DK2260875T3 - Folatreceptor-targetede billeddannelsesmidler - Google Patents
Folatreceptor-targetede billeddannelsesmidlerInfo
- Publication number
- DK2260875T3 DK2260875T3 DK10179508.6T DK10179508T DK2260875T3 DK 2260875 T3 DK2260875 T3 DK 2260875T3 DK 10179508 T DK10179508 T DK 10179508T DK 2260875 T3 DK2260875 T3 DK 2260875T3
- Authority
- DK
- Denmark
- Prior art keywords
- imaging agents
- folate receptor
- targeted imaging
- targeted
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37857102P | 2002-05-06 | 2002-05-06 | |
EP09171503.7A EP2151250B1 (en) | 2002-05-06 | 2003-05-06 | Vitamin-Targeted imaging agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2260875T3 true DK2260875T3 (da) | 2014-06-30 |
Family
ID=29401611
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10179508.6T DK2260875T3 (da) | 2002-05-06 | 2003-05-06 | Folatreceptor-targetede billeddannelsesmidler |
DK09171503.7T DK2151250T3 (da) | 2002-05-06 | 2003-05-06 | Vitamin-targetede billeddannelsesmidler |
DK10179448.5T DK2258401T3 (da) | 2002-05-06 | 2003-05-06 | Folat-receptor targetede billeddannelsesmidler |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09171503.7T DK2151250T3 (da) | 2002-05-06 | 2003-05-06 | Vitamin-targetede billeddannelsesmidler |
DK10179448.5T DK2258401T3 (da) | 2002-05-06 | 2003-05-06 | Folat-receptor targetede billeddannelsesmidler |
Country Status (19)
Country | Link |
---|---|
US (5) | US7128893B2 (da) |
EP (4) | EP2258401B1 (da) |
JP (1) | JP4801348B2 (da) |
KR (1) | KR100978418B1 (da) |
CN (2) | CN100528241C (da) |
AT (1) | ATE448799T1 (da) |
AU (1) | AU2003239383C1 (da) |
CA (1) | CA2484345C (da) |
CY (1) | CY1114733T1 (da) |
DE (1) | DE60330135D1 (da) |
DK (3) | DK2260875T3 (da) |
ES (4) | ES2472423T3 (da) |
HK (1) | HK1141440A1 (da) |
IL (1) | IL164811A (da) |
NZ (1) | NZ536467A (da) |
PT (2) | PT2260875E (da) |
SI (2) | SI2260875T1 (da) |
WO (1) | WO2003092742A1 (da) |
ZA (1) | ZA200408664B (da) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE427948T1 (de) | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
KR20040015234A (ko) | 2001-05-02 | 2004-02-18 | 펄듀 리서치 파운데이션 | 대식세포 매개된 질환의 치료와 진단 |
US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
DK2260875T3 (da) | 2002-05-06 | 2014-06-30 | Endocyte Inc | Folatreceptor-targetede billeddannelsesmidler |
AU2003243226A1 (en) * | 2002-05-15 | 2003-12-02 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
DK1592457T3 (da) | 2003-01-27 | 2012-10-22 | Endocyte Inc | Folat-vinblastin-konjugat som lægemiddel |
JP2007526238A (ja) * | 2003-05-06 | 2007-09-13 | パーデュー・リサーチ・ファウンデーション | マクロファージまたは葉酸受容体を標的とする狼瘡治療法 |
ATE412897T1 (de) | 2003-05-30 | 2008-11-15 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
US7977500B2 (en) * | 2004-11-10 | 2011-07-12 | University Of South Florida | Platinum complexes for targeted drug delivery |
CA2592302C (en) * | 2004-12-23 | 2013-10-29 | Purdue Research Foundation | Positron emission tomography imaging method |
EP1863816B1 (en) * | 2005-03-16 | 2014-06-25 | Endocyte, Inc. | Synthesis and purification of pteroic acid and conjugates thereof |
JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
EP2382995A3 (en) | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
CN103893778A (zh) * | 2005-08-19 | 2014-07-02 | 恩多塞特公司 | 多药物配体缀合物 |
WO2007038346A2 (en) | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
