DK1991690T3 - Fremgangsmåde til fremstilling af sialylerede oligosaccharider - Google Patents

Fremgangsmåde til fremstilling af sialylerede oligosaccharider

Info

Publication number
DK1991690T3
DK1991690T3 DK07726672.4T DK07726672T DK1991690T3 DK 1991690 T3 DK1991690 T3 DK 1991690T3 DK 07726672 T DK07726672 T DK 07726672T DK 1991690 T3 DK1991690 T3 DK 1991690T3
Authority
DK
Denmark
Prior art keywords
preparing
procedure
sialylated oligosaccharides
sialylated
oligosaccharides
Prior art date
Application number
DK07726672.4T
Other languages
English (en)
Inventor
Eric Samain
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of DK1991690T3 publication Critical patent/DK1991690T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK07726672.4T 2006-03-09 2007-03-07 Fremgangsmåde til fremstilling af sialylerede oligosaccharider DK1991690T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78035006P 2006-03-09 2006-03-09
PCT/EP2007/052114 WO2007101862A1 (en) 2006-03-09 2007-03-07 Method of producing sialylated oligosaccharides

Publications (1)

Publication Number Publication Date
DK1991690T3 true DK1991690T3 (da) 2014-04-14

Family

ID=38197625

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07726672.4T DK1991690T3 (da) 2006-03-09 2007-03-07 Fremgangsmåde til fremstilling af sialylerede oligosaccharider

Country Status (13)

