DK1979370T3 - Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider - Google Patents

Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider

Info

Publication number
DK1979370T3
DK1979370T3 DK07703919.6T DK07703919T DK1979370T3 DK 1979370 T3 DK1979370 T3 DK 1979370T3 DK 07703919 T DK07703919 T DK 07703919T DK 1979370 T3 DK1979370 T3 DK 1979370T3
Authority
DK
Denmark
Prior art keywords
enzymatic hydrolysis
butyl ester
selective enzymatic
peptides
terminal
Prior art date
Application number
DK07703919.6T
Other languages
English (en)
Inventor
Ivo Franci Eggen
Carmen G Boeriu
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of DK1979370T3 publication Critical patent/DK1979370T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK07703919.6T 2006-01-17 2007-01-16 Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider DK1979370T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100420 2006-01-17
PCT/EP2007/050409 WO2007082890A1 (en) 2006-01-17 2007-01-16 SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES

Publications (1)

Publication Number Publication Date
DK1979370T3 true DK1979370T3 (da) 2010-06-28

Family

ID=37025119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07703919.6T DK1979370T3 (da) 2006-01-17 2007-01-16 Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider

Country Status (8)

Country Link
US (2) US20090093016A1 (da)
EP (1) EP1979370B1 (da)
AT (1) ATE461208T1 (da)
BR (1) BRPI0706400A2 (da)
DE (1) DE602007005349D1 (da)
DK (1) DK1979370T3 (da)
ES (1) ES2340885T3 (da)
WO (1) WO2007082890A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008155381A1 (en) * 2007-06-19 2008-12-24 Dsm Ip Assets B.V. Process for selective enzymatic hydrolysis of pendant esters of a polymer
US8450084B2 (en) 2007-10-12 2013-05-28 Enzypep B.V. Chemo-enzymatic peptide synthesis via C-terminal ester interconversion
BR112023018676A2 (pt) 2021-03-18 2023-10-10 Seagen Inc Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3733222A1 (de) * 1987-10-01 1989-04-13 Hoechst Ag Verfahren zur herstellung von optisch reinem homophenylalanin
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5256814A (en) * 1990-12-07 1993-10-26 Scios Nova Inc. Excitatory amino acid antagonists
ES2051647B1 (es) * 1992-12-10 1995-01-16 Lipotec Sa Procedimiento para la preparacion de calcitonina de salmon.
US6187579B1 (en) * 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5981267A (en) * 1996-01-24 1999-11-09 The Scripps Research Institute Enantioselection of amines using homocarbonates with hydrolase
TW505654B (en) * 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
CA2331783C (en) * 1998-07-02 2009-12-29 Genencor International, Inc. Chemically modified proteins with a carbohydrate moiety
FR2814744B1 (fr) * 2000-10-04 2002-11-29 Commissariat Energie Atomique Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
NL1017258C2 (nl) * 2001-02-01 2002-08-02 Univ Delft Tech Werkwijze voor het maken van vernette enzymaggregaten.
AU2002310050A1 (en) * 2001-05-23 2002-12-03 Diversa Corporation Peptide synthesis method
IL150600A (en) * 2001-07-19 2005-09-25 Akzo Nobel Nv Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
US7084247B2 (en) * 2004-03-11 2006-08-01 Peptimmune, Inc. Identification of self and non-self antigens implicated in autoimmune diseases
US8124372B2 (en) * 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides

Also Published As

Publication number Publication date
US20090093016A1 (en) 2009-04-09
BRPI0706400A2 (pt) 2011-03-29
EP1979370A1 (en) 2008-10-15
US20120231497A1 (en) 2012-09-13
ATE461208T1 (de) 2010-04-15
DE602007005349D1 (de) 2010-04-29
WO2007082890A1 (en) 2007-07-26
ES2340885T3 (es) 2010-06-10
EP1979370B1 (en) 2010-03-17

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