DK2536399T3 - Fremgangsmåde til aktivering og konjugering af biomolekyler - Google Patents

Fremgangsmåde til aktivering og konjugering af biomolekyler Download PDF

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Publication number
DK2536399T3
DK2536399T3 DK11745404.1T DK11745404T DK2536399T3 DK 2536399 T3 DK2536399 T3 DK 2536399T3 DK 11745404 T DK11745404 T DK 11745404T DK 2536399 T3 DK2536399 T3 DK 2536399T3
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DK
Denmark
Prior art keywords
conjuging
biomolecules
activating
procedure
conjuging biomolecules
Prior art date
Application number
DK11745404.1T
Other languages
English (en)
Inventor
Jens H Vogel
Chi Shung Brian To
Carolina Lucia Bianco
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Application granted granted Critical
Publication of DK2536399T3 publication Critical patent/DK2536399T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/025Reverse osmosis; Hyperfiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2315/00Details relating to the membrane module operation
    • B01D2315/10Cross-flow filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2315/00Details relating to the membrane module operation
    • B01D2315/16Diafiltration
DK11745404.1T 2010-02-21 2011-02-21 Fremgangsmåde til aktivering og konjugering af biomolekyler DK2536399T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30651310P 2010-02-21 2010-02-21
PCT/US2011/025592 WO2011103531A1 (en) 2010-02-21 2011-02-21 Method for Activation and Conjugation of Biomolecules

Publications (1)

Publication Number Publication Date
DK2536399T3 true DK2536399T3 (da) 2020-02-10

Family

ID=44483343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11745404.1T DK2536399T3 (da) 2010-02-21 2011-02-21 Fremgangsmåde til aktivering og konjugering af biomolekyler

Country Status (35)

Country Link
US (1) US9254336B2 (da)
EP (1) EP2536399B1 (da)
JP (1) JP5726915B2 (da)
KR (1) KR101776976B1 (da)
CN (2) CN105664175B (da)
AU (1) AU2011217794B2 (da)
BR (1) BR112012020855B8 (da)
CA (1) CA2790401C (da)
CL (1) CL2012002306A1 (da)
CO (1) CO6592111A2 (da)
CR (1) CR20120437A (da)
CU (1) CU20120121A7 (da)
CY (1) CY1122711T1 (da)
DK (1) DK2536399T3 (da)
EA (1) EA201290804A1 (da)
EC (1) ECSP12012112A (da)
ES (1) ES2769629T3 (da)
GT (1) GT201200244A (da)
HK (2) HK1225652A1 (da)
HR (1) HRP20192164T1 (da)
HU (1) HUE047661T2 (da)
IL (1) IL221447A (da)
LT (1) LT2536399T (da)
MX (1) MX2012009674A (da)
NZ (1) NZ601905A (da)
PE (1) PE20130003A1 (da)
PH (1) PH12016501602A1 (da)
PL (1) PL2536399T3 (da)
PT (1) PT2536399T (da)
RS (1) RS59827B1 (da)
SG (1) SG183309A1 (da)
SI (1) SI2536399T1 (da)
UA (1) UA115221C2 (da)
WO (1) WO2011103531A1 (da)
ZA (2) ZA201206215B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE481323A (da) * 1947-04-10
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
EP3892294A1 (en) 2013-08-28 2021-10-13 AbbVie Stemcentrx LLC Site-specific antibody conjugation methods and compositions
CN105813650A (zh) 2013-11-06 2016-07-27 施特姆森特克斯股份有限公司 新型抗-密蛋白抗体和使用方法
KR20160097336A (ko) 2013-12-12 2016-08-17 스템센트알엑스 인코포레이티드 신규 항-dpep3 항체 및 이의 사용 방법
KR20170008202A (ko) 2014-02-21 2017-01-23 애브비 스템센트알엑스 엘엘씨 흑색종에 사용하기 위한 항-dll3 항체 및 약물 접합체
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2358730T3 (es) * 2002-07-15 2011-05-13 Board Of Regents, The University Of Texas System Anticuerpos seleccionados y péptidos de duramicina que se enlazan a fosfolípidos aniónicos y aminofosfolípidos y sus usos en el tratamiento de infecciones virales y del cáncer.
US7384909B2 (en) 2002-07-15 2008-06-10 Board Of Regents, The University Of Texas System Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents
AU2003300139B2 (en) 2002-12-31 2008-08-28 Nektar Therapeutics Maleamic acid polymer derivatives and their bioconjugates
US20050175619A1 (en) * 2004-02-05 2005-08-11 Robert Duffy Methods of producing antibody conjugates
EP1824988B1 (en) * 2004-11-12 2017-04-19 Bayer HealthCare LLC Site-directed modification of fviii
US20070173634A1 (en) 2006-01-24 2007-07-26 Olsson Nils U Methods for one-step purification of organic polymers using tangential flow filtration
US20080220448A1 (en) * 2006-09-01 2008-09-11 Blincko Stuart J Antigenic protein conjugates and process for preparing same
US8207298B2 (en) * 2008-05-01 2012-06-26 Archemix Corp. Methods of separating biopolymer conjugated molecules from unconjugated molecules
ES2597954T3 (es) * 2009-07-27 2017-01-24 Baxalta GmbH Conjugados de proteína de la coagulación sanguínea
MX337070B (es) * 2009-12-22 2016-02-11 Celldex Therapeutics Inc Método para preparar un conjugado klh-egfrviii.