EP2109466B1 (en) * | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
WO2008098788A2 (en) * | 2007-02-16 | 2008-08-21 | Ktb Tumorforschungsgesellschaft Mbh | Receptor and antigen targeted prodrug |
WO2008101231A2 (en) * | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
NZ599239A (en) | 2007-03-14 | 2013-10-25 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins |
EP2146995A1 (en) * | 2007-04-11 | 2010-01-27 | Merck Eprova AG | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
PL2146944T3 (pl) | 2007-04-11 | 2014-05-30 | Merck & Cie | Sposób otrzymywania folianów znakowanych fluorem-18 |
WO2008148001A2 (en) * | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
AU2008268432B2 (en) * | 2007-06-25 | 2015-01-15 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
PL2187965T3 (pl) * | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
JP2011500835A (ja) | 2007-10-25 | 2011-01-06 | エンドサイト,インコーポレイテッド | チューブリシン類および調製プロセス |
CN101903037A (zh) * | 2007-11-15 | 2010-12-01 | 恩多塞特公司 | 施用偶合物的方法 |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US8426398B2 (en) | 2009-01-13 | 2013-04-23 | Emory University | Conjugates of noscapine and folic acid and their use in treating cancer |
EP2403863B1 (en) | 2009-03-02 | 2013-08-28 | Alnylam Pharmaceuticals Inc. | Nucleic acid chemical modifications |
WO2010102238A1 (en) * | 2009-03-05 | 2010-09-10 | Purdue Research Foundation | Method for early imaging of atherosclerosis |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
CA2794522C (en) | 2010-04-05 | 2019-11-26 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
WO2011130716A2 (en) | 2010-04-16 | 2011-10-20 | Access Pharmaceuticals, Inc. | A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers |
US20130260460A1 (en) | 2010-04-22 | 2013-10-03 | Isis Pharmaceuticals Inc | Conformationally restricted dinucleotide monomers and oligonucleotides |
US10913767B2 (en) | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
CN103501821A (zh) | 2011-03-08 | 2014-01-08 | 艾克塞斯制药公司 | 用于递送活性剂穿过生物膜的靶向纳米载体*** |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
CN103732595B (zh) | 2011-08-17 | 2017-02-08 | 默克及其合伙人公司 | 叶酸的白蛋白‑结合实体缀合物 |
US9884123B2 (en) | 2012-01-03 | 2018-02-06 | Invictus Oncology Pvt. Ltd. | Ligand-targeted molecules and methods thereof |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
WO2013130776A1 (en) * | 2012-02-29 | 2013-09-06 | Purdue Research Foundation | Folate receptor alpha binding ligands |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
EP2877095A4 (en) * | 2012-07-25 | 2016-04-20 | Univ Emory | IMAGING AND THERAPEUTIC METHODS FOR THE TREATMENT OF PARATHYROID TUMORS |
CA2887727A1 (en) | 2012-10-16 | 2014-04-24 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
KR101551232B1 (ko) | 2012-10-26 | 2015-09-10 | 한국원자력연구원 | N3s1형의 새로운 킬레이터가 접합된 폴레이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암 진단 또는 치료용 조성물 |
SG10201706618UA (en) | 2012-11-15 | 2017-09-28 | Endocyte Inc | Conjugates for treating diseases caused by psma expressing cells |
WO2014150943A1 (en) * | 2013-03-15 | 2014-09-25 | Purdue Research Foundation | Asthma imaging and therapy |
US9879313B2 (en) | 2013-06-25 | 2018-01-30 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
EP3495355A1 (en) | 2013-10-18 | 2019-06-12 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
CN108514646B (zh) * | 2013-11-14 | 2021-07-16 | 恩多塞特公司 | 用于正电子发射断层术的化合物 |
