DK2032575T3 - Hidtil ukendt 1,4-diaza-bicyklo[3.2.2]nonyl-oxadiazolyl-derivat og medicinsk anvendelse heraf - Google Patents

Hidtil ukendt 1,4-diaza-bicyklo[3.2.2]nonyl-oxadiazolyl-derivat og medicinsk anvendelse heraf

Info

Publication number: DK2032575T3
Authority: DK; Denmark
Prior art keywords: diseases; disorders; diaza; bicyclo; nonyl
Prior art date: 2006-05-30

Application number

DK07729591.3T

Other languages

English (en)

Inventor

Dan Peters

Gunnar M Olsen

Elsebet Oestergaard Nielsen

Daniel B Timmermann

Steven Charles Loechel

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-30

Filing date

2007-05-29

Publication date

2010-07-12

2007-05-29 Application filed by Neurosearch As filed Critical Neurosearch As

2010-07-12 Application granted granted Critical

2010-07-12 Publication of DK2032575T3 publication Critical patent/DK2032575T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Neurology (AREA)
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Addiction (AREA)
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Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Pulmonology (AREA)
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Pregnancy & Childbirth (AREA)
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Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
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Diabetes (AREA)
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Urology & Nephrology (AREA)
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DK07729591.3T 2006-05-30 2007-05-29 Hidtil ukendt 1,4-diaza-bicyklo[3.2.2]nonyl-oxadiazolyl-derivat og medicinsk anvendelse heraf DK2032575T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US80902406P	2006-05-30	2006-05-30
DKPA200600731		2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en)	2006-05-30	2007-05-29	Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number	Publication Date
DK2032575T3 true DK2032575T3 (da)	2010-07-12

Family

ID=40616686

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK07729591.3T DK2032575T3 (da)	2006-05-30	2007-05-29	Hidtil ukendt 1,4-diaza-bicyklo[3.2.2]nonyl-oxadiazolyl-derivat og medicinsk anvendelse heraf
DK07729590.5T DK2032574T3 (da)	2006-05-30	2007-05-29	Hidtil ukendt 1,4-diaza-bicyclo[3.2.2]nonyloxadiazolyl-derivater og medicinsk anvendelse deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK07729590.5T DK2032574T3 (da)	2006-05-30	2007-05-29	Hidtil ukendt 1,4-diaza-bicyclo[3.2.2]nonyloxadiazolyl-derivater og medicinsk anvendelse deraf

Country Status (23)

