DK1327143T3 - Krystalstruktur af BACE og anvendelse deraf - Google Patents
Krystalstruktur af BACE og anvendelse derafInfo
- Publication number
- DK1327143T3 DK1327143T3 DK01973243T DK01973243T DK1327143T3 DK 1327143 T3 DK1327143 T3 DK 1327143T3 DK 01973243 T DK01973243 T DK 01973243T DK 01973243 T DK01973243 T DK 01973243T DK 1327143 T3 DK1327143 T3 DK 1327143T3
- Authority
- DK
- Denmark
- Prior art keywords
- bace
- crystal structure
- agents
- alzheimer
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23457600P | 2000-09-22 | 2000-09-22 | |
PCT/US2001/029387 WO2002025276A1 (en) | 2000-09-22 | 2001-09-19 | Crystal structure of bace and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1327143T3 true DK1327143T3 (da) | 2007-07-02 |
Family
ID=22881945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01973243T DK1327143T3 (da) | 2000-09-22 | 2001-09-19 | Krystalstruktur af BACE og anvendelse deraf |
Country Status (8)
Country | Link |
---|---|
US (1) | US7630838B2 (da) |
EP (1) | EP1327143B1 (da) |
AT (1) | ATE355520T1 (da) |
AU (1) | AU2001292843A1 (da) |
DE (1) | DE60126970T2 (da) |
DK (1) | DK1327143T3 (da) |
ES (1) | ES2282292T3 (da) |
WO (1) | WO2002025276A1 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1196609A2 (en) | 1999-06-28 | 2002-04-17 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
US7806980B2 (en) | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
US7601528B1 (en) * | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
US7217556B1 (en) * | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
US7524668B1 (en) | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
US7384773B1 (en) | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
CA2464736A1 (en) | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
US20040014194A1 (en) * | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
US7166454B1 (en) | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
US20040096950A1 (en) * | 2002-07-26 | 2004-05-20 | Vuillard Laurent Michel Marie | Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof |
WO2004035606A2 (en) * | 2002-10-15 | 2004-04-29 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
EP2156830A1 (en) | 2002-10-16 | 2010-02-24 | Isis Innovation Limited | Modulators of asparaginyl hydoxylase activity of FIH |
US7906625B2 (en) | 2005-01-24 | 2011-03-15 | Amgen Inc. | Humanized anti-amyloid antibody |
CN101142194B (zh) * | 2005-03-14 | 2012-10-10 | 顶点制药有限责任公司 | 吲哚衍生物,组合物及用作β-分泌酶抑制剂的方法 |
JP2009505979A (ja) * | 2005-08-10 | 2009-02-12 | オクラホマ メディカル リサーチ ファンデーション | アルツハイマー病の治療に使用するためのトランケート型メマプシン2 |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
EP2261254A3 (en) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Anti-amyloid antibodies and uses thereof |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
AR083819A1 (es) | 2010-11-10 | 2013-03-27 | Genentech Inc | UN ANTICUERPO QUE SE UNE A BACE1 (ENZIMA 1 DE DISOCIACION DE PROTEINA PRECURSORA DEL AMILOIDE DE SITIO b), METODOS Y COMPOSICIONES PARA INMUNOTERAPIA PARA ENFERMEDAD NEURAL |
WO2012069428A1 (en) | 2010-11-22 | 2012-05-31 | Noscira, S.A. | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
US20180107782A1 (en) * | 2014-01-20 | 2018-04-19 | Stevan Hubbard | Atomic model for janus kinase-2 (jak2) and uses thereof |
CN107108745B (zh) | 2014-11-19 | 2021-01-12 | 基因泰克公司 | 抗bace1的抗体和其用于神经疾病免疫疗法的用途 |
JP6993228B2 (ja) | 2014-11-19 | 2022-03-03 | ジェネンテック, インコーポレイテッド | 抗トランスフェリン受容体/抗bace1多重特異性抗体および使用方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
US5942400A (en) * | 1995-06-07 | 1999-08-24 | Elan Pharmaceuticals, Inc. | Assays for detecting β-secretase |
