DK2270044T3 - Flydende immunglobulin G (IgG) produkt - Google Patents
Flydende immunglobulin G (IgG) produkt Download PDFInfo
- Publication number
- DK2270044T3 DK2270044T3 DK10011725.8T DK10011725T DK2270044T3 DK 2270044 T3 DK2270044 T3 DK 2270044T3 DK 10011725 T DK10011725 T DK 10011725T DK 2270044 T3 DK2270044 T3 DK 2270044T3
- Authority
- DK
- Denmark
- Prior art keywords
- igg
- product
- virus
- immunoglobulin
- iga
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Claims (14)
1. Flydende immunglobulin G (IgG) produkt udvundet af rå plasma eller af en rå plasmaproteinfraktion, med følgende egenskaber: a) en renhed på mere end 95%, b) et indhold af IgG monomere og dimere på mindst 95%, og c) et indhold af I g A på mindre end 6 mg IgA/l, hvori koncentrationen af IgG er 1 - 20 vægt-%.
2. IgG-produkt ifølge krav 1, hvori renheden er mindst 97%.
3. IgG-produkt ifølge krav 2, hvori renheden er mindst 98%.
4. IgG-produkt ifølge ethvert af de foregående krav, hvori indholdet af IgG monomere og dimere er mindst 97%.
5. IgG-produkt ifølge krav 4, hvori indholdet af IgG monomere og dimere er mindst 98%.
6. IgG-produkt ifølge ethvert af de foregående krav, hvori indholdet af IgA er mindre end 4 mg IgA/l.
7. IgG-produkt ifølge krav 6, hvori indholdet af IgA er mindre end 3 mg IgA/l.
8. IgG-produkt ifølge krav 7, hvori indholdet af IgA er mindre end 2 mg IgA/l.
9. IgG-produkt ifølge ethvert af de foregående krav, og som ikke indeholder albumin som stabilisator.
10. IgG-produkt ifølge ethvert af de foregående krav, og som ikke omfatter non-ionisk afspændingsmiddel, PEG eller albumin som stabilisator.
11. IgG-produkt ifølge ethvert af de foregående krav, hvori pH er i området 5,1 -5, 7.
12. IgG-produkt ifølge ethvert af de foregående krav, hvori koncentrationen af IgG er 5 eller 10 vægt-%.
13. IgG-produkt ifølge ethvert af krav 1 til 11, hvori koncentrationen af IgG er 12, 14, 16, 18 eller 20 vægt-%.
14. IgG-produkt ifølge ethvert af de foregående krav, og som indeholder mindre end 1,5% polymere og aggregater.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98201909 | 1998-06-09 | ||
US10205598P | 1998-09-28 | 1998-09-28 | |
EP04077620A EP1493751A1 (en) | 1998-06-09 | 1999-06-09 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2270044T3 true DK2270044T3 (da) | 2015-01-26 |
Family
ID=44193921
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10011725.8T DK2270044T3 (da) | 1998-06-09 | 1999-06-09 | Flydende immunglobulin G (IgG) produkt |
DK10184829.9T DK2272870T3 (da) | 1998-06-09 | 1999-06-09 | Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10184829.9T DK2272870T3 (da) | 1998-06-09 | 1999-06-09 | Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter. |
Country Status (4)
Country | Link |
---|---|
US (2) | US6281336B1 (da) |
JP (1) | JP4685238B2 (da) |
DK (2) | DK2270044T3 (da) |
ES (2) | ES2421736T3 (da) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
US6962700B1 (en) * | 2000-09-13 | 2005-11-08 | Atopix Pharmaceuticals Corporation | Method of manufacturing immune globulin |
ES2184594B1 (es) * | 2001-01-17 | 2004-01-01 | Probitas Pharma Sa | Procedimiento para la produccion de gammaglobulina g humana inactivada de virus. |
IL157753A0 (en) * | 2001-03-09 | 2004-03-28 | Diapharm Ltd | Natural antibody active against hiv virus |
US6957672B2 (en) * | 2001-07-25 | 2005-10-25 | Imperial Chemical Industries Plc | Method for ensuring that coating compositions have correct color |
WO2003049117A2 (en) * | 2001-12-05 | 2003-06-12 | Cangene Corporation | Immune globulin formulations for the treatment and prevention of an orthopoxvirus infection |
WO2003066669A2 (en) * | 2002-02-04 | 2003-08-14 | Millipore Corporation | Process for removing protein aggregates and virus from a protein solution |
