DK1945647T3 - Fremgangsmåder til fremstilling af maytansinol - Google Patents

Fremgangsmåder til fremstilling af maytansinol

Info

Publication number
DK1945647T3
DK1945647T3 DK06844315.9T DK06844315T DK1945647T3 DK 1945647 T3 DK1945647 T3 DK 1945647T3 DK 06844315 T DK06844315 T DK 06844315T DK 1945647 T3 DK1945647 T3 DK 1945647T3
Authority
DK
Denmark
Prior art keywords
maytansinol
methods
bridged
preparing maytansinol
preparing
Prior art date
Application number
DK06844315.9T
Other languages
Danish (da)
English (en)
Inventor
Ravi V J Chari
Wayne C Widdison
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Application granted granted Critical
Publication of DK1945647T3 publication Critical patent/DK1945647T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK06844315.9T 2005-11-08 2006-11-08 Fremgangsmåder til fremstilling af maytansinol DK1945647T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73433005P 2005-11-08 2005-11-08
PCT/US2006/043718 WO2007056550A2 (en) 2005-11-08 2006-11-08 Processes for preparation of maytansinol

Publications (1)

Publication Number Publication Date
DK1945647T3 true DK1945647T3 (da) 2012-05-07

Family

ID=38024003

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06844315.9T DK1945647T3 (da) 2005-11-08 2006-11-08 Fremgangsmåder til fremstilling af maytansinol

Country Status (10)

Country Link
US (1) US7411063B2 (ja)
EP (1) EP1945647B9 (ja)
JP (1) JP5117390B2 (ja)
AT (1) ATE540956T1 (ja)
AU (1) AU2006311485B2 (ja)
CA (1) CA2625867C (ja)
DK (1) DK1945647T3 (ja)
ES (1) ES2380687T3 (ja)
PL (1) PL1945647T3 (ja)
WO (1) WO2007056550A2 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
ES2334494T5 (es) 2001-05-11 2013-05-29 Ludwig Institute For Cancer Research Ltd. Proteínas de unión específicas y usos de las mismas
MX2009007987A (es) 2007-01-25 2010-03-01 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
MX2009009782A (es) 2007-03-15 2010-09-10 Ludwig Inst Cancer Res Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.
EP2188311B1 (en) 2007-08-14 2016-10-05 Ludwig Institute for Cancer Research Ltd. Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
FR2949469A1 (fr) * 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
CN108449940B (zh) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147719A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
JP7343604B2 (ja) 2019-03-01 2023-09-12 セルジーン コーポレイション メイタンシノールの調製
ES2942915T3 (es) 2019-04-18 2023-06-07 Indena Spa Procedimiento diasteroselectivo para la preparación de ésteres de maitansinoides que contienen tiol o disulfuro y sus intermedios
US11555019B2 (en) 2019-07-10 2023-01-17 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
US20230030526A1 (en) 2019-11-29 2023-02-02 Microbiopharm Japan Co., Ltd. Method for enzymatically producing maytansinol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5566586A (en) * 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
JP2005525423A (ja) * 2002-05-13 2005-08-25 スミスクライン・ビーチャム・コーポレイション メイタンシノールの調製方法

Also Published As

Publication number Publication date
US7411063B2 (en) 2008-08-12
ATE540956T1 (de) 2012-01-15
WO2007056550A3 (en) 2007-12-06
JP2009514978A (ja) 2009-04-09
PL1945647T3 (pl) 2012-04-30
ES2380687T3 (es) 2012-05-17
EP1945647B1 (en) 2012-01-11
AU2006311485A1 (en) 2007-05-18
AU2006311485B2 (en) 2012-09-27
US20070112188A1 (en) 2007-05-17
CA2625867A1 (en) 2007-05-18
WO2007056550A2 (en) 2007-05-18
EP1945647A2 (en) 2008-07-23
JP5117390B2 (ja) 2013-01-16
EP1945647A4 (en) 2010-10-20
CA2625867C (en) 2014-12-23
EP1945647B9 (en) 2012-11-14

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