NO20044508L - 1-eller 3-tia-henzonaftoazulener som inhibitorer av tumornektrosefaktorproduksjon og mellomprodukter for fremstilling derav - Google Patents

1-eller 3-tia-henzonaftoazulener som inhibitorer av tumornektrosefaktorproduksjon og mellomprodukter for fremstilling derav

Info

Publication number
NO20044508L
NO20044508L NO20044508A NO20044508A NO20044508L NO 20044508 L NO20044508 L NO 20044508L NO 20044508 A NO20044508 A NO 20044508A NO 20044508 A NO20044508 A NO 20044508A NO 20044508 L NO20044508 L NO 20044508L
Authority
NO
Norway
Prior art keywords
intermediates
preparation
necrosis factor
tumor necrosis
thiazonaphthoazulenes
Prior art date
Application number
NO20044508A
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Dijana Pesic
Rudolf Trojko
Ivana Ozimec
Original Assignee
Pliva Istrazivacki Inst Doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst Doo filed Critical Pliva Istrazivacki Inst Doo
Publication of NO20044508L publication Critical patent/NO20044508L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår benzonaftoazulen-derivater av tiofenklasse, deres farmakologisk akseptable salter og solvater, fremgangsmåter og mellomprodukter for fremstilling derav, så vel som deres anti-inflammatoriske effekter, spesielt hemning av tumomekrosefaktor-a- (TNF-(a) produksjon og hemning av interieukin-1 - (IL-1) produksjon, så vel som deres analgetiske virkning.
NO20044508A 2002-04-10 2004-10-21 1-eller 3-tia-henzonaftoazulener som inhibitorer av tumornektrosefaktorproduksjon og mellomprodukter for fremstilling derav NO20044508L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20020303A HRP20020303A8 (en) 2002-04-10 2002-04-10 Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
PCT/HR2003/000014 WO2003084961A1 (en) 2002-04-10 2003-04-09 1- or 3-thia-benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof

Publications (1)

Publication Number Publication Date
NO20044508L true NO20044508L (no) 2004-11-09

Family

ID=28686901

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044508A NO20044508L (no) 2002-04-10 2004-10-21 1-eller 3-tia-henzonaftoazulener som inhibitorer av tumornektrosefaktorproduksjon og mellomprodukter for fremstilling derav

Country Status (24)

Country Link
US (2) US20050137249A1 (no)
EP (1) EP1492795B1 (no)
JP (1) JP2005526827A (no)
KR (1) KR20050014806A (no)
CN (1) CN1649876A (no)
AT (1) ATE310005T1 (no)
AU (1) AU2003259958A1 (no)
BR (1) BR0309097A (no)
CA (1) CA2481850A1 (no)
DE (1) DE60302344T2 (no)
ES (1) ES2253694T3 (no)
HR (1) HRP20020303A8 (no)
IL (1) IL164395A0 (no)
IS (1) IS7472A (no)
MX (1) MXPA04009872A (no)
NO (1) NO20044508L (no)
NZ (1) NZ535622A (no)
PL (1) PL374005A1 (no)
RU (1) RU2318827C2 (no)
SI (1) SI1492795T1 (no)
UA (1) UA78297C2 (no)
WO (1) WO2003084961A1 (no)
YU (1) YU88104A (no)
ZA (1) ZA200408059B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020304B1 (en) * 2002-04-10 2008-04-30 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
JP5606440B2 (ja) * 2009-07-28 2014-10-15 日本臓器製薬株式会社 チアベンゾアズレンプロピオン酸誘導体の製造法
CN109248310B (zh) * 2011-06-02 2022-07-01 加利福尼亚大学董事会 利用θ-防御素的炎性蛋白酶的阻断
CN104163811A (zh) * 2013-05-16 2014-11-26 重庆圣华曦药业股份有限公司 一种制备度洛西汀盐酸盐的新方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711489A (en) * 1971-03-31 1973-01-16 Pfizer Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
CA967573A (en) 1972-12-22 1975-05-13 Joseph G. Lombardino Tetracyclic anti-inflammatory agents
US4198421A (en) * 1978-11-30 1980-04-15 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
HRP20000310A2 (en) * 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors

Also Published As

Publication number Publication date
MXPA04009872A (es) 2005-08-16
US20050137249A1 (en) 2005-06-23
NZ535622A (en) 2006-03-31
ZA200408059B (en) 2005-10-06
HRP20020303A2 (en) 2003-10-31
HRP20020303B8 (en) 2009-03-31
WO2003084961A1 (en) 2003-10-16
CA2481850A1 (en) 2003-10-16
HRP20020303A8 (en) 2009-03-31
JP2005526827A (ja) 2005-09-08
SI1492795T1 (sl) 2006-04-30
HRP20020303B1 (en) 2007-05-31
BR0309097A (pt) 2005-02-09
ATE310005T1 (de) 2005-12-15
RU2318827C2 (ru) 2008-03-10
IL164395A0 (en) 2005-12-18
EP1492795B1 (en) 2005-11-16
DE60302344D1 (de) 2005-12-22
CN1649876A (zh) 2005-08-03
AU2003259958A1 (en) 2003-10-20
DE60302344T2 (de) 2006-07-27
UA78297C2 (en) 2007-03-15
US20050130964A1 (en) 2005-06-16
IS7472A (is) 2004-09-27
US7262309B2 (en) 2007-08-28
YU88104A (sh) 2006-08-17
EP1492795A1 (en) 2005-01-05
PL374005A1 (en) 2005-09-19
KR20050014806A (ko) 2005-02-07
RU2004132866A (ru) 2005-06-10
ES2253694T3 (es) 2006-06-01

Similar Documents

Publication Publication Date Title
NO20044508L (no) 1-eller 3-tia-henzonaftoazulener som inhibitorer av tumornektrosefaktorproduksjon og mellomprodukter for fremstilling derav
RS100104A (en) 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
EA200501900A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
IL164396A0 (en) 2-Thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
EA200600898A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
RS100004A (en) 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
EA200501925A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
RS99404A (en) 1-oxa-dibenzoazulenes as inhibitors of tumour necrosis facto production and intermediates for the preparation thereof
DK1492797T3 (da) 1-Oxa-3-aza-dibenzoazulener som inhibitorer af tumornekrosefaktorproduktion og mellemprodukter til fremstilling deraf
RS100204A (en) 1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
EA200600455A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200600456A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
NO20060922L (no) Ny fremgangsmate for syntesen av perindopril og dens farmasoytiske akseptable salter
EA200600454A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200600249A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application