ES2860173T3 (es) | 2013-11-19 | 2021-10-04 | Purdue Research Foundation | Método de selección de pacientes para inflamación |
KR20160132496A (ko) | 2014-04-03 | 2016-11-18 | 인빅터스 온콜로지 피비티. 엘티디. | 초분자 조합 치료제 |
WO2015200187A1 (en) * | 2014-06-27 | 2015-12-30 | Reiley Pharmaceuticals, Inc. | Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging |
US20160166679A1 (en) * | 2014-12-12 | 2016-06-16 | Purdue Research Foundation | Method of treatment using folate conjugates and tyrosine kinase inhibitors |
AU2015364508A1 (en) | 2014-12-18 | 2017-07-06 | Alnylam Pharmaceuticals, Inc. | ReversirTM compounds |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
US10053478B2 (en) | 2015-01-09 | 2018-08-21 | Reiley Pharmaceuticals, Inc. | COX-2-targeting, platinum-containing conjugates and their use in the treatment of tumors and cancers |
EP4119677B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
CA2989970A1 (en) | 2015-07-17 | 2017-01-26 | Alnylam Pharmaceuticals, Inc. | Multi-targeted single entity conjugates |
ES2811347T3 (es) * | 2015-08-14 | 2021-03-11 | Endocyte Inc | Método de formación de imágenes con un compuesto quelante |
CN115369161A (zh) | 2015-12-04 | 2022-11-22 | 10X 基因组学有限公司 | 用于核酸分析的方法和组合物 |
EP3429637A4 (en) | 2016-03-16 | 2020-03-11 | Endocyte, Inc. | CONJUGATES OF CARBONIC ANHYDRASE IX INHIBITORS AND USES THEREOF |
AU2017234676A1 (en) * | 2016-03-16 | 2018-09-20 | Purdue Research Foundation | Carbonic anhydrase IX targeting agents and methods |
US20170296679A1 (en) | 2016-04-18 | 2017-10-19 | Intuitive Surgical Operations, Inc. | Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands |
CN111225688A (zh) | 2017-08-22 | 2020-06-02 | 普渡研究基金会 | 靶向碳酸酐酶阳性癌症的基于fbsa的治疗和放射性成像缀合物 |
JP7353301B2 (ja) | 2018-05-07 | 2023-09-29 | アルニラム ファーマスーティカルズ インコーポレイテッド | 肝臓外送達 |
EP3856907A1 (en) | 2018-09-28 | 2021-08-04 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
US20220211743A1 (en) | 2019-05-17 | 2022-07-07 | Alnylam Pharmaceuticals, Inc. | Oral delivery of oligonucleotides |
WO2021086982A2 (en) | 2019-10-28 | 2021-05-06 | Beckman Coulter, Inc. | Compounds for the identification of microbial classes and uses thereof |
BR112022007795A2 (pt) | 2019-11-06 | 2022-07-05 | Alnylam Pharmaceuticals Inc | Administração extra-hepática |
EP4055165A1 (en) | 2019-11-06 | 2022-09-14 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US20230257745A1 (en) | 2020-07-10 | 2023-08-17 | Alnylam Pharmaceuticals, Inc. | Circular siRNAs |
EP4237087A1 (en) | 2020-10-30 | 2023-09-06 | Speer, Tod | Oligonucleotide-based therapeutics and uses thereof |
JP2024501857A (ja) | 2020-12-31 | 2024-01-16 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 環状ジスルフィド修飾リン酸ベースのオリゴヌクレオチドプロドラッグ |
EP4271695A2 (en) | 2020-12-31 | 2023-11-08 | Alnylam Pharmaceuticals, Inc. | 2'-modified nucleoside based oligonucleotide prodrugs |
EP4274619A1 (en) * | 2021-01-08 | 2023-11-15 | Lycia Therapeutics, Inc. | Bifunctional folate receptor binding compounds |
WO2023283403A2 (en) | 2021-07-09 | 2023-01-12 | Alnylam Pharmaceuticals, Inc. | Bis-rnai compounds for cns delivery |
CA3226887A1 (en) | 2021-07-21 | 2023-01-26 | Alnylam Pharmaceuticals, Inc. | Metabolic disorder-associated target gene irna compositions and methods of use thereof |
CA3234887A1 (en) | 2021-10-15 | 2023-04-20 | Alnylam Pharmaceuticals, Inc. | Extra-hepatic delivery irna compositions and methods of use thereof |
