DK162739B - Indretning til paafoering af et vaevsklaebestof - Google Patents
Indretning til paafoering af et vaevsklaebestof Download PDFInfo
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- DK162739B DK162739B DK288886A DK288886A DK162739B DK 162739 B DK162739 B DK 162739B DK 288886 A DK288886 A DK 288886A DK 288886 A DK288886 A DK 288886A DK 162739 B DK162739 B DK 162739B
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- solution
- protein
- tissue adhesive
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Links
- 239000000853 adhesive Substances 0.000 title description 8
- 230000001070 adhesive effect Effects 0.000 title description 8
- 239000004753 textile Substances 0.000 title 1
- 239000003106 tissue adhesive Substances 0.000 claims abstract description 16
- 108090000190 Thrombin Proteins 0.000 claims abstract description 15
- 229960004072 thrombin Drugs 0.000 claims abstract description 15
- 239000012460 protein solution Substances 0.000 claims abstract description 13
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 10
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 10
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 10
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims abstract description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims abstract description 3
- 241001465754 Metazoa Species 0.000 claims abstract description 3
- 235000021120 animal protein Nutrition 0.000 claims abstract description 3
- 239000003114 blood coagulation factor Substances 0.000 claims abstract description 3
- 210000000056 organ Anatomy 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 23
- 235000018102 proteins Nutrition 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 5
- 230000023555 blood coagulation Effects 0.000 claims description 4
- 235000004252 protein component Nutrition 0.000 claims description 4
- 241000555745 Sciuridae Species 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 229940075469 tissue adhesives Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 description 9
- 108010039627 Aprotinin Proteins 0.000 description 3
- 229960004405 aprotinin Drugs 0.000 description 3
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- 102100035861 Cytosolic 5'-nucleotidase 1A Human genes 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 101000802744 Homo sapiens Cytosolic 5'-nucleotidase 1A Proteins 0.000 description 1
- 101000840267 Homo sapiens Immunoglobulin lambda-like polypeptide 1 Proteins 0.000 description 1
- 102100029616 Immunoglobulin lambda-like polypeptide 1 Human genes 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940012444 factor xiii Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Description
DK 162739 B
Den foreliggende opfindelse angår en indretning til påføring af et vævsklæbestof på basis af humane eller animalske proteiner til sømløs henholdsvis sømunderstøttet forbindelse af humane eller animalske vævs- eller organdele, til sårlukning, 5 blodstandsning og tilsvarende, hvilket vævsklæbestof ved sammenføring med blodstørkningsfremmende størkn ingsfaktorer hærdes in situ, hvilken indretning omfatter to i tilslutnings-stykker endende sprøjtelegemer, der er udstyret med i fællesskab drivbare stempler, og hvor det ene sprøjtelegeme indehol-10 der en proteinopløsning og det andet indeholder en trombinop-løsning, og hvor der på sprøjtelegemernes tilslutningsstykker kan sættes et forbindelseshoved, der har en selvstændig transportkanal for hver komponent, der skal påføres, og i givet fald for en medicinsk drivgas.
15
Indretninger af denne art er beskrevet i AT-B-366.916 og AT-B-379.311 . Som komponenter kan man dels benytte en faktor XIII og fibrinogenindeholdende proteinopløsning (vævsklæbestof) og dels en trombi nindehoIdende opløsning. Disse kompo-20 nenter blandes i en på bland i ngshovedet påsat blandekany1e og påføres på det sårsted, der skal behandles henholdsvis beskyttes .
