DK199885A - Amidinohydrazoner af tetralin-, chromon-, thiochromon- og tetrahydroquinolin-derivater, fremgangsmaader til deres fremstilling samt deresanvendelse i laegemidler - Google Patents
Amidinohydrazoner af tetralin-, chromon-, thiochromon- og tetrahydroquinolin-derivater, fremgangsmaader til deres fremstilling samt deresanvendelse i laegemidler Download PDFInfo
- Publication number
- DK199885A DK199885A DK199885A DK199885A DK199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A
- Authority
- DK
- Denmark
- Prior art keywords
- thiochromon
- hydrazons
- chromon
- tetralin
- amidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
Description
A betyder en binding, CR4R5, CR6R7-CR8R9, CR10R1;L-CR12R13--CR14R15, CR16=CR17 CO eller C=NOH, hvori r\ R2, R4-R·*·7 er ens eller forskellige og betyder hydrogen eller substituenter valgt blandt halogen, alkyl, alkoxy, alkylthio, alkyl-sulfinyl, cyano, hydroxy, nitro, mono-eller polyfluoralkyl, mono- eller polyfluoralkoxy, monoeller polyfluoralkylthio, amino, monoalkylaroino eller di-alkylamino eller betyder en aromatisk eller heteroaromatisk gruppe, som eventuelt er substitueret med 1-5 ens eller forskellige substituenter valgt blandt hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono- eller polyfluoralkyl, mono- eller polyfluoralkoxy, mono- eller polyfluoralkylthio, amino, monoalkyl-amino eller dialkylamino, R betyder hydrogen, alkyl, aryl, acyl eller alkansulfonyl, som eventuelt er substitueret med 1-5 ens eller forskellige substituenter valgt blandt hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono- eller polyfluoralkyl, mono- eller polyfluoralkoxy, mono- eller polyfluoralkylthio, amino, monoalkylamino eller dialkylamino, i form af isomere, isomerblandinger, racemater og optiske antipoder samt deres farmaceutisk uskadelige salte, er anvendelige i lægemidler, især lægemidler til påvirkning af kredsløbet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3416695 | 1984-05-05 | ||
DE19843416695 DE3416695A1 (de) | 1984-05-05 | 1984-05-05 | Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
Publications (2)
Publication Number | Publication Date |
---|---|
DK199885D0 DK199885D0 (da) | 1985-05-02 |
DK199885A true DK199885A (da) | 1985-11-06 |
Family
ID=6235059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK199885A DK199885A (da) | 1984-05-05 | 1985-05-02 | Amidinohydrazoner af tetralin-, chromon-, thiochromon- og tetrahydroquinolin-derivater, fremgangsmaader til deres fremstilling samt deresanvendelse i laegemidler |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0163888A1 (da) |
JP (1) | JPS60239454A (da) |
KR (1) | KR850008672A (da) |
AU (1) | AU4200885A (da) |
DE (1) | DE3416695A1 (da) |
DK (1) | DK199885A (da) |
ES (1) | ES8607271A1 (da) |
FI (1) | FI851736L (da) |
GR (1) | GR851073B (da) |
HU (1) | HUT38609A (da) |
ZA (1) | ZA853328B (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4839368A (en) * | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
HU197331B (en) * | 1986-06-26 | 1989-03-28 | Alkaloida Vegyeszeti Gyar | Process for producing benzopiran derivatives, as well as insecticide and nematocide compositions comprising these compounds as active ingredient |
JP2602037B2 (ja) * | 1987-10-31 | 1997-04-23 | 持田製薬株式会社 | 1−アシル−2,3−ジヒドロ−4(1h)−キノリノン−4−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物 |
US5238941A (en) * | 1988-03-25 | 1993-08-24 | Ciba-Geigy Corporation | Arylhydrazones and pharmaceutical compositions thereof |
US5395855A (en) * | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
AU645799B2 (en) * | 1990-05-07 | 1994-01-27 | Novartis Ag | Hydrazones |
US5474998A (en) * | 1990-08-17 | 1995-12-12 | E. I. Du Pont De Nemours And Company | Arthropodicidal pyrazolines, pyrazolidines and hydrazines |
FR2669927B1 (fr) * | 1990-11-29 | 1994-04-08 | Adir Cie | Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
CA2316944A1 (en) | 1998-02-20 | 1999-08-26 | Mitsuru Shiraishi | Aminoguanidinehydrazone derivative, production and use thereof |
WO2000075115A1 (fr) * | 1999-06-03 | 2000-12-14 | Takeda Chemical Industries, Ltd. | Preparations s'administrant par voie nasale |
TWI366565B (en) | 2007-06-06 | 2012-06-21 | Otsuka Pharma Co Ltd | Quinolone compound and pharmaceutical composition |
TWI492943B (zh) | 2008-12-05 | 2015-07-21 | 大塚製藥股份有限公司 | 喹啉酮化合物及藥學組成物(二) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1493677A1 (de) * | 1964-10-01 | 1969-06-19 | Bayer Ag | Verfahren zur Herstellung von Guanylhydrazonen |
FR2036989A1 (en) * | 1969-04-28 | 1970-12-31 | Anvar | Amidino hydrazone antivirals |
NL7407469A (nl) * | 1974-06-01 | 1975-12-03 | Akzo Nv | Nieuwe amidinohydrazonverbindingen. |
DE2736064A1 (de) * | 1977-08-10 | 1979-02-22 | Bayer Ag | Antimalaria-mittel |
-
1984
- 1984-05-05 DE DE19843416695 patent/DE3416695A1/de not_active Withdrawn
-
1985
- 1985-04-20 EP EP85104825A patent/EP0163888A1/de not_active Withdrawn
- 1985-04-26 ES ES542615A patent/ES8607271A1/es not_active Expired
- 1985-05-01 JP JP60092390A patent/JPS60239454A/ja active Pending
- 1985-05-02 FI FI851736A patent/FI851736L/fi not_active Application Discontinuation
- 1985-05-02 DK DK199885A patent/DK199885A/da not_active Application Discontinuation
- 1985-05-03 ZA ZA853328A patent/ZA853328B/xx unknown
- 1985-05-03 HU HU851696A patent/HUT38609A/hu unknown
- 1985-05-03 GR GR851073A patent/GR851073B/el unknown
- 1985-05-03 KR KR1019850003017A patent/KR850008672A/ko not_active IP Right Cessation
- 1985-05-06 AU AU42008/85A patent/AU4200885A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES8607271A1 (es) | 1986-05-16 |
KR850008672A (ko) | 1985-12-21 |
HUT38609A (en) | 1986-06-30 |
AU4200885A (en) | 1985-11-07 |
DK199885D0 (da) | 1985-05-02 |
DE3416695A1 (de) | 1985-11-07 |
JPS60239454A (ja) | 1985-11-28 |
FI851736L (fi) | 1985-11-06 |
ZA853328B (en) | 1985-12-24 |
FI851736A0 (fi) | 1985-05-02 |
ES542615A0 (es) | 1986-05-16 |
EP0163888A1 (de) | 1985-12-11 |
GR851073B (da) | 1985-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ATS | Application withdrawn |