DK2029554T3 - Pyrazinderivater og anvendelser heraf til nyreovervågning - Google Patents
Pyrazinderivater og anvendelser heraf til nyreovervågningInfo
- Publication number
- DK2029554T3 DK2029554T3 DK07809706.0T DK07809706T DK2029554T3 DK 2029554 T3 DK2029554 T3 DK 2029554T3 DK 07809706 T DK07809706 T DK 07809706T DK 2029554 T3 DK2029554 T3 DK 2029554T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- pyrazine derivatives
- renal monitoring
- renal
- monitoring
- Prior art date
Links
- 238000012544 monitoring process Methods 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81571206P | 2006-06-22 | 2006-06-22 | |
PCT/US2007/014370 WO2007149479A1 (en) | 2006-06-22 | 2007-06-20 | Pyrazine derivatives and uses thereof in renal monitoring |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2029554T3 true DK2029554T3 (da) | 2014-06-10 |
Family
ID=38577613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07809706.0T DK2029554T3 (da) | 2006-06-22 | 2007-06-20 | Pyrazinderivater og anvendelser heraf til nyreovervågning |
Country Status (10)
Country | Link |
---|---|
US (6) | US8115000B2 (da) |
EP (1) | EP2029554B1 (da) |
JP (1) | JP2009534396A (da) |
CN (1) | CN101351454A (da) |
AU (1) | AU2007261398A1 (da) |
CA (1) | CA2628661A1 (da) |
DK (1) | DK2029554T3 (da) |
ES (1) | ES2456042T3 (da) |
IL (1) | IL189221A0 (da) |
WO (1) | WO2007149479A1 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2456042T3 (es) * | 2006-06-22 | 2014-04-21 | Medibeacon, LLC | Derivados de pirazina y usos de los mismos en la monitorización renal |
WO2007149478A2 (en) * | 2006-06-22 | 2007-12-27 | Mallinckrodt Inc. | Pyrazine derivatives with extended conjugation and uses thereof |
WO2008108944A2 (en) * | 2007-03-01 | 2008-09-12 | Mallinckrodt Inc. | Integrated photoactive small molecules and uses thereof |
WO2009061473A2 (en) * | 2007-11-07 | 2009-05-14 | Mallinckrodt Inc. | Photonic shell-core cross linked and functionalized nanostructures for biological applications |
CA2641297A1 (en) * | 2008-07-11 | 2010-01-11 | Richard B. Dorshow | Pyrazine derivatives, methods of use, and methods for preparing same |
US8697033B2 (en) | 2008-12-17 | 2014-04-15 | Medibeacon, LLC | Modified pyrazine derivatives and uses thereof |
US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
CN103002921A (zh) | 2010-05-14 | 2013-03-27 | 马林克罗特有限公司 | 用于联合的光学成像和治疗的功能***联纳米结构 |
US11077211B2 (en) | 2013-11-11 | 2021-08-03 | Medibeacon Inc. | Compositions and methods for assessing gut function |
HUE045725T2 (hu) | 2014-02-13 | 2020-01-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
ES2672797T3 (es) | 2014-02-13 | 2018-06-18 | Incyte Corporation | Ciclopropilaminas como inhibidores de LSD1 |
ES2760261T3 (es) | 2014-02-13 | 2020-05-13 | Incyte Corp | Ciclopropilaminas como inhibidores de LSD1 |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
MX2017012699A (es) | 2015-04-03 | 2018-02-09 | Incyte Corp | Compuestos heterociclicos como inhibidores de demetilasa 1 especifica de lisina (lsd1). |
JP6560766B2 (ja) * | 2015-05-12 | 2019-08-14 | メディビーコン,インク. | 目の血管系を評価するための組成物及び方法 |
KR20180051523A (ko) | 2015-08-12 | 2018-05-16 | 인사이트 코포레이션 | Lsd1 저해제의 염 |
SG11201809299QA (en) | 2016-04-22 | 2018-11-29 | Incyte Corp | Formulations of an lsd1 inhibitor |
RU2721652C1 (ru) | 2017-01-30 | 2020-05-21 | Медибикон Инк. | Способ неинвазивного мониторинга флуоресцентного индикаторного агента с меченым атомом с коррекциями диффузионного отражения |
IL269617B1 (en) | 2017-10-27 | 2024-05-01 | Medibeacon Inc | Compositions and systems for determining renal activity |
