DK2342223T3 - Modificerede dyre-erythropoietin-polypeptider og deres anvendelser - Google Patents

Modificerede dyre-erythropoietin-polypeptider og deres anvendelser Download PDF

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Publication number
DK2342223T3
DK2342223T3 DK09816953.5T DK09816953T DK2342223T3 DK 2342223 T3 DK2342223 T3 DK 2342223T3 DK 09816953 T DK09816953 T DK 09816953T DK 2342223 T3 DK2342223 T3 DK 2342223T3
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DK
Denmark
Prior art keywords
limited
fepo
amino acid
amino acids
protein
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Application number
DK09816953.5T
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English (en)
Inventor
Feng Tian
Putnam Anna-Maria A Hays
Frank Song
Stephanie Chu
Joseph Sheffer
Richard S Barnett
Marc Siladi
Kyle Atkinson
Darin Lee
Peter C Canning
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Ambrx Inc
Lilly Co Eli
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Application filed by Ambrx Inc, Lilly Co Eli filed Critical Ambrx Inc
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Publication of DK2342223T3 publication Critical patent/DK2342223T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (5)

1. Katte-erythropoietin-polypeptid (fEPO-polypeptid) omfattende en ikke naturligt kodet aminosyre bundet til en vandopløselig polymer, hvor: aminosyren svarende til position 1 med SEQ ID No 2 er substitueret med den ikke naturligt kodede aminosyre; den ikke naturligt kodede aminosyre er para-acetylphenylalanin; og den vandopløselige polymer omfatter en oxyaminopoly(ethylenglycol)-enhed med en molekylvægt på 20kD, 30kD eller 40 kD.
2. Katte-erythropoietin-polypeptid (fEPO-polypeptid) ifølge krav 1, hvor den vandopløselige polymer omfatter en oxyaminopoly(ethylenglycol)-enhed med en molekylvægt på 30kD.
3. Sammensætning omfattende fEPO-polypeptidet ifølge krav 1 eller krav 2 og en farmaceutisk acceptabel bærer.
4. fEPO-polypeptid ifølge krav 1 eller krav 2 til anvendelse som et medikament.
5. fEPO-polypeptid ifølge krav 1 eller krav 2 til anvendelse ved behandling af anæmi.
DK09816953.5T 2008-09-26 2009-09-25 Modificerede dyre-erythropoietin-polypeptider og deres anvendelser DK2342223T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10069208P 2008-09-26 2008-09-26
US10067908P 2008-09-26 2008-09-26
PCT/US2009/058482 WO2010036964A2 (en) 2008-09-26 2009-09-25 Modified animal erythropoietin polypeptides and their uses

Publications (1)

Publication Number Publication Date
DK2342223T3 true DK2342223T3 (da) 2017-07-24

Family

ID=42060418

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09816953.5T DK2342223T3 (da) 2008-09-26 2009-09-25 Modificerede dyre-erythropoietin-polypeptider og deres anvendelser

Country Status (23)

Country Link
US (4) US8278418B2 (da)
EP (2) EP3216800A1 (da)
JP (1) JP5694171B2 (da)
KR (1) KR101647164B1 (da)
CN (2) CN107022020A (da)
AU (1) AU2009296397B2 (da)
BR (2) BRPI0919403A2 (da)
CA (1) CA2737026C (da)
CL (1) CL2011000613A1 (da)
CO (1) CO6362016A2 (da)
DK (1) DK2342223T3 (da)
EA (1) EA019653B1 (da)
ES (1) ES2631915T3 (da)
HU (1) HUE035168T2 (da)
IL (1) IL211600A (da)
MX (2) MX346001B (da)
NZ (2) NZ592250A (da)
PE (1) PE20110832A1 (da)
PL (1) PL2342223T3 (da)
PT (1) PT2342223T (da)
UA (1) UA106731C2 (da)
WO (1) WO2010036964A2 (da)
ZA (1) ZA201102716B (da)

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