Ved gennemføring af vævsklæbninger henholdsvis -behandlinger 25 fås almindeligvis proteinopløsningen og trombinopløsningen ved opløsning af 1yofi 1 i sater. Herunder kan der især ved et kirurgisk nødstilfælde fremkomme den vanskelighed, at proteinopløsningens tilberednig p.g.a. den tunge opløselighed for disse komponenter tager en uønsket lang tid. Det er ganske vist mu-30 ligt at afkorte proteinkomponenternes opløsningsvarighed ved anvendelse af en større mængde opløsningsmiddel, men ved pro-- teinopløsningens blanding med trombinopløsningen i rumforholdet på 1;1 som hidtil almindeligt fortyndes også den koagulerende (tysk: clottierende) blanding så meget, at der forekom-35 mer en signifikant forringelse af klæbningens rivestyrke.
Opfindelsen tilsigter at undgå denne vanskelighed og har til formål at udforme den kendte indretning således, at det bliver
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2 muligt at forkorte opløsningstiden ved tilberedningen af pro-teinopløsningen fra et lyofilisat, uden at man må tage en forringelse af rivestyrken med i købet.
5 Dette formål opnås ved, at en indretning af den indledningsvist omtalte art ifølge opfindelsen er ejendommeligt ved, at sprøjtel egernerne har samme effektive slaglængde og at det ene af disse, nemlig det til optagelse af proteinopløsningen bestemte sprøjtelegeme, har en to til ni gange større tværsnits-10 flade end det andet således, at forholdet mellem sprøjtelegemernes rumfang ligeledes er beliggende i området fra 2:1 til 9:1.
Ifølge en foretrukken udførelsesform kan sprøjtelegemerne være 15 udformet som dobbeltkammersprøjtelegemer, idet proteinkomponenterne og trombinkomponenterne i begge tilfælde i lyofili-seret form kan anbringes i de mod mundingen vendende kamre, og at opløsningsmidlet bringes i de andre kamre.
20 Opfindelsen angår også anvendelsen af indretningen til påføring af proteinvævsklæøbestofopløsningen ifølge krav 1, idet proteinvævsklæbestofopløsningen har et fibrinogenindhold fra 2 til 12¾. 1 2 3 4 5 6 7 8 9 10 11
Opfindelsen beror på det princip, at man opnår et gunstigt 2 forhold mellem den nødvendige rekonstitutionstid for protein- 3 lyofilisatet og klæbningernes styrke, når det hidtil alminde 4 lige blandingsforhold for proteinopløsningen og trombinopløs 5 ningen ændres fra 1:1 på en sådan måde, at proteinkomponen- 6 terne opløses i et forholdsvis større rumfang, og at den deraf 7 resulterende lavere proteinkoncentration kompenseres ved 8 opløsning af trombinkomponenterne i et forholdsvis mindre rum 9 fang efter de to komponenters blanding. Kræves der på den an 10 den side klæbninger med en særlig stor styrke, så kan der 11 ifølge opfindelsen opnås en forøgelse af klæbeproteinernes koncentration efter, at de to komponenter er blandet uden at man må tage en forlængelse af rekonstitutionstiden med i kø-
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3 bet. En tilnærmelsesvis nøjagtig blanding af de to komponenter i et fra 1 afgivende forhold ville være vanskelig fra to adskilte sprøjter og muliggøres først ved dobbeltsprøjten ifølge opfindelsen.
5
Indretningen ifølge opfindelsen er forklaret nærmere på grundlag af udførelseseksemplerne vist på tegningen, hvor fig. 1 og 2 viser apparatet set fra siden delvis i snit.
10 I fig. 1 ses det til optagelse af proteinopløsningen bestemte sprøjtelegeme i og det til optagelse af trombinopløsni ngen bestemte sprøjtelegeme 2. De er hensigtsmæssigt udformet som énve jssprøjtelegemer og består af plast. De er i fællesskab ind-15 sat i U-formede render 4, 5 i en holde indretning 3.
For enden af holdeindretningen er der fingergreb 6, der rager ind i sprøjtelegemernes flangeender 7 og 8 således, at disse er fikseret i retning af deres pågældende længdeakse. I sprøj-20 telegemerne styres stempler 21, 22, hvis stempel stænger 9 og 10 rager ud. De har en fælles betjeningsindretning 11. Henvis-ningstallet 12 angiver en styrestang, der er ført gennem en boring i holdeindretningen.