EP3700579A4 (en) * | 2017-10-27 | 2021-07-21 | MediBeacon Inc. | PROCEDURE FOR DETERMINING RENAL FUNCTION |
BR112019021044A2 (pt) | 2017-11-20 | 2020-05-12 | Medibeacon Inc. | Método para preparação e análise de compostos fluorescentes em plasma |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
WO2020122998A1 (en) * | 2018-12-12 | 2020-06-18 | Medibeacon Inc. | Uses of transdermal glomerular filtration rate measurement in continuous renal replacement therapy |
WO2020149885A1 (en) * | 2019-01-16 | 2020-07-23 | Medibeacon Inc. | Two piece sensor assembly and method of use |
CA3125975A1 (en) | 2019-01-28 | 2020-08-06 | Medibeacon Inc. | Systems and methods for home transdermal gfr monitoring |
WO2023016483A1 (zh) * | 2021-08-11 | 2023-02-16 | 杭州中美华东制药有限公司 | 制备作为荧光示踪剂的吡嗪羧酸类衍生物的方法 |
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JP4112877B2 (ja) | 2001-03-09 | 2008-07-02 | ダイセル化学工業株式会社 | 環状イミド系化合物で構成された触媒、及びこの触媒を用いた有機化合物の製造法 |
DE10222738A1 (de) | 2002-05-23 | 2003-12-11 | Johannes Wohlrab | Ketoprofen-enthaltende Arzneiformulierungen zur Anwendung für die Photodynamische Therapie |
JP2005304473A (ja) * | 2004-03-24 | 2005-11-04 | Nippon Soda Co Ltd | 生体表面を着色する染色方法 |
CN101010107A (zh) * | 2004-08-26 | 2007-08-01 | 马林克罗特公司 | 监测肾功能的发光金属络合物 |
WO2007106436A2 (en) | 2006-03-10 | 2007-09-20 | Mallinckrodt Inc. | Photoactive compounds and compositions and uses thereof |
JP2008525487A (ja) | 2004-12-23 | 2008-07-17 | マリンクロッド・インコーポレイテッド | 蛍光ピラジン誘導体および腎機能評価におけるその使用方法 |
ES2456042T3 (es) * | 2006-06-22 | 2014-04-21 | Medibeacon, LLC | Derivados de pirazina y usos de los mismos en la monitorización renal |
CA2641297A1 (en) * | 2008-07-11 | 2010-01-11 | Richard B. Dorshow | Pyrazine derivatives, methods of use, and methods for preparing same |
-
2007
- 2007-06-20 ES ES07809706.0T patent/ES2456042T3/es active Active
- 2007-06-20 US US11/995,223 patent/US8115000B2/en active Active
- 2007-06-20 DK DK07809706.0T patent/DK2029554T3/da active
- 2007-06-20 JP JP2009506648A patent/JP2009534396A/ja active Pending
- 2007-06-20 EP EP07809706.0A patent/EP2029554B1/en active Active
- 2007-06-20 CN CNA2007800010016A patent/CN101351454A/zh active Pending
- 2007-06-20 WO PCT/US2007/014370 patent/WO2007149479A1/en active Application Filing
- 2007-06-20 CA CA002628661A patent/CA2628661A1/en not_active Abandoned
- 2007-06-20 AU AU2007261398A patent/AU2007261398A1/en not_active Abandoned
-
2008
- 2008-02-03 IL IL189221A patent/IL189221A0/en unknown
-
2012
- 2012-01-04 US US13/343,231 patent/US8722685B2/en active Active
-
2014
- 2014-03-24 US US14/223,042 patent/US9114160B2/en not_active Ceased
-
2015
- 2015-07-21 US US14/805,048 patent/US9480687B2/en not_active Ceased
-
2017
- 2017-08-02 US US15/667,427 patent/USRE47413E1/en active Active
- 2017-08-03 US US15/668,254 patent/USRE47255E1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2029554A1 (en) | 2009-03-04 |
US20140286874A1 (en) | 2014-09-25 |
US9480687B2 (en) | 2016-11-01 |
ES2456042T3 (es) | 2014-04-21 |
CA2628661A1 (en) | 2007-12-27 |
EP2029554B1 (en) | 2014-03-19 |
US9114160B2 (en) | 2015-08-25 |
US20090198053A1 (en) | 2009-08-06 |
USRE47413E1 (en) | 2019-06-04 |
CN101351454A (zh) | 2009-01-21 |
JP2009534396A (ja) | 2009-09-24 |
US20120100078A1 (en) | 2012-04-26 |
IL189221A0 (en) | 2008-06-05 |
US8115000B2 (en) | 2012-02-14 |
US20150320745A1 (en) | 2015-11-12 |
US8722685B2 (en) | 2014-05-13 |
AU2007261398A1 (en) | 2007-12-27 |
WO2007149479A1 (en) | 2007-12-27 |
USRE47255E1 (en) | 2019-02-26 |
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