US20030201229A1 (en) * | 2002-02-04 | 2003-10-30 | Martin Siwak | Process for prefiltration of a protein solution |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
JPWO2004087761A1 (ja) * | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
PL1648940T3 (pl) | 2003-07-28 | 2016-12-30 | Redukcja wycieku białka A w trakcie chromatografii powinowactwa z białkiem A | |
WO2005072772A1 (en) * | 2004-01-30 | 2005-08-11 | Suomen Punainen Risti Veripalvelu | Pharmaceutical compositions |
NZ576986A (en) | 2004-01-30 | 2010-12-24 | Shire Pharmaceuticals Ireland Ltd | Production and purification of recombinant arylsulfatase A |
EP1718675B2 (en) * | 2004-02-27 | 2017-01-25 | Octapharma AG | A method of providing a purified, virus safe antibody preparation |
US20080038253A1 (en) * | 2004-03-04 | 2008-02-14 | Cascalho Marilia I | Methods For Altering T Cell Diversity |
AU2005279347A1 (en) * | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Affinity- plus ion exchange- chromatography for purifying antibodies |
TWI320788B (en) * | 2005-05-25 | 2010-02-21 | Hoffmann La Roche | Method for the purification of antibodies |
JP2008543839A (ja) | 2005-06-14 | 2008-12-04 | アムジェン インコーポレーテッド | 自己緩衝タンパク質製剤 |
US20070049732A1 (en) * | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
US8293242B2 (en) * | 2005-09-01 | 2012-10-23 | Plasma Technologies, Llc | Ultra-high yield of alpha-1-anti-trypsin |
US7879332B2 (en) * | 2005-09-01 | 2011-02-01 | Plasma Technologies, Llc | Ultra-high yield intravenous immune globulin preparation |
EP1963367A4 (en) * | 2005-12-06 | 2009-05-13 | Amgen Inc | POLISHING STEPS IN MULTI-STAGE PROTEIN PURIFICATION TREATMENTS |
FR2899111B1 (fr) * | 2006-03-31 | 2010-09-03 | Lab Francais Du Fractionnement | Concentre d'immunoglobulines specifiques du chikungunya en tant que medicament. |
NZ568728A (en) * | 2006-04-04 | 2011-09-30 | Shire Pharmaceuticals Ireland Ltd | A process for concentration of a aryl sulfatase A |
EP2029164B1 (en) * | 2006-06-07 | 2015-12-23 | The Board of Trustees of the Leland Stanford Junior University | Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy |
US20080031903A1 (en) * | 2006-07-27 | 2008-02-07 | Andrea Gambotto | Method of treating ocular infections |
US7714111B2 (en) * | 2006-09-08 | 2010-05-11 | Wyeth Llc | Arginine derivative wash in protein purification using affinity chromatography |
WO2008045563A2 (en) * | 2006-10-12 | 2008-04-17 | Wyeth | Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates |
DE102007001521A1 (de) * | 2007-01-10 | 2008-07-17 | Matthias, Torsten, Dr. | Verwendung von Cohn-Oncley-Fraktionen II und II/III zur Behandlung des systemischen Lupus erythematodes |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
CA2707483A1 (en) * | 2007-11-30 | 2009-06-11 | Wolfgang Fraunhofer | Protein formulations and methods of making same |
AU2013204044B2 (en) * | 2007-11-30 | 2017-08-31 | Abbvie Biotechnology Ltd. | Protein formulations and methods of making same |
EP2257804B1 (en) * | 2008-02-29 | 2013-12-11 | Baxter International Inc. | Anti-amyloid activity of intravenous immunoglobulin (ivig) in vitro |
MX2011012576A (es) * | 2009-05-27 | 2012-05-08 | Baxter Int | Metodo para producir una preparacion altamente concentrada de inmunoglobulina de uso subcutaneo. |
BR112012001843A2 (pt) | 2009-07-30 | 2016-03-15 | Hoffmann La Roche | separador de coluna de cromatografia móvel |
WO2011035282A1 (en) * | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
WO2011037983A1 (en) * | 2009-09-23 | 2011-03-31 | Medarex, Inc. | Cation exchange chromatography |
US8304248B2 (en) | 2009-11-16 | 2012-11-06 | Torres Anthony R | Protein separation via ion-exchange chromatography and associated methods, systems, and devices |
