DK1305406T3 - Modulering af gamma-sekretaseaktivitet - Google Patents
Modulering af gamma-sekretaseaktivitetInfo
- Publication number
- DK1305406T3 DK1305406T3 DK01935260T DK01935260T DK1305406T3 DK 1305406 T3 DK1305406 T3 DK 1305406T3 DK 01935260 T DK01935260 T DK 01935260T DK 01935260 T DK01935260 T DK 01935260T DK 1305406 T3 DK1305406 T3 DK 1305406T3
- Authority
- DK
- Denmark
- Prior art keywords
- app
- gamma
- secretase
- assay
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Holo Graphy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20350600P | 2000-05-11 | 2000-05-11 | |
PCT/US2001/015089 WO2001085924A2 (en) | 2000-05-11 | 2001-05-09 | MODULATION OF η-SECRETASE ACTIVITY |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1305406T3 true DK1305406T3 (da) | 2007-01-08 |
DK1305406T4 DK1305406T4 (da) | 2015-02-02 |
Family
ID=22754280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01935260.8T DK1305406T4 (da) | 2000-05-11 | 2001-05-09 | Modulering af gamma-sekretaseaktivitet |
Country Status (8)
Country | Link |
---|---|
US (2) | US6579689B2 (da) |
EP (1) | EP1305406B2 (da) |
JP (1) | JP2003532413A (da) |
AT (1) | ATE339496T1 (da) |
AU (1) | AU2001261368A1 (da) |
DE (1) | DE60123074T3 (da) |
DK (1) | DK1305406T4 (da) |
WO (1) | WO2001085924A2 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001075435A2 (en) * | 2000-04-03 | 2001-10-11 | Bristol-Myers Squibb Company | Fluorescence assay for gamma-secretase activity and inhibitors |
US20030022251A1 (en) * | 2001-07-04 | 2003-01-30 | Boehringer Ingelheim Pharma Kg | Gamma-secretase in vitro screening assay |
WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
WO2003091278A1 (fr) * | 2002-04-24 | 2003-11-06 | Hiroshi Mori | Inhibiteurs de gamma secretase |
CA2603676A1 (en) * | 2005-01-07 | 2006-07-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds |
WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4372888A (en) † | 1980-08-26 | 1983-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Nondenaturing zwitterionic detergents |
CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
GB9608657D0 (en) | 1996-04-26 | 1996-07-03 | Smithkline Beecham Plc | Novel treatment |
WO1998015828A1 (en) * | 1996-10-07 | 1998-04-16 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
US6313268B1 (en) † | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
DE19941039A1 (de) | 1999-08-28 | 2001-03-01 | Boehringer Ingelheim Pharma | gamma-Sekretase in vitro Testsystem |
DE10000161A1 (de) | 2000-01-06 | 2001-07-19 | Boehringer Ingelheim Pharma | Verfahren zur Identifikation eines Proteaseinhibitors |
WO2001075435A2 (en) | 2000-04-03 | 2001-10-11 | Bristol-Myers Squibb Company | Fluorescence assay for gamma-secretase activity and inhibitors |
-
2001
- 2001-05-09 EP EP01935260.8A patent/EP1305406B2/en not_active Expired - Lifetime
- 2001-05-09 AU AU2001261368A patent/AU2001261368A1/en not_active Abandoned
- 2001-05-09 DE DE60123074.4T patent/DE60123074T3/de not_active Expired - Lifetime
- 2001-05-09 US US09/852,914 patent/US6579689B2/en not_active Expired - Lifetime
- 2001-05-09 AT AT01935260T patent/ATE339496T1/de not_active IP Right Cessation
- 2001-05-09 WO PCT/US2001/015089 patent/WO2001085924A2/en active IP Right Grant
- 2001-05-09 DK DK01935260.8T patent/DK1305406T4/da active
- 2001-05-09 JP JP2001582513A patent/JP2003532413A/ja active Pending
-
2003
- 2003-06-17 US US10/464,036 patent/US20030211559A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1305406B2 (en) | 2014-11-12 |
ATE339496T1 (de) | 2006-10-15 |
DE60123074D1 (de) | 2006-10-26 |
US6579689B2 (en) | 2003-06-17 |
DK1305406T4 (da) | 2015-02-02 |
US20010055782A1 (en) | 2001-12-27 |
US20030211559A1 (en) | 2003-11-13 |
EP1305406B1 (en) | 2006-09-13 |
DE60123074T3 (de) | 2015-01-29 |
WO2001085924A3 (en) | 2003-02-27 |
JP2003532413A (ja) | 2003-11-05 |
DE60123074T2 (de) | 2007-03-01 |
EP1305406A2 (en) | 2003-05-02 |
WO2001085924A2 (en) | 2001-11-15 |
AU2001261368A1 (en) | 2001-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1210411T3 (da) | Sammensætninger og fremgangsmåder til forbedret celledyrkning | |
ATE450635T1 (de) | Elektrochemische herstellung von peroxo- dischwefelsäure unter einsatz von diamantbeschichteten elektroden | |
HUP0301245A2 (hu) | Eljárás K-vitamin-függż fehérjék elżállítására | |
ATE293696T1 (de) | Mutierte alpha-amylase enzyme mit erhöhter stabilität | |
WO2003104418A3 (en) | RECONSTITUTED POLYPEPTIDES | |
ATE430807T1 (de) | Verfahren zur kultivierung von circovirus | |
ATE498011T1 (de) | Modifizierte embryonale stammzellen und embryonales stammzellspezifisches gen | |
EA200401591A1 (ru) | Керамические аноды и способ их изготовления | |
ATE430589T1 (de) | Wasserbehandlung zur kontrolle von biobewuchs mittels stabilisierter bromlösungen | |
ATE437652T1 (de) | Verwendung von hmgb1 zur aktivierung dendritischer zellen | |
IL150168A0 (en) | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods bsed thereon | |
DE69942459D1 (de) | Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung | |
DK1266011T3 (da) | Svampetranskriptionsaktivator, der er anvendelig i fremgangsmåder til fremstilling af polypeptider | |
MXPA03005548A (es) | Metodos para la produccion de proteinas multimericas, y composiciones relacionadas. | |
ATE397084T1 (de) | Lentivirale verpackungskonstrukte | |
DK1117798T3 (da) | Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider | |
DK1305406T3 (da) | Modulering af gamma-sekretaseaktivitet | |
WO2004011637A3 (en) | Modified adamts4 molecules and method of use thereof | |
DK0866848T3 (da) | Forbedrede neurospora-værter til fremstilling af rekombinante proteiner og fremgangsmåde til fremstilling af samme | |
WO2003021265A8 (en) | Genetic construct intracellular monitoring system | |
WO2003012089A3 (en) | Crystal structure of beta-site app cleaving enzyme (bace) and use thereof | |
AU7843101A (en) | Furin polypeptides with improved characteristics | |
GB9720693D0 (en) | Assay | |
ATE334592T1 (de) | Biologische bekämpfung von nematoden | |
WO1999037758A3 (en) | Expression of proteolytically-sensitive peptides |