DK1618195T3 - Fremgangsmåde til selektiv inhibering af humant N-myc-gen i N-myc-udtrykkende tumorer via antisense- og antigen-peptidnucleinsyrer (PNA) - Google Patents

Fremgangsmåde til selektiv inhibering af humant N-myc-gen i N-myc-udtrykkende tumorer via antisense- og antigen-peptidnucleinsyrer (PNA)

Info

Publication number
DK1618195T3
DK1618195T3 DK04730318T DK04730318T DK1618195T3 DK 1618195 T3 DK1618195 T3 DK 1618195T3 DK 04730318 T DK04730318 T DK 04730318T DK 04730318 T DK04730318 T DK 04730318T DK 1618195 T3 DK1618195 T3 DK 1618195T3
Authority
DK
Denmark
Prior art keywords
myc
nucleic acids
peptide nucleic
pna
antigen peptide
Prior art date
Application number
DK04730318T
Other languages
Danish (da)
English (en)
Inventor
Roberto Tonelli
Raffaele Fronza
Andrea Pession
Stefano Sforza
Roberto Corradini
Rosangela Marchelli
Original Assignee
Univ Bologna Alma Mater
Univ Parma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bologna Alma Mater, Univ Parma filed Critical Univ Bologna Alma Mater
Application granted granted Critical
Publication of DK1618195T3 publication Critical patent/DK1618195T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK04730318T 2003-04-29 2004-04-29 Fremgangsmåde til selektiv inhibering af humant N-myc-gen i N-myc-udtrykkende tumorer via antisense- og antigen-peptidnucleinsyrer (PNA) DK1618195T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000860A ITMI20030860A1 (it) 2003-04-29 2003-04-29 Metodo per l'inibizione selettiva del gene n-myc
PCT/IB2004/001297 WO2004096826A2 (en) 2003-04-29 2004-04-29 Method for selective inhibition of human n-myc gene in n-myc expressing tumors through antisense and antigen peptido-nucleic acids (pna)

Publications (1)

Publication Number Publication Date
DK1618195T3 true DK1618195T3 (da) 2008-07-07

Family

ID=33398059

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04730318T DK1618195T3 (da) 2003-04-29 2004-04-29 Fremgangsmåde til selektiv inhibering af humant N-myc-gen i N-myc-udtrykkende tumorer via antisense- og antigen-peptidnucleinsyrer (PNA)

Country Status (12)

Country Link
US (1) US7947657B2 (ja)
EP (1) EP1618195B1 (ja)
JP (1) JP4719670B2 (ja)
AT (1) ATE389017T1 (ja)
CA (1) CA2522890C (ja)
DE (1) DE602004012404T2 (ja)
DK (1) DK1618195T3 (ja)
ES (1) ES2303636T3 (ja)
IT (1) ITMI20030860A1 (ja)
PL (1) PL1618195T3 (ja)
PT (1) PT1618195E (ja)
WO (1) WO2004096826A2 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006019430A2 (en) 2004-04-20 2006-02-23 Nastech Pharmaceutical Company Inc. Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
US20060040882A1 (en) * 2004-05-04 2006-02-23 Lishan Chen Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
EP1970075B1 (en) * 2005-12-26 2012-04-11 Riken THERAPEUTIC AGENT FOR NEUROBLASTOMA TARGETING ARID3b
US20070281900A1 (en) * 2006-05-05 2007-12-06 Nastech Pharmaceutical Company Inc. COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
ITMI20120275A1 (it) 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
EP3625344A1 (en) * 2017-05-15 2020-03-25 University of Florida Research Foundation, Inc. Core master regulators of glioblastoma stem cells
JPWO2020246584A1 (ja) * 2019-06-06 2020-12-10

Also Published As

Publication number Publication date
DE602004012404D1 (de) 2008-04-24
US20070020632A1 (en) 2007-01-25
CA2522890C (en) 2013-07-02
EP1618195A2 (en) 2006-01-25
JP4719670B2 (ja) 2011-07-06
PT1618195E (pt) 2008-06-24
EP1618195B1 (en) 2008-03-12
CA2522890A1 (en) 2004-11-11
WO2004096826A2 (en) 2004-11-11
PL1618195T3 (pl) 2008-09-30
WO2004096826A3 (en) 2005-05-26
ATE389017T1 (de) 2008-03-15
ES2303636T3 (es) 2008-08-16
ITMI20030860A1 (it) 2004-10-30
DE602004012404T2 (de) 2009-03-26
JP2006525010A (ja) 2006-11-09
US7947657B2 (en) 2011-05-24

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