DK129835B - Analogifremgangsmåde til fremstilling af 2-chlor-6α-fluor-16α-methyl-pregna-1,4-dien-3,20-dioner. - Google Patents

Analogifremgangsmåde til fremstilling af 2-chlor-6α-fluor-16α-methyl-pregna-1,4-dien-3,20-dioner.

Info

Publication number
DK129835B
DK129835B DK559768AA DK559768A DK129835B DK 129835 B DK129835 B DK 129835B DK 559768A A DK559768A A DK 559768AA DK 559768 A DK559768 A DK 559768A DK 129835 B DK129835 B DK 129835B
Authority
DK
Denmark
Prior art keywords
pregna
diones
diene
fluoro
chloro
Prior art date
Application number
DK559768AA
Other languages
English (en)
Other versions
DK129835C (da
Inventor
G Anner
L Ehmann
J Kalvoda
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to DK285874A priority Critical patent/DK133109C/da
Publication of DK129835B publication Critical patent/DK129835B/da
Application granted granted Critical
Publication of DK129835C publication Critical patent/DK129835C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R33/00—Coupling devices specially adapted for supporting apparatus and having one part acting as a holder providing support and electrical connection via a counterpart which is structurally associated with the apparatus, e.g. lamp holders; Separate parts thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
DK559768AA 1967-11-17 1968-11-15 Analogifremgangsmåde til fremstilling af 2-chlor-6α-fluor-16α-methyl-pregna-1,4-dien-3,20-dioner. DK129835B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK285874A DK133109C (da) 1967-11-17 1974-05-27 Analogifremgangsmade til fremstilling af 2-chlor-6alfa-fluor-16alfa-methyl-pregna-1,4-dien-11beta,17alfa,21-triol-3,20-dioner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1610167A CH510655A (de) 1967-11-17 1967-11-17 Verfahren zur Herstellung neuer Halogenpregnadiene

Publications (2)

Publication Number Publication Date
DK129835B true DK129835B (da) 1974-11-25
DK129835C DK129835C (da) 1975-05-05

Family

ID=4414467

Family Applications (1)

Application Number Title Priority Date Filing Date
DK559768AA DK129835B (da) 1967-11-17 1968-11-15 Analogifremgangsmåde til fremstilling af 2-chlor-6α-fluor-16α-methyl-pregna-1,4-dien-3,20-dioner.

Country Status (15)

Country Link
US (1) US3652554A (da)
JP (1) JPS4829221B1 (da)
AT (3) AT293633B (da)
BE (1) BE723905A (da)
BR (1) BR6804024D0 (da)
CH (4) CH540244A (da)
DK (1) DK129835B (da)
FR (2) FR1594773A (da)
GB (1) GB1245292A (da)
MY (1) MY7400317A (da)
NL (1) NL161767C (da)
PL (1) PL80570B1 (da)
SE (1) SE351634B (da)
SU (1) SU424352A3 (da)
YU (4) YU34138B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2010458B2 (de) * 1970-02-28 1979-04-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 21-Halogensteroide
CH558787A (de) * 1970-12-10 1975-02-14 Ciba Geigy Ag Verfahren zur herstellung eines neuen halogenpregnadiens.
GB1377608A (en) * 1970-12-17 1974-12-18 Glaxo Lab Ltd 3alpha-hydroxy or acyloxy pregnene-21-ethers
NL7502252A (nl) * 1974-02-27 1975-08-29 Pierrel Spa Werkwijze voor het bereiden van een geneesmid- del met anti-inflammatoire werking, gevormd ge- neesmiddel verkregen volgens deze werkwijze alsmede werkwijze voor het bereiden van in het geneesmiddel gebruikte nieuwe steroiden.
SE418294B (sv) * 1974-03-27 1981-05-18 Plurichemie Anstalt Sett att framstella en 16alfa- eller 16beta-9alfa-klor eller -fluorsteroidester
FR2291760A1 (fr) * 1974-11-19 1976-06-18 Pierrel Spa Nouveaux steroides a base de 2-chloro-6 b-fluoro-pregna-1,4-diene-3,20-diones
GB1505701A (en) * 1975-06-14 1978-03-30 Pierrel Spa 2-chloro-6beta-fluoropregnanes
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
WO2005021515A2 (en) * 2003-08-29 2005-03-10 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-iv
EP1694655A2 (en) * 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
JP2009512677A (ja) * 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ホスホジエステラーゼタイプｉｖ阻害剤の組成物
CA2626612A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
EP2066661A2 (en) * 2006-09-22 2009-06-10 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
CA2664247A1 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-iv
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
AU2008224541B2 (en) * 2007-03-14 2013-08-22 Sun Pharmaceutical Industries Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
CN102827229B (zh) * 2011-06-17 2016-01-20 重庆华邦胜凯制药有限公司 一种纯化卤米松羧酸酯的方法
CN104370987B (zh) * 2014-10-22 2016-09-14 湖南明瑞制药有限公司 一种卤米松的精制方法
CN111944004B (zh) * 2020-09-25 2023-11-17 湖南新合新生物医药有限公司 一种卤米松的制备方法

Also Published As

Publication number Publication date
AT298695B (de) 1972-05-25
SU424352A3 (da) 1974-04-15
SE351634B (da) 1972-12-04
YU30675A (en) 1982-05-31
BR6804024D0 (pt) 1973-01-02
NL161767C (nl) 1980-03-17
YU34138B (en) 1978-12-31
CH534144A (de) 1973-02-28
BE723905A (da) 1969-05-14
US3652554A (en) 1972-03-28
DK129835C (da) 1975-05-05
GB1245292A (en) 1971-09-08
AT298690B (de) 1972-04-15
YU30775A (en) 1982-05-31
YU267368A (en) 1978-06-30
DE1807980A1 (de) 1969-06-04
PL80570B1 (da) 1975-08-30
CH510655A (de) 1971-07-31
CH540244A (de) 1973-08-15
NL6816337A (da) 1969-05-20
FR1594773A (da) 1970-06-08
MY7400317A (en) 1974-12-31
DE1807980B2 (de) 1975-11-06
AT293633B (de) 1971-10-25
YU30875A (en) 1982-05-31
CH513845A (de) 1971-10-15
JPS4829221B1 (da) 1973-09-08
FR8278M (da) 1970-11-02

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