IT1397061B1 (it) | 2009-12-28 | 2012-12-28 | Kedrion Spa | Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale. |
RU2467783C2 (ru) * | 2010-07-30 | 2012-11-27 | Закрытое акционерное общество "БиоХимМак СТ" | Способ хроматографического выделения иммуноглобулина |
CA2814781A1 (en) * | 2010-11-01 | 2012-05-10 | Diderik Reinder Kremer | Single unit ion exchange chromatography antibody purification |
CA2824218C (en) | 2011-02-02 | 2019-12-03 | Andreas Blaschyk | Chromatography column support |
SI3318571T1 (sl) * | 2011-03-16 | 2021-08-31 | F. Hoffmann-La Roche Ag | Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze |
FR2974301B1 (fr) | 2011-04-20 | 2013-08-23 | Lab Francais Du Fractionnement | Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes |
IL212911A0 (en) * | 2011-05-16 | 2011-07-31 | Omrix Biopharmaceuticals Ltd | Immunoglobulin reduced in thrombogenic contaminants and preparation thereof |
CN103619868A (zh) * | 2011-06-16 | 2014-03-05 | 帝斯曼知识产权资产管理有限公司 | 单一单元色谱抗体纯化 |
WO2013009686A2 (en) | 2011-07-08 | 2013-01-17 | Shire Human Genetic Therapies, Inc. | Methods for purification of arylsulfatase a |
WO2013023362A1 (zh) * | 2011-08-16 | 2013-02-21 | 深圳市卫武光明生物制品有限公司 | 静注巨细胞病毒人免疫球蛋白及其制备方法 |
JP6165143B2 (ja) * | 2011-08-26 | 2017-07-19 | バクスアルタ ゲーエムベーハー | 血漿由来の免疫グロブリン組成物の血栓塞栓症の可能性を軽減する方法 |
ES2381828B1 (es) * | 2012-03-20 | 2012-11-16 | Grifols, S.A. | PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO |
EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
CA2884182C (en) | 2012-09-07 | 2022-06-14 | Coherus Biosciences, Inc. | Stable aqueous formulations of adalimumab |
AU2014205441B2 (en) | 2013-01-09 | 2019-12-12 | Takeda Pharmaceutical Company Limited | Methods for purification of arylsulfatase A |
AU2013203043B2 (en) * | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
KR102382662B1 (ko) * | 2013-07-01 | 2022-04-06 | 체에스엘 베링 아게 | 방법 |
EP3058084A4 (en) | 2013-10-16 | 2017-07-05 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
US9663553B2 (en) | 2014-01-29 | 2017-05-30 | Hemarus Therapeutics Limited | Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma |
US10414816B2 (en) * | 2014-03-11 | 2019-09-17 | Green Cross Holdings Corporation | Method for purifying immunoglobulin |
FR3018450B1 (fr) * | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
US9556253B2 (en) | 2014-12-02 | 2017-01-31 | Hemarus Therapeutics Limited | Process for increased yield of immunoglobulin from human plasma |
KR101657690B1 (ko) * | 2015-06-05 | 2016-09-19 | 주식회사 녹십자홀딩스 | 혈장 유래 b형 간염 사람 면역글로불린 제제의 제조방법 |
PT3135687T (pt) * | 2015-08-31 | 2019-05-21 | Inst Grifols S A | Método para preparação de imunoglobulinas |
WO2017058879A1 (en) * | 2015-09-29 | 2017-04-06 | Kieu Hoang | A method of manufacturing intravenous immunoglobulin from fraction iii |
US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
EP3275897A1 (en) * | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
TWI712612B (zh) * | 2016-09-26 | 2020-12-11 | 西班牙商格里佛機構有限公司 | 製備免疫球蛋白溶液的方法 |
CN114917185B (zh) | 2016-10-21 | 2023-11-14 | 美国安进公司 | 药物配制品及其制备方法 |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
KR20190047376A (ko) * | 2017-10-27 | 2019-05-08 | 주식회사 녹십자 | 개선된 면역글로불린의 정제방법 |
WO2021198220A1 (en) | 2020-03-30 | 2021-10-07 | Allero Therapeutics B.V. | Treatment and prevention of secondary inflammation in patients suffering from a viral infection |
AU2021318515A1 (en) * | 2020-07-27 | 2023-03-16 | Martin H. Bluth | Immunoglobulin mediated vaccinations against viral diseases |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3869436A (en) * | 1971-06-01 | 1975-03-04 | Statens Bakteriologiska Lab | Method for fractionating plasma proteins using peg and ion-exchangers |