Country Link
US (1) US8507227B2 (da)
EP (1) EP1991690B1 (da)
CN (1) CN101415834B (da)
AU (1) AU2007222375B2 (da)
CA (1) CA2645141C (da)
DK (1) DK1991690T3 (da)
ES (1) ES2456292T3 (da)
MY (1) MY148510A (da)
PL (1) PL1991690T3 (da)
PT (1) PT1991690E (da)
RU (1) RU2473695C2 (da)
SI (1) SI1991690T1 (da)
WO (1) WO2007101862A1 (da)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820422B2 (en) * 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
US20070202578A1 (en) * 2005-08-26 2007-08-30 Centre National De La Recherche Scientifique (Cnrs) Production of globosides oligosaccharides using metabolically engineered microorganisms
CN102257128A (zh) 2008-12-19 2011-11-23 詹内怀恩生物技术股份有限公司 岩藻糖化化合物的合成
NZ605093A (en) * 2010-07-12 2014-05-30 Univ Gent Metabolically engineered organisms for the production of added value bio-products
MX354145B (es) * 2010-11-03 2018-02-14 Terravia Holdings Inc Aceites microbianos con puntos de fluidez reducidos, fluidos dielectricos producidos a partir de estos y metodos relacionados.
US9816107B2 (en) 2011-07-29 2017-11-14 The University Of Wyoming Transgenic insect cells comprising a bacterial GlcNAc-6-P 2′-epimerase
WO2013019625A2 (en) 2011-07-29 2013-02-07 The University Of Wyoming Methods of using a bacterial glcnac-6-p 2'-epimerase to promote sialylation of glycoconjugates
EP2900829B1 (en) * 2012-09-25 2019-06-26 Glycom A/S Glycoconjugate synthesis
WO2014135167A1 (en) * 2013-03-08 2014-09-12 Glycom A/S Purification of oligosaccaharides by reversible derivatization
DK2970872T3 (da) * 2013-03-14 2019-01-02 Glycosyn LLC Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og N-acetylglucosamin-holdige oligosaccharider
PL2999358T3 (pl) 2013-05-22 2021-12-20 Glycom A/S Syntetyczna mieszanina oligosacharydów do leczenia mikrobioty ssaka
CN104342469B (zh) * 2013-08-01 2017-06-30 东北师范大学 一种生物转化制备单唾液酸四己糖神经节苷脂的方法
WO2015032413A1 (en) 2013-09-06 2015-03-12 Glycom A/S Fermentative production of oligosaccharides
CN103602627B (zh) * 2013-11-25 2015-03-18 武汉中科光谷绿色生物技术有限公司 一种产n-乙酰神经氨酸大肠杆菌工程菌及其构建方法和应用
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
US10731193B2 (en) 2014-06-27 2020-08-04 Glycom A/S Oligosaccharide production
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
CN107108677B (zh) 2014-10-24 2020-08-07 格礼卡姆股份公司 Hmo的混合物
JP7182872B2 (ja) 2014-10-29 2022-12-05 グリコム・アクティーゼルスカブ 過敏性腸症候群の治療のための合成組成物および方法
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
DK3212198T3 (en) 2014-10-29 2021-03-29 Glycom As Synthetic composition and method for promoting mucosal healing
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
JP6765372B2 (ja) * 2014-11-14 2020-10-07 インビオース エヌ.ヴェ.Inbiose N.V. ラクトース死滅に耐性である変異体微生物
CN107106584A (zh) 2014-12-08 2017-08-29 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
DK3277287T3 (da) 2015-03-31 2024-01-08 Glycom As Blandinger af humane mælke-oligosaccharider, der omfatter 3 '-o-sialyllactose
ES2870973T3 (es) 2015-06-09 2021-10-28 Glycom As Mezclas ternarias de 6'-SL, LNnT y LST c
EP3141610A1 (en) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
DK3349763T3 (en) 2015-09-14 2021-11-15 Glycom As Composition for use in microbiota modulation
PL3368046T3 (pl) 2015-10-28 2022-11-28 Glycom A/S Syntetyczna kompozycja i sposób modulowania funkcji mózgu i zachowania
US10780103B2 (en) 2015-10-28 2020-09-22 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
CN108348536B (zh) 2015-11-17 2021-09-24 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
CA3006400A1 (en) 2015-11-30 2017-06-08 Limmatech Biologics Ag Methods of producing glycosylated proteins
MY186217A (en) 2015-12-15 2021-06-30 Nestle Sa Mixture of hmos
WO2017101958A1 (en) 2015-12-18 2017-06-22 Glycom A/S Fermentative production of oligosaccharides
EP3419630A4 (en) 2016-02-24 2019-11-06 Glycom A/S SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION
EP3426670A4 (en) 2016-03-07 2019-11-13 Glycom A/S SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
PL3452050T3 (pl) 2016-05-05 2023-06-12 Glycom A/S Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej
WO2017198276A1 (en) 2016-05-19 2017-11-23 Glycom A/S Synthetic composition
US11419884B2 (en) 2016-06-24 2022-08-23 Glycom A/S Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3562951A1 (en) 2016-12-27 2019-11-06 Inbiose N.V. In vivo synthesis of sialylated compounds
WO2018157900A1 (en) 2017-03-01 2018-09-07 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
EP3630123A4 (en) 2017-05-24 2020-10-28 Glycom A/S SYNTHETIC COMPOSITION WITH ONE OR MORE HUMAN MILK OLIGOSACCHARIDES (HMOS)
US20200123184A1 (en) 2017-06-30 2020-04-23 Glycom A/S Purification of oligosaccharides
US11505567B2 (en) 2017-07-12 2022-11-22 Glycom A/S Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component
EP3658678A1 (en) 2017-07-26 2020-06-03 Jennewein Biotechnologie GmbH Sialyltransferases and their use in producing sialylated oligosaccharides
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms
EP3456836A1 (en) 2017-09-13 2019-03-20 Glycom A/S Separation of sialylated oligosaccharides from fermentation broth
EP3703698A4 (en) 2017-11-02 2021-08-18 Glycom A/S ONE OR MORE HMOS TO REDUCE OR PREVENT FATIGUE AND / OR IMPROVE CONCENTRATION
KR20200096263A (ko) 2017-11-30 2020-08-11 글리콤 에이/에스 밀 민감증을 치료하기 위한 hmo 혼합물
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
CA3085931A1 (en) * 2017-12-15 2019-06-20 Glycosyn LLC Sialyltransferases and uses thereof
US11304966B2 (en) 2017-12-22 2022-04-19 Glycom A/S Composition comprising HMOs for preventing or reducing nociception
GB2573539A (en) 2018-05-09 2019-11-13 Mjn Us Holdings Llc Wellbeing supplement for postpartum maternal nutrition
PL3575404T3 (pl) 2018-05-28 2023-02-06 Chr. Hansen HMO GmbH Fermentacyjna produkcja sacharydów sialilowanych
KR20210016557A (ko) 2018-05-31 2021-02-16 글리콤 에이/에스 자가면역 질환 치료를 위한 hmo 혼합물
PL3801037T3 (pl) * 2018-06-01 2023-01-23 Chr. Hansen HMO GmbH Prosty sposób oczyszczania sialilolaktozy
JP2022513524A (ja) 2018-12-19 2022-02-08 グリコム・アクティーゼルスカブ 低fodmap食を使用してヒトを治療するための組成物および方法
CN109852651B (zh) * 2018-12-27 2022-03-15 大连大学 一种重组大肠杆菌质周腔内生产唾液酸修饰n-糖基化重组蛋白方法
CN110195043A (zh) * 2019-05-15 2019-09-03 武汉格莱利生物科技有限公司 一种高水溶性的cgta酶及其制备方法和应用
EP3789495A1 (en) * 2019-09-03 2021-03-10 Jennewein Biotechnologie GmbH Production of sialylated oligosaccharides in bacillus cells
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
WO2021094133A2 (en) 2019-11-13 2021-05-20 Basf Se Enzymatic hydrolysis of 2',3-difucosyllactose
CN114901825A (zh) 2019-12-18 2022-08-12 因比奥斯公司 在宿主细胞中产生唾液酸化寡糖
KR20220116001A (ko) * 2019-12-19 2022-08-19 글리콤 에이/에스 발효액으로부터 시알릴화된 올리고사카라이드의 분리
EP3848471A1 (en) * 2020-01-10 2021-07-14 Chr. Hansen HMO GmbH Sequential fermentative production of oligosaccharides
WO2021170620A1 (en) 2020-02-24 2021-09-02 Carbocode S.A. Synthesis of glycosyl fluorides
EP4110934A1 (en) 2020-02-24 2023-01-04 Carbocode S.A. Synthesis of c-glycosides of interest
EP4110935A2 (en) 2020-02-24 2023-01-04 Carbocode S.A. Synthesis of glycosylated sphingoid bases of interest or analogues thereof
CN111500660A (zh) * 2020-04-23 2020-08-07 武汉糖智药业有限公司 一种单唾液酸四己糖神经节苷脂的合成方法
EP3954769A1 (en) * 2020-08-10 2022-02-16 Inbiose N.V. Production of oligosaccharide mixtures by a cell
FR3110176B1 (fr) 2020-05-12 2022-05-13 Institut Nat Des Sciences Appliquees De Toulouse Souche et procédé de production d’oligosaccharides
WO2022034067A1 (en) 2020-08-10 2022-02-17 Inbiose N.V. Production of an oligosaccharide mixture by a cell
EP4281564A1 (en) 2021-01-22 2023-11-29 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos
CA3209837A1 (en) 2021-01-29 2022-08-04 Centre National De La Recherche Scientifique (Cnrs) Novel sialosides and their use in therapy
CN117157394A (zh) 2021-04-16 2023-12-01 因比奥斯公司 发酵生产
KR20230170961A (ko) * 2021-04-16 2023-12-19 인바이오스 엔.브이. 시알릴화 이당 및/또는 올리고당의 세포 생산
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
WO2022242860A1 (en) 2021-05-20 2022-11-24 Chr. Hansen A/S Sequential fermentative production of oligosaccharides
WO2022263425A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
EP4355464A1 (en) 2021-06-15 2024-04-24 DSM IP Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
WO2022263424A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
WO2022263426A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
WO2023097604A1 (zh) * 2021-12-02 2023-06-08 岩唐生物科技(杭州)有限责任公司 分离的多肽及其应用
DK181319B1 (en) 2022-03-02 2023-08-10 Dsm Ip Assets Bv Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl
WO2023166035A2 (en) 2022-03-02 2023-09-07 Dsm Ip Assets B.V. New sialyltransferases for in vivo synthesis of 3'sl and 6'sl
DK202270078A1 (en) 2022-03-02 2023-12-04 Dsm Ip Assets Bv New sialyltransferases for in vivo synthesis of lst-a
CN114965543B (zh) * 2022-06-13 2023-10-20 青岛科技大学 壳寡糖nmr波谱的归属及脱乙酰度相关指标的测定方法
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
DK202200591A1 (en) 2022-06-20 2024-02-15 Dsm Ip Assets Bv New sialyltransferases for in vivo synthesis of lst-c

