DK1883397T3 - Opløselig bosertan-tablet - Google Patents

Opløselig bosertan-tablet

Info

Publication number: DK1883397T3
Authority: DK; Denmark
Prior art keywords: bosertan; tablet; soluble; pyrimidin; benzenesulfonamide
Prior art date: 2005-05-17

Application number

DK06744942.1T

Other languages

English (en)

Inventor

Lovelace Holman

Timm Trenktrog

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-17

Filing date

2006-05-15

Publication date

2010-04-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37431647&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1883397(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-05-15 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2010-04-06 Application granted granted Critical

2010-04-06 Publication of DK1883397T3 publication Critical patent/DK1883397T3/da

Links

GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000007919 dispersible tablet Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK06744942.1T 2005-05-17 2006-05-15 Opløselig bosertan-tablet DK1883397T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP2005005367		2005-05-17
PCT/IB2006/051519 WO2006123285A2 (en)	2005-05-17	2006-05-15	Dispersible bosertan tablet

Publications (1)

Publication Number	Publication Date
DK1883397T3 true DK1883397T3 (da)	2010-04-06

Family

ID=37431647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06744942.1T DK1883397T3 (da)	2005-05-17	2006-05-15	Opløselig bosertan-tablet

Country Status (24)

Country	Link
US (3)	US7959945B2 (da)
EP (1)	EP1883397B1 (da)
JP (1)	JP4219399B2 (da)
KR (2)	KR20080014002A (da)
CN (1)	CN101175484B (da)
AT (1)	ATE451914T1 (da)
AU (1)	AU2006248593B2 (da)
BR (1)	BRPI0610187B8 (da)
CA (1)	CA2607098C (da)
CY (1)	CY1110610T1 (da)
DE (1)	DE602006011150D1 (da)
DK (1)	DK1883397T3 (da)
ES (1)	ES2336943T3 (da)
HK (1)	HK1120212A1 (da)
IL (1)	IL187383A (da)
MX (1)	MX2007014454A (da)
NO (1)	NO339781B1 (da)
NZ (1)	NZ564167A (da)
PL (1)	PL1883397T3 (da)
PT (1)	PT1883397E (da)
RU (2)	RU2404774C2 (da)
SI (1)	SI1883397T1 (da)
WO (1)	WO2006123285A2 (da)
ZA (1)	ZA200710903B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006123285A2 (en) *	2005-05-17	2006-11-23	Actelion Pharmaceuticals Ltd	Dispersible bosertan tablet
CA2694242C (en)	2007-06-29	2013-10-01	Generics [Uk] Limited	Process for introduction of hydroxyethoxy side chain in bosentan
ES2650247T3 (es)	2008-02-08	2018-01-17	Generics [Uk] Limited	Procedimiento de preparación del bosentán
AU2009321375A1 (en)	2008-11-03	2010-06-03	Generics [Uk] Limited	HPLC method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
JP5850576B2 (ja) *	2010-07-06	2016-02-03	富士化学工業株式会社	ボセンタン固体分散体
CN102114005B (zh) *	2010-12-06	2012-12-12	武汉武药科技有限公司	一种波生坦胶囊及其制备方法
WO2012139736A1 (en)	2011-04-11	2012-10-18	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Pharmaceutical composition comprising bosentan
US9945862B2 (en)	2011-06-03	2018-04-17	Eisai R&D Management Co., Ltd.	Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
EP2848245A4 (en)	2012-05-11	2016-01-27	Hanall Biopharma Co Ltd	ORAL PREPARATION WITH CONTROLLED RELEASE OF BOSENTAN
KR101451327B1 (ko) *	2013-01-08	2014-11-03	안국약품 주식회사	보센탄의 제어방출성 다층 정제 및 그 제조방법
RU2559424C1 (ru) *	2014-06-18	2015-08-10	Федеральное государственное бюджетное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения Российской Федерации (ФГБУ "РКНПК" Минздрава России)	Способ подбора лекарственной терапии больным с идиопатической легочной гипертензией
PL3524595T3 (pl)	2014-08-28	2022-10-31	Eisai R&D Management Co., Ltd.	Pochodna chinoliny o wysokiej czystości i sposób jej wytwarzania
HUE064614T2 (hu)	2015-02-25	2024-04-28	Eisai R&D Man Co Ltd	Eljárás egy kinolin-származék keserû ízének elnyomására
CN104840965B (zh) *	2015-05-05	2018-05-08	重庆华邦制药有限公司	波生坦的制剂及其稳定剂
KR20160141045A (ko)	2015-05-27	2016-12-08	한올바이오파마주식회사	보센탄을 함유한 약학적 조성물
BR112017027227B1 (pt)	2015-06-16	2023-12-12	Eisai R&D Management Co., Ltd	Agente anti-câncer
CN108703956A (zh) *	2018-08-21	2018-10-26	天津双硕医药科技有限公司	一种含有波生坦的固体药物组合物
AU2020408323A1 (en)	2019-12-16	2022-08-11	Tenax Therapeutics, Inc.	Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HF-pEF)
WO2023107066A2 (en) *	2021-12-07	2023-06-15	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	Bosentan pharmaceutical compositions
WO2023128902A1 (en) *	2021-12-30	2023-07-06	Pharmactive Ilac Sanayi Ve Ticaret A.S.	Pharmaceutical compositions comprising bosentan and relevant excipients
CN114533738A (zh) *	2022-02-19	2022-05-27	苏州海景医药科技有限公司	一种波生坦固体药物组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2086544C1 (ru) *	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
ES2082723B1 (es) *	1994-07-20	1996-10-01	Lilly Sa	Formulacion farmaceutica de fluoxetina en forma dispersable.
US6635648B2 (en) *	2000-08-18	2003-10-21	Queen's University At Kingston	Combination therapy using sympathetic nervous system antagonists and endothelin antagonists
ES2299720T3 (es) *	2002-05-31	2008-06-01	Schering Corporation	Formas polimorfas de un inhibidor de xantina-fosfodiesterasa v.
KR100604034B1 (ko)	2003-10-08	2006-07-24	주식회사유한양행	암로디핀 유리염기를 함유한 구강 속붕해정 및 그의 조성물
WO2006123285A2 (en)	2005-05-17	2006-11-23	Actelion Pharmaceuticals Ltd	Dispersible bosertan tablet

2006
- 2006-05-15 WO PCT/IB2006/051519 patent/WO2006123285A2/en active Application Filing
- 2006-05-15 SI SI200630581T patent/SI1883397T1/sl unknown
- 2006-05-15 PT PT06744942T patent/PT1883397E/pt unknown
- 2006-05-15 PL PL06744942T patent/PL1883397T3/pl unknown
- 2006-05-15 EP EP06744942A patent/EP1883397B1/en active Active
- 2006-05-15 US US11/914,652 patent/US7959945B2/en active Active
- 2006-05-15 NZ NZ564167A patent/NZ564167A/en unknown
- 2006-05-15 DE DE602006011150T patent/DE602006011150D1/de active Active
- 2006-05-15 CN CN2006800166119A patent/CN101175484B/zh active Active
- 2006-05-15 MX MX2007014454A patent/MX2007014454A/es active IP Right Grant
- 2006-05-15 DK DK06744942.1T patent/DK1883397T3/da active
- 2006-05-15 CA CA2607098A patent/CA2607098C/en not_active Expired - Fee Related
- 2006-05-15 AT AT06744942T patent/ATE451914T1/de active
- 2006-05-15 BR BRPI0610187A patent/BRPI0610187B8/pt active IP Right Grant
- 2006-05-15 KR KR1020077028463A patent/KR20080014002A/ko active Application Filing
- 2006-05-15 KR KR1020107014762A patent/KR20100093105A/ko not_active Application Discontinuation
- 2006-05-15 AU AU2006248593A patent/AU2006248593B2/en active Active
- 2006-05-15 ES ES06744942T patent/ES2336943T3/es active Active
- 2006-05-15 JP JP2008510716A patent/JP4219399B2/ja active Active
- 2006-05-15 RU RU2007146395/15A patent/RU2404774C2/ru active
2007
- 2007-11-15 IL IL187383A patent/IL187383A/en active IP Right Grant
- 2007-12-10 NO NO20076325A patent/NO339781B1/no unknown
- 2007-12-14 ZA ZA200710903A patent/ZA200710903B/xx unknown
2008
- 2008-11-04 HK HK08112061.1A patent/HK1120212A1/xx unknown
2010
- 2010-03-09 CY CY20101100220T patent/CY1110610T1/el unknown
- 2010-07-16 RU RU2010129460/15A patent/RU2010129460A/ru not_active Application Discontinuation
2011
- 2011-06-07 US US13/154,588 patent/US8309126B2/en active Active
2012
- 2012-09-27 US US13/628,780 patent/US20130023547A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE451914T1 (de)	2010-01-15
CA2607098C (en)	2012-04-10
EP1883397A2 (en)	2008-02-06
BRPI0610187A2 (pt)	2010-06-01
DE602006011150D1 (de)	2010-01-28
CY1110610T1 (el)	2015-04-29
JP4219399B2 (ja)	2009-02-04
EP1883397B1 (en)	2009-12-16
KR20080014002A (ko)	2008-02-13
NO339781B1 (no)	2017-01-30
US20130023547A1 (en)	2013-01-24
NO20076325L (no)	2008-02-04
IL187383A (en)	2011-09-27
JP2008540512A (ja)	2008-11-20
NZ564167A (en)	2009-12-24
CA2607098A1 (en)	2006-11-23
CN101175484B (zh)	2012-02-01
RU2010129460A (ru)	2012-01-27
HK1120212A1 (en)	2009-03-27
WO2006123285A2 (en)	2006-11-23
CN101175484A (zh)	2008-05-07
WO2006123285A3 (en)	2007-07-05
AU2006248593B2 (en)	2011-03-17
AU2006248593A1 (en)	2006-11-23
PT1883397E (pt)	2010-02-23
US8309126B2 (en)	2012-11-13
ZA200710903B (en)	2008-12-31
RU2007146395A (ru)	2009-06-27
US20110245281A1 (en)	2011-10-06
US7959945B2 (en)	2011-06-14
SI1883397T1 (sl)	2010-04-30
US20080193528A1 (en)	2008-08-14
BRPI0610187B1 (pt)	2020-03-03
KR20100093105A (ko)	2010-08-24
RU2404774C2 (ru)	2010-11-27
ES2336943T3 (es)	2010-04-19
BRPI0610187B8 (pt)	2021-05-25
IL187383A0 (en)	2008-02-09
MX2007014454A (es)	2008-02-07
PL1883397T3 (pl)	2010-05-31

Publication	Publication Date	Title
DK1883397T3 (da)	2010-04-06	Opløselig bosertan-tablet
UY29500A1 (es)	2006-11-30	Proceso quimico
IL193725A0 (en)	2009-05-04	Hiv inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
NZ594385A (en)	2013-02-22	Aminopyrimidines useful as kinase inhibitors
DE602004032321D1 (de)	2011-06-01	Die hiv-replikation inhibierende indan-substituierte pyrimidine
ATE500232T1 (de)	2011-03-15	Kristalline form von 2-chlor-5-ä3,6-dihydro-3- methyl-2,6-dioxo-4-(trifluormethyl)-1-(2h)- pyrimidinylü-4-fluor-n-äämethyl-(1- methylethyl)aminoüsulfonylübenzamid
ATE420646T1 (de)	2009-01-15	Aminopyrimidine als kinase-modulatoren
WO2007027238A3 (en)	2007-09-13	Jak kinase inhibitors and their uses
MA30725B1 (fr)	2009-09-01	Administration d'inhibiteurs de la dipeptidyl peptidase
MY159522A (en)	2017-01-13	Administration of dipeptidyl peptidase inhibitors
TW200800968A (en)	2008-01-01	Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
HRP20041177B1 (hr)	2013-03-31	Mikrobicidni pirimidini ili triazini za prevenciju prijenosa hiv seksualnim putem
GEP20125564B (en)	2012-06-25	Pyrimidine derivatives as kinase inhibitors
EA201200565A1 (ru)	2012-09-28	ГИДРОКСИЛЬНЫЕ, КЕТО И ГЛЮКУРОНИДНЫЕ ПРОИЗВОДНЫЕ 3-(4-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1Н-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА
MX2010004576A (es)	2010-05-17	Derivados de pirimidina novedosos.
DK2203444T3 (da)	2013-10-28	Faste former af (S)-ethyl-2-amino-3-(4-(2-amino-6-((R)-1-(4-chlor-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluorethoxy)pyrimidin-4-yl)phenyl)propanoat
PL1869056T3 (pl)	2011-04-29	Nowe 5-podstawione pochodne 7-amino-[1,3]tiazolo[4,5-d]pirymidyny
ZA200702656B (en)	2008-08-27	HIV inhibiting 5-substituted pyrimidines
TN2010000070A1 (en)	2011-09-26	Fused bicyclic pyrimidines
NZ705225A (en)	2016-11-25	Process for preparing antiviral compounds
UA83314C2 (ru)	2008-06-25	2-(пиридин-2-ил)пиримидиновые соединения и их применение для борьбы с вредными грибами
CR8184A (es)	2006-10-06	Pirimidinas 2-sustituidas
HK1149003A1 (en)	2011-09-23	4-aminopyrimidine derivatives as histamine h4 receptor antagonists
NZ627113A (en)	2016-07-29	Substituted pyrimidine compounds and their use as syk inhibitors
MX2011005611A (es)	2011-09-15	Sintesis y formas de sales novedosas de (r)-5-((e)-2-(pirrolidin-3 -il-vinil)pirimidina.