DK1482924T3 - Cathepsin-cystein-protease-inhibotorer - Google Patents

Cathepsin-cystein-protease-inhibotorer

Info

Publication number
DK1482924T3
DK1482924T3 DK03716238T DK03716238T DK1482924T3 DK 1482924 T3 DK1482924 T3 DK 1482924T3 DK 03716238 T DK03716238 T DK 03716238T DK 03716238 T DK03716238 T DK 03716238T DK 1482924 T3 DK1482924 T3 DK 1482924T3
Authority
DK
Denmark
Prior art keywords
cysteine protease
inhibotorer
cathepsin cysteine
compounds
cathepsin
Prior art date
Application number
DK03716238T
Other languages
English (en)
Inventor
Chun Sing Li
Dan Mckay
Christophe Mellon
Jacques Yves Gauthier
Cheuk Lau
Vouy-Linh Truong
Michael J Green
Bernard L Hirschbein
James W Janc
James T Palmer
Chitra Baskaran
Christopher I Bayly
Cameron Black
Serge Leger
Michel Therien
Original Assignee
Merck Frosst Canada Ltd
Axys Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27807943&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1482924(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Frosst Canada Ltd, Axys Pharm Inc filed Critical Merck Frosst Canada Ltd
Application granted granted Critical
Publication of DK1482924T3 publication Critical patent/DK1482924T3/da

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    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/17—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and doubly-bound oxygen atoms bound to the same acyclic carbon skeleton
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
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    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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