Country	Link
US (4)	US7807667B2 (da)
EP (3)	EP2032575B1 (da)
JP (2)	JP2009538866A (da)
KR (1)	KR101458194B1 (da)
CN (2)	CN101432286A (da)
AT (3)	ATE467634T1 (da)
AU (2)	AU2007267174B2 (da)
BR (1)	BRPI0708843A2 (da)
CA (2)	CA2653769A1 (da)
DE (2)	DE602007006486D1 (da)
DK (2)	DK2032575T3 (da)
ES (1)	ES2342334T3 (da)
IL (1)	IL193925A (da)
MX (2)	MX2008014887A (da)
MY (1)	MY147764A (da)
NO (1)	NO20085398L (da)
NZ (1)	NZ571288A (da)
PL (1)	PL2032575T3 (da)
PT (1)	PT2032575E (da)
RU (1)	RU2427581C2 (da)
UA (1)	UA95946C2 (da)
WO (2)	WO2007138038A1 (da)
ZA (1)	ZA200807756B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7807667B2 (en)	2006-05-30	2010-10-05	Neurosearch A/S	1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
CA2667545A1 (en) *	2006-10-25	2008-05-02	Neurosearch A/S	Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
EP2190848A1 (en)	2007-08-17	2010-06-02	Neurosearch A/S	Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
US8106042B2 (en)	2008-03-11	2012-01-31	Neurosearch A/S	1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
US20110112078A1 (en) *	2008-06-10	2011-05-12	Neurosearch A/S	Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010043539A1 (en) *	2008-10-13	2010-04-22	Neurosearch A/S	Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) *	2008-12-04	2011-10-20	Neurosearch A/S	Novel diaza-bicyclononyl-phenyl derivatives and their medical use
CN102300574A (zh)	2009-01-26	2011-12-28	神经研究公司	新的吲哚基-*二唑基-二氮杂二环壬烷衍生物及它们的医药和诊断用途
WO2010086280A1 (en)	2009-01-27	2010-08-05	Neurosearch A/S	Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086279A1 (en)	2009-01-27	2010-08-05	Neurosearch A/S	Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086278A1 (en)	2009-01-27	2010-08-05	Neurosearch A/S	Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010130768A1 (en) *	2009-05-14	2010-11-18	Neurosearch A/S	Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar)	2009-09-22	2018-09-16	Novartis Ag	إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
EP2498826A1 (en)	2009-11-11	2012-09-19	NeuroSearch AS	Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
EP2513097A1 (en)	2009-12-18	2012-10-24	NeuroSearch AS	Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en)	2011-04-15	2015-03-24	Danpet Ab	Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
BR122020005073A2 (pt)	2017-08-04	2020-10-13	Skyhawk Therapeutics, Inc.	Composto, composição farmacêutica e uso do composto
KR20210003160A (ko)	2018-04-18	2021-01-11	콘스텔레이션 파마슈티칼스, 인크.	메틸 변형 효소 조절제, 이의 조성물 및 용도
CA3100977A1 (en)	2018-05-21	2019-11-28	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
KR20210135242A (ko) *	2019-02-04	2021-11-12	스카이호크 테라퓨틱스, 인코포레이티드	스플라이싱을 조절하는 방법 및 조성물
KR20210135241A (ko)	2019-02-05	2021-11-12	스카이호크 테라퓨틱스, 인코포레이티드	스플라이싱을 조절하는 방법 및 조성물
KR20210135507A (ko)	2019-02-06	2021-11-15	스카이호크 테라퓨틱스, 인코포레이티드	스플라이싱을 조절하는 방법 및 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2809732B1 (fr)	2000-05-31	2002-07-19	Sanofi Synthelabo	DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr)	2000-05-31	2002-07-19	Sanofi Synthelabo	Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2832713B1 (fr)	2001-11-23	2004-02-13	Sanofi Synthelabo	Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2832712B1 (fr)	2001-11-23	2004-02-13	Sanofi Synthelabo	Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
KR20050062575A (ko) *	2002-09-30	2005-06-23	뉴로서치 에이/에스	신규한 1,4-디아자바이사이클로알칸 유도체, 이의 제법 및용도
PL375025A1 (en)	2002-09-30	2005-11-14	Neurosearch A/S	Novel 1,4-diazabicycloalkane derivatives, their preparation and use
ATE345342T1 (de) *	2002-11-11	2006-12-15	Neurosearch As	1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung
US6996399B2 (en) *	2003-01-13	2006-02-07	Micrel, Inc.	Wireless device and method using frequency hopping and sweep modes
EP2172469A1 (en) *	2004-02-04	2010-04-07	NeuroSearch A/S	Diazabicyclic aryl derivatives as cholinergic receptor modulators
WO2006087306A2 (en)	2005-02-16	2006-08-24	Neurosearch A/S	Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
US7807667B2 (en)	2006-05-30	2010-10-05	Neurosearch A/S	1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

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Also Published As

Publication number	Publication date
EP2032574B1 (en)	2010-05-12
EP2194056B1 (en)	2011-08-03
NO20085398L (no)	2008-12-29
RU2427581C2 (ru)	2011-08-27
CA2653818A1 (en)	2007-12-06
DE602007005802D1 (de)	2010-05-20
ATE467634T1 (de)	2010-05-15
CA2653769A1 (en)	2007-12-06
IL193925A (en)	2013-08-29
ATE463497T1 (de)	2010-04-15
EP2032575A1 (en)	2009-03-11
DE602007006486D1 (de)	2010-06-24
KR101458194B1 (ko)	2014-11-03
KR20090015155A (ko)	2009-02-11
US20120172353A1 (en)	2012-07-05
JP2009538866A (ja)	2009-11-12
EP2032574A1 (en)	2009-03-11
US20100216780A1 (en)	2010-08-26
UA95946C2 (ru)	2011-09-26
US8158619B2 (en)	2012-04-17
WO2007138037A1 (en)	2007-12-06
AU2007267174B2 (en)	2012-08-02
BRPI0708843A2 (pt)	2011-06-14
EP2194056A1 (en)	2010-06-09
US20100317654A1 (en)	2010-12-16
AU2007267174A1 (en)	2007-12-06
US20090118266A1 (en)	2009-05-07
RU2008139481A (ru)	2010-07-10
PT2032575E (pt)	2010-07-09
JP2009538867A (ja)	2009-11-12
US8372832B2 (en)	2013-02-12
ZA200807756B (en)	2009-11-25
MX2008014887A (es)	2008-12-05
MY147764A (en)	2013-01-31
NZ571288A (en)	2011-05-27
JP5290964B2 (ja)	2013-09-18
US7807667B2 (en)	2010-10-05
US8101598B2 (en)	2012-01-24
WO2007138038A1 (en)	2007-12-06
CN101426790B (zh)	2012-03-14
EP2032575B1 (en)	2010-04-07
PL2032575T3 (pl)	2010-09-30
MX2008014886A (es)	2008-12-05
CN101426790A (zh)	2009-05-06
ES2342334T3 (es)	2010-07-05
CN101432286A (zh)	2009-05-13
DK2032574T3 (da)	2010-09-20
AU2007267175A1 (en)	2007-12-06
ATE518862T1 (de)	2011-08-15

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