DK1390351T3 - Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer - Google Patents

Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer

Info

Publication number
DK1390351T3
DK1390351T3 DK02730443T DK02730443T DK1390351T3 DK 1390351 T3 DK1390351 T3 DK 1390351T3 DK 02730443 T DK02730443 T DK 02730443T DK 02730443 T DK02730443 T DK 02730443T DK 1390351 T3 DK1390351 T3 DK 1390351T3
Authority
DK
Denmark
Prior art keywords
inhibitors
pyrimidine derivatives
derivatives useful
selective cox
cox
Prior art date
Application number
DK02730443T
Other languages
Danish (da)
English (en)
Inventor
Jeremy John Payne
Alan Naylor
Neil Anthony Pegg
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DK1390351T3 publication Critical patent/DK1390351T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK02730443T 2001-05-25 2002-05-23 Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer DK1390351T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0112802.4A GB0112802D0 (en) 2001-05-25 2001-05-25 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
DK1390351T3 true DK1390351T3 (da) 2006-08-07

Family

ID=9915322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02730443T DK1390351T3 (da) 2001-05-25 2002-05-23 Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer

Country Status (29)

Country Link
US (2) US7026327B2 (pt)
EP (2) EP1493735B1 (pt)
JP (1) JP4291688B2 (pt)
KR (1) KR100889427B1 (pt)
CN (1) CN1255387C (pt)
AR (1) AR036028A1 (pt)
AT (2) ATE412637T1 (pt)
AU (1) AU2002302764B2 (pt)
BR (1) BR0209787A (pt)
CA (1) CA2448192A1 (pt)
CO (1) CO5540311A2 (pt)
CZ (1) CZ20033204A3 (pt)
DE (2) DE60229669D1 (pt)
DK (1) DK1390351T3 (pt)
ES (2) ES2316918T3 (pt)
GB (1) GB0112802D0 (pt)
HK (1) HK1063311A1 (pt)
HU (1) HUP0401280A3 (pt)
IL (1) IL158799A0 (pt)
MX (1) MXPA03010583A (pt)
MY (1) MY130750A (pt)
NO (1) NO326949B1 (pt)
NZ (1) NZ529719A (pt)
PL (1) PL366514A1 (pt)
PT (1) PT1390351E (pt)
SI (1) SI1390351T1 (pt)
TW (1) TWI327140B (pt)
WO (1) WO2002096885A1 (pt)
ZA (1) ZA200308826B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
AU2003258630A1 (en) 2002-08-19 2004-03-11 Glaxo Group Limited Pyrimidine derivatives as selective cox-2 inhibitors
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
GB0227443D0 (en) * 2002-11-25 2002-12-31 Glaxo Group Ltd Pyrimidine derivatives
WO2005048999A2 (en) * 2003-11-19 2005-06-02 Glaxo Group Limited Use of cyclooxygenase-2 inhibitors for the treatment of depressive disorders
WO2005049034A2 (en) * 2003-11-19 2005-06-02 Glaxo Group Limited Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders
EP4027993A4 (en) * 2019-09-13 2023-09-20 The Broad Institute Inc. CYCLOOXYGENASE INHIBITORS AND USES THEREOF

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149109A (en) * 1962-02-20 1964-09-15 Searle & Co Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines
GB1121922A (en) * 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DE69432193T2 (de) * 1993-11-30 2004-01-15 Searle & Co Substituierte Pyrazolyl-benzolsulfonamide und ihre Verwendung als CyclooxygenaseII Inhibitoren
PT781766E (pt) 1994-09-09 2004-07-30 Nippon Shinyaku Co Ltd Derivado heterociclico e medicamento
US5596008A (en) 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
US6342510B1 (en) 1995-06-12 2002-01-29 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6020343A (en) * 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
JPH09241161A (ja) 1996-03-08 1997-09-16 Nippon Shinyaku Co Ltd 医 薬
JPH09266197A (ja) * 1996-03-28 1997-10-07 Mitsubishi Electric Corp 半導体装置およびその製造方法
EE03680B1 (et) * 1996-07-18 2002-04-15 Merck Frosst Canada & Co. / Merck Frosst Canada &Cie. Asendatud püridiinid, nende kasutamine ja farmatseutilised kompositsioonid
DK0932402T3 (da) 1996-10-15 2004-11-08 Searle Llc Metode til anvendelse af cyclooxygenase-2-inhibitorer ved behandling og forebyggelse af neoplasi
AR038955A1 (es) 1996-12-05 2005-02-02 Amgen Inc Compuestos de pirimidinona y piridona sustituidos y metodos para su uso
US6103737A (en) 1997-07-03 2000-08-15 Dupont Pharmaceuticals Company Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists
YU11900A (sh) * 1997-09-05 2002-11-15 Glaxo Group Limited Derivati 2,3-diaril-pirazolo (1,5-b) piridazina, njihovo dobijanje i njihova upotreba kao inhibitora ciklooksigenaze 2(cox-2)
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6306866B1 (en) * 1998-03-06 2001-10-23 American Cyanamid Company Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
DE19909541A1 (de) 1998-03-06 1999-10-14 American Cyanamid Co Herbizide 2-Aryloxy- bzw. 2-Arylthio-6-arylpyrimidine
US6313072B1 (en) * 1999-02-18 2001-11-06 American Cyanamid Company Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
US6498166B1 (en) * 1999-02-27 2002-12-24 Smithkline Beecham Corporation Pyrazolopyridines
GB9927844D0 (en) * 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
GB9930358D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0003224D0 (en) * 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
US6756498B2 (en) * 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112803D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
US6861249B1 (en) * 2002-04-09 2005-03-01 David Kent Microbial spray for animal waste