25 På sprøjtelegemernes 1, 2 konusser kan der sættes et forbindelseshoved 16 med transportkanaler 17 og 18, der ender ved det sokkel formede forbindelseshovedes forside 19. På denne sokkel påsættes blandekanylen 20.
30 Som vist på tegningen har sprøjtel egernet 1 et større tværsnit end sprøjtelegemet 2. I det viste eksempel er størrelsesforholdet 3:1 således, at også rumfangene forholder sig som 3:1.
De to sprøjtelegemers effektive slaglængde dvs. den pågældende afstand af det punkterede viste stempels 21 henholdsvis 22's 35 afstand fra mundingssidens 23, 24 stemmer overens.
Ved den ændrede udførelsesform vist i fig. 2 er sprøjtelegemet udformet som et dobbeltkammersprøjtelegeme, idet sprøjtekam-
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4 meret l's mod mundingen vendende kammer 25 er fyldt med lyofi-liseret klæbeprotein 26 og sprøjtelegemet 2’s mod mundingen vendende kammer 27 er fyldt med trombin. I de pågældende længst fra mundingen beliggende kamre 29 og 30 befinder opløs-5 ningsmidlet sig, idet der i kammeret 29 er en opløsning, der indeholder aprothinin og, der i kammeret 30 er en opløsning, der indeholder calciumchlorid. Kamrene 25 og 29 er adskilt ved et svømmende stempel 31 og kamrene 27 og 30 er adskilt fra hinanden ved et svømmestempel 32. Henvisningstallene 33 og 34 10 betegner brodannelses ledni nger.
Stemplerne 21 og 22 er fastgjort på stempel stængerne 9 og 10. Efter deres betjening presses væske ud af kamrene 29, 30 via de brodannende ledninger ind i kamrene 25 og 28 og de til på-15 føring nødvendige opløsninger tilberedes. Også i denne udførelsesform andrager tværsnitsforholdet mellem sprøjtel egernet 1 og sprøjtelegemet 2 3:1.
I nedenstående tabel er der vist sammenligningsforsøg, hvor 20 der som vist i spalten "standard" blev blandet en klæbeprote-inopløsning på kendt måde under anvendelse af den kendte indretning ifølge AT-B-366.916 med en trombinopløsning i rumfangsforholdet 1:1. Som vist i spalterne 2 til 9 blandes klæ-beproteinopløsninger med forskelligt fibrinogenindhold under 25 anvendelse af indretningen ifølge opfindelsen med trombinop-løsninger i forskellige blandingsforhold og de hærdede klæbestoffers egenskaber blev undersøgt.
Forsøgene gennemførtes med lyofiliseret vævsklæbestof svarende 30 til det, der er beskrevet i AT-B-359.652, hvorved de i endebeholderne indeholdte sterile, lyofiliserede præparater (indeholdende hver 370 mg tørsubstans, deraf 200 mg fibrinogen) først opløstes under anvendelse af den i AT-B-371.719 beskrevne fremgangsmåde med så meget opløsningsmiddel (aqua ad 35 injectabilia eller aprotininopløsning), at man fik den i tabellens spalte 2 angivne fibrinogenkoncentration. Den i hvert tilfælde nødvendige opløsningstid blev fastslået og er angivet i tabellens spalte 4.
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5
De som beskrevet opnåede vævsklæbestofopløsninger (første komponent) blandedes hurtigt med en trombi n-CaC^-opløsning (anden komponent) af den i spalterne 5 og 6 angivne sammensætning under anvendelse af påføringsapparatet ifølge opfin-5 delsen, i det i spalte 7 angivne rumforhold, og indførtes derefter i normerede, delbare støbeforme, og inkuberedes i 30 min. ved 37eC. Derefter udtoges de hærdede prøver fra støbeformene og rivestyrken blev bestemt af et rivestyrkemåleapparat over et normeret tværsnit (0,0314 cm2). pe opnåede resul-10 tater (middelværdier fra hver gang tre målinger, idet enkeltværdierne ikke afviger mere end 15% fra middelværdien) er angivet i tabellens sidste spalte.
