DK1623023T3 - Kulturer af E1-immortaliserede celler og fremgangsmåder til dyrkning deraf til forögelse af produktudbytter derfra - Google Patents
Kulturer af E1-immortaliserede celler og fremgangsmåder til dyrkning deraf til forögelse af produktudbytter derfraInfo
- Publication number
- DK1623023T3 DK1623023T3 DK04741521T DK04741521T DK1623023T3 DK 1623023 T3 DK1623023 T3 DK 1623023T3 DK 04741521 T DK04741521 T DK 04741521T DK 04741521 T DK04741521 T DK 04741521T DK 1623023 T3 DK1623023 T3 DK 1623023T3
- Authority
- DK
- Denmark
- Prior art keywords
- cultures
- cells
- cultivating
- methods
- product yields
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0350155 | 2003-05-09 | ||
EP0350390 | 2003-09-01 | ||
EP0350940 | 2003-12-04 | ||
EP2004050061 | 2004-01-30 | ||
PCT/EP2004/050724 WO2004099396A1 (en) | 2003-05-09 | 2004-05-06 | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1623023T3 true DK1623023T3 (da) | 2009-03-02 |
Family
ID=33437116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04741521T DK1623023T3 (da) | 2003-05-09 | 2004-05-06 | Kulturer af E1-immortaliserede celler og fremgangsmåder til dyrkning deraf til forögelse af produktudbytter derfra |
Country Status (16)
Country | Link |
---|---|
US (4) | US7291484B2 (da) |
EP (1) | EP1623023B1 (da) |
JP (1) | JP4865539B2 (da) |
KR (1) | KR101183770B1 (da) |
CN (2) | CN100383238C (da) |
AT (1) | ATE414144T1 (da) |
AU (1) | AU2004236440B2 (da) |
BR (1) | BRPI0409895B8 (da) |
CA (1) | CA2520891C (da) |
DE (1) | DE602004017709D1 (da) |
DK (1) | DK1623023T3 (da) |
EA (1) | EA008670B1 (da) |
HK (1) | HK1080115A1 (da) |
IL (2) | IL171680A (da) |
NZ (1) | NZ542585A (da) |
WO (1) | WO2004099396A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
ES2297028T3 (es) | 2001-12-07 | 2008-05-01 | Crucell Holland B.V. | Produccion de virus, aislados virales y vacunas. |
ATE414144T1 (de) | 2003-05-09 | 2008-11-15 | Crucell Holland Bv | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon |
PL1720972T3 (pl) | 2004-03-05 | 2014-06-30 | Dpx Holdings Bv | Proces hodowli komórek poprzez ciągłą perfuzję i zmienny przepływ styczny |
EP1835022B1 (en) | 2005-01-05 | 2015-02-11 | Chugai Seiyaku Kabushiki Kaisha | Cell culture method and utilization of the same |
DE102005054628A1 (de) * | 2005-11-16 | 2007-05-24 | Cevec Pharmaceuticals Gmbh | Verfahren zur Herstellung von permanenten humanen Zelllinien |
AU2007208368B2 (en) | 2006-01-23 | 2013-05-23 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
EP1870450A1 (en) * | 2006-06-21 | 2007-12-26 | DSMIP Assets B.V. | Process for the culturing of E1-immortalized HER cells |
AU2011211462C1 (en) * | 2006-07-14 | 2015-01-22 | Dpx Holdings B.V. | Improved process for the culturing of cells |
EP2041259B1 (en) * | 2006-07-14 | 2015-10-14 | DPx Holdings B.V. | Improved process for the culturing of cells |
EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
TWI601823B (zh) | 2007-04-26 | 2017-10-11 | Chugai Pharmaceutical Co Ltd | Cell culture methods using media containing high concentrations of amino acids |
WO2009023562A2 (en) * | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
KR101640962B1 (ko) | 2009-04-23 | 2016-07-19 | 크루셀 홀란드 비.브이. | 재조합 인간 알파1-항트립신 |
SI2454364T1 (sl) | 2009-07-16 | 2014-08-29 | Crucell Holland B.V. | Izdelava polio virusa v visokih titrih za izdelavo cepiva |
CN102791852B (zh) | 2009-10-15 | 2014-05-07 | 克鲁塞尔荷兰公司 | 纯化腺病毒颗粒的方法 |
MX2012004221A (es) | 2009-10-15 | 2012-06-08 | Crucell Holland Bv | Proceso para purificacion de adenovirus de cultivos de alta densidad celular. |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