DE2364792A1 (de) * | 1973-01-15 | 1974-07-18 | South African Inventions | Verfahren zum reinigen von gammaglobulin |
US4272521A (en) * | 1979-07-16 | 1981-06-09 | Cutter Laboratories, Inc. | Purified immune serum globulin |
US4315919A (en) | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
US4314997A (en) | 1980-10-06 | 1982-02-09 | Edward Shanbrom | Purification of plasma protein products |
US4764369A (en) | 1983-07-14 | 1988-08-16 | New York Blood Center Inc. | Undenatured virus-free biologically active protein derivatives |
JPS6042336A (ja) | 1983-08-18 | 1985-03-06 | Nippon Seiyaku Kk | 免疫グロブリンの製造方法 |
NZ216094A (en) | 1985-05-15 | 1989-06-28 | Commw Serum Lab Commission | Method for purification of an immunoglobulin |
DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
JP2547556B2 (ja) * | 1987-02-06 | 1996-10-23 | 株式会社 ミドリ十字 | r−グロブリンの液状製剤 |
US5177194A (en) * | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
DK0447585T4 (da) * | 1990-03-22 | 2003-09-01 | Biotest Pharma Gmbh | Fremgangsmåde til fremstilling af et intravenøst tolerant immunglobulin-G-præparat |
DE4118912C1 (da) * | 1991-06-08 | 1992-07-02 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
FR2706466B1 (fr) * | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
EP0659767B2 (de) * | 1993-12-27 | 2002-11-06 | ZLB Bioplasma AG | Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält |
TW491855B (en) | 1996-08-07 | 2002-06-21 | Csl Ltd | Purification of immunoglobulins |
US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
EP0911037B2 (en) | 1997-10-23 | 2007-06-13 | Mitsubishi Pharma Corporation | Room temperature storable immunoglobulin preparation for intravenous injection |
US6162904A (en) * | 1997-12-24 | 2000-12-19 | Alpha Therapeutic Corporation | Manufacturing method for intraveneously administrable immune globulin and resultant product |
UA64742C2 (uk) | 1997-12-24 | 2004-03-15 | Альфа Терапевтик Корпорейшн | СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ) |
-
1999
- 1999-06-09 US US09/328,497 patent/US6281336B1/en not_active Expired - Lifetime
- 1999-06-09 DK DK10011725.8T patent/DK2270044T3/da active
- 1999-06-09 JP JP2000553468A patent/JP4685238B2/ja not_active Expired - Lifetime
- 1999-06-09 ES ES10184829T patent/ES2421736T3/es not_active Expired - Lifetime
- 1999-06-09 ES ES10011725.8T patent/ES2527915T3/es not_active Expired - Lifetime
- 1999-06-09 DK DK10184829.9T patent/DK2272870T3/da active
-
2001
- 2001-07-10 US US09/902,174 patent/US7138120B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2002517516A (ja) | 2002-06-18 |
US7138120B2 (en) | 2006-11-21 |
ES2527915T3 (es) | 2015-02-02 |
US6281336B1 (en) | 2001-08-28 |
DK2272870T3 (da) | 2013-08-05 |
JP4685238B2 (ja) | 2011-05-18 |
ES2421736T3 (es) | 2013-09-05 |
US20010051708A1 (en) | 2001-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2270044T3 (da) | Flydende immunglobulin G (IgG) produkt | |
EP1084147B1 (en) | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products | |
US6806355B2 (en) | Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product | |
EA034602B1 (ru) | Способ получения обогащенной igg-композиции из криосупернатантной плазмы | |
EP0764447B1 (en) | Preparation of virally inactivated intravenously injectable immune serum globulin | |
AU764066B2 (en) | Purification process for production of mannan-binding lectin and an MBL medicinal product | |
AU2002321012B2 (en) | A purification process for large scale production of Gc-globulin, product obtained thereby and their use in medicine | |
AU2002321012A1 (en) | A purification process for large scale production of Gc-globulin, product obtained thereby and their use in medicine | |
MXPA00012230A (en) | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |