DK1307237T3 - Perfluoroalkyl-containing complexes with polar groups, process for their preparation and use - Google Patents

Perfluoroalkyl-containing complexes with polar groups, process for their preparation and use

Info

Publication number: DK1307237T3
Authority: DK; Denmark
Prior art keywords: perfluoroalkyl; preparation; polar groups; containing complexes; complexes
Prior art date: 2000-08-11

Application number

DK01958005T

Other languages

Danish (da)

Inventor

Johannes Platzek

Peter Mareski

Ulrich Niedballa

Bernd Raduechel

Hanns-Joachim Weinmann

Bernd Misselwitz

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-11

Filing date

2001-07-23

Publication date

2007-07-02

2001-07-23 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2007-07-02 Application granted granted Critical

2007-07-02 Publication of DK1307237T3 publication Critical patent/DK1307237T3/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Radiology & Medical Imaging (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK01958005T 2000-08-11 2001-07-23 Perfluoroalkyl-containing complexes with polar groups, process for their preparation and use DK1307237T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10040858A DE10040858C2 (en)	2000-08-11	2000-08-11	Perfluoroalkyl-containing complexes with polar residues, process for their preparation and their use
PCT/EP2001/008500 WO2002013875A2 (en)	2000-08-11	2001-07-23	Complexes containing perfluoroalkyl with polar radicals, method for the production and use thereof

Publications (1)

Publication Number	Publication Date
DK1307237T3 true DK1307237T3 (en)	2007-07-02

Family

ID=7653176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01958005T DK1307237T3 (en)	2000-08-11	2001-07-23	Perfluoroalkyl-containing complexes with polar groups, process for their preparation and use

Country Status (30)

Country	Link
EP (1)	EP1307237B9 (en)
JP (1)	JP2004506026A (en)
KR (2)	KR20030022381A (en)
CN (1)	CN1468113A (en)
AR (1)	AR035342A1 (en)
AT (1)	ATE359093T1 (en)
AU (2)	AU7977701A (en)
BG (1)	BG107541A (en)
BR (1)	BR0113187A (en)
CA (1)	CA2419259A1 (en)
CZ (1)	CZ2003341A3 (en)
DE (2)	DE10040858C2 (en)
DK (1)	DK1307237T3 (en)
EE (1)	EE200300060A (en)
ES (1)	ES2284671T3 (en)
HR (1)	HRP20030171A2 (en)
HU (1)	HUP0300769A3 (en)
IL (1)	IL154329A0 (en)
MX (1)	MXPA03001286A (en)
NO (1)	NO20030649L (en)
NZ (1)	NZ524080A (en)
PL (1)	PL365367A1 (en)
PT (1)	PT1307237E (en)
RU (1)	RU2289579C2 (en)
SK (1)	SK286239B6 (en)
UA (1)	UA74004C2 (en)
UY (1)	UY26873A1 (en)
WO (1)	WO2002013875A2 (en)
YU (1)	YU10503A (en)
ZA (1)	ZA200301947B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7344704B2 (en)	2002-07-10	2008-03-18	Schering Ag	Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (en) *	2002-07-10	2006-10-05	Schering Ag	Use of perfluoroalkyl-containing metal complexes as contrast agents in MR imaging for the presentation of intravascular thrombi
DE102005033903B4 (en) *	2005-07-15	2007-08-09	Bayer Schering Pharma Ag	Perfluoroalkyl-containing complexes, processes for their preparation, and their use and pharmaceutical compositions containing them
DE102005033902B3 (en) *	2005-07-15	2007-04-05	Schering Ag	Perfluoroalkyl-containing complexes, processes for their preparation, and their use and pharmaceutical compositions containing them
WO2007009637A2 (en) *	2005-07-15	2007-01-25	Bayer Schering Pharma Aktiengesellschaft	Complexes containing perfluoroalkyl, their use as contrast media for nmr, x-ray and radio diagnosis and radiotherapy
DE102006049821A1 (en)	2006-10-18	2008-04-24	Bayer Schering Pharma Aktiengesellschaft	New, well tolerated metal chelates, for use as radiodiagnostic, radiotherapeutic or NMR and X-ray diagnostic agents, contain chelator and perfluorinated polyethylene glycol residues
DE102007015598A1 (en) *	2007-03-29	2008-10-02	Heinrich-Heine-Universität Düsseldorf	Use of fluorochemical compounds for diagnostic purposes using imaging techniques
EP3101012A1 (en)	2015-06-04	2016-12-07	Bayer Pharma Aktiengesellschaft	New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (en)	2016-11-28	2022-11-08	바이엘 파마 악티엔게젤샤프트	High Relaxation Gadolinium Chelate Compounds for Use in Magnetic Resonance Imaging
RU2681319C1 (en) *	2017-10-27	2019-03-06	Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский экономический университет имени Г.В. Плеханова" (ФГБОУ ВО "РЭУ им. Г.В. Плеханова")	Ultra-fibrous biopolymer material with bactericidal effect
BR112021007707A2 (en)	2018-11-23	2021-07-27	Bayer Aktiengesellschaft	formulation of contrast media and its preparation process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4317588C2 (en) *	1993-05-24	1998-04-16	Schering Ag	Macrocyclic metal complexes containing fluorine, process for their preparation and their use
DE19603033A1 (en) *	1996-01-19	1997-07-24	Schering Ag	Perfluoroalkyl-containing metal complexes, processes for their preparation and their use in NMR diagnostics
DE19608278A1 (en) *	1996-02-23	1997-08-28	Schering Ag	Pharmaceutical compositions containing perfluoroalkyl-containing metal complexes, and their use in tumor therapy and interventional radiology
DE19729013A1 (en) *	1997-07-03	1999-02-04	Schering Ag	Oligomeric, perfluoroalkyl-containing compounds, processes for their preparation and their use in NMR diagnostics
DE19744004C1 (en) *	1997-09-26	1999-07-22	Schering Ag	Lipophilic metal complexes for necrosis and infarct imaging