ES2556454T3 (es) | 2010-10-05 | 2016-01-18 | Novo Nordisk Health Care Ag | Proceso para producción de proteínas |
DK2702164T3 (da) | 2011-04-29 | 2016-02-01 | Biocon Res Ltd | Fremgangsmåde til reduktion af heterogenitet af antistoffer og fremgangsmåde til fremstilling af disse antistoffer |
CN102994547B (zh) * | 2011-09-08 | 2015-05-13 | 哈药集团技术中心 | 重组人促红素-ctp融合蛋白生产工艺及应用 |
EP2905342A4 (en) * | 2012-10-03 | 2016-03-16 | Kyowa Hakko Kirin Co Ltd | METHOD FOR PREVENTING POLYPEPTIDE REDUCTION BY ADDITION OF AMINO ACID TO A LIQUID CULTURE MEDIUM |
SG10201808061WA (en) | 2013-09-30 | 2018-10-30 | Janssen Vaccines & Prevention Bv | Method for the clarification of high density crude cell culture harvest |
JP6385559B2 (ja) | 2014-07-24 | 2018-09-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 細胞培養体からのポリオウイルスの精製プロセス |
RU2672318C1 (ru) * | 2017-09-19 | 2018-11-13 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Способ получения моноклональных антител терапевтического назначения с помощью непрерывного культивирования клеток сно |
EP3976753A4 (en) | 2019-05-28 | 2023-07-19 | Wuxi Biologics Ireland Limited | INTEGRATED RAMAN SPECTROSCOPY PERFUSION CELL CULTURE SYSTEM FOR AUTOMATICALLY MONITORING AND CONTROL OF PERFUSION CELL CULTURE |
CN115369069B (zh) * | 2022-08-22 | 2023-12-19 | 上海健士拜生物科技有限公司 | 293细胞补料培养基及其制备和应用 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
FR2573436B1 (fr) | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
US5192539A (en) * | 1988-07-21 | 1993-03-09 | Akzo N.V. | Infectious bursal disease virus production in continuous cell lines |
US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
GB8900483D0 (en) * | 1989-01-10 | 1989-03-08 | Celltech Ltd | Recombinant dna method |
DE3923963A1 (de) * | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
DK0596881T3 (da) | 1991-08-01 | 1997-10-13 | Fond Nat Transfusion Sanguine | Ekspression i ikke-tumurale humane lymofoblastoider med en integrativ vektor |
US5384249A (en) * | 1991-12-17 | 1995-01-24 | Kyowa Hakko Kogyo Co., Ltd. | α2→3 sialyltransferase |
ZA946122B (en) | 1993-08-17 | 1995-03-20 | Amgen Inc | Erythropoietin analogs |
US5631158A (en) * | 1993-10-25 | 1997-05-20 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from non-native DNA |
US5830851A (en) * | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
US5773569A (en) * | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5789247A (en) * | 1994-04-01 | 1998-08-04 | Ballay; Annick | Expression in non-tumoral human lymphoblastoid lines with an integrative vector |
US5610043A (en) | 1994-04-28 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Human prostatic cell lines immortalized by adenovirus 12-simian virus 40 (AD12/SV40) hybrid virus |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
US6265212B1 (en) | 1995-06-15 | 2001-07-24 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
US5989805A (en) | 1995-10-27 | 1999-11-23 | Board Of Trustees Operating Michigan State University | Immortal avian cell line to grow avian and animal viruses to produce vaccines |
ES2259182T3 (es) | 1995-11-13 | 2006-09-16 | Takara Bio Inc. | Metodo de introduccion de genes en celulas diana por medio de retrovirus. |
US5681597A (en) * | 1996-02-06 | 1997-10-28 | Liquid Container L.P. | Vacuum conveyor picker for blow bottle container |
US5856292A (en) | 1996-04-08 | 1999-01-05 | Colgate Palmolive Company | Light duty liquid cleaning compositions |
US5835382A (en) * | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