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2125092C1 (ru) * 1991-10-15 1999-01-20 Дзе Скриппс Рисерч Инститьют Способ получения фукозилированного углевода, способ получения фукозилированной сиалилированной углеводной молекулы, реакционная система in vitro
US6194178B1 (en) * 1998-09-03 2001-02-27 Synsorb Biotech Inc. Method for the production of sialylated oligosaccharides
FR2796082B1 (fr) * 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
EP1484406B1 (en) 2002-02-28 2016-04-13 Kyowa Hakko Bio Co., Ltd. Process for producing n-acetylneuraminic acid
JP4932699B2 (ja) 2004-03-17 2012-05-16 グライコフィ, インコーポレイテッド 真菌および酵母におけるシチジンモノホスフェート−シアル酸合成経路を操作する方法
US20080145899A1 (en) 2004-09-17 2008-06-19 Neose Technologies Inc Production of Oligosaccharides By Microorganisms

Also Published As

Publication number Publication date
CN101415834A (zh) 2009-04-22
MY148510A (en) 2013-04-30
CN101415834B (zh) 2014-09-24
RU2008139968A (ru) 2010-04-20
US8507227B2 (en) 2013-08-13
WO2007101862A1 (en) 2007-09-13
AU2007222375B2 (en) 2012-12-20
SI1991690T1 (sl) 2014-06-30
ES2456292T3 (es) 2014-04-21
PL1991690T3 (pl) 2014-07-31
EP1991690B1 (en) 2014-01-15
US20110014661A1 (en) 2011-01-20
RU2473695C2 (ru) 2013-01-27
AU2007222375A1 (en) 2007-09-13
CA2645141A1 (en) 2007-09-13
EP1991690A1 (en) 2008-11-19
PT1991690E (pt) 2014-04-22
CA2645141C (en) 2018-07-10

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