DK1509530T3 - 2-Thia-dibenzoazulener som inhibitorer af tumornekrosefaktorproduktion og mellemprodukter til fremstilling deraf - Google Patents
2-Thia-dibenzoazulener som inhibitorer af tumornekrosefaktorproduktion og mellemprodukter til fremstilling derafInfo
- Publication number
- DK1509530T3 DK1509530T3 DK03745849T DK03745849T DK1509530T3 DK 1509530 T3 DK1509530 T3 DK 1509530T3 DK 03745849 T DK03745849 T DK 03745849T DK 03745849 T DK03745849 T DK 03745849T DK 1509530 T3 DK1509530 T3 DK 1509530T3
- Authority
- DK
- Denmark
- Prior art keywords
- thia
- intermediates
- preparation
- necrosis factor
- dibenzoazulenes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20020305A HRP20020305A8 (en) | 2002-04-10 | 2002-04-10 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1509530T3 true DK1509530T3 (da) | 2006-07-17 |
Family
ID=28686903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03745849T DK1509530T3 (da) | 2002-04-10 | 2003-04-09 | 2-Thia-dibenzoazulener som inhibitorer af tumornekrosefaktorproduktion og mellemprodukter til fremstilling deraf |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7435834B2 (ru) |
| EP (1) | EP1509530B1 (ru) |
| JP (1) | JP2005526828A (ru) |
| CN (1) | CN1649875A (ru) |
| AT (1) | ATE320433T1 (ru) |
| AU (1) | AU2003259963A1 (ru) |
| BR (1) | BR0309094A (ru) |
| CA (1) | CA2481514A1 (ru) |
| CY (1) | CY1105036T1 (ru) |
| DE (1) | DE60304048T2 (ru) |
| DK (1) | DK1509530T3 (ru) |
| ES (1) | ES2260637T3 (ru) |
| HR (1) | HRP20020305A8 (ru) |
| IL (1) | IL164396A0 (ru) |
| IS (1) | IS7474A (ru) |
| MX (1) | MXPA04009943A (ru) |
| NO (1) | NO20044506L (ru) |
| NZ (1) | NZ535620A (ru) |
| PL (1) | PL372748A1 (ru) |
| PT (1) | PT1509530E (ru) |
| RU (1) | RU2334749C2 (ru) |
| SI (1) | SI1509530T1 (ru) |
| UA (1) | UA79277C2 (ru) |
| WO (1) | WO2003084962A1 (ru) |
| YU (1) | YU88304A (ru) |
| ZA (1) | ZA200408063B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020452A2 (en) * | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| EP1968583A4 (en) * | 2005-12-20 | 2010-09-15 | Harvard College | COMPOUNDS, TESTS AND METHODS OF TREATMENT |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
| CA967573A (en) | 1972-12-22 | 1975-05-13 | Joseph G. Lombardino | Tetracyclic anti-inflammatory agents |
| NL7605526A (nl) | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| US4198421A (en) | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
| FR2504140A1 (fr) | 1981-04-16 | 1982-10-22 | Centre Nat Rech Scient | Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant |
| EP0125484A1 (de) | 1983-04-12 | 1984-11-21 | Ciba-Geigy Ag | Polycyclische Carbonsäureverbindungen, Verfahren zu ihrer Herstellung und Präparate enthaltend solche Carbonsäureverbindungen, sowie deren Verwendung |
| IE62754B1 (en) | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
| IT1227527B (it) | 1988-12-05 | 1991-04-12 | Ciatti Maurizio | Spazzolino da denti a setole rotanti |
| US5552399A (en) | 1994-11-02 | 1996-09-03 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives |
| PL183618B1 (pl) | 1994-11-02 | 2002-06-28 | Janssen Pharmaceutica Nv | Nowy związek, pochodna podstawionej tetracyklicznej oksazepiny lub tiazepiny, kompozycja farmaceutyczna i sposób wytwarzania pochodnej podstawionej tetracyklicznej oksazepiny lub tiazepiny |
| KR100389298B1 (ko) | 1996-04-12 | 2003-10-30 | 얀센 파마슈티카 엔.브이. | 치환된테트라사이클릭테트라하이드로퓨란유도체 |
