DK1356037T3 - Bibliotek med en samling af celler - Google Patents
Bibliotek med en samling af cellerInfo
- Publication number
- DK1356037T3 DK1356037T3 DK02709979.5T DK02709979T DK1356037T3 DK 1356037 T3 DK1356037 T3 DK 1356037T3 DK 02709979 T DK02709979 T DK 02709979T DK 1356037 T3 DK1356037 T3 DK 1356037T3
- Authority
- DK
- Denmark
- Prior art keywords
- novel
- cells
- libraries
- host cells
- library
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Eye Examination Apparatus (AREA)
- Holo Graphy (AREA)
- Aerials With Secondary Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100128 | 2001-01-25 | ||
DKPA200100679 | 2001-05-01 | ||
US30086301P | 2001-06-27 | 2001-06-27 | |
PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1356037T3 true DK1356037T3 (da) | 2011-06-27 |
Family
ID=43646216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02709979.5T DK1356037T3 (da) | 2001-01-25 | 2002-01-25 | Bibliotek med en samling af celler |
Country Status (9)
Country | Link |
---|---|
US (2) | US7838287B2 (da) |
EP (1) | EP1356037B1 (da) |
JP (2) | JP2004525624A (da) |
AT (1) | ATE501251T1 (da) |
AU (1) | AU2002227883A1 (da) |
CA (1) | CA2474172C (da) |
DE (1) | DE60239386D1 (da) |
DK (1) | DK1356037T3 (da) |
WO (1) | WO2002059297A2 (da) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004009618A2 (en) | 2002-07-18 | 2004-01-29 | Crucell Holland B.V. | Recombinant production of mixtures of antibodies |
DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
US20050164162A1 (en) * | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
EP1529110B1 (en) * | 2002-08-01 | 2011-10-05 | Evolva Ltd. | Methods of mixing large numbers of heterologous genes |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
EP1639009B1 (en) | 2003-05-30 | 2013-02-27 | Merus B.V. | Fab library for the preparation of a mixture of antibodies |
CA2554054C (en) * | 2004-01-20 | 2013-06-04 | Merus B.V. | Mixtures of binding proteins |
CN101218352B (zh) | 2005-03-18 | 2013-09-04 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
IN2012DN00720A (da) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
MX349121B (es) | 2010-06-02 | 2017-07-12 | Evolva Inc | Produccion recombinante de esteviol glucosidos. |
DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
EP3248982A1 (en) | 2011-07-19 | 2017-11-29 | Wave Life Sciences Ltd. | Thiosulfonate reagents for the synthesis of functionalized nucleic acids |
EP3009508B1 (en) | 2011-08-08 | 2020-11-25 | Evolva SA | Recombinant production of steviol glycosides |
MX360110B (es) | 2012-04-20 | 2018-10-23 | Merus Nv | Metodos y medios para la produccion de moleculas de tipo ig. |
WO2013191950A2 (en) | 2012-06-22 | 2013-12-27 | Monsanto Technology Llc | Unique modular vector design |
RU2677639C2 (ru) | 2012-07-13 | 2019-01-18 | Шин Ниппон Биомедикал Лэбораториз, Лтд. | Хиральный адъювант нуклеиновой кислоты |
EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
CN104684893B (zh) | 2012-07-13 | 2016-10-26 | 日本波涛生命科学公司 | 不对称辅助基团 |
WO2014066374A1 (en) * | 2012-10-22 | 2014-05-01 | Refactored Materials, Inc. | Cellular reprogramming for product optimization |
JP6379112B2 (ja) | 2013-02-06 | 2018-08-22 | エヴォルヴァ エスアー.Evolva Sa. | レバウディオサイドdおよびレバウディオサイドmの改良された産生方法 |
KR20150128705A (ko) | 2013-02-11 | 2015-11-18 | 에볼바 에스아 | 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성 |
ES2887366T3 (es) | 2013-09-17 | 2021-12-22 | Bolt Threads Inc | Métodos y composiciones para sintetizar fibras de seda mejoradas |
US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
SG10201901007PA (en) | 2014-08-11 | 2019-03-28 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
SG11201701677UA (en) | 2014-09-09 | 2017-04-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
WO2016120486A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
WO2017178632A1 (en) | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US11447532B2 (en) | 2016-09-14 | 2022-09-20 | Bolt Threads, Inc. | Long uniform recombinant protein fibers |
CN110100006A (zh) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
JP7212982B1 (ja) | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
WO2024075756A1 (ja) * | 2022-10-05 | 2024-04-11 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
WO2024137877A1 (en) * | 2022-12-21 | 2024-06-27 | Clara Foods Co. | Systems and methods for high yielding recombinant microorganisms and uses thereof |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
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CA1341116C (en) | 1983-02-22 | 2000-10-17 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein |
ATE116442T1 (de) | 1988-04-22 | 1995-01-15 | Massachusetts Inst Technology | Verfahren zum formen und zum gebrauch von mikrotröpchen. |
DK0481008T3 (da) | 1989-07-07 | 1998-05-04 | Unilever Plc | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. |
