DK148632C - Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf - Google Patents

Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf

Info

Publication number
DK148632C
DK148632C DK564278A DK564278A DK148632C DK 148632 C DK148632 C DK 148632C DK 564278 A DK564278 A DK 564278A DK 564278 A DK564278 A DK 564278A DK 148632 C DK148632 C DK 148632C
Authority
DK
Denmark
Prior art keywords
analogue
preparation
acceptable salts
physiologically acceptable
optical antipodes
Prior art date
Application number
DK564278A
Other languages
English (en)
Other versions
DK148632B (da
DK564278A (da
Inventor
Aake John Erik Helgstrand
Karl Nils-Gunnar Johansson
Alfons Misiorny
Jan-Olof Noren
Goeran Bertil Stening
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of DK564278A publication Critical patent/DK564278A/da
Publication of DK148632B publication Critical patent/DK148632B/da
Application granted granted Critical
Publication of DK148632C publication Critical patent/DK148632C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK564278A 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf DK148632C (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
GB5358277 1977-12-22
GB5358377 1977-12-22
GB5358177 1977-12-22
GB5358077 1977-12-22
GB5358377 1977-12-22
GB5358277 1977-12-22
GB5358077 1977-12-22
GB5358177 1977-12-22
GB7828548 1978-07-03
GB7828548 1978-07-03
GB7828555 1978-07-03
GB7828553 1978-07-03
GB7828553 1978-07-03
GB7828555 1978-07-03
GB7828552 1978-07-03
GB7828552 1978-07-03

Publications (3)

Publication Number Publication Date
DK564278A DK564278A (da) 1979-06-23
DK148632B DK148632B (da) 1985-08-19
DK148632C true DK148632C (da) 1986-03-03

Family

ID=27571200

Family Applications (2)

Application Number Title Priority Date Filing Date
DK564278A DK148632C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf
DK564178A DK148631C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller fysiologisk acceptable salte og/eller optiske isomerer deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK564178A DK148631C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller fysiologisk acceptable salte og/eller optiske isomerer deraf

Country Status (14)

Country Link
US (4) US4372894A (da)
EP (2) EP0003275B1 (da)
JP (2) JPS54109951A (da)
AT (1) AT369017B (da)
AU (1) AU530031B2 (da)
CA (2) CA1140049A (da)
DE (2) DE2861045D1 (da)
DK (2) DK148632C (da)
FI (2) FI65438C (da)
HK (1) HK33584A (da)
IE (1) IE48011B1 (da)
MY (1) MY8500058A (da)
NO (2) NO156611C (da)
SG (1) SG82383G (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140049A (en) * 1977-12-22 1983-01-25 Dke J.E. Helgstran Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid
GB8501374D0 (en) * 1985-01-18 1985-02-20 Wellcome Found Treatment of aids
US4806532A (en) * 1985-10-08 1989-02-21 Mayo Foundation For Medical Education And Research Inhibition of epithelial phosphate transport
US6492352B1 (en) * 1985-10-31 2002-12-10 Astra Lakemedel Aktiebolag Method for the control and treatment of acquired immunodeficiency syndrome (AIDS)
US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5166386A (en) * 1989-09-18 1992-11-24 E. R. Squibb & Sons, Inc. Process of making isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5132414A (en) * 1990-05-10 1992-07-21 Dana-Farber Cancer Institute, Inc. Dideoxynucleoside-5'-phosphonoformic acid compounds
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
US5869469A (en) * 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
WO1999008685A1 (en) * 1997-08-18 1999-02-25 Queen's University At Kingston Phosphono-carboxylate compounds for treating amyloidosis
ES2392391T3 (es) * 1998-02-11 2012-12-10 Bhi Limited Partnership Método para modular la activación de macrófagos
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
US6329356B1 (en) 1998-04-10 2001-12-11 Neurochem, Inc. Phosphono-carboxylate compounds for treating amyloidosis
US6310073B1 (en) 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
IL146143A0 (en) * 1999-04-28 2002-07-25 Univ Kingston Compositions and methods for treating amyloidosis
US6562836B1 (en) 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
WO2001085093A2 (en) * 1999-12-23 2001-11-15 Neurochem, Inc. Compounds and methods for modulating cerebral amyloid angiopathy
JP2005526102A (ja) * 2002-04-01 2005-09-02 ファイザー インコーポレイテッド Ｃ型肝炎ウイルスｒｎａ依存性ｒｎａポリメラーゼのピラノンおよびピランジオン阻害剤
DOP2003000641A (es) * 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) * 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
US20040214178A1 (en) * 2003-04-24 2004-10-28 Agouron Pharmaceuticals, Inc. Reporter-selectable Hepatitis C virus replicon
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
PL1781662T3 (pl) * 2004-08-18 2011-08-31 Pfizer Inhibitory zależnej od RNA polimerazy RNA wirusa zapalenia wątroby typu C, i kompozycje i terapie wykorzystujące je
ITMI20041822A1 (it) * 2004-09-24 2004-12-24 Pharmaproducts Uk Ltd "agente terapeutico utile per il trattamento di neoplasie plasmacellulari"
US20060167057A1 (en) * 2004-11-16 2006-07-27 Xianqi Kong Compounds for the treatment of CNS and amyloid associated diseases
US8044100B2 (en) 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
CA2634871A1 (en) * 2005-12-22 2007-11-08 Neurochem (International) Limited Treatment of renal disorders, diabetic nephopathy and dyslipidemias
FI3851447T3 (fi) 2006-10-12 2023-11-15 Bellus Health Inc Menetelmiä, yhdisteitä, koostumuksia ja vehikkeleitä 3-amino-1-propaanisulfonihapon vapauttamiseksi
JP2010529947A (ja) * 2006-12-22 2010-09-02 ベラス ヘルス（インターナショナル）リミテッド 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物
US20080293648A1 (en) * 2007-01-05 2008-11-27 Saha Pharmaceuticals, Inc. Compositions and Methods for Cancer Treatment
DE102012103717A1 (de) * 2012-04-27 2013-11-14 Westfälische Wilhelms-Universität Münster Arzneimittel zur Behandlung von Tumorerkrankungen
CN105830271B (zh) * 2013-12-19 2018-11-16 宇部兴产株式会社 非水电解液、使用了其的蓄电装置及其中使用的膦酰基甲酸化合物
ES2578902B1 (es) * 2014-12-29 2017-07-07 Agencia Pública Empresarial Sanitaria Costa Del Sol Uso de análogos del ión pirofosfato para el tratamiento de la infección por VPH
CN109400645A (zh) * 2017-08-18 2019-03-01 四川海思科制药有限公司 一种磷酸衍生物及制备方法和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155597A (en) * 1961-06-23 1964-11-03 Monsanto Co Extractive separation process
CH513590A (de) 1968-05-24 1971-10-15 Du Pont Carbamoylphosphonat enthaltender Pflanzenwachstumsregler
US3846512A (en) * 1968-05-24 1974-11-05 Du Pont Carbamoylphosphonates
US3997544A (en) * 1968-05-24 1976-12-14 E. I. Du Pont De Nemours And Company Plant growth regulant carbamoylphosphonates
US3533995A (en) * 1968-08-27 1970-10-13 Fmc Corp Heat stabilization of polyester resin with alkyl dialkoxyphosphinyl formate
GB1317768A (en) 1969-08-14 1973-05-23 Du Pont Plant growth regulants
US3849102A (en) * 1969-08-14 1974-11-19 Du Pont Plant growth regulant method
US3767795A (en) * 1971-02-25 1973-10-23 Abbott Lab Method for combating certain virus infection
US3943201A (en) * 1973-07-23 1976-03-09 E. I. Du Pont De Nemours And Comapny Alkoxy carboxycarbonylphosphonic acid esters
HU171255B (hu) * 1973-07-23 1977-12-28 Du Pont Kompozicii dlja regulirovki rosta rastenijj
US4017297A (en) * 1975-08-29 1977-04-12 E. I. Du Pont De Nemours And Company Phosphonates for the control of bindweed
CA1069526A (en) * 1976-04-30 1980-01-08 Thomas R. Herrin Phosphorus esters of phosphonoacetic acid
US4052439A (en) * 1976-04-30 1977-10-04 Abbott Laboratories Carboxylic esters of phosphonoacetic acid
US4092412A (en) * 1976-04-30 1978-05-30 Abbott Laboratories Treatment of herpes simplex infections
SE7607496L (sv) * 1976-07-01 1978-01-02 Astra Laekemedel Ab Sett for bekempning av virusinfektioner
CA1140049A (en) * 1977-12-22 1983-01-25 Dke J.E. Helgstran Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid

Also Published As

Publication number Publication date
FI65438B (fi) 1984-01-31
AU530031B2 (en) 1983-06-30
DK564178A (da) 1979-06-23
DK148631B (da) 1985-08-19
IE48011B1 (en) 1984-09-05
EP0003007A2 (en) 1979-07-11
US4591583A (en) 1986-05-27
US4372894A (en) 1983-02-08
SG82383G (en) 1985-03-08
NO156611C (no) 1987-10-21
AT369017B (de) 1982-11-25
FI783932A (fi) 1979-06-23
JPS54109951A (en) 1979-08-29
US4386081A (en) 1983-05-31
DE2861729D1 (en) 1982-05-19
DK148632B (da) 1985-08-19
DE2861045D1 (en) 1981-11-26
EP0003007A3 (en) 1979-08-08
ATA921778A (de) 1982-04-15
JPS54106431A (en) 1979-08-21
MY8500058A (en) 1985-12-31
JPS6254118B2 (da) 1987-11-13
NO156611B (no) 1987-07-13
HK33584A (en) 1984-04-27
NO154751C (no) 1986-12-17
JPS6330885B2 (da) 1988-06-21
IE782493L (en) 1979-06-22
FI65438C (fi) 1984-05-10
CA1140049A (en) 1983-01-25
DK564278A (da) 1979-06-23
NO784331L (no) 1979-06-25
CA1144937A (en) 1983-04-19
EP0003275B1 (en) 1981-09-02
FI783931A (fi) 1979-06-23
DK148631C (da) 1986-03-03
FI68626C (fi) 1985-10-10
EP0003007B1 (en) 1982-04-07
AU4268278A (en) 1979-06-28
FI68626B (fi) 1985-06-28
NO154751B (no) 1986-09-08
NO784330L (no) 1979-06-25
US4536400A (en) 1985-08-20
EP0003275A1 (en) 1979-08-08

Similar Documents

Publication Publication Date Title
DK148632C (da) Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf
DK163244C (da) Analogifremgangsmaade til fremstilling af 7-oe2-(2-aminothiazol-4-yl)-2-oxyimino-acetamidoaa-ceph-3-em-4-carboxylsyrederivater eller fysiologisk acceptable salte deraf
DK149594C (da) Analogifremgangsmaade til fremstilling af dipeptidderivater eller syreadditionssalte heraf
DK149449C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater eller farmaceutisk acceptable salte deraf
DK164545C (da) Analogifremgangsmaade til fremstilling af sulfonylamino- eller sulfonylaminoalkylphenoxyalkylcarbonsyrederivater eller fysiologisk uskadelige salte deraf
DK160300C (da) Analogifremgangsmaade til fremstilling af substituerede phenoxybenzyloxycarbonylderivater og cyclopropancarboxylsyreestere til anvendelse som udgangsforbindelser herved
DK162714C (da) Analogifremgangsmaade til fremstilling af glycinamidderivater eller syreadditionssalte deraf
DK151009C (da) Analogifremgangsmaade til fremstilling af benzhydrylsulfinylforbindelser og fysiologisk acceptable syreadditionssalte deraf
DK145260C (da) Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK152114C (da) Analogifremgangsmaade til fremstilling af propenylaminer eller farmaceutisk acceptable salte deraf
DK162444C (da) Analogifremgangsmaade til fremstilling af azabicyklooctancarboxylsyrer og farmaceutisk acceptable salte heraf
DK157862C (da) Analogifremgangsmaade til fremstilling af imidazolylphenylamidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK158658C (da) Analogifremgangsmaade til fremstilling af 9-aminoalkylfluorener eller farmaceutisk acceptable salte deraf
DK149231C (da) Analogifremgangsmaade til fremstilling af enkephalin-analoge tetrapeptidamider eller syreadditionssalte deraf
DK155670C (da) Analogifremgangsmaade til fremstilling af sesquiterpenderivater eller farmaceutisk acceptable salte deraf
DK145263C (da) Analogifremgangsmaade til fremstilling af imidazothiaziner eller farmaceutisk acceptable salte deraf
DK152208C (da) Analogifremgangsmaade til fremstilling af 2-phenylamino-phenyleddikesyreamider eller farmaceutisk acceptable salte deraf
DK149625C (da) Analogifremgangsmaade til fremstilling af n-substituerede (8-halogen- eller -trifluormethyl-4-quinolylamino)-benzamider eller et farmaceutiskacceptabelt syreadditionssalt deraf
DK165005C (da) Analogifremgangsmaade til fremstilling af 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater eller terapeutisk acceptable salte deraf
DK162102C (da) Analogifremgangsmaade til fremstilling af 3-o-(beta-d-glucoronopyranosyl)-sojasapogenol b eller farmaceutisk acceptable salte deraf
DK148019C (da) Analogifremgangsmaade til fremstilling af 2-pyridylaminobenzoesyrer eller farmaceutisk acceptable salte deraf
DK150521C (da) Analogifremgangsmaade til fremstilling af n2-arylsulfonyl-l-argininamider eller farmaceutisk acceptable salte deraf
DK164169C (da) Analogifremgangsmaade til fremstilling af 7-alfa-methoxycephalosporiner eller farmaceutisk acceptable salte deraf samt et mellemprodukt til anvendelse herved
DK152491C (da) Analogifremgangsmaade til fremstilling af esterholdige phenoxypropanolaminer eller farmaceutisk anvendelige salte deraf
DK157021C (da) Analogifremgangsmaade til fremstilling af 2,3-polymethylen-4-oxo-4h-pyrido- eller -azepinooe1,2-aaapyrimidiner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf

Legal Events

Date Code Title Description
PUP Patent expired