2000
- 2000-08-11 DE DE10040858A patent/DE10040858C2/en not_active Expired - Fee Related
2001
- 2001-07-23 NZ NZ524080A patent/NZ524080A/en unknown
- 2001-07-23 ES ES01958005T patent/ES2284671T3/en not_active Expired - Lifetime
- 2001-07-23 EP EP01958005A patent/EP1307237B9/en not_active Expired - Lifetime
- 2001-07-23 PL PL01365367A patent/PL365367A1/en unknown
- 2001-07-23 MX MXPA03001286A patent/MXPA03001286A/en not_active Application Discontinuation
- 2001-07-23 EE EEP200300060A patent/EE200300060A/en unknown
- 2001-07-23 AT AT01958005T patent/ATE359093T1/en not_active IP Right Cessation
- 2001-07-23 CA CA002419259A patent/CA2419259A1/en not_active Abandoned
- 2001-07-23 IL IL15432901A patent/IL154329A0/en not_active IP Right Cessation
- 2001-07-23 DK DK01958005T patent/DK1307237T3/en active
- 2001-07-23 UA UA2003032068A patent/UA74004C2/en unknown
- 2001-07-23 JP JP2002519013A patent/JP2004506026A/en not_active Withdrawn
- 2001-07-23 BR BR0113187-7A patent/BR0113187A/en not_active IP Right Cessation
- 2001-07-23 SK SK155-2003A patent/SK286239B6/en unknown
- 2001-07-23 WO PCT/EP2001/008500 patent/WO2002013875A2/en active IP Right Grant
- 2001-07-23 AU AU7977701A patent/AU7977701A/en active Pending
- 2001-07-23 DE DE50112336T patent/DE50112336D1/en not_active Expired - Fee Related
- 2001-07-23 RU RU2003105813/04A patent/RU2289579C2/en not_active IP Right Cessation
- 2001-07-23 AU AU2001279777A patent/AU2001279777B2/en not_active Ceased
- 2001-07-23 KR KR10-2003-7001937A patent/KR20030022381A/en not_active Application Discontinuation
- 2001-07-23 PT PT01958005T patent/PT1307237E/en unknown
- 2001-07-23 HU HU0300769A patent/HUP0300769A3/en unknown
- 2001-07-23 CZ CZ2003341A patent/CZ2003341A3/en unknown
- 2001-07-23 CN CNA018170765A patent/CN1468113A/en active Pending
- 2001-07-23 YU YU10503A patent/YU10503A/en unknown
- 2001-07-23 KR KR1020087003857A patent/KR20080027397A/en not_active Application Discontinuation
- 2001-08-07 UY UY26873A patent/UY26873A1/en not_active Application Discontinuation
- 2001-08-10 AR ARP010103832A patent/AR035342A1/en unknown
2003
- 2003-02-07 BG BG107541A patent/BG107541A/en unknown
- 2003-02-10 NO NO20030649A patent/NO20030649L/en not_active Application Discontinuation
- 2003-03-10 HR HR20030171A patent/HRP20030171A2/en not_active Application Discontinuation
- 2003-03-10 ZA ZA200301947A patent/ZA200301947B/en unknown

Also Published As

Publication number	Publication date
AR035342A1 (en)	2004-05-12
SK1552003A3 (en)	2003-09-11
DE10040858A1 (en)	2002-03-28
UA74004C2 (en)	2005-10-17
KR20030022381A (en)	2003-03-15
BG107541A (en)	2004-01-30
NO20030649L (en)	2003-04-11
WO2002013875A2 (en)	2002-02-21
CZ2003341A3 (en)	2003-05-14
UY26873A1 (en)	2002-03-22
JP2004506026A (en)	2004-02-26
ATE359093T1 (en)	2007-05-15
EE200300060A (en)	2004-12-15
PT1307237E (en)	2007-07-02
DE50112336D1 (en)	2007-05-24
HUP0300769A2 (en)	2003-09-29
ES2284671T3 (en)	2007-11-16
YU10503A (en)	2006-08-17
CN1468113A (en)	2004-01-14
EP1307237A2 (en)	2003-05-07
EP1307237B9 (en)	2008-01-09
AU2001279777B2 (en)	2006-08-31
WO2002013875A3 (en)	2002-08-22
ZA200301947B (en)	2004-06-25
EP1307237B1 (en)	2007-04-11
DE10040858C2 (en)	2003-12-18
RU2289579C2 (en)	2006-12-20
CA2419259A1 (en)	2002-02-21
BR0113187A (en)	2003-07-01
NZ524080A (en)	2005-10-28
NO20030649D0 (en)	2003-02-10
PL365367A1 (en)	2004-12-27
HUP0300769A3 (en)	2009-03-02
MXPA03001286A (en)	2004-04-20
AU7977701A (en)	2002-02-25
HRP20030171A2 (en)	2004-06-30
KR20080027397A (en)	2008-03-26
IL154329A0 (en)	2003-09-17
SK286239B6 (en)	2008-06-06

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