DK178386A - Rekombinant dna-udtrykkelsesvektor og dna-forbindelser, der udtrykker isopenicillin n synthetase - Google Patents

Rekombinant dna-udtrykkelsesvektor og dna-forbindelser, der udtrykker isopenicillin n synthetase Download PDF

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Publication number
DK178386A
DK178386A DK178386A DK178386A DK178386A DK 178386 A DK178386 A DK 178386A DK 178386 A DK178386 A DK 178386A DK 178386 A DK178386 A DK 178386A DK 178386 A DK178386 A DK 178386A
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DK
Denmark
Prior art keywords
isopenicillin
synthetase
expression vector
dna
recombinant dna
Prior art date
Application number
DK178386A
Other languages
Afrikaans (af)
Danish (da)
English (en)
Other versions
DK178386D0 (da
Inventor
Thomas Dominick Ingolia
Stephen Wyatt Queener
Suellen Mary Samson
Paul Luther Skatrud
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK178386D0 publication Critical patent/DK178386D0/da
Publication of DK178386A publication Critical patent/DK178386A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK178386A 1985-04-22 1986-04-18 Rekombinant dna-udtrykkelsesvektor og dna-forbindelser, der udtrykker isopenicillin n synthetase DK178386A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72587085A 1985-04-22 1985-04-22
US72587085 1985-04-22
US79938485A 1985-11-18 1985-11-18
US79938485 1985-11-18

Publications (2)

Publication Number Publication Date
DK178386D0 DK178386D0 (da) 1986-04-18
DK178386A true DK178386A (da) 1986-10-23

Family

ID=27111238

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178386A DK178386A (da) 1985-04-22 1986-04-18 Rekombinant dna-udtrykkelsesvektor og dna-forbindelser, der udtrykker isopenicillin n synthetase

Country Status (14)

Country Link
EP (1) EP0200425B1 (el)
JP (1) JPH0787788B2 (el)
KR (1) KR860008287A (el)
CN (1) CN86102604A (el)
AU (2) AU592791B2 (el)
BG (2) BG45047A3 (el)
CA (1) CA1309673C (el)
DE (1) DE3683080D1 (el)
DK (1) DK178386A (el)
ES (3) ES8800344A1 (el)
FI (1) FI95810C (el)
HU (1) HU202279B (el)
IE (1) IE58780B1 (el)
IL (1) IL78531A0 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE56471T1 (de) 1980-04-03 1990-09-15 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
IL85535A (en) * 1987-03-04 1994-02-27 Lilly Co Eli AND Recombinant expression vectors encoding datastoxysplosporin C synthetase and datacetylsephalosporin C synthetase
GB2208077A (en) * 1987-04-24 1989-02-22 Antibioticos Sa Isopenicillin n synthetase gene derived from aspergillus nidulans
EP0303364A1 (en) * 1987-08-10 1989-02-15 The Governors of the University of Alberta Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from streptomyces clavuligerus
US4885252A (en) * 1987-09-08 1989-12-05 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from aspergillus nidulans
US4950603A (en) * 1987-11-02 1990-08-21 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from Streptomyces lipmanii
US6258555B1 (en) 1987-12-09 2001-07-10 Beecham Group P.L.C. DNA encoding ACV synthetase
GB8728811D0 (en) * 1987-12-09 1988-01-27 Beecham Group Plc Novel substance
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
EP0437378B1 (en) * 1990-01-12 1999-05-19 Glaxo Group Limited DNA sequence for an antibiotic biosynthesis enzyme
US5882883A (en) * 1994-09-28 1999-03-16 Novo Nordisk A/S Process for the production of secondary metabolites
DE19755302A1 (de) * 1997-12-12 1999-06-17 Hoechst Marion Roussel De Gmbh Neuer Transkriptionsfaktor CPCR1 zur Regulation des Isopenicillin N-Synthetase-Gens (pcbC) und des AC-/ACV-Synthetase-Gens (pcbAB)
CA2361848A1 (en) * 1999-04-02 2000-10-12 Dupont Pharmaceuticals Company Novel lactam inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330003A1 (de) * 1982-10-21 1984-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Dna-sequenz und dna-strukturen und sie verwendendes verfahren zur herstellung von penicillin-acylase
CA1278540C (en) * 1983-07-22 1991-01-02 Eli Lilly And Company Modified antibiotic resistance gene
US4762786A (en) * 1984-09-27 1988-08-09 Eli Lilly And Company Vectors and conditions which allow genetic transformation of cephalosporium
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum

Also Published As

Publication number Publication date
FI861653A (fi) 1986-10-23
ES8800344A1 (es) 1987-11-01
JPS61254192A (ja) 1986-11-11
KR860008287A (ko) 1986-11-14
AU4234789A (en) 1990-01-11
IE861029L (en) 1986-10-22
ES557829A0 (es) 1989-01-16
FI861653A0 (fi) 1986-04-18
ES8802585A1 (es) 1988-08-16
BG45219A3 (el) 1989-04-14
CA1309673C (en) 1992-11-03
EP0200425B1 (en) 1991-12-27
AU5643186A (en) 1986-10-30
FI95810C (fi) 1996-03-25
IL78531A0 (en) 1986-08-31
BG45047A3 (el) 1989-03-15
FI95810B (fi) 1995-12-15
HU202279B (en) 1991-02-28
IE58780B1 (en) 1993-11-17
CN86102604A (zh) 1986-11-26
ES554218A0 (es) 1987-11-01
ES8900142A1 (es) 1989-01-16
DE3683080D1 (de) 1992-02-06
DK178386D0 (da) 1986-04-18
HUT40705A (en) 1987-01-28
EP0200425A2 (en) 1986-11-05
ES557658A0 (es) 1988-08-16
AU592791B2 (en) 1990-01-25
AU619596B2 (en) 1992-01-30
JPH0787788B2 (ja) 1995-09-27
EP0200425A3 (en) 1988-07-06

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