DK2358866T3 - Corynebakteriestamme med forstærket 5'-xanthosinmonophosphat-produktivitet og fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat under anvendelse af denne - Google Patents
Corynebakteriestamme med forstærket 5'-xanthosinmonophosphat-produktivitet og fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat under anvendelse af denne Download PDFInfo
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- DK2358866T3 DK2358866T3 DK09833645.6T DK09833645T DK2358866T3 DK 2358866 T3 DK2358866 T3 DK 2358866T3 DK 09833645 T DK09833645 T DK 09833645T DK 2358866 T3 DK2358866 T3 DK 2358866T3
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- DK
- Denmark
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- gene
- mqo
- strain
- malate dehydrogenase
- xmp
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (8)
1. Anvendelse af en corynebakteriestamme til fremstilling af xanthosin-5'-monophosphat, hvor corynebakteriestammen har en malatdehydrogenase-aktivitet, der er højere end sin endogene vildtypeaktivitet, ved at øge antallet af mqo-geneksemplarer, der koder malatdehydrogenasen, eller ved at erstatte eller modificere en promotor af et mqo-gen.
2. Anvendelse ifølge krav 1, hvor malatdehydrogenaseaktiviteten er forbedret som et resultat af en øgning i mqo-genekspression.
3. Anvendelse ifølge krav 2, hvor mqo-genet har SEQ ID NO: 7.
4. Anvendelse ifølge krav 1, hvor stammen er transformeret med en rekom-binant vektor omfattende et mqo-gen.
5. Anvendelse ifølge krav 4, hvor mqo-genet har SEQ ID NO: 7.
6. Anvendelse ifølge krav 1, hvor corynebakteriestammen er corynebakterie-ammoniakgener.
7. Fremgangsmåde til fremstilling af xanthosin-5'-monophosphat, omfattende at dyrke en corynebakteriestamme med en malatdehydrogenaseaktivitet, der er højere end dens endogene vildtypeaktivitet, ved at øge antallet af mqo-geneksemplarer, der koder malatdehydrogenasen, eller ved at erstatte eller modificere en promotor af et mqo-gen; og at opnå xanthosin-5'-monophosphat ud fra kulturen.
8. Corynebakterie-ammoniakgenstamme med øget xanthosin-5'-monophos-phat-produktivitet, hvilken har en malatdehydrogenaseaktivitet, der er højere end dens endogene vildtypeaktivitet, ved at øge antallet af mqo-geneksemplarer, der koder malatdehydrogenasen, eller ved at erstatte eller modificere en promotor af et mqo-gen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020080128847A KR101072708B1 (ko) | 2008-12-17 | 2008-12-17 | 5'-크산틸산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산의 생산방법 |
PCT/KR2009/007559 WO2010071367A2 (en) | 2008-12-17 | 2009-12-17 | A corynebacteria strain having enhanced 5'-xanthosine monophosphate productivity and a method of producing 5'-xanthosine monophosphate using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2358866T3 true DK2358866T3 (da) | 2015-11-23 |
Family
ID=42269248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09833645.6T DK2358866T3 (da) | 2008-12-17 | 2009-12-17 | Corynebakteriestamme med forstærket 5'-xanthosinmonophosphat-produktivitet og fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat under anvendelse af denne |
Country Status (8)
Country | Link |
---|---|
US (1) | US8815545B2 (da) |
EP (1) | EP2358866B1 (da) |
JP (1) | JP5553842B2 (da) |
KR (1) | KR101072708B1 (da) |
CN (2) | CN102317433B (da) |
DK (1) | DK2358866T3 (da) |
ES (1) | ES2553571T3 (da) |
WO (1) | WO2010071367A2 (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101072720B1 (ko) * | 2008-12-17 | 2011-10-11 | 씨제이제일제당 (주) | 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-구아닐산의 생산방법 |
KR101929158B1 (ko) * | 2018-06-07 | 2018-12-13 | 씨제이제일제당 (주) | 5'-크산틸산을 생산하는 미생물 및 이를 이용한 5'-크산틸산의 제조방법 |