Also Published As

Publication number Publication date
GT201200244A (es) 2014-09-02
PE20130003A1 (es) 2013-01-19
PH12016501602A1 (en) 2017-06-05
CO6592111A2 (es) 2013-01-02
HK1225652A1 (zh) 2017-09-15
IL221447A (en) 2015-09-24
CN105664175B (zh) 2019-07-23
CL2012002306A1 (es) 2013-01-18
CN102970988B (zh) 2016-03-16
NZ601905A (en) 2014-09-26
PT2536399T (pt) 2020-02-06
AU2011217794A1 (en) 2012-09-20
HRP20192164T1 (hr) 2020-03-06
JP2013520441A (ja) 2013-06-06
CU20120121A7 (es) 2013-01-30
LT2536399T (lt) 2020-03-10
ECSP12012112A (es) 2012-10-30
WO2011103531A1 (en) 2011-08-25
BR112012020855B1 (pt) 2021-05-04
US20130040362A1 (en) 2013-02-14
SI2536399T1 (sl) 2020-02-28
KR101776976B1 (ko) 2017-09-08
HK1182330A1 (zh) 2013-11-29
JP5726915B2 (ja) 2015-06-03
ES2769629T3 (es) 2020-06-26
BR112012020855A2 (pt) 2017-08-29
CR20120437A (es) 2012-12-07
EP2536399B1 (en) 2019-11-20
US9254336B2 (en) 2016-02-09
PL2536399T3 (pl) 2020-06-29
MX2012009674A (es) 2012-09-07
CN105664175A (zh) 2016-06-15
ZA201206215B (en) 2014-10-29
IL221447A0 (en) 2012-10-31
SG183309A1 (en) 2012-09-27
UA115221C2 (uk) 2017-10-10
EP2536399A1 (en) 2012-12-26
KR20120120966A (ko) 2012-11-02
EA201290804A1 (ru) 2013-03-29
CA2790401C (en) 2018-05-29
CA2790401A1 (en) 2011-08-25
ZA201405941B (en) 2018-05-31
RS59827B1 (sr) 2020-02-28
EP2536399A4 (en) 2016-02-24
CN102970988A (zh) 2013-03-13
AU2011217794B2 (en) 2015-01-29
BR112012020855B8 (pt) 2021-05-25
HUE047661T2 (hu) 2020-05-28
CY1122711T1 (el) 2021-03-12

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