DK1318986T3 - Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler - Google Patents

Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler

Info

Publication number
DK1318986T3
DK1318986T3 DK01979066T DK01979066T DK1318986T3 DK 1318986 T3 DK1318986 T3 DK 1318986T3 DK 01979066 T DK01979066 T DK 01979066T DK 01979066 T DK01979066 T DK 01979066T DK 1318986 T3 DK1318986 T3 DK 1318986T3
Authority
DK
Denmark
Prior art keywords
amino
group
tetrahydrobenzothiazoles
alkyl
preparation
Prior art date
Application number
DK01979066T
Other languages
English (en)
Inventor
Theodorus Hendricus Ant Peters
Karel Pospisilik
Hans Jan Hoorn
Jacobus Maria Lemmens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of DK1318986T3 publication Critical patent/DK1318986T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Steroid Compounds (AREA)
DK01979066T 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler DK1318986T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Publications (1)

Publication Number Publication Date
DK1318986T3 true DK1318986T3 (da) 2006-10-02

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01979066T DK1318986T3 (da) 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler
DK01981155T DK1318987T3 (da) 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01981155T DK1318987T3 (da) 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Country Status (10)

Country Link
US (3) US6770761B2 (da)
EP (2) EP1318986B1 (da)
AT (2) ATE327985T1 (da)
AU (2) AU2002211055A1 (da)
DE (1) DE60120197T2 (da)
DK (2) DK1318986T3 (da)
ES (3) ES2187249B1 (da)
PT (2) PT1318986E (da)
SI (1) SI1318986T1 (da)
WO (2) WO2002022590A1 (da)

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IL162408A0 (en) * 2001-12-11 2005-11-20 Univ Virginia Use of pramipexole to treat amyotrophic lateral scelrosis
AR040682A1 (es) 2002-07-25 2005-04-13 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
CA2560128A1 (en) 2004-03-19 2005-10-06 Dipharma S.P.A. Intermediates for the preparation of pramipexole
US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
CA2572864C (en) 2004-08-13 2014-02-11 Boehringer Ingelheim International Gmbh Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
KR20070050081A (ko) * 2004-08-13 2007-05-14 베링거 인겔하임 인터내셔날 게엠베하 프라미펙솔 또는 약제학적으로 허용되는 이의 염을포함하는 연장 방출형 펠렛 제형, 이의 제조방법 및 이의용도
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
DE112005003227T5 (de) * 2004-12-30 2007-11-15 Chemagis Ltd. Neues Verfahren zur Herstellung von Pramipexol und dem Gemisch seiner optischen Isomeren durch Reduktion mit Natriumtriacetoxyborhydrid
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
CA2619217A1 (en) * 2005-08-15 2007-02-22 University Of Virginia Patent Foundation Neurorestoration with r(+) pramipexole
EP1926486A4 (en) * 2005-09-21 2009-06-10 Chemagis Ltd NOVEL (S) -2,6-DIAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE MONOTARTRATE POLYMORPHS AND METHODS OF MAKING AND USING THE SAME
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
EP1988875A2 (en) * 2006-02-10 2008-11-12 Boehringer Ingelheim International GmbH Modified release formulation
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
WO2007137071A2 (en) 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods of using the same
EP1878731B1 (en) * 2006-06-26 2008-08-20 Helm AG Process for producing pramipexole
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
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WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CA2734491A1 (en) 2008-08-19 2010-02-25 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
CA2765876A1 (en) * 2009-06-19 2010-12-23 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
DK3019167T3 (da) 2013-07-12 2021-03-15 Knopp Biosciences Llc Behandling af forhøjede niveauer af eosinophiler og/eller basophiler
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
EP3033081B1 (en) 2013-08-13 2021-05-12 Knopp Biosciences LLC Compositions and methods for treating chronic urticaria
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304A (zh) * 2023-03-10 2023-05-30 中国药科大学 一种盐酸普拉克索的合成方法

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EP0207696A1 (en) 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazoles and oxazoles
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
AU2002212815A1 (en) 2002-03-26
US6727367B2 (en) 2004-04-27
PT1318986E (pt) 2006-10-31
PT1318987E (pt) 2005-10-31
US20020103240A1 (en) 2002-08-01
EP1318987B1 (en) 2005-08-10
US20040029936A1 (en) 2004-02-12
ATE327985T1 (de) 2006-06-15
DE60120197D1 (de) 2006-07-06
SI1318986T1 (sl) 2006-10-31
US20040068119A1 (en) 2004-04-08
DK1318987T3 (da) 2005-12-12
WO2002022591A1 (en) 2002-03-21
EP1318986A1 (en) 2003-06-18
AU2002211055A1 (en) 2002-03-26
ES2242778T3 (es) 2005-11-16
US6770761B2 (en) 2004-08-03
DE60120197T2 (de) 2007-03-15
EP1318987A1 (en) 2003-06-18
ES2187249A1 (es) 2003-05-16
ATE301646T1 (de) 2005-08-15
EP1318986B1 (en) 2006-05-31
ES2187249B1 (es) 2004-09-16
ES2260296T3 (es) 2006-11-01
WO2002022590A1 (en) 2002-03-21

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