| UA52778C2 (ru) | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозамещенные тетрациклические производные тетрагидрофурана, способ их получения и композиции на их основе |
| HRP20000310A2 (en) | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20030957A2 (en) | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
-
2002
- 2002-04-10 HR HR20020305A patent/HRP20020305A8/xx not_active Application Discontinuation
-
2003
- 2003-04-09 EP EP03745849A patent/EP1509530B1/en not_active Expired - Lifetime
- 2003-04-09 JP JP2003582159A patent/JP2005526828A/ja active Pending
- 2003-04-09 DE DE60304048T patent/DE60304048T2/de not_active Expired - Fee Related
- 2003-04-09 CA CA002481514A patent/CA2481514A1/en not_active Abandoned
- 2003-04-09 BR BR0309094-9A patent/BR0309094A/pt not_active IP Right Cessation
- 2003-04-09 AU AU2003259963A patent/AU2003259963A1/en not_active Abandoned
- 2003-04-09 CN CNA038094932A patent/CN1649875A/zh active Pending
- 2003-04-09 ES ES03745849T patent/ES2260637T3/es not_active Expired - Lifetime
- 2003-04-09 YU YU88304A patent/YU88304A/sh unknown
- 2003-04-09 SI SI200330275T patent/SI1509530T1/sl unknown
- 2003-04-09 IL IL16439603A patent/IL164396A0/xx unknown
- 2003-04-09 PL PL03372748A patent/PL372748A1/xx not_active Application Discontinuation
- 2003-04-09 DK DK03745849T patent/DK1509530T3/da active
- 2003-04-09 PT PT03745849T patent/PT1509530E/pt unknown
- 2003-04-09 RU RU2004132868/04A patent/RU2334749C2/ru not_active IP Right Cessation
- 2003-04-09 WO PCT/HR2003/000016 patent/WO2003084962A1/en active IP Right Grant
- 2003-04-09 AT AT03745849T patent/ATE320433T1/de not_active IP Right Cessation
- 2003-04-09 NZ NZ535620A patent/NZ535620A/xx unknown
- 2003-04-09 MX MXPA04009943A patent/MXPA04009943A/es active IP Right Grant
- 2003-04-09 US US10/510,866 patent/US7435834B2/en not_active Expired - Fee Related
- 2003-09-04 UA UA20041008547A patent/UA79277C2/uk unknown
-
2004
- 2004-09-27 IS IS7474A patent/IS7474A/is unknown
- 2004-10-06 ZA ZA200408063A patent/ZA200408063B/en unknown
- 2004-10-21 NO NO20044506A patent/NO20044506L/no not_active Application Discontinuation
-
2006
- 2006-05-18 CY CY20061100649T patent/CY1105036T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60304048D1 (de) | 2006-05-11 |
| PT1509530E (pt) | 2006-07-31 |
| SI1509530T1 (sl) | 2006-08-31 |
| ATE320433T1 (de) | 2006-04-15 |
| US20050182126A1 (en) | 2005-08-18 |
| HRP20020305A8 (en) | 2009-03-31 |
| NZ535620A (en) | 2006-03-31 |
| WO2003084962A1 (en) | 2003-10-16 |
| ES2260637T3 (es) | 2006-11-01 |
| DE60304048T2 (de) | 2006-10-19 |
| CY1105036T1 (el) | 2010-03-03 |
| MXPA04009943A (es) | 2005-09-30 |
| UA79277C2 (en) | 2007-06-11 |
| CA2481514A1 (en) | 2003-10-16 |
| US7435834B2 (en) | 2008-10-14 |
| YU88304A (sh) | 2006-08-17 |
| RU2004132868A (ru) | 2005-06-10 |
| IS7474A (is) | 2004-09-27 |
| BR0309094A (pt) | 2005-02-09 |
| RU2334749C2 (ru) | 2008-09-27 |
| IL164396A0 (en) | 2005-12-18 |
| NO20044506L (no) | 2004-11-09 |
| JP2005526828A (ja) | 2005-09-08 |
| PL372748A1 (en) | 2005-08-08 |
| EP1509530A1 (en) | 2005-03-02 |
| EP1509530B1 (en) | 2006-03-15 |
| HRP20020305A2 (en) | 2003-10-31 |
| AU2003259963A1 (en) | 2003-10-20 |
| CN1649875A (zh) | 2005-08-03 |
| ZA200408063B (en) | 2006-07-26 |
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