DK1979370T3 - Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider - Google Patents
Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptiderInfo
- Publication number
- DK1979370T3 DK1979370T3 DK07703919.6T DK07703919T DK1979370T3 DK 1979370 T3 DK1979370 T3 DK 1979370T3 DK 07703919 T DK07703919 T DK 07703919T DK 1979370 T3 DK1979370 T3 DK 1979370T3
- Authority
- DK
- Denmark
- Prior art keywords
- enzymatic hydrolysis
- butyl ester
- selective enzymatic
- peptides
- terminal
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 210000004899 c-terminal region Anatomy 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000007071 enzymatic hydrolysis Effects 0.000 title abstract 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000787 Subtilisin Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06100420 | 2006-01-17 | ||
PCT/EP2007/050409 WO2007082890A1 (en) | 2006-01-17 | 2007-01-16 | SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1979370T3 true DK1979370T3 (da) | 2010-06-28 |
Family
ID=37025119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07703919.6T DK1979370T3 (da) | 2006-01-17 | 2007-01-16 | Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider |
Country Status (8)
Country | Link |
---|---|
US (2) | US20090093016A1 (da) |
EP (1) | EP1979370B1 (da) |
AT (1) | ATE461208T1 (da) |
BR (1) | BRPI0706400A2 (da) |
DE (1) | DE602007005349D1 (da) |
DK (1) | DK1979370T3 (da) |
ES (1) | ES2340885T3 (da) |
WO (1) | WO2007082890A1 (da) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008155381A1 (en) * | 2007-06-19 | 2008-12-24 | Dsm Ip Assets B.V. | Process for selective enzymatic hydrolysis of pendant esters of a polymer |
US8450084B2 (en) | 2007-10-12 | 2013-05-28 | Enzypep B.V. | Chemo-enzymatic peptide synthesis via C-terminal ester interconversion |
BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3733222A1 (de) * | 1987-10-01 | 1989-04-13 | Hoechst Ag | Verfahren zur herstellung von optisch reinem homophenylalanin |
ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5275950A (en) * | 1990-05-11 | 1994-01-04 | Abbott Laboratories | Process for the preparation of a renin inhibiting compound |
US5256814A (en) * | 1990-12-07 | 1993-10-26 | Scios Nova Inc. | Excitatory amino acid antagonists |
ES2051647B1 (es) * | 1992-12-10 | 1995-01-16 | Lipotec Sa | Procedimiento para la preparacion de calcitonina de salmon. |
US6187579B1 (en) * | 1993-10-28 | 2001-02-13 | Carlsberg A/S | Customized proteases |
US5981267A (en) * | 1996-01-24 | 1999-11-09 | The Scripps Research Institute | Enantioselection of amines using homocarbonates with hydrolase |
TW505654B (en) * | 1996-07-30 | 2002-10-11 | Hoffmann La Roche | Synthesis of analogs of PTH and PTHrP |
CA2331783C (en) * | 1998-07-02 | 2009-12-29 | Genencor International, Inc. | Chemically modified proteins with a carbohydrate moiety |
FR2814744B1 (fr) * | 2000-10-04 | 2002-11-29 | Commissariat Energie Atomique | Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese |
NL1017258C2 (nl) * | 2001-02-01 | 2002-08-02 | Univ Delft Tech | Werkwijze voor het maken van vernette enzymaggregaten. |
AU2002310050A1 (en) * | 2001-05-23 | 2002-12-03 | Diversa Corporation | Peptide synthesis method |
IL150600A (en) * | 2001-07-19 | 2005-09-25 | Akzo Nobel Nv | Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component |
TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
US8124372B2 (en) * | 2007-06-25 | 2012-02-28 | N.V. Organon | Selective enzymatic amidation of C-terminal esters or acids of peptides |
-
2007
- 2007-01-16 WO PCT/EP2007/050409 patent/WO2007082890A1/en active Application Filing
- 2007-01-16 EP EP07703919A patent/EP1979370B1/en active Active
- 2007-01-16 BR BRPI0706400-4A patent/BRPI0706400A2/pt active IP Right Grant
- 2007-01-16 AT AT07703919T patent/ATE461208T1/de not_active IP Right Cessation
- 2007-01-16 DK DK07703919.6T patent/DK1979370T3/da active
- 2007-01-16 US US12/087,849 patent/US20090093016A1/en not_active Abandoned
- 2007-01-16 ES ES07703919T patent/ES2340885T3/es active Active
- 2007-01-16 DE DE602007005349T patent/DE602007005349D1/de active Active
-
2012
- 2012-05-17 US US13/474,125 patent/US20120231497A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090093016A1 (en) | 2009-04-09 |
BRPI0706400A2 (pt) | 2011-03-29 |
EP1979370A1 (en) | 2008-10-15 |
US20120231497A1 (en) | 2012-09-13 |
ATE461208T1 (de) | 2010-04-15 |
DE602007005349D1 (de) | 2010-04-29 |
WO2007082890A1 (en) | 2007-07-26 |
ES2340885T3 (es) | 2010-06-10 |
EP1979370B1 (en) | 2010-03-17 |
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