DK1802749T3 - KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser - Google Patents

KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser

Info

Publication number
DK1802749T3
DK1802749T3 DK05797320.8T DK05797320T DK1802749T3 DK 1802749 T3 DK1802749 T3 DK 1802749T3 DK 05797320 T DK05797320 T DK 05797320T DK 1802749 T3 DK1802749 T3 DK 1802749T3
Authority
DK
Denmark
Prior art keywords
kaspp
lrrk2
gene
preparation
detection
Prior art date
Application number
DK05797320.8T
Other languages
English (en)
Inventor
Thomas Meitinger
Tim Matthias Strom
Marius Ueffing
Elisabeth Kremmer
Thomas Gasser
Petra Leitner
Friedrich Asmus
Nadja Patenge
Alexander Zimprich
Matthew J Farrer
Jennifer M Kachergus
Sara J Lincoln
Mary M Hulihan
Zibigniew Wszolek
Ryan Uitti
Saskia Biskup
Christian J Gloeckner
Original Assignee
Mayo Foundation
Helmholtz Zentrum Muenchen
Univ Eberhard Karls
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation, Helmholtz Zentrum Muenchen, Univ Eberhard Karls filed Critical Mayo Foundation
Application granted granted Critical
Publication of DK1802749T3 publication Critical patent/DK1802749T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
DK05797320.8T 2004-10-21 2005-09-27 KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser DK1802749T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62089304P 2004-10-21 2004-10-21
US62116904P 2004-10-22 2004-10-22
PCT/EP2005/010428 WO2006045392A2 (en) 2004-10-21 2005-09-27 Kaspp (lrrke) gene, its production and use for the detection and treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
DK1802749T3 true DK1802749T3 (da) 2012-11-26

Family

ID=35965998

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05797320.8T DK1802749T3 (da) 2004-10-21 2005-09-27 KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser

Country Status (7)

Country Link
US (2) US8029986B2 (da)
EP (2) EP1802749B1 (da)
AU (1) AU2005299089B2 (da)
CA (1) CA2584489C (da)
DK (1) DK1802749T3 (da)
ES (1) ES2393926T3 (da)
WO (1) WO2006045392A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO323175B1 (no) 2004-12-23 2007-01-15 Jan O Aasly Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme
US20100035251A1 (en) * 2006-06-20 2010-02-11 Yunsheng He BioMarkers for the Progression of Alzheimer's Disease
US8206942B2 (en) * 2007-04-05 2012-06-26 Medical Research Council Methods of identifying LRRK2 inhibitors
WO2009005730A1 (en) * 2007-06-27 2009-01-08 Cornell University Transgenic animal models of parkinson's disease
EP2321417B1 (en) * 2008-08-20 2015-07-15 Brainco Biopharma, S.L. Stxbp1 as psychiatric biomarker in murine model system and its uses
US20100175140A1 (en) * 2008-12-19 2010-07-08 The Johns Hopkins University Leucine-rich repeat kinase (LRRK2) drosophila model for parkinson's disease: wildtype1 (WT1) and G2019S mutant flies
EP2611772B1 (en) 2010-09-02 2014-09-24 GlaxoSmithKline Intellectual Property Development Limited 2-(benzyloxy)benzamides as lrrk2 kinase inhibitors
MX342177B (es) 2011-09-30 2016-09-20 Ipsen Pharma Sas Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.
EP3255049A1 (en) 2012-06-29 2017-12-13 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
MA39219B1 (fr) 2014-01-29 2018-11-30 Glaxosmithkline Ip Dev Ltd Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique
WO2015176010A1 (en) 2014-05-15 2015-11-19 The United States Of America, As Represented By The Secretary, Departmentof Health & Human Services Treatment or prevention of an intestinal disease or disorder
WO2016007540A2 (en) 2014-07-10 2016-01-14 The J. David Gladstone Institutes Compositions and methods for treating dengue virus infection
AU2015316801B2 (en) 2014-09-17 2019-03-07 Oncodesign S.A. Macrocyclic LRRK2 kinase inhibitors
KR102161364B1 (ko) 2015-09-14 2020-09-29 화이자 인코포레이티드 LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체
US10907160B2 (en) 2016-01-05 2021-02-02 Ionis Pharmaceuticals, Inc. Methods for reducing LRRK2 expression
CA3069554A1 (en) 2017-07-14 2019-01-17 Glaxosmithkline Intellectual Property Development Limited Inhibitors of leucine rich repeat kinase 2
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JPH08512300A (ja) * 1993-07-10 1996-12-24 バイオグノスティック・ゲゼルシャフト・フュア・バイオモレキュラーレ・ダイアグノスティック・ミット・ベシュレンクテル・ハフツング ニューロン損傷、変性及び細胞壊死の予防及び／又は治療、並びに腫瘍の治療を目的とするアンチセンス核酸を含む医薬用組成物
NZ502323A (en) 1996-06-04 2001-09-28 Univ Utah Res Found Monitoring a fluorescence energy transfer pair during hybridization of first probe labelled with fluorescein to second probe labelled with Cy5 or Cy5.5
AU2002327419A1 (en) * 2001-08-02 2003-02-17 Incyte Genomics, Inc. Kinases and phosphatases
WO2003101283A2 (en) * 2002-06-04 2003-12-11 Incyte Corporation Diagnostics markers for lung cancer
US20040197792A1 (en) * 2002-07-15 2004-10-07 Sugen, Inc. Novel Kinases
WO2004023973A2 (en) * 2002-09-12 2004-03-25 Incyte Corporation Molecules for diagnostics and therapeutics

Also Published As

Publication number Publication date
AU2005299089A1 (en) 2006-05-04
WO2006045392A3 (en) 2006-08-10
AU2005299089B2 (en) 2011-08-18
CA2584489A1 (en) 2006-05-04
US20120035072A1 (en) 2012-02-09
EP2316927A2 (en) 2011-05-04
EP2316927A3 (en) 2011-10-19
US8409809B2 (en) 2013-04-02
EP1802749B1 (en) 2012-08-22
EP2316927B1 (en) 2014-11-05
ES2393926T3 (es) 2013-01-02
US8029986B2 (en) 2011-10-04
EP1802749A2 (en) 2007-07-04
WO2006045392A2 (en) 2006-05-04
US20100235933A1 (en) 2010-09-16
CA2584489C (en) 2014-07-22

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