DK147812B - Fremgangsmaade til fremstilling af et stabilt lyofiliseret urokinasepraeparat - Google Patents

Fremgangsmaade til fremstilling af et stabilt lyofiliseret urokinasepraeparat Download PDF

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Publication number
DK147812B
DK147812B DK195079AA DK195079A DK147812B DK 147812 B DK147812 B DK 147812B DK 195079A A DK195079A A DK 195079AA DK 195079 A DK195079 A DK 195079A DK 147812 B DK147812 B DK 147812B
Authority
DK
Denmark
Prior art keywords
urokinase
hsa
lyophilized
amino acid
preparation
Prior art date
Application number
DK195079AA
Other languages
Danish (da)
English (en)
Other versions
DK195079A (da
Inventor
Yoshiya Yamahira
Keiji Fujioka
Yoshiko Okuzawa
Seiko Miura
Shigeji Sato
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of DK195079A publication Critical patent/DK195079A/da
Publication of DK147812B publication Critical patent/DK147812B/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6462Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21073Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK195079AA 1978-05-12 1979-05-10 Fremgangsmaade til fremstilling af et stabilt lyofiliseret urokinasepraeparat DK147812B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5682678A JPS54147916A (en) 1978-05-12 1978-05-12 Preparation of urokinase injection
JP5682678 1978-05-12

Publications (2)

Publication Number Publication Date
DK195079A DK195079A (da) 1979-11-13
DK147812B true DK147812B (da) 1984-12-17

Family

ID=13038173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK195079AA DK147812B (da) 1978-05-12 1979-05-10 Fremgangsmaade til fremstilling af et stabilt lyofiliseret urokinasepraeparat

Country Status (10)

Country Link
US (1) US4244943A (sv)
JP (1) JPS54147916A (sv)
CA (1) CA1115206A (sv)
CH (1) CH641046A5 (sv)
DE (1) DE2917899A1 (sv)
DK (1) DK147812B (sv)
FR (1) FR2425245A1 (sv)
GB (1) GB2021412B (sv)
IT (1) IT7949032A0 (sv)
SE (1) SE7904118L (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5813521A (ja) * 1981-07-16 1983-01-26 Green Cross Corp:The ミエロペルオキシダ−ゼの粉末製剤
US4350659A (en) * 1981-07-30 1982-09-21 Corning Glass Works Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives
JPS59139323A (ja) * 1983-01-28 1984-08-10 Green Cross Corp:The ウロキナ−ゼ乾燥製剤
SU1128601A1 (ru) * 1983-05-10 1985-07-15 Всесоюзный кардиологический научный центр АМН СССР Урокиназа,иммобилизированна на фибриногене
JPS6051119A (ja) * 1983-08-30 1985-03-22 Green Cross Corp:The ウロキナ−ゼ乾燥製剤
JPS61111684A (ja) * 1984-11-05 1986-05-29 Terumo Corp 精製されたウロキナ−ゼ複合体の製造方法
JPS61124383A (ja) * 1984-11-16 1986-06-12 Unitika Ltd 固定化線維素溶解活性酵素の安定化法
EP0208785B1 (en) * 1985-01-14 1992-12-30 Shiseido Company Limited Fibrinophilic urokinase complex and process for its preparation
JPS61238732A (ja) * 1985-04-16 1986-10-24 Green Cross Corp:The ウロキナーゼ前駆体乾燥製剤
CA1336585C (en) * 1985-04-16 1995-08-08 Kazuo Morimoto Method of stabilizing urokinase precursor and dry preparation containing said precursor
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型tPA含有注射用組成物
WO1990001334A1 (en) * 1988-08-05 1990-02-22 Codon Formulations for plasminogen activator using aspartate
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
JPH02268681A (ja) * 1989-04-07 1990-11-02 Green Cross Corp:The ウロキナーゼ前駆体の安定化方法及び乾燥製剤
AU635541B2 (en) * 1989-05-17 1993-03-25 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
DE69012675T2 (de) * 1989-06-30 1995-05-04 Ucar Carbon Tech Graphitfolie.
EP2236617A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
EP2563809B1 (en) * 2010-04-27 2020-04-01 Scil Technology GmbH Stable aqueous mia/cd-rap formulations
CN104906054B (zh) * 2015-06-15 2017-08-25 武汉人福药业有限责任公司 一种尿激酶冻干剂的制备方法
CN111450052A (zh) * 2020-04-22 2020-07-28 南京南大药业有限责任公司 一种尿激酶注射液制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665076A (sv) * 1963-12-23 1965-12-08
JPS5137343B2 (sv) * 1972-12-07 1976-10-15

Also Published As

Publication number Publication date
DE2917899A1 (de) 1979-11-22
US4244943A (en) 1981-01-13
CA1115206A (en) 1981-12-29
FR2425245B1 (sv) 1983-03-11
IT7949032A0 (it) 1979-05-11
GB2021412A (en) 1979-12-05
SE7904118L (sv) 1979-11-13
DK195079A (da) 1979-11-13
JPS54147916A (en) 1979-11-19
CH641046A5 (de) 1984-02-15
FR2425245A1 (fr) 1979-12-07
GB2021412B (en) 1982-08-25

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