GB9626022D0 (en) * | 1996-12-14 | 1997-01-29 | Smithkline Beecham Plc | Novel compounds |
EP0848062A3 (en) * | 1996-12-14 | 2000-07-05 | Smithkline Beecham Corporation | Aspartic protease ASP1 |
GB9701684D0 (en) * | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
US6313268B1 (en) * | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
EP1196609A2 (en) * | 1999-06-28 | 2002-04-17 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2001
- 2001-09-19 DE DE60126970T patent/DE60126970T2/de not_active Expired - Fee Related
- 2001-09-19 DK DK01973243T patent/DK1327143T3/da active
- 2001-09-19 EP EP01973243A patent/EP1327143B1/en not_active Expired - Lifetime
- 2001-09-19 AT AT01973243T patent/ATE355520T1/de not_active IP Right Cessation
- 2001-09-19 WO PCT/US2001/029387 patent/WO2002025276A1/en active IP Right Grant
- 2001-09-19 US US09/955,737 patent/US7630838B2/en not_active Expired - Fee Related
- 2001-09-19 AU AU2001292843A patent/AU2001292843A1/en not_active Abandoned
- 2001-09-19 ES ES01973243T patent/ES2282292T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2001292843A1 (en) | 2002-04-02 |
ATE355520T1 (de) | 2006-03-15 |
US20020055459A1 (en) | 2002-05-09 |
EP1327143A1 (en) | 2003-07-16 |
US7630838B2 (en) | 2009-12-08 |
EP1327143A4 (en) | 2005-02-09 |
EP1327143B1 (en) | 2007-02-28 |
DE60126970D1 (de) | 2007-04-12 |
WO2002025276A1 (en) | 2002-03-28 |
ES2282292T3 (es) | 2007-10-16 |
DE60126970T2 (de) | 2007-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1327143T3 (da) | Krystalstruktur af BACE og anvendelse deraf | |
ATE350044T1 (de) | Thrombopoietinmimetika | |
EE05507B1 (et) | Rosuvastatiini ZD4522) kasutamine heterosgootseperekondliku hperkolesteroleemia raviks | |
DE60025632D1 (de) | Thrombopoietin-mimetika | |
PT1169370E (pt) | Solucoes de poliuretano contendo unidades estruturais de alcoxissilano. | |
DE60025812D1 (de) | Jak-3 hemmer zur behandlung von allergischen störungen | |
MY136707A (en) | Thrombopoietin mimetics | |
CO5611160A2 (es) | Conjugados de agentes terapeuticos o citotoxicos y peptidos biologicamente activos | |
ATE245032T1 (de) | Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen | |
BR0107691A (pt) | Sapogeninas substituìdas e seu uso | |
BR0007527A (pt) | Fenilfenantridinas com atividade inibitória depde-iv | |
HUP0104709A2 (hu) | Eritropoietin vagy eritropoietrinszármazékok alkalmazása agyi iszkémiák kezelésére használható gyógyszer előállítására | |
NO20031860D0 (no) | Kahalaolid F | |
EE04055B1 (et) | Ühendid ja kompositsioonid seriinproteaasse, eriti trüptaasse aktiivsusega seotud haiguste raviks, ja nende kasutamine | |
DE50103006D1 (de) | Mikrobizid wirksame tenside | |
TR199802704T2 (xx) | H�V tedavisinde Vx478, Zidov�din, FTC ve/veya 3TC i�eren kombinasyonlar�n kullan�m�. | |
FI960850A0 (fi) | Kinoksaliinien käyttö proteaasi-inhibiittoreihin yhdistettyinä lääkkeeksi AIDS:in ja/tai HIV-tartuntojen hoitamiseksi | |
DE60101559D1 (de) | Benutzung von comt-inhibitoren als analgetika | |
TR200402030T4 (tr) | İkame edilen I-aminobutan-3-ol-türevleri | |
CY1108053T1 (el) | Ενωση της κυαμεμαζινης και ενος ατυπου νευροληπτικου | |
DE60110087D1 (de) | Verwendung von Carboanhydrase-Inhibitoren zur Prävention von diabetischer Retinopathie bei Diabetikern | |
TR200002939T2 (tr) | Paroksetin maleat | |
EA200400751A1 (ru) | Применение дезоксипеганина для лечения клинической депрессии | |
BR9914722A (pt) | Derivados de anticonvulsivo úteis no tratamento de dependência, vìcio e abuso do álcool | |
ATE262362T1 (de) | Verwendung von cyamemazin zur behandlung von entwöhnungserscheinungen der benzodiazepinbehandlung |