541B1 (en) | 2015-01-28 |
EP1692139B1 (en) | 2013-02-13 |
WO2005049621A1 (en) | 2005-06-02 |
EP1692139A1 (en) | 2006-08-23 |
DK2708541T3 (da) | 2015-02-23 |
EP2708541A1 (en) | 2014-03-19 |
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