US5316922A (en) | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
DK1650303T3 (da) | 1993-10-27 | 2008-09-08 | Univ Columbia | Fremgangsmåde til generering af et subtraheret cDNA-bibliotek og anvendelse af det genererede bibliotek |
US6268140B1 (en) | 1994-02-03 | 2001-07-31 | Neugenesis | Combinatorial metabolic libraries |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
KR20040041639A (ko) | 1995-04-24 | 2004-05-17 | 크로막솜 코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
US6004788A (en) | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
US6030779A (en) | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US20010041333A1 (en) | 1997-06-16 | 2001-11-15 | Short Jay M. | High throughput screening for a bioactivity or biomolecule |
GB9603803D0 (en) * | 1996-02-22 | 1996-04-24 | Zeneca Ltd | Production of proteins, plasmids coding therefor and organisms containing such plasmids |
US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
AU2887897A (en) | 1996-05-21 | 1997-12-09 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
US5763239A (en) | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
US6294325B1 (en) * | 1996-07-05 | 2001-09-25 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of thermostable multi genes and proteins and uses thereof |
AU6487196A (en) | 1996-07-09 | 1998-02-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Transformation-associated recombination cloning |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
WO1998031837A1 (en) | 1997-01-17 | 1998-07-23 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
DK0983498T3 (da) | 1997-02-27 | 2004-08-16 | Cellomics Inc | System for cellebaseret screening |
AU6571598A (en) | 1997-03-18 | 1998-10-12 | Chromaxome Corporation | Methods for screening compounds using encapsulated cells |
WO1998054339A1 (en) | 1997-05-27 | 1998-12-03 | Hanil Synthetic Fiber Co., Ltd. | PROCESS FOR PREPARING RECOMBINANT PROTEINS USING HIGHLY EFFICIENT EXPRESSION VECTOR FROM $i(SACCHAROMYCES CEREVISIAE) |
GB9727512D0 (en) | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
JP2002505121A (ja) | 1998-03-04 | 2002-02-19 | ディベルサ コーポレーション | 平均化dnaライブラリーの作製及び使用 |
WO2000006715A1 (en) | 1998-07-27 | 2000-02-10 | Genotypes Inc. | Automatic eukaryotic artificial chromosome vector |
CA2339734A1 (en) | 1998-08-07 | 2000-02-17 | Jan Trnovsky | Gel microdrops in genetic analysis |
EP1109889A1 (en) | 1998-08-31 | 2001-06-27 | Maxygen, Inc. | Transformation, selection, and screening of sequence-shuffled polynucleotides for development and optimization of plant phenotypes |
AU6048599A (en) | 1998-09-18 | 2000-04-10 | Cellomics, Inc. | A system for cell-based screening |
IL145165A0 (en) | 1999-03-09 | 2002-06-30 | Diversa Corp | End selection in directed evolution |
JP2004500019A (ja) | 1999-03-26 | 2004-01-08 | ディベルサ コーポレーション | 定方向進化におけるエキソヌクレアーゼ仲介核酸再集合 |
GB9908814D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
AU7646000A (en) | 1999-11-05 | 2001-05-14 | Novozymes A/S | Methods to screen microorganisms or gene libraries for products secreted from a cell |
US20010049104A1 (en) | 2000-03-24 | 2001-12-06 | Stemmer Willem P.C. | Methods for modulating cellular and organismal phenotypes |
WO2002059330A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
NZ527208A (en) | 2001-01-25 | 2005-05-27 | Evolva Ltd | Concatemers of differentially expressed multiple genes |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
AU2002227884A1 (en) | 2001-01-25 | 2002-08-06 | Evolva Biotech A/S | A method for evolving a cell having desired phenotype and envolved cells |
US20050164162A1 (en) | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
US20030232395A1 (en) | 2002-06-14 | 2003-12-18 | Dyax Corporation | Recombination of nucleic acid library members |
US20030235823A1 (en) | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
EP1529110B1 (en) | 2002-08-01 | 2011-10-05 | Evolva Ltd. | Methods of mixing large numbers of heterologous genes |
-
2002
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en active Application Filing
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 EP EP02709979A patent/EP1356037B1/en not_active Expired - Lifetime
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2474172A1 (en) | 2002-08-01 |
EP1356037A2 (en) | 2003-10-29 |
WO2002059297A2 (en) | 2002-08-01 |
JP2010043108A (ja) | 2010-02-25 |
AU2002227883A1 (en) | 2002-08-06 |
CA2474172C (en) | 2012-07-10 |
US7838287B2 (en) | 2010-11-23 |
US20120094870A1 (en) | 2012-04-19 |
ATE501251T1 (de) | 2011-03-15 |
WO2002059297A8 (en) | 2004-04-15 |
WO2002059297A3 (en) | 2003-04-10 |
US20040241672A1 (en) | 2004-12-02 |
JP2004525624A (ja) | 2004-08-26 |
EP1356037B1 (en) | 2011-03-09 |
DE60239386D1 (de) | 2011-04-21 |
JP4965625B2 (ja) | 2012-07-04 |
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