Also Published As

Publication number Publication date
CO5540311A2 (es) 2005-07-29
DE60211149D1 (de) 2006-06-08
HK1063311A1 (en) 2004-12-24
JP4291688B2 (ja) 2009-07-08
ES2262809T3 (es) 2006-12-01
DE60229669D1 (de) 2008-12-11
KR100889427B1 (ko) 2009-03-23
WO2002096885A1 (en) 2002-12-05
TWI327140B (en) 2010-07-11
CZ20033204A3 (en) 2004-03-17
CA2448192A1 (en) 2002-12-05
ES2316918T3 (es) 2009-04-16
EP1390351B1 (en) 2006-05-03
EP1390351A1 (en) 2004-02-25
NO20035206D0 (no) 2003-11-24
HUP0401280A2 (hu) 2004-12-28
US20050032821A1 (en) 2005-02-10
US7026327B2 (en) 2006-04-11
ZA200308826B (en) 2005-02-14
SI1390351T1 (sl) 2006-10-31
CN1537104A (zh) 2004-10-13
US20050187235A1 (en) 2005-08-25
EP1493735A1 (en) 2005-01-05
EP1493735B1 (en) 2008-10-29
NO326949B1 (no) 2009-03-16
MY130750A (en) 2007-07-31
MXPA03010583A (es) 2004-03-09
ATE325103T1 (de) 2006-06-15
NZ529719A (en) 2006-02-24
DE60211149T2 (de) 2006-09-07
AU2002302764B2 (en) 2005-12-01
GB0112802D0 (en) 2001-07-18
AR036028A1 (es) 2004-08-04
PL366514A1 (en) 2005-02-07
KR20040030629A (ko) 2004-04-09
NO20035206L (no) 2003-11-24
HUP0401280A3 (en) 2009-06-29
BR0209787A (pt) 2004-06-01
PT1390351E (pt) 2006-06-30
ATE412637T1 (de) 2008-11-15
IL158799A0 (en) 2004-05-12
JP2005511485A (ja) 2005-04-28
CN1255387C (zh) 2006-05-10

Similar Documents

Publication Publication Date Title
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1581532T3 (da) Pyrazolo-3,4-B pyridinforbindelser og deres anvendelse som phosphodiesterase inhibitorer
NO20053775D0 (no) Diazepinoindol derivater som kinaseinhibitorer.
NO20043793L (no) Nikotinamidderivater anvendelige som PDE4 inhibitorer
NO20053340D0 (no) Substituerte dihydropyrano-indol-3,4-dion-derivater som inhibitorer for plasmigogenaktivator-1 (CPAI-1).
DK1385825T3 (da) Substituerede 2-pyridincyclohexan-1,4-diaminderivater
NO20050665L (no) Pyrrolidonderivater som MAOE inhibitoere
NO20023828L (no) Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer
NO20053215D0 (no) Pyrazolderivater med anvendelse som COX-1-inhibitorer.
NO20052887D0 (no) Pyridazinonderivater som GSK-3Beta inhibitorer.
DK1944305T3 (da) Quinolinderivater som phosphodiesteraseinhibitorer
DK1419152T3 (da) HIV-hæmmende pyrimidin-derivater
NO20053356L (no) Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
DK1289985T3 (da) Beta-carbolinderivater anvendelige som phosphodiesteraseinhibitorer
NO20044654L (no) Piperidinoylpiperidiner som 5-HTIF-agonister
DK1425014T3 (da) Diarylcycloalkylderivater, fremgangsmåde til deres fremstilling og deres anvendelse som PPAR-aktivatorer
DK1761505T3 (da) Pyrimidin-urinstof-derivater som kinaseinhibitorer
DK1276738T3 (da) 2-amino-3- (alkyl) - pyrimidinderivater som GSK3-betainhibitorer
DK1763517T3 (da) Pyrimidinderivater som 11beta-HSD1-inhibitorer
DK1711177T3 (da) 1H-thieno-2,3-c-pyrazolderivater, der er egnede som kinase-I-inhibitorer
DK1534707T5 (da) Substituerede 2,4-dihydropyrrolo[3,4-b]quinolin-9-on-derivater egnede som phosphodiesteraseinhibitorer
NO20016201D0 (no) Tienopyrimidiner som fosfodiesteraseinhibitorer
NO20021959L (no) Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
DK1651640T3 (da) Nicotinamid derivater, der er anvendelige som PDE4 inhibitorer
DK1390351T3 (da) Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer