DK1866324T3 - Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer - Google Patents

Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer

Info

Publication number
DK1866324T3
DK1866324T3 DK06710096.6T DK06710096T DK1866324T3 DK 1866324 T3 DK1866324 T3 DK 1866324T3 DK 06710096 T DK06710096 T DK 06710096T DK 1866324 T3 DK1866324 T3 DK 1866324T3
Authority
DK
Denmark
Prior art keywords
cancer
treatment
nucleoside compounds
phosphoramidate derivatives
compounds
Prior art date
Application number
DK06710096.6T
Other languages
English (en)
Inventor
Christopher Mcguigan
Kenneth Mills
Costantino Congiatu
Original Assignee
Cardiff Protides Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiff Protides Ltd filed Critical Cardiff Protides Ltd
Application granted granted Critical
Publication of DK1866324T3 publication Critical patent/DK1866324T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06710096.6T 2005-03-21 2006-03-16 Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer DK1866324T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds
PCT/GB2006/000932 WO2006100439A1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
DK1866324T3 true DK1866324T3 (da) 2010-09-27

Family

ID=34531603

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06710096.6T DK1866324T3 (da) 2005-03-21 2006-03-16 Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer

Country Status (20)

Country Link
US (1) US8263575B2 (da)
EP (1) EP1866324B1 (da)
JP (2) JP5345381B2 (da)
CN (2) CN101175763A (da)
AT (1) ATE471334T1 (da)
AU (1) AU2006226182C1 (da)
BR (1) BRPI0609704B8 (da)
CA (1) CA2602324C (da)
CY (1) CY1111538T1 (da)
DE (1) DE602006014949D1 (da)
DK (1) DK1866324T3 (da)
ES (1) ES2348741T3 (da)
GB (1) GB0505781D0 (da)
IL (1) IL186104A (da)
MX (1) MX2007011666A (da)
PL (1) PL1866324T3 (da)
PT (1) PT1866324E (da)
SI (1) SI1866324T1 (da)
WO (1) WO2006100439A1 (da)
ZA (1) ZA200709011B (da)

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EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
BRPI1004575A2 (pt) 2009-01-09 2016-04-05 Inhibitex Inc composto, composição farmacêutica, método de tratamento de infecções virais, método de separação dos diaestereômeros de fósforo
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GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
EP2658857B1 (en) 2010-12-29 2016-11-02 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
CN103403014B (zh) * 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途
DK3031812T3 (da) * 2011-03-01 2018-09-17 NuCana plc Kemiske forbindelser
WO2012125900A1 (en) 2011-03-16 2012-09-20 Enanta Pharmaceuticals, Inc. 2'-allene-substituted nucleoside derivatives
NZ708177A (en) 2012-11-16 2017-08-25 Univ College Cardiff Consultants Ltd Process for preparing nucleoside prodrugs
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
AU2014354775A1 (en) * 2013-11-27 2016-05-19 Idenix Pharmaceuticals Llc Nucleotides for the treatment of liver cancer
RU2016149761A (ru) * 2014-05-28 2018-07-02 АЙДЕНИКС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Производные нуклеозидов для лечения ракового заболевания
CA2947939A1 (en) * 2014-05-28 2015-12-03 Idenix Pharmaceuticals Llc Nucleoside derivatives for the treatment of cancer
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
IL295418B2 (en) 2015-03-06 2023-10-01 Atea Pharmaceuticals Inc Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus
MX2018005872A (es) 2015-11-16 2019-05-16 Ichorion Therapeutics Inc Profarmacos de acido nucleico.
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609602D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201609601D0 (en) * 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
LU100724B1 (en) 2016-07-14 2018-07-31 Atea Pharmaceuticals Inc Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
WO2018071675A1 (en) * 2016-10-12 2018-04-19 Georgetown University Cd99 inhibitors and their uses
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
CN113549076B (zh) * 2021-07-23 2022-12-06 中国药科大学 一种多取代嘌呤类化合物及其制备方法和应用

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Also Published As

Publication number Publication date
CY1111538T1 (el) 2015-08-05
JP2013173786A (ja) 2013-09-05
JP5345381B2 (ja) 2013-11-20
US20090215715A1 (en) 2009-08-27
JP2008533191A (ja) 2008-08-21
WO2006100439A1 (en) 2006-09-28
DE602006014949D1 (de) 2010-07-29
CA2602324A1 (en) 2006-09-28
MX2007011666A (es) 2007-11-14
AU2006226182C1 (en) 2012-06-14
BRPI0609704B1 (pt) 2020-12-01
ATE471334T1 (de) 2010-07-15
EP1866324B1 (en) 2010-06-16
JP5863702B2 (ja) 2016-02-17
IL186104A0 (en) 2008-01-20
ES2348741T3 (es) 2010-12-13
US8263575B2 (en) 2012-09-11
PL1866324T3 (pl) 2010-12-31
GB0505781D0 (en) 2005-04-27
SI1866324T1 (sl) 2010-10-29
AU2006226182B2 (en) 2011-09-01
CA2602324C (en) 2015-02-24
BRPI0609704A2 (pt) 2010-04-20
ZA200709011B (en) 2009-01-28
BRPI0609704B8 (pt) 2021-09-28
CN101175763A (zh) 2008-05-07
IL186104A (en) 2013-06-27
EP1866324A1 (en) 2007-12-19
PT1866324E (pt) 2010-09-16
AU2006226182A1 (en) 2006-09-28
CN103936807A (zh) 2014-07-23

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