DK1950200T3 - [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR - Google Patents

[[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR

Info

Publication number: DK1950200T3
Authority: DK; Denmark
Prior art keywords: dioxoethyl; phenylmethyl; indol; oxy; ethyl
Prior art date: 1994-04-01

Application number

DK08001265.1T

Other languages

English (en)

Inventor

Nicholas James Bach

Susan Elizabeth Draheim

Robert Delane Dillard

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-01

Filing date

1995-03-31

Publication date

2012-04-10

1995-03-31 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2012-04-10 Application granted granted Critical

2012-04-10 Publication of DK1950200T3 publication Critical patent/DK1950200T3/da

Links

-1 2-AMINO-1,2-DIOXOETHYL Chemical class 0.000 title 1
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title 1
KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
AWMLDBKLOPNOAR-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxoacetamide Chemical class C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

DK08001265.1T 1994-04-01 1995-03-31 [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR DK1950200T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22191694A	1994-04-01	1994-04-01
EP00203897A EP1081135A3 (en)	1994-04-01	1995-03-31	1H-indole-3-glyoxylamide spla2 inhibitors

Publications (1)

Publication Number	Publication Date
DK1950200T3 true DK1950200T3 (da)	2012-04-10

Family

ID=22829963

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK95302166T DK0675110T3 (da)	1994-04-01	1995-03-31	1H-indol-3-glyoxylamid-sPLA2-inhibitorer
DK08001265.1T DK1950200T3 (da)	1994-04-01	1995-03-31	[[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK95302166T DK0675110T3 (da)	1994-04-01	1995-03-31	1H-indol-3-glyoxylamid-sPLA2-inhibitorer

Country Status (29)

Country	Link
US (6)	US5654326A (da)
EP (5)	EP1197484A2 (da)
JP (1)	JP3109974B2 (da)
KR (1)	KR100368707B1 (da)
CN (1)	CN1067054C (da)
AT (2)	ATE220394T1 (da)
AU (1)	AU688458B2 (da)
BR (1)	BR9501404A (da)
CA (1)	CA2146097C (da)
CO (1)	CO4370099A1 (da)
CZ (1)	CZ82295A3 (da)
DE (1)	DE69527322T2 (da)
DK (2)	DK0675110T3 (da)
ES (2)	ES2377223T3 (da)
FI (1)	FI114793B (da)
HU (1)	HUT72048A (da)
IL (1)	IL113210A (da)
MX (1)	MX9501608A (da)
MY (1)	MY112897A (da)
NO (1)	NO304186B1 (da)
NZ (1)	NZ270848A (da)
PE (1)	PE18696A1 (da)
PL (1)	PL180523B1 (da)
PT (1)	PT675110E (da)
RU (1)	RU2128169C1 (da)
SI (1)	SI0675110T1 (da)
TW (1)	TW383302B (da)
UA (1)	UA47387C2 (da)
ZA (1)	ZA952693B (da)

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1995
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 FI FI951553A patent/FI114793B/fi not_active IP Right Cessation
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
- 1997-12-16 US US08/991,149 patent/US5919943A/en not_active Expired - Lifetime
1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
2000
- 2000-11-16 US US09/714,364 patent/US6433001B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO951252D0 (no)	1995-03-31
ES2179088T3 (es)	2003-01-16
AU1621795A (en)	1995-10-12
AU688458B2 (en)	1998-03-12
HU9500957D0 (en)	1995-05-29
UA47387C2 (uk)	2002-07-15
NZ270848A (en)	1997-05-26
DE69527322D1 (de)	2002-08-14
EP1197484A2 (en)	2002-04-17
KR950032117A (ko)	1995-12-20
DE69527322T2 (de)	2003-02-27
FI951553A0 (fi)	1995-03-31
US5919943A (en)	1999-07-06
US6175021B1 (en)	2001-01-16
MY112897A (en)	2001-10-31
RU2128169C1 (ru)	1999-03-27
US5654326A (en)	1997-08-05
CZ82295A3 (en)	1995-12-13
CA2146097A1 (en)	1995-10-02
ATE540923T1 (de)	2012-01-15
PL180523B1 (pl)	2001-02-28
BR9501404A (pt)	1996-03-05
EP0675110A1 (en)	1995-10-04
IL113210A0 (en)	1995-06-29
HUT72048A (en)	1996-03-28
EP1950200B1 (en)	2012-01-11
PT675110E (pt)	2002-11-29
IL113210A (en)	2001-01-28
TW383302B (en)	2000-03-01
FI951553A (fi)	1995-10-02
US5733923A (en)	1998-03-31
JP3109974B2 (ja)	2000-11-20
SI0675110T1 (en)	2002-12-31
RU95104885A (ru)	1997-04-27
NO951252L (no)	1995-10-02
ATE220394T1 (de)	2002-07-15
US6433001B1 (en)	2002-08-13
PE18696A1 (es)	1996-05-30
CN1067054C (zh)	2001-06-13
US5919810A (en)	1999-07-06
EP0675110B1 (en)	2002-07-10
NO304186B1 (no)	1998-11-09
ES2377223T3 (es)	2012-03-23
EP2341045A1 (en)	2011-07-06
KR100368707B1 (ko)	2003-06-02
DK0675110T3 (da)	2002-10-07
CO4370099A1 (es)	1996-10-07
EP1081135A2 (en)	2001-03-07
EP1950200A1 (en)	2008-07-30
MX9501608A (es)	1997-02-28
PL307951A1 (en)	1995-10-02
ZA952693B (en)	1996-09-30
EP1081135A3 (en)	2003-11-05
CA2146097C (en)	2000-03-21
FI114793B (fi)	2004-12-31
JPH07285933A (ja)	1995-10-31
CN1114310A (zh)	1996-01-03

Publication	Publication Date	Title
DK1950200T3 (da)	2012-04-10	[[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR
DE69830335D1 (de)	2005-06-30	MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER
YU20194A (sh)	1997-09-30	1H-INDOL-3-ACETAMIDI KAO INHIBITORI s PLA2
EP1100492A4 (en)	2001-10-24	SPLA 2 INHIBITORS? INDOLE TYPE
ATE280155T1 (de)	2004-11-15	Inhibitorische ester für spla 2
AU5873400A (en)	2001-02-05	spla2 inhibitors
BR0010448A (pt)	2002-02-13	éster de morfolino-n-etila derivado de um inibidor de spla2 de indol
AU7053700A (en)	2001-04-24	Novel spla2 inhibitors
WO2002050028A8 (en)	2005-03-17	Substituted benzoindoles as spla2 inhibitors
WO2001049662A3 (en)	2002-06-27	Carbazole derivatives as inhibitors of spla2
AU2002245019A1 (en)	2002-07-30	Benz(g) indoles and their use as spla2 inhibitors