I spalterne 8 til 11 er siutkoncentrationerne af fibrinogen, 15 aprotinin, trombin og CaCl2 angivet efter de to komponenters bland i ng.
Af resultaterne fremgår, at den nødvendige opløsningstid afhænger af den tilstræbte fibrinogenkoncentration i den første 20 komponent (vævsklæbestofopløsningen) før komponenternes blanding mens rivestyrken derimod afhænger af fibrinogenslutkon-centrationen efter de to komponenters blanding.
Herved bliver det ved anvendelse af påfør ingsindretningen 25 ifølge opfindelsen muligt at forkorte den nødvendige opløs ningstid uden at forringe rivestyrken (eksemplerne 1, 2, 3, 5, 6 og 7) eller omvendt, uden at få en forlænget opløsningstid i tilgift, yderligere at forøge rivestyrken (eksemplerne 8 og 9). Eksempel 4 viser, at man i tilfælde, hvor en noget forrin-30 get rivestyrke er tilstrækkelig, kan opnå ekstremt korte opløsningstider ved anvendelse af påfør ingsapparatet ifølge opfindelsen.
Eksempel 5 viser, at påfør ingsindretningen ifølge opfindelsen 35 også er egnet til anvendelse af store trombinkoncentrationer.
I dette tilfælde forekommer vævsklæbestoffets hærdning imidlertid så hurtigt, at støbningen af normerede klumper af 6
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størknet blod og dermed bestemmelse af rivestyrken ikke længere er mulig. Inden for kirurgisk praksis er imidlertid anvendelsen af store trombinkoncentrationer af stor betydning især til standsning af blødninger.
5
Ved at sammenligne eksemplerne 6 og 7 med eksemplerne 1 og 3 fremgår endvidere, at hverken den nødvendige opløsningstid eller den opnåede rivestyrke afhænger væsentligt af, om det lyofi 1iserede vævsklæbestofs opløsning sker med aqua ad injec-10 tabilia eller med en aprotininopløsning.
15 20 25 1 35
7 DK 162739 B
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Claims (3)
1. Indretning til påføring af et vævsklæbestof på basis af 5 humane eller animalske proteiner til sømløs henholdsvis sømunderstøttet forbindelse af humane eller animalske væv- eller organdele, til sårlukning, blodstandsning -og tilsvarende, hvilket vævsklæbestof hærdes in situ ved sammenføring med blodstørkningsfremmende størkningsfaktorer, hvilken indretning 10 omfatter to i tilslutningsstykker endende sprøjtelegemer (1, . 2), der er udstyret med i fællesskab drivbare stempler (21, 22), og hvor det ene sprøjtelegeme (1) indeholder en protein-' opløsning og det andet (2) indeholder en trombi nopløsni ng, og hvor der på sprøjtelegemernes tilslutningsstykker (14, 15) kan 15 placeres et forbindelseshoved (16), der har en selvstændig transportkanal (17, 18) for hver komponent, der skal påføres, og i givet fald for en medi ci nsk drivgas, kendetegnet ved, at sprøjtelegemerne (1, 2) har samme effektive sdlaglængde, og at det ene af disse, nemlig det til optagelse 20 af proteinopløsningen bestemte sprøjtel egerne (1) har en to til ni gange større tværsnitsflade end det andet sprøjtelegeme (2) således, at forholdet mellem sprøjtel egernernes rumfang ligeledes er beliggende i området fra 2:1 til 9:1.
2. Indretning ifølge krav 1, kendetegnet ved, at sprøjtelegemet (1, 2) er udformet som et dobbeltkammersprøjte-legeme, og at proteinkomponenterne (25) og trombinkomponenterne (28) hver i lyofiliseret form kan anbringes i de mod mundingen vendende kamre (25, 27), mens opløsningsmidlet kan 30 anbringes i de andre kamre (29, 30).
3. Anvendelse af en indretning til påføring af proteinvævsklæbestof opl øsn i ng ifølge krav 1 eller 2, kendetegnet ved, at proteinvævsklæbestofopløsningen har et fibrinogenind-35 hold fra 2 til 12%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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AT0183885A AT382783B (de) | 1985-06-20 | 1985-06-20 | Vorrichtung zur applikation eines gewebeklebstoffes |
AT183885 | 1985-06-20 |
Publications (3)
Publication Number | Publication Date |
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DK288886D0 DK288886D0 (da) | 1986-06-19 |
DK288886A DK288886A (da) | 1986-12-21 |
DK162739B true DK162739B (da) | 1991-12-09 |
Family
ID=3522110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DK288886A DK162739B (da) | 1985-06-20 | 1986-06-19 | Indretning til paafoering af et vaevsklaebestof |
Country Status (8)
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US (1) | US4735616A (da) |
EP (1) | EP0210160B2 (da) |
JP (1) | JPS61293443A (da) |
AT (2) | AT382783B (da) |
CA (1) | CA1249194A (da) |
DE (1) | DE3663109D1 (da) |
DK (1) | DK162739B (da) |
ES (1) | ES8707668A1 (da) |
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Family Cites Families (8)
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AT9324B (de) * | 1901-10-30 | 1902-10-10 | Max Dr Med Schachmann | Medicinische Doppelspritze. |
FR1051010A (fr) * | 1952-02-21 | 1954-01-12 | Nouvelle seringue pour injection | |
US3223083A (en) * | 1960-09-09 | 1965-12-14 | President And Directors Of Geo | Method for adhesively securing together skin and other soft tissue and bone |
US4040420A (en) * | 1976-04-22 | 1977-08-09 | General Dynamics | Packaging and dispensing kit |
AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
AT371719B (de) * | 1980-08-25 | 1983-07-25 | Immuno Ag | Verfahren und vorrichtung zur beschleunigung des aufloesens von schwerloeslichen lyophilisierten arzneimitteln |
AT379311B (de) * | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
-
1985
- 1985-06-20 AT AT0183885A patent/AT382783B/de not_active IP Right Cessation
-
1986
- 1986-06-11 CA CA000511285A patent/CA1249194A/en not_active Expired
- 1986-06-12 AT AT86890174T patent/ATE42683T1/de not_active IP Right Cessation
- 1986-06-12 EP EP86890174A patent/EP0210160B2/de not_active Expired - Lifetime
- 1986-06-12 DE DE8686890174T patent/DE3663109D1/de not_active Expired
- 1986-06-17 US US06/875,080 patent/US4735616A/en not_active Expired - Lifetime
- 1986-06-19 JP JP61144679A patent/JPS61293443A/ja active Pending
- 1986-06-19 DK DK288886A patent/DK162739B/da not_active Application Discontinuation
- 1986-06-19 ES ES556300A patent/ES8707668A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3663109D1 (en) | 1989-06-08 |
ATE42683T1 (de) | 1989-05-15 |
DK288886A (da) | 1986-12-21 |
DK288886D0 (da) | 1986-06-19 |
AT382783B (de) | 1987-04-10 |
CA1249194A (en) | 1989-01-24 |
ES556300A0 (es) | 1987-08-16 |
ES8707668A1 (es) | 1987-08-16 |
ATA183885A (de) | 1986-09-15 |
EP0210160B2 (de) | 1992-07-15 |
EP0210160A1 (de) | 1987-01-28 |
EP0210160B1 (de) | 1989-05-03 |
US4735616A (en) | 1988-04-05 |
JPS61293443A (ja) | 1986-12-24 |
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