EP0939816A1 (en) | 1996-10-25 | 1999-09-08 | G.D. SEARLE & CO. | Circularly permuted erythropoietin receptor agonists |
US7732129B1 (en) * | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
JP2000509614A (ja) | 1997-03-04 | 2000-08-02 | バクスター インターナショナル インコーポレイテッド | アデノウイルスe1−相補性細胞系 |
CA2221819A1 (en) * | 1997-03-27 | 1998-09-27 | Thomas A. Gigliatti | Insect expression vectors |
EP1012319B1 (en) | 1997-03-27 | 2005-03-02 | The University Of British Columbia | Insect expression vectors |
US5997128A (en) * | 1997-05-30 | 1999-12-07 | Hewlett-Packard Company | Translational service station for imaging inkjet printheads |
CA2298015C (en) | 1997-07-23 | 2015-01-27 | Roche Diagnostics Gmbh | Production of erythropoietin by endogenous gene activation |
JP4220125B2 (ja) | 1997-12-03 | 2009-02-04 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 高い比活性を有するエリスロポエチン |
US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
JP2002518010A (ja) | 1998-06-16 | 2002-06-25 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 94個のヒト分泌タンパク質 |
JP2003520194A (ja) | 1999-04-13 | 2003-07-02 | ザ ケネス エス.ウォーレン インスティテュート,インコーポレーテッド | 末梢投与したエリスロポエチンによる興奮組織機能のモジュレート |
US6855544B1 (en) * | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7297680B2 (en) * | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
SI1533380T1 (sl) * | 1999-04-15 | 2010-03-31 | Crucell Holland Bv | Proizvajanje rekombinantnega proteina v človeški celici ki obsega vsaj en protein E adenovirusa |
US20050164386A1 (en) | 1999-04-15 | 2005-07-28 | Uytdehaag Alphonsus G. | Overexpression of enzymes involved in post-translational protein modifications in human cells |
EP1171615B1 (en) | 1999-04-26 | 2006-12-13 | Genentech, Inc. | Cell culture process for glycoproteins |
US6215499B1 (en) * | 1999-05-06 | 2001-04-10 | Phillips Petroleum Company | Method and apparatus for interactive curved surface seismic interpretation and visualization |
US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6558948B1 (en) * | 1999-11-23 | 2003-05-06 | Stefan Kochanek | Permanent amniocytic cell line, its production and use for the production of gene transfer vectors |
EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
EP1184458A1 (en) | 2000-08-28 | 2002-03-06 | U-BISys B.V. | Differentially expressed CD46 epitopes, proteinaceous molecules capable of binding thereto, and uses thereof |
PA8536201A1 (es) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
JP2004532642A (ja) * | 2001-06-13 | 2004-10-28 | ジェネンテック・インコーポレーテッド | 動物細胞の培養方法と動物細胞でのポリペプチド産生 |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
WO2003029459A2 (en) * | 2001-09-28 | 2003-04-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Micro-rna molecules |
AU2002225509A1 (en) | 2001-12-07 | 2003-06-17 | Crucell Holland B.V. | Production and of viruses, viral isolates and vaccines |
ES2297028T3 (es) | 2001-12-07 | 2008-05-01 | Crucell Holland B.V. | Produccion de virus, aislados virales y vacunas. |
WO2003051927A2 (en) | 2001-12-17 | 2003-06-26 | Crucell Holland B.V. | Production of f(ab')2 fragments in mammalian cells |
WO2003093441A2 (en) * | 2002-05-03 | 2003-11-13 | Duke University | A method of regulating gene expression |
KR20060019501A (ko) | 2002-07-01 | 2006-03-03 | 더 케네쓰 에스. 워렌 인스티튜트 인코포레이티드 | 응답 세포, 조직 및 기관을 보호, 회복 및 향상시키기위한 재조합 조직 보호 사이토카인 및 이를 코딩하는 핵산 |
US20040268441A1 (en) * | 2002-07-19 | 2004-12-30 | University Of South Carolina | Compositions and methods for the modulation of gene expression in plants |