WO2023220744A2 (en) | 2022-05-13 | 2023-11-16 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
WO2024006999A2 (en) | 2022-06-30 | 2024-01-04 | Alnylam Pharmaceuticals, Inc. | Cyclic-disulfide modified phosphate based oligonucleotide prodrugs |
WO2024073732A1 (en) | 2022-09-30 | 2024-04-04 | Alnylam Pharmaceuticals, Inc. | Modified double-stranded rna agents |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2816110A (en) * | 1956-11-23 | 1957-12-10 | Merck & Co Inc | Methods for the production of substituted pteridines |
US5140104A (en) * | 1982-03-09 | 1992-08-18 | Cytogen Corporation | Amine derivatives of folic acid analogs |
US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
NZ217821A (en) | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
WO1992013572A1 (en) * | 1991-02-08 | 1992-08-20 | Diatech, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US6335434B1 (en) * | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
US5159079A (en) * | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
US6022966A (en) | 1993-11-22 | 2000-02-08 | Neorx Corporation | Pretargeting methods and compounds |
DE4311023C2 (de) * | 1993-03-31 | 1996-05-02 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
DE4311021A1 (de) * | 1993-03-31 | 1994-10-27 | Diagnostikforschung Inst | Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel |
DE4310999C2 (de) * | 1993-03-31 | 1996-07-18 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ XN¶1¶S¶1¶X' für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
DE4311022C2 (de) * | 1993-03-31 | 1996-07-11 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
DE4425781A1 (de) * | 1994-07-14 | 1996-01-18 | Schering Ag | Technetium-Sulfonamid-Komplexe, deren Verwendung, diese enthaltende pharmazeutische Mittel, sowie Verfahren zur Herstellung der Komplexe und Mittel |
US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
US6093382A (en) * | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
US6323313B1 (en) * | 1999-06-01 | 2001-11-27 | The University Of Washington | Annexin derivative with endogenous chelation sites |
JP5448284B2 (ja) * | 2000-06-02 | 2014-03-19 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | エチレンジシステイン(ec)−薬物結合体 |
KR20040015234A (ko) * | 2001-05-02 | 2004-02-18 | 펄듀 리서치 파운데이션 | 대식세포 매개된 질환의 치료와 진단 |
DK2260875T3 (da) * | 2002-05-06 | 2014-06-30 | Endocyte Inc | Folatreceptor-targetede billeddannelsesmidler |
DK1592457T3 (da) * | 2003-01-27 | 2012-10-22 | Endocyte Inc | Folat-vinblastin-konjugat som lægemiddel |
JP2007526238A (ja) * | 2003-05-06 | 2007-09-13 | パーデュー・リサーチ・ファウンデーション | マクロファージまたは葉酸受容体を標的とする狼瘡治療法 |
-
2003
- 2003-05-06 DK DK10179508.6T patent/DK2260875T3/da active
- 2003-05-06 DE DE60330135T patent/DE60330135D1/de not_active Expired - Lifetime
- 2003-05-06 JP JP2004500925A patent/JP4801348B2/ja not_active Expired - Fee Related
- 2003-05-06 ES ES10179508.6T patent/ES2472423T3/es not_active Expired - Lifetime
- 2003-05-06 DK DK09171503.7T patent/DK2151250T3/da active
- 2003-05-06 PT PT101795086T patent/PT2260875E/pt unknown
- 2003-05-06 CN CNB038146835A patent/CN100528241C/zh not_active Expired - Fee Related
- 2003-05-06 EP EP10179448.5A patent/EP2258401B1/en not_active Expired - Lifetime
- 2003-05-06 KR KR1020047017608A patent/KR100978418B1/ko active IP Right Grant
