DK1615632T3 - Flydende orale formularer for kontrolleret udskillelse af betain - Google Patents
Flydende orale formularer for kontrolleret udskillelse af betainInfo
- Publication number
- DK1615632T3 DK1615632T3 DK04728127T DK04728127T DK1615632T3 DK 1615632 T3 DK1615632 T3 DK 1615632T3 DK 04728127 T DK04728127 T DK 04728127T DK 04728127 T DK04728127 T DK 04728127T DK 1615632 T3 DK1615632 T3 DK 1615632T3
- Authority
- DK
- Denmark
- Prior art keywords
- betaine
- liquid oral
- oral forms
- formulation
- controlled excretion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE200300248 | 2003-04-17 | ||
PCT/BE2004/000053 WO2004091601A1 (fr) | 2003-04-17 | 2004-04-18 | Formulations orales flottantes pour la liberation controlee de la betaine |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1615632T3 true DK1615632T3 (da) | 2007-04-10 |
Family
ID=33163520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04728127T DK1615632T3 (da) | 2003-04-17 | 2004-04-18 | Flydende orale formularer for kontrolleret udskillelse af betain |
Country Status (7)
Country | Link |
---|---|
US (2) | US20060034918A1 (da) |
EP (1) | EP1615632B1 (da) |
AT (1) | ATE347358T1 (da) |
DE (1) | DE602004003577T2 (da) |
DK (1) | DK1615632T3 (da) |
ES (1) | ES2278314T3 (da) |
WO (1) | WO2004091601A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7608640B2 (en) | 1999-03-02 | 2009-10-27 | Jallal Messadek | Glycine betaine and its use |
BE1013958A6 (fr) * | 2001-02-05 | 2003-01-14 | Messadek Jallal | Antagonistes glycoproteiques. |
BE1015608A6 (fr) | 2003-07-15 | 2005-06-07 | Messadek Jallal | Traitement des arterites. |
US20060160896A1 (en) * | 2002-02-04 | 2006-07-20 | Jallal Messadek | Therapeutic treatment |
ES2278314T3 (es) * | 2003-04-17 | 2007-08-01 | Jallal Messadek | Formulaciones orales para la liberacion controlada de la betaina. |
BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
WO2006050581A2 (en) | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
EP2242489A1 (en) | 2005-02-15 | 2010-10-27 | Jallal Messadek | Combination therapeutic compositions and method of use |
BRPI0610249A2 (pt) | 2005-04-27 | 2010-06-08 | Jallal Messadek | associação ou combinação farmacêutica, composição farmacêutica, processo de co-cristalização e o uso de insulina ou análogo de insulina |
WO2007041079A2 (en) * | 2005-09-30 | 2007-04-12 | Alza Corporation | Banded controlled release nanoparticle active agent formulation dosage forms and methods |
EP2176326B1 (en) | 2007-08-03 | 2011-07-20 | Cable Components Group LLC | Perfluoropolymer foamable composition |
WO2009065193A1 (en) * | 2007-11-21 | 2009-05-28 | Jallal Messadek | Treatment of aspirin resistance with betaine and/or betaine enriched molasses |
US8791045B2 (en) | 2011-11-09 | 2014-07-29 | Kimberly-Clark Worldwide, Inc. | Non-tacky wetness indicator composition for application on a polymeric substrate |
US9889222B2 (en) | 2011-11-09 | 2018-02-13 | Kimberly-Clark Worldwide, Inc. | Aqueous medium-sensitive coating compositions for triggered release of active ingredients and visual indication for wetness |
US9585826B2 (en) | 2012-11-07 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of active chemistry |
US9119780B2 (en) | 2013-10-30 | 2015-09-01 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of proactive chemistry |
CN105796542A (zh) * | 2016-03-15 | 2016-07-27 | 四川九章生物科技有限公司 | 绿原酸在制备治疗以lag-3为靶点的疾病的药物中的用途 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE644568C (de) * | 1934-04-19 | 1937-05-07 | Bristol Aeroplane Co Ltd | Kopierfraesmaschine |
US3577534A (en) * | 1968-06-20 | 1971-05-04 | Canada Packers Ltd | Stable orally active heparinoid complexes |