US8524477B2 (en) * | 2002-10-29 | 2013-09-03 | Crucell Holland B.V. | Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby |
CN100402660C (zh) * | 2002-12-23 | 2008-07-16 | 布里斯托尔-迈尔斯斯奎布公司 | 用于蛋白质生产的哺乳动物细胞培养方法中产物质量提高 |
ATE414144T1 (de) * | 2003-05-09 | 2008-11-15 | Crucell Holland Bv | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon |
US20050144669A1 (en) * | 2003-07-01 | 2005-06-30 | Whitehead Institute For Biomedical Research | MicroRNAs in plants |
US20050120415A1 (en) * | 2003-10-09 | 2005-06-02 | E.I. Du Pont De Nemours And Company | Gene silencing |
US7642078B2 (en) * | 2005-12-28 | 2010-01-05 | Crucell Holland B.V. | Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby |
EP2081589B1 (en) * | 2006-11-16 | 2010-10-06 | Crucell Holland B.V. | Complementation of factor xi deficiency by factor v mutants |
-
2004
- 2004-05-06 AT AT04741521T patent/ATE414144T1/de active
- 2004-05-06 EA EA200501774A patent/EA008670B1/ru not_active IP Right Cessation
- 2004-05-06 DK DK04741521T patent/DK1623023T3/da active
- 2004-05-06 CN CNB2004800126042A patent/CN100383238C/zh not_active Expired - Fee Related
- 2004-05-06 CA CA2520891A patent/CA2520891C/en not_active Expired - Lifetime
- 2004-05-06 WO PCT/EP2004/050724 patent/WO2004099396A1/en active Application Filing
- 2004-05-06 EP EP04741521A patent/EP1623023B1/en not_active Expired - Lifetime
- 2004-05-06 AU AU2004236440A patent/AU2004236440B2/en not_active Ceased
- 2004-05-06 NZ NZ542585A patent/NZ542585A/en not_active IP Right Cessation
- 2004-05-06 BR BRPI0409895A patent/BRPI0409895B8/pt not_active IP Right Cessation
- 2004-05-06 CN CN2008100838691A patent/CN101328473B/zh not_active Expired - Fee Related
- 2004-05-06 KR KR1020057021254A patent/KR101183770B1/ko active IP Right Grant
- 2004-05-06 DE DE602004017709T patent/DE602004017709D1/de not_active Expired - Lifetime
- 2004-05-06 JP JP2006505590A patent/JP4865539B2/ja not_active Expired - Lifetime
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2005
- 2005-10-26 US US11/259,245 patent/US7291484B2/en not_active Expired - Lifetime
- 2005-10-31 IL IL171680A patent/IL171680A/en active IP Right Grant
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2006
- 2006-01-13 US US11/331,861 patent/US7608431B2/en active Active
- 2006-03-01 HK HK06102692.1A patent/HK1080115A1/xx not_active IP Right Cessation
- 2006-10-09 US US11/544,490 patent/US20070031932A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
BRPI0409895B1 (pt) | 2018-09-18 |
NZ542585A (en) | 2007-11-30 |
EA008670B1 (ru) | 2007-06-29 |
HK1080115A1 (en) | 2006-04-21 |
BRPI0409895B8 (pt) | 2021-05-25 |
US20070031932A1 (en) | 2007-02-08 |
AU2004236440B2 (en) | 2008-10-09 |
AU2004236440A1 (en) | 2004-11-18 |
KR101183770B1 (ko) | 2012-09-17 |
ATE414144T1 (de) | 2008-11-15 |
CA2520891A1 (en) | 2004-11-18 |
EP1623023B1 (en) | 2008-11-12 |
WO2004099396A1 (en) | 2004-11-18 |
CN101328473A (zh) | 2008-12-24 |
US20060121611A1 (en) | 2006-06-08 |
JP4865539B2 (ja) | 2012-02-01 |
US20100311160A1 (en) | 2010-12-09 |
KR20060003081A (ko) | 2006-01-09 |
IL198861A (en) | 2011-12-29 |
US7291484B2 (en) | 2007-11-06 |
CN1784489A (zh) | 2006-06-07 |
EP1623023A1 (en) | 2006-02-08 |
US20060240513A1 (en) | 2006-10-26 |
JP2006525800A (ja) | 2006-11-16 |
EA200501774A1 (ru) | 2006-04-28 |
US8008043B2 (en) | 2011-08-30 |
CN100383238C (zh) | 2008-04-23 |
CA2520891C (en) | 2014-07-08 |
CN101328473B (zh) | 2012-05-02 |
IL171680A (en) | 2010-05-31 |
BRPI0409895A (pt) | 2006-05-23 |
DE602004017709D1 (de) | 2008-12-24 |
US7608431B2 (en) | 2009-10-27 |
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