DK1606242T3 - Azidfri fremgangsmåde til fremstilling af 1,2-diaminoforbindelser - Google Patents

Azidfri fremgangsmåde til fremstilling af 1,2-diaminoforbindelser

Info

Publication number
DK1606242T3
DK1606242T3 DK04718940T DK04718940T DK1606242T3 DK 1606242 T3 DK1606242 T3 DK 1606242T3 DK 04718940 T DK04718940 T DK 04718940T DK 04718940 T DK04718940 T DK 04718940T DK 1606242 T3 DK1606242 T3 DK 1606242T3
Authority
DK
Denmark
Prior art keywords
sup
azide
preparation
diamino compounds
free process
Prior art date
Application number
DK04718940T
Other languages
English (en)
Inventor
Jack D Brown
Peter John Harrington
Robert C Hughes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1606242T3 publication Critical patent/DK1606242T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04718940T 2003-03-13 2004-03-10 Azidfri fremgangsmåde til fremstilling af 1,2-diaminoforbindelser DK1606242T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/388,064 US7122684B2 (en) 2003-03-13 2003-03-13 Process for preparing 1,2-diamino compounds
PCT/EP2004/002428 WO2004080944A1 (en) 2003-03-13 2004-03-10 Azide free process for preparing 1,2-diamino compounds

Publications (1)

Publication Number Publication Date
DK1606242T3 true DK1606242T3 (da) 2007-07-23

Family

ID=32962044

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04718940T DK1606242T3 (da) 2003-03-13 2004-03-10 Azidfri fremgangsmåde til fremstilling af 1,2-diaminoforbindelser

Country Status (13)

Country Link
US (1) US7122684B2 (da)
EP (1) EP1606242B1 (da)
JP (1) JP4237224B2 (da)
KR (1) KR100724170B1 (da)
CN (1) CN100545145C (da)
AT (1) ATE356797T1 (da)
CA (1) CA2517458C (da)
DE (1) DE602004005323T2 (da)
DK (1) DK1606242T3 (da)
ES (1) ES2282851T3 (da)
MX (1) MXPA05009668A (da)
TW (1) TWI351394B (da)
WO (1) WO2004080944A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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WO2007077570A1 (en) * 2006-01-02 2007-07-12 Hetero Drugs Limited Process for obtaining pure oseltamivir
US20080009639A1 (en) * 2006-07-10 2008-01-10 Apotex Pharmachem Inc. Preparation of oseltamivir phosphate (Tamiflu) and intermediates starting from D-glucose or D-xylose
MX2009012951A (es) * 2007-06-05 2010-03-03 Akzo Nobel Paints Llc Composicion de recubrimiento que se puede curar por radiacion derivada de aceites vegetales epoxidados.
RU2539981C2 (ru) 2009-03-05 2015-01-27 Акцо Нобель Коатингс Интернэшнл Б.В. Привитые акриловые сополимеры масляных полиолов с гидроксильными функциональными группами
CN102267961B (zh) * 2010-06-02 2013-10-02 上海迪赛诺医药发展有限公司 制备(3r,4r,5s)-4,5-环氧基-3-(1-乙基丙氧基)-1-环己烯-1-甲酸乙酯的方法
WO2012089656A2 (en) 2010-12-28 2012-07-05 Akzo Nobel Coatings International B.V. Radiation curable coating compositions for metal
ES2599253T3 (es) 2011-12-21 2017-01-31 Akzo Nobel Coatings International B.V. Composiciones de revestimiento basadas en disolvente
US9260625B2 (en) 2011-12-21 2016-02-16 Akzo Nobel Coatings International B.V. Water-based coating compositions
CN103304437B (zh) * 2013-05-16 2015-07-01 广州同隽医药科技有限公司 一种无叠氮合成磷酸奥司他韦的方法
RU2639158C1 (ru) * 2016-07-01 2017-12-20 Общество с ограниченной ответственностью Научно-производственный центр "Химические технологии" Этил (3s,4r,5s)-4-ацетамидо-5-амино-3-(1-этилпропокси)циклогекс-1-ен-1-карбоксилата этоксисукцинат в качестве противовирусного препарата и способ его получения
CN109890790B (zh) * 2017-06-20 2020-04-21 广东东阳光药业有限公司 一种奥司他韦及其异构体的制备方法
CN109574869B (zh) * 2018-12-29 2021-11-05 博瑞生物医药（苏州）股份有限公司 一种磷酸奥司他韦的制备方法
CN109627180B (zh) * 2018-12-29 2021-07-30 博瑞生物医药（苏州）股份有限公司 磷酸奥司他韦的制备方法
CN111978195B (zh) * 2019-05-23 2023-04-28 好医生药业集团有限公司 奥司他韦的合成方法
CN114867714A (zh) * 2019-10-25 2022-08-05 西北大学 γ-氨基丁酸(GABA)的氟取代的环己烯类似物
CN113024396B (zh) * 2019-12-25 2024-01-30 上海奥博生物医药股份有限公司 一种奥司他韦的制备方法及其中间体
CN111153818B (zh) * 2020-03-13 2023-03-28 遂成药业股份有限公司 一种制备抗病毒药物达菲中间体叔丁胺衍生物i的方法
CN111253276B (zh) * 2020-03-30 2021-01-08 宜昌东阳光长江药业股份有限公司 一种磷酸奥司他韦的制备方法
CN111747861A (zh) * 2020-06-16 2020-10-09 宜昌东阳光长江药业股份有限公司 一种叠氮工艺制备磷酸奥司他韦的方法
CN113277957A (zh) * 2021-05-29 2021-08-20 弘健制药(上海)有限公司 一种磷酸奥司他韦关键中间体盐酸盐的制备方法
CN113307744A (zh) * 2021-05-29 2021-08-27 弘健制药(上海)有限公司 一种磷酸奥司他韦的制备方法
CN113549033A (zh) * 2021-07-29 2021-10-26 福建省福抗药业股份有限公司 一种高纯度的奥司他韦磷酸盐的中间体5的结晶方法
CN114478290A (zh) * 2022-01-24 2022-05-13 广东中润药物研发有限公司 奥司他韦中间体的合成方法
CN116693719A (zh) * 2022-09-06 2023-09-05 湖南津安生物科技有限公司 一种新型的超高阳离子生物高分子及其合成方法
CN115850102A (zh) * 2022-12-29 2023-03-28 浙江工业大学 一种奥司他韦的制备方法

