DK1456212T3 - 6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse - Google Patents

6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse

Info

Publication number: DK1456212T3
Authority: DK; Denmark
Prior art keywords: aminomorphinan; derivatives; processes; preparation; compounds
Prior art date: 2001-12-17

Application number

DK02804904T

Other languages

Danish (da)

English (en)

Inventor

Johannes Schuetz

Helmut Schmidhammer

Original Assignee

Alcasynn Pharmaceuticals Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-17

Filing date

2002-12-16

Publication date

2007-04-02

2002-12-16 Application filed by Alcasynn Pharmaceuticals Gmbh filed Critical Alcasynn Pharmaceuticals Gmbh

2007-04-02 Application granted granted Critical

2007-04-02 Publication of DK1456212T3 publication Critical patent/DK1456212T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Transplantation (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Child & Adolescent Psychology (AREA)

DK02804904T 2001-12-17 2002-12-16 6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse DK1456212T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10161963A DE10161963A1 (de)	2001-12-17	2001-12-17	6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
PCT/EP2002/014343 WO2003051888A1 (de)	2001-12-17	2002-12-16	6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung

Publications (1)

Publication Number	Publication Date
DK1456212T3 true DK1456212T3 (da)	2007-04-02

Family

ID=7709535

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02804904T DK1456212T3 (da)	2001-12-17	2002-12-16	6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse

Country Status (18)

Country	Link
US (2)	US7538118B2 (ru)
EP (1)	EP1456212B1 (ru)
JP (1)	JP5017629B2 (ru)
CN (1)	CN1604900A (ru)
AT (1)	ATE347555T1 (ru)
AU (1)	AU2002356660B2 (ru)
BR (1)	BR0215027A (ru)
CA (1)	CA2470809C (ru)
DE (2)	DE10161963A1 (ru)
DK (1)	DK1456212T3 (ru)
ES (1)	ES2278083T3 (ru)
HU (1)	HUP0500024A3 (ru)
NO (1)	NO20043016L (ru)
NZ (1)	NZ533966A (ru)
PL (1)	PL371127A1 (ru)
RU (1)	RU2306314C2 (ru)
WO (1)	WO2003051888A1 (ru)
ZA (1)	ZA200404752B (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10161963A1 (de) *	2001-12-17	2003-07-03	Johannes Schuetz	6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
TW200619206A (en) *	2004-09-29	2006-06-16	Anormed Inc	Chemokine-binding heterocyclic compound salts, and methods of use thereof
WO2006126529A1 (ja) *	2005-05-25	2006-11-30	Shionogi & Co., Ltd.	６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP1762569A1 (en) *	2005-09-12	2007-03-14	Alcasynn Pharmaceuticals Gmbh	Novel 6-amino-morphinan derivatives, method of manufacturing them and their application as analgesics
AU2006313137B2 (en) *	2005-11-09	2013-01-17	Toray Industries, Inc.	Therapeutic or prophylactic agent for functional bowel disorder
AU2007267510B2 (en) *	2006-05-26	2013-01-31	Signature Therapeutics, Inc.	Controlled release of phenolic opioids
FR2939796B1 (fr) *	2008-12-11	2010-12-17	Sanofi Aventis	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CA2764915C (en) *	2009-06-11	2017-07-11	Mallinckrodt Llc	Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
EP2440561B1 (en) *	2009-06-11	2014-04-30	Mallinckrodt LLC	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
US10131672B2 (en) *	2010-01-29	2018-11-20	Toray Industries, Inc.	Therapeutic or prophylactic agent for biliary diseases
EP2420503A1 (en)	2010-07-27	2012-02-22	Universität Innsbruck	Process for the synthesis of 14-oxygenated morphinan-6-ones
AU2011327113B9 (en)	2010-11-12	2015-07-30	Shionogi & Co., Ltd.	Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
PL2718294T3 (pl)	2011-06-09	2019-04-30	SpecGx LLC	Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru
DE102012112839A1 (de)	2012-12-21	2014-06-26	L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude	Verfahren zur Inbetriebnahme einer Anlage für die Herstellung von Propylen
AU2015233880A1 (en) *	2014-03-21	2016-10-06	Chironwells Gmbh	6-(amino acid)-morphinan derivatives in combination with permeation enhancers for use as an orally, rectally, transdermally or nasally administered medicament
MA41790B1 (fr)	2015-03-17	2022-02-28	Nippon Chemiphar Co	Dérivé de morphinane
CN117122598A (zh)	2016-09-16	2023-11-28	日本化学药品株式会社	***喃衍生物的在阿片δ受体激动剂相关疾病的治疗中的应用
WO2020012245A1 (en)	2018-07-13	2020-01-16	Alkermes Pharma Ireland Limited	Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en)	2018-07-13	2020-01-16	Alkermes Pharma Ireland Limited	Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en)	2018-11-05	2020-05-14	Alkermes Pharma Ireland Limited	Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US136951A (en) *		1873-03-18		Improvement in truss bridges
JPS4118823B1 (ru) *	1964-02-03	1966-10-31
US4730048A (en) *	1985-12-12	1988-03-08	Regents Of The University Of Minnesota	Gut-selective opiates
US4806556A (en) *	1985-12-12	1989-02-21	Regents Of The University Of Minnesota	Gut-selective opiates
US4912114A (en) *	1988-03-18	1990-03-27	Sandoz Ltd.	Morphinan derivatives
JP2525552B2 (ja) *	1992-01-23	1996-08-21	東レ株式会社	モルヒナン誘導体および医薬用途
EP0661283B1 (en) *	1993-07-19	1998-10-21	Toray Industries, Inc.	Brain cell protective
NZ268969A (en) *	1993-07-23	1997-06-24	Toray Industries	Morphinan derivatives and pharmaceutical compositions
JP2002501923A (ja) *	1998-01-29	2002-01-22	モナシュユニバーシティ	治療用化合物
US6469030B2 (en)	1999-11-29	2002-10-22	Adolor Corporation	Methods for the treatment and prevention of ileus
AU4743601A (en) *	2000-03-15	2001-09-24	Wolfgang Sadee	Neutral antagonists and use thereof in treating drug abuse
DE10161963A1 (de) *	2001-12-17	2003-07-03	Johannes Schuetz	6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung

2001
- 2001-12-17 DE DE10161963A patent/DE10161963A1/de not_active Ceased
2002
- 2002-12-16 CA CA002470809A patent/CA2470809C/en not_active Expired - Fee Related
- 2002-12-16 AU AU2002356660A patent/AU2002356660B2/en not_active Ceased
- 2002-12-16 ES ES02804904T patent/ES2278083T3/es not_active Expired - Lifetime
- 2002-12-16 CN CNA028251288A patent/CN1604900A/zh active Pending
- 2002-12-16 JP JP2003552770A patent/JP5017629B2/ja not_active Expired - Fee Related
- 2002-12-16 WO PCT/EP2002/014343 patent/WO2003051888A1/de active IP Right Grant
- 2002-12-16 HU HU0500024A patent/HUP0500024A3/hu unknown
- 2002-12-16 AT AT02804904T patent/ATE347555T1/de active
- 2002-12-16 DK DK02804904T patent/DK1456212T3/da active
- 2002-12-16 EP EP02804904A patent/EP1456212B1/de not_active Expired - Lifetime
- 2002-12-16 US US10/499,133 patent/US7538118B2/en not_active Expired - Fee Related
- 2002-12-16 BR BR0215027-1A patent/BR0215027A/pt not_active IP Right Cessation
- 2002-12-16 NZ NZ533966A patent/NZ533966A/en not_active IP Right Cessation
- 2002-12-16 DE DE50208918T patent/DE50208918D1/de not_active Expired - Lifetime
- 2002-12-16 RU RU2004121952/04A patent/RU2306314C2/ru not_active IP Right Cessation
- 2002-12-16 PL PL02371127A patent/PL371127A1/xx not_active Application Discontinuation
2004
- 2004-06-15 ZA ZA2004/04752A patent/ZA200404752B/en unknown
- 2004-07-15 NO NO20043016A patent/NO20043016L/no not_active Application Discontinuation
2009
- 2009-04-27 US US12/430,495 patent/US20090209570A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5017629B2 (ja)	2012-09-05
NZ533966A (en)	2006-05-26
RU2004121952A (ru)	2006-01-20
AU2002356660A1 (en)	2003-06-30
WO2003051888A1 (de)	2003-06-26
JP2005516937A (ja)	2005-06-09
AU2002356660B2 (en)	2006-03-16
RU2306314C2 (ru)	2007-09-20
ZA200404752B (en)	2005-04-26
NO20043016L (no)	2004-07-15
ATE347555T1 (de)	2006-12-15
HUP0500024A3 (en)	2009-01-28
ES2278083T3 (es)	2007-08-01
CA2470809A1 (en)	2003-06-26
DE10161963A1 (de)	2003-07-03
BR0215027A (pt)	2004-11-09
CA2470809C (en)	2009-07-21
HUP0500024A2 (hu)	2005-04-28
US20090209570A1 (en)	2009-08-20
US7538118B2 (en)	2009-05-26
EP1456212A1 (de)	2004-09-15
US20050038061A1 (en)	2005-02-17
PL371127A1 (en)	2005-06-13
EP1456212B1 (de)	2006-12-06
CN1604900A (zh)	2005-04-06
DE50208918D1 (de)	2007-01-18

Publication	Publication Date	Title
DK1456212T3 (da)	2007-04-02	6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse
NO20041493L (no)	2004-04-13	Kjemiske forbindelser.
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
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