GB1509979A (en) * | 1975-11-28 | 1978-05-10 | Fisons Ltd | Pharmaceutical compositions containing aspirin or indomethacin |
US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
US4605548A (en) * | 1983-05-31 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Drug administration material |
GB8325627D0 (en) * | 1983-09-24 | 1983-10-26 | Scras | Therapeutic compositions |
PL149493B1 (en) * | 1985-04-12 | 1990-02-28 | Method of obtaining a tablet capable to buoy over surface of gastric juice | |
AU607172B2 (en) * | 1986-12-22 | 1991-02-28 | Cygnus, Inc. | Diffusion matrix for transdermal drug administration |
US4902718A (en) * | 1988-04-08 | 1990-02-20 | Bayless Robert K | Calcium homeostasis compositions and methods for controlling calcium metabolism |
US4968719A (en) * | 1989-04-03 | 1990-11-06 | Sigma Tau, Industrie Farmaceutiche Riunite Spa | Method for treating vascular disease |
EP0441119A3 (en) * | 1990-01-09 | 1992-10-14 | Richard D. Levere | The use of l-arginine in the treatment of hypertension and other vascular disorders |
US5405614A (en) * | 1992-04-08 | 1995-04-11 | International Medical Associates, Inc. | Electronic transdermal drug delivery system |
US5342621A (en) * | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5876780A (en) * | 1993-04-29 | 1999-03-02 | Cultor, Ltd. | Compositions for treating coccidiosis |
US5716941A (en) * | 1993-07-07 | 1998-02-10 | Biogenesys | Use of methyl donor compounds to treat neurological dysfunction associated with immune defects |
US5814599A (en) * | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
US6355166B1 (en) * | 1994-08-25 | 2002-03-12 | The University Of Iowa Research Foundation | Magnetically enhanced composite materials and methods for making and using the same |
US6056958A (en) * | 1994-12-09 | 2000-05-02 | Dupont Pharmaceuticals | Method of treatment of arterial and venous thromboembolic disorders |
US5961999A (en) * | 1995-06-08 | 1999-10-05 | Wella Aktiengesellschaft | Method of skin care using a skin care preparation containing a betaine ester and an α-hydroxy acid |
US6162926A (en) * | 1995-07-31 | 2000-12-19 | Sphere Biosystems, Inc. | Multi-substituted fullerenes and methods for their preparation and characterization |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
AU2260397A (en) * | 1996-01-31 | 1997-08-22 | Trustees Of The University Of Pennsylvania, The | Remote control drug delivery device |
US5688499A (en) * | 1996-03-13 | 1997-11-18 | Queen's University At Kingston | Antagonism of endothelin actions |
US5880098A (en) * | 1996-04-12 | 1999-03-09 | Pharmacia & Upjohn Aktiebolag | Therapeutic treatment |
IL119029A0 (en) * | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
US6008221A (en) * | 1996-11-06 | 1999-12-28 | Bristol-Myers Squibb Company | Method for treating Alzheimer's disease with folic acid |
US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
RU2219924C2 (ru) * | 1998-04-14 | 2003-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения нейропсихиатрических расстройств |
US6287765B1 (en) * | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
BE1012495A3 (fr) * | 1999-03-02 | 2000-11-07 | Messadek Jallal | La glycine-betaine pour son usage antithrombotique. |
US7608640B2 (en) * | 1999-03-02 | 2009-10-27 | Jallal Messadek | Glycine betaine and its use |
BE1013958A6 (fr) * | 2001-02-05 | 2003-01-14 | Messadek Jallal | Antagonistes glycoproteiques. |
CA2407027C (en) * | 2000-04-20 | 2011-02-15 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
CA2412490A1 (en) * | 2000-06-23 | 2002-01-03 | Moshe Fleshner-Barak | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
US6881420B2 (en) * | 2000-06-23 | 2005-04-19 | Teva Pharmaceutical Industries Ltd. | Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation |
US6476006B2 (en) * | 2000-06-23 | 2002-11-05 | Teva Pharmaceutical Industries, Ltd. | Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates |
FR2811227A1 (fr) * | 2000-07-07 | 2002-01-11 | Philippe Maincent | Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs |
JP2004517074A (ja) * | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
FI114538B (fi) * | 2001-01-12 | 2004-11-15 | Finnfeeds Finland Ltd | Glysiinibetaiinin käyttö verenpainetta alentavan tuotteen valmistukseen |
ES2298342T3 (es) * | 2001-02-05 | 2008-05-16 | Jallal Messadek | Glicina betaina y su uso como agente anti-hemorragico. |
US20040072750A1 (en) * | 2001-05-03 | 2004-04-15 | David Phillips | Compounds and methods for the modulation of CD154 |
US6531171B2 (en) * | 2001-07-03 | 2003-03-11 | Nutricia Usa, Inc. | Food products containing betaine |
WO2003020260A1 (en) * | 2001-08-31 | 2003-03-13 | Metaproteomics, Llc | Arginine compositions for coordinate modification of multiple cardiovascular risk factors |
US20030170223A1 (en) * | 2002-02-01 | 2003-09-11 | Board Of Trustees Of Michigan State University | Pulmonary vasodilator surfactant compositions and method of use |
US20060160896A1 (en) * | 2002-02-04 | 2006-07-20 | Jallal Messadek | Therapeutic treatment |
US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
AU2003225724A1 (en) * | 2002-03-11 | 2003-09-29 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
US7985422B2 (en) * | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
US20040067986A1 (en) * | 2002-10-04 | 2004-04-08 | Nathan Sassover | Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer |
AU2002343174A1 (en) * | 2002-11-25 | 2004-06-18 | Rachid Ennamany | Betaine and salicylic acid compositions |
ES2278314T3 (es) * | 2003-04-17 | 2007-08-01 | Jallal Messadek | Formulaciones orales para la liberacion controlada de la betaina. |
US7097968B2 (en) * | 2003-07-10 | 2006-08-29 | General Atomics | Methods and compositions for assaying homocysteine |
US20060128657A1 (en) * | 2003-08-04 | 2006-06-15 | Jallal Messadek | Selected betaines and their uses |
EP1755599A4 (en) * | 2004-04-23 | 2007-06-06 | Celgene Corp | METHOD OF USING THALIDOMIDE AND COMPOSITIONS THEREOF FOR TREATING AND MANAGING PULMONARY HYPERTENSION |
BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
EP2242489A1 (en) * | 2005-02-15 | 2010-10-27 | Jallal Messadek | Combination therapeutic compositions and method of use |
BRPI0610249A2 (pt) * | 2005-04-27 | 2010-06-08 | Jallal Messadek | associação ou combinação farmacêutica, composição farmacêutica, processo de co-cristalização e o uso de insulina ou análogo de insulina |
-
2004
- 2004-04-18 ES ES04728127T patent/ES2278314T3/es not_active Expired - Lifetime
- 2004-04-18 DE DE602004003577T patent/DE602004003577T2/de not_active Expired - Lifetime
- 2004-04-18 DK DK04728127T patent/DK1615632T3/da active
- 2004-04-18 AT AT04728127T patent/ATE347358T1/de not_active IP Right Cessation
- 2004-04-18 EP EP04728127A patent/EP1615632B1/fr not_active Expired - Lifetime
- 2004-04-18 WO PCT/BE2004/000053 patent/WO2004091601A1/fr active IP Right Grant
-
2005
- 2005-10-17 US US11/251,737 patent/US20060034918A1/en not_active Abandoned
-
2010
- 2010-02-11 US US12/704,294 patent/US20100221330A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004091601A1 (fr) | 2004-10-28 |
US20100221330A1 (en) | 2010-09-02 |
ATE347358T1 (de) | 2006-12-15 |
EP1615632B1 (fr) | 2006-12-06 |
EP1615632A1 (fr) | 2006-01-18 |
DE602004003577D1 (de) | 2007-01-18 |
DE602004003577T2 (de) | 2007-09-20 |
ES2278314T3 (es) | 2007-08-01 |
US20060034918A1 (en) | 2006-02-16 |
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