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Publication number Priority date Publication date Assignee Title
DE1593775A1 (de) 1967-04-13 1971-03-25 Basf Ag Verfahren zur Herstellung von 1,2-Diaminen
US5866601A (en) 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
DE759917T1 (de) 1995-02-27 1998-10-22 Gilead Sciences Inc Neue selektive inhibitoren viraler oder bakterieller neuraminidasen
US5763483A (en) 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6518438B2 (en) * 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
NZ507106A (en) 1996-08-23 2003-01-31 Gilead Sciences Inc Preparation of cyclohexene carboxylate derivatives
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
US5886213A (en) 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
IL134691A0 (en) 1997-09-17 2001-04-30 Gilead Sciences Inc Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
DE60002949T2 (de) 1999-06-11 2004-05-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796
BR0010525A (pt) 1999-10-19 2002-11-26 Abbott Lab cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase
US6403824B2 (en) 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
US6518048B2 (en) 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency

Also Published As

Publication number Publication date
EP1606242B1 (en) 2007-03-14
JP2006521305A (ja) 2006-09-21
TWI351394B (en) 2011-11-01
CA2517458C (en) 2011-04-19
CA2517458A1 (en) 2004-09-23
MXPA05009668A (es) 2005-10-20
KR100724170B1 (ko) 2007-05-31
ES2282851T3 (es) 2007-10-16
WO2004080944A1 (en) 2004-09-23
DE602004005323T2 (de) 2008-02-21
JP4237224B2 (ja) 2009-03-11
CN1759093A (zh) 2006-04-12
KR20050107796A (ko) 2005-11-15
EP1606242A1 (en) 2005-12-21
DE602004005323D1 (de) 2007-04-26
US7122684B2 (en) 2006-10-17
CN100545145C (zh) 2009-09-30
ATE356797T1 (de) 2007-04-15
US20040180933A1 (en) 2004-09-16
TW200424148A (en) 2004-11-16

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