- 2003-05-06 CN CN200910151274XA patent/CN101648028B/zh not_active Expired - Fee Related
- 2003-05-06 NZ NZ536467A patent/NZ536467A/en not_active IP Right Cessation
- 2003-05-06 EP EP03733967A patent/EP1501551B1/en not_active Expired - Lifetime
- 2003-05-06 SI SI200332355T patent/SI2260875T1/sl unknown
- 2003-05-06 ES ES09171503.7T patent/ES2438008T3/es not_active Expired - Lifetime
- 2003-05-06 ES ES03733967T patent/ES2336780T3/es not_active Expired - Lifetime
- 2003-05-06 CA CA2484345A patent/CA2484345C/en not_active Expired - Fee Related
- 2003-05-06 SI SI200332331T patent/SI2151250T1/sl unknown
- 2003-05-06 AT AT03733967T patent/ATE448799T1/de not_active IP Right Cessation
- 2003-05-06 EP EP10179508.6A patent/EP2260875B1/en not_active Expired - Lifetime
- 2003-05-06 DK DK10179448.5T patent/DK2258401T3/da active
- 2003-05-06 WO PCT/US2003/014379 patent/WO2003092742A1/en active Application Filing
- 2003-05-06 ES ES10179448.5T patent/ES2500922T3/es not_active Expired - Lifetime
- 2003-05-06 EP EP09171503.7A patent/EP2151250B1/en not_active Expired - Lifetime
- 2003-05-06 PT PT91715037T patent/PT2151250E/pt unknown
- 2003-05-06 AU AU2003239383A patent/AU2003239383C1/en not_active Ceased
- 2003-05-06 US US10/430,519 patent/US7128893B2/en not_active Expired - Lifetime
-
2004
- 2004-10-25 IL IL164811A patent/IL164811A/en active IP Right Grant
- 2004-10-26 ZA ZA200408664A patent/ZA200408664B/en unknown
-
2006
- 2006-10-11 US US11/546,099 patent/US7862798B2/en not_active Expired - Fee Related
-
2009
- 2009-09-11 US US12/558,163 patent/US8313728B2/en not_active Expired - Lifetime
-
2010
- 2010-08-16 HK HK10107801.2A patent/HK1141440A1/xx not_active IP Right Cessation
-
2012
- 2012-10-18 US US13/654,527 patent/US8865126B2/en not_active Expired - Fee Related
-
2013
- 2013-03-11 US US13/793,624 patent/US8834842B2/en not_active Expired - Fee Related
- 2013-12-27 CY CY20131101164T patent/CY1114733T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2260875T3 (da) | Folatreceptor-targetede billeddannelsesmidler | |
ATE413175T1 (de) | Spiroinden- und spiroindan-verbindungen | |
BR0307924A (pt) | N-aril-2-oxazolidinona-5-carboxamidas e seus derivados | |
CY1113054T1 (el) | Παραγωγα διαμινης | |
ATE302775T1 (de) | Carbolinderivate | |
CY1114284T1 (el) | Σουλφονυλοπυρρολες ως hdac αναστολεις | |
DE60334567D1 (de) | Universal-shunt-verschluss | |
DK1414828T3 (da) | Antitumoranaloger | |
DK1453512T3 (da) | Acetylenderivater med mGluR5 antagonistisk virkning | |
DE60110844D1 (de) | Chinazolone derivate als alfa 1a/b adrenozeptor antagonisten | |
ATE346067T1 (de) | Carbolinderivate | |
ITMI20011306A0 (it) | Poliuretani vulcanizzabili | |
NO20010100L (no) | Beltestyreenhet | |
MY146098A (en) | Oxazole derivatives of tetracyclines | |
ATE330603T1 (de) | Benzothiazolderivaten | |
BRPI0409143A (pt) | n-aril-2-oxazolidinona-5-carboxamidas e seus derivados | |
BRPI0413744A (pt) | n-aril-2-ciano-oxazolidinonas e seus derivados | |
ATE321760T1 (de) | N-aryl-2-oxazolidinone und deren derivate | |
ATE478155T1 (de) | Glycopeptidantibiotika | |
ATE324370T1 (de) | Fungizide thiazolderivate | |
CY1115764T1 (el) | Αναστολεις iap | |
DE60219659D1 (de) | Heterocyclische retioidverbindungen | |
UA4789S (uk) | Фурнітура до замка | |
FI5333U1 (fi) | Porakoneen lisälaite | |
TW200712760A (en) | Resin compound containing norbornene derivatives and photosensitive composition containing the same |