DK1421069T3 - Fremgangsmåde til fremstilling af cyclopenta[G]-quinazolinderivater - Google Patents
Fremgangsmåde til fremstilling af cyclopenta[G]-quinazolinderivaterInfo
- Publication number
- DK1421069T3 DK1421069T3 DK02755271.0T DK02755271T DK1421069T3 DK 1421069 T3 DK1421069 T3 DK 1421069T3 DK 02755271 T DK02755271 T DK 02755271T DK 1421069 T3 DK1421069 T3 DK 1421069T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopenta
- preparation
- quinazoline derivatives
- formula
- aryloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Paints Or Removers (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0121214.1A GB0121214D0 (en) | 2001-08-31 | 2001-08-31 | Synthetic method |
US34024401P | 2001-12-18 | 2001-12-18 | |
PCT/GB2002/003967 WO2003020706A1 (en) | 2001-08-31 | 2002-08-30 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[g]QUINAZOLINE DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1421069T3 true DK1421069T3 (da) | 2011-11-21 |
Family
ID=9921361
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02755271.0T DK1421069T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstilling af cyclopenta[G]-quinazolinderivater |
DK10003257.2T DK2213664T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstillingen af cyclopenta[g]quinazolinderivater |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10003257.2T DK2213664T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstillingen af cyclopenta[g]quinazolinderivater |
Country Status (11)
Country | Link |
---|---|
US (1) | US7250511B2 (da) |
EP (2) | EP1421069B1 (da) |
JP (2) | JP4405798B2 (da) |
AT (1) | ATE519747T1 (da) |
CY (1) | CY1112711T1 (da) |
DK (2) | DK1421069T3 (da) |
ES (1) | ES2371334T3 (da) |
GB (1) | GB0121214D0 (da) |
HK (1) | HK1145321A1 (da) |
PT (1) | PT1421069E (da) |
WO (1) | WO2003020706A1 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2005103398A (ru) * | 2002-07-09 | 2006-06-27 | Актелион Фармасьютикалз Лтд. (Ch) | Производные 7,8,9,10-тетрагидро-6h-азепино-, 6,7,8,9-тетрагидропиридо-и 2,3-дигидро-2h-пирроло-[2,1-b]-хиназолинона |
US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
KR20090079191A (ko) | 2006-08-23 | 2009-07-21 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서 4-(n-아자사이클로알킬) 아닐리드의 유도체 |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
CN101578259A (zh) * | 2006-11-28 | 2009-11-11 | 威朗国际制药公司 | 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物 |
US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
WO2012011939A2 (en) * | 2010-07-19 | 2012-01-26 | Onyx Pharmaceuticals, Inc. | Synthesis of cyclopentaquinazolines |
JP2014513663A (ja) * | 2010-12-22 | 2014-06-05 | オニックス ファーマシューティカルズ,インコーポレイティド | 効率的なペプチドカップリングおよびシクロペンタ[g]キナゾリン3ナトリウム塩の合成および単離でのそれらの使用 |
US9717797B2 (en) | 2013-12-05 | 2017-08-01 | International Business Machines Corporation | Polycarbonates bearing aromatic N-heterocycles for drug delivery |
GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
DE60110896T2 (de) * | 2000-01-18 | 2006-01-12 | Novartis Ag | Carboxamide und ihre verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und der apolipoprotein b (apo b) sekretion |
-
2001
- 2001-08-31 GB GBGB0121214.1A patent/GB0121214D0/en not_active Ceased
-
2002
- 2002-08-30 DK DK02755271.0T patent/DK1421069T3/da active
- 2002-08-30 EP EP02755271A patent/EP1421069B1/en not_active Expired - Lifetime
- 2002-08-30 JP JP2003524977A patent/JP4405798B2/ja not_active Expired - Lifetime
- 2002-08-30 EP EP10003257.2A patent/EP2213664B1/en not_active Expired - Lifetime
- 2002-08-30 PT PT02755271T patent/PT1421069E/pt unknown
- 2002-08-30 DK DK10003257.2T patent/DK2213664T3/da active
- 2002-08-30 AT AT02755271T patent/ATE519747T1/de active
- 2002-08-30 WO PCT/GB2002/003967 patent/WO2003020706A1/en active Search and Examination
- 2002-08-30 ES ES02755271T patent/ES2371334T3/es not_active Expired - Lifetime
- 2002-08-30 US US10/487,863 patent/US7250511B2/en not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009192490A patent/JP5275945B2/ja not_active Expired - Lifetime
-
2010
- 2010-12-13 HK HK10111597.2A patent/HK1145321A1/xx not_active IP Right Cessation
-
2011
- 2011-11-07 CY CY20111101068T patent/CY1112711T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1421069E (pt) | 2011-11-21 |
DK2213664T3 (da) | 2014-07-21 |
GB0121214D0 (en) | 2001-10-24 |
CY1112711T1 (el) | 2016-02-10 |
EP2213664B1 (en) | 2014-04-30 |
ES2371334T3 (es) | 2011-12-29 |
HK1145321A1 (en) | 2011-04-15 |
JP4405798B2 (ja) | 2010-01-27 |
JP2005507384A (ja) | 2005-03-17 |
ATE519747T1 (de) | 2011-08-15 |
EP2213664A1 (en) | 2010-08-04 |
US7250511B2 (en) | 2007-07-31 |
EP1421069B1 (en) | 2011-08-10 |
JP2009280609A (ja) | 2009-12-03 |
EP1421069A1 (en) | 2004-05-26 |
JP5275945B2 (ja) | 2013-08-28 |
US20040266798A1 (en) | 2004-12-30 |
WO2003020706A1 (en) | 2003-03-13 |
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