KR102258159B1 (ko) * | 2021-01-29 | 2021-05-27 | 씨제이제일제당 (주) | 신규한 말레이트 디하이드로게나제 변이체 및 이를 이용한 l-라이신 생산 방법 |
KR102288398B1 (ko) * | 2021-01-29 | 2021-08-10 | 씨제이제일제당 주식회사 | 신규한 nad(p)-의존성 산화환원효소 변이체 및 이를 이용한 xmp 또는 gmp 생산 방법 |
KR102273637B1 (ko) * | 2021-01-29 | 2021-07-06 | 씨제이제일제당 주식회사 | 신규한 펩티딜-디펩티다제 변이체 및 이를 이용한 xmp 또는 gmp 생산 방법 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19912384A1 (de) * | 1999-03-19 | 2000-09-21 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
US20020028490A1 (en) | 1999-03-19 | 2002-03-07 | Douwe Molenaar | Process for the production of L-amino acids by fermentation using coryneform bacteria |
JP2004501651A (ja) * | 2000-06-23 | 2004-01-22 | ノボザイムス アクティーゼルスカブ | 遺伝子の安定した染色体多コピー組み込みのための方法 |
DE10032350A1 (de) * | 2000-07-04 | 2002-01-24 | Degussa | Neue für das mdhA-Gen kodierende Nukleotidsequenzen |
KR100405990B1 (ko) | 2000-10-04 | 2003-11-20 | 김성준 | 유기게르마늄 함유 동충하초의 제조방법 |
RU2209249C2 (ru) | 2000-11-22 | 2003-07-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения ксантозин-5'-монофосфата, штамм corynebacterium ammoniagenes - продуцент ксантозин-5'-монофосфата (варианты) |
KR100402320B1 (ko) | 2001-01-05 | 2003-10-22 | 씨제이 주식회사 | 5'-크산틸산을 고수율로 생산하는 미생물 코리네박테리움암모니아게네스 엔브이4-82-9 및 그를 이용한 5'-크산틸산생산방법 |
DE10117816A1 (de) * | 2001-04-10 | 2002-10-17 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
KR100505925B1 (ko) * | 2002-12-11 | 2005-08-03 | 씨제이 주식회사 | 5’-크산틸산을 생산하는 미생물 |
KR20040051731A (ko) * | 2002-12-11 | 2004-06-19 | 씨제이 주식회사 | 5’-크산틸산을 생산하는 미생물 |
KR100542568B1 (ko) * | 2003-12-10 | 2006-01-11 | 씨제이 주식회사 | 5'-크산틸산을 생산하는 미생물 |
KR101283119B1 (ko) | 2005-01-12 | 2013-07-05 | 유노보, 인크. | 용기를 배기하고 밀봉하기 위한 방법 및 장치 |
EP3170889A1 (en) * | 2006-09-15 | 2017-05-24 | CJ Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
KR100789274B1 (ko) * | 2007-01-15 | 2008-01-02 | 씨제이 주식회사 | 코리네박테리움 글루타미쿰에서 유래한 신규한 프로모터핵산 분자, 그 프로모터를 포함하는 재조합 벡터, 그재조합 벡터를 포함하는 숙주 세포 및 그 숙주 세포를이용하여 유전자를 발현하는 방법 |
KR100957690B1 (ko) | 2008-01-22 | 2010-05-12 | 씨제이제일제당 (주) | 5'-크산틸산 생산능이 향상된 코리네박테리움 속 미생물및 이를 이용한 5'-크산틸산의 생산 방법 |
KR101072720B1 (ko) | 2008-12-17 | 2011-10-11 | 씨제이제일제당 (주) | 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-구아닐산의 생산방법 |
KR101210704B1 (ko) * | 2010-03-19 | 2012-12-10 | 씨제이제일제당 (주) | 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법 |
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2008
- 2008-12-17 KR KR1020080128847A patent/KR101072708B1/ko active IP Right Grant
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2009
- 2009-12-17 JP JP2011542009A patent/JP5553842B2/ja active Active
- 2009-12-17 US US13/140,321 patent/US8815545B2/en active Active
- 2009-12-17 CN CN200980154009.5A patent/CN102317433B/zh active Active
- 2009-12-17 ES ES09833645.6T patent/ES2553571T3/es active Active
- 2009-12-17 EP EP09833645.6A patent/EP2358866B1/en active Active
- 2009-12-17 CN CN201410352698.3A patent/CN104130966A/zh active Pending
- 2009-12-17 DK DK09833645.6T patent/DK2358866T3/da active
- 2009-12-17 WO PCT/KR2009/007559 patent/WO2010071367A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
KR101072708B1 (ko) | 2011-10-11 |
EP2358866A4 (en) | 2012-08-22 |
CN102317433B (zh) | 2016-09-07 |
CN102317433A (zh) | 2012-01-11 |
EP2358866A2 (en) | 2011-08-24 |
US20110300582A1 (en) | 2011-12-08 |
JP5553842B2 (ja) | 2014-07-16 |
EP2358866B1 (en) | 2015-10-07 |
WO2010071367A3 (en) | 2010-11-04 |
JP2012511925A (ja) | 2012-05-31 |
ES2553571T3 (es) | 2015-12-10 |
CN104130966A (zh) | 2014-11-05 |
US8815545B2 (en) | 2014-08-26 |
KR20100070219A (ko) | 2010-06-25 |
WO2010071367A2